JPH0217110A - Gypsum material for tooth form model - Google Patents

Abstract

PURPOSE:To provide the subject gypsum material itself having an excellent antibacterial activity and capable of preventing the contamination due to bacteria and virus transferred from an impression material by adding benzethonium chloride and/or benzalkonium chloride in a specific rate to gypsum powder. CONSTITUTION:A gypsum material for dental form models comprises 100pts.wt. of gypsum powder and 0.025-1.0pt.wt. of benzethonium chloride of formula I and/or benzalkonium chloride of formula II (R is C8H17-C18H37) (these compounds both have antibacterial agents having wide antibacterial spectra and HBS antigen-inactivating actions, respectively). Since the gypsum material itself is provided with a bacterium-removing functions, the danger of various infections to dental technicians can be avoided. The gypsum material is excellent in the own characteristics such as curability, volume change in the curing, strength, etc.

Description

[Detailed Description of the Invention] (Industrial Application Field) The present invention is applicable to teeth Ij:! in dentistry. Concerning plaster materials used for making models.

(Prior art and its problems) In general, dental molds are created by pressing an impression material based on alginate or agar over the patient's teeth and gums and hardening (gelling) to create a concave impression. obtained,
A dental technician injects plaster into the concave mold of the impression material to be taken.
This procedure involves removing a hardened plaster mold and making it into a tooth model.

Because it comes into direct contact with the inside of the cavity, body fluids such as saliva and blood, as well as stains such as dental plaque and food residue, adhere to it, and it is inevitably contaminated with bacteria and viruses carried by the patient.

Naturally, contamination will also transfer from this contaminated impression material to the plaster mold that will be molded.

Therefore, among dental medical professionals, especially dental technicians involved in making tooth impressions, they are reluctant to remove contaminated plaster molds (and are reluctant to use sharp tools such as °ζ carbide burs during the procedure). There are many opportunities to get scratches on hands and fingers due to the use of gFg, and to inhale fine powder produced by gFg plaster mold processing, which poses a high risk of various infections. There are concerns about infection.

(Means for Solving the Problems) In view of the above-mentioned circumstances, the present invention provides an innovative plaster material that is used for making dental models and which itself has a sterilization function, thereby providing dental care. The aim is to eliminate the risk of various infections in the laboratory.

Here, in order to achieve the above-mentioned purpose, the above-mentioned impression material is made of benzethonium chloride or /' and henzalkonium chloride 0.
025 to 1.0 A composition in which 1 part of FF is blended is adopted.

(Detailed structure and operation of the invention) In the present invention, it is represented by penze chloride mixed into plaster, and benzalkonium chloride is represented by the following structural formula; It is known as an antibacterial agent with a broad antibacterial spectrum and an anti-HBs (hepatitis B surface resistance) inactivation effect, but it has particularly excellent compatibility with plaster for dental models. I am doing it myself.

In other words, as an antibacterial agent for plaster formulation, in order to prevent the plaster powder containing it from solidifying before use, C.
It must be solid and contain as little free water as possible, and when the C71 plaster is dissolved in water to form a mold, it must immediately dissolve in the water and exert an antibacterial effect, of course. In addition, compounds are required to have good stability and long-lasting action. Therefore, both benzethonium chloride and benzalkonium chloride can be obtained in powder form at room temperature, and are easily water-soluble and have a low molecular weight.
It is a compound that exhibits high antibacterial activity (for example, the minimum effective concentration for TL B s anti-apical inactivation is 0.01% for benzethonium chloride and 0.04% for benzalkonium chloride), and has excellent stability. Therefore, all the necessary characteristics for the above-mentioned gypsum compound are set as i[11fl.

Antibacterial agents that have a broad antibacterial spectrum and exhibit HRs antigen inactivation effects against dirt include chlorine-based antibacterial agents such as sodium chlorate and high-grade salt powder, and cocoyl alginate ester (CAE...6N''- Cocoyl
-1,-arIHinine eLhylesLe
rOL, -pyroglr+1asic acid
Cationic surfactant-based antibacterial agents such as Irgasan DP-300 (trade name 5 of Chiha Geigy, Switzerland)
2,4,4-trichloro-2°-hydroquine-diphenyl ether) and the like are known, but none of these are suitable for use in gypsum formulations. In other words, chlorine-based antibacterial agents have poor stability and difficulty in maintaining antibacterial action, and there are also problems with toxicity and corrosion due to C12 gas produced by decomposition, and CA
Since E and Irgasan DP-300 are N-soluble in water, they have the disadvantage of being difficult to exhibit antibacterial action.

The amount of henzethonium chloride and/or benzalkonium chloride in the plaster material for dental models of the present invention should be in the range of 0.025 to 1 g part per 100 parts by weight of the plaster powder. That is, this blending amount is 0.0
25 If it is less than the 1st section of the city, 9 has been transferred from the impression material.
1. The antibacterial effect against bacteria is insufficient, and on the contrary, 1. OM
Even if the amount exceeds 9 parts, the antibacterial properties are almost saturated, and it is also expensive, making it uneconomical. Note that benzethonium chloride and henzalkonium chloride may be used together.

Is this henzetoni chloride? As a means of blending zum or/and henzalkonium chloride into the gypsum powder, 'ζ can be mixed with the gypsum powder in the form of the Song Dynasty, in addition to the method of mixing it with the gypsum powder in the field, or the method of mixing it with the gypsum powder in a small amount such as highly concentrated ethyl alcohol (for example, 1 to 3
It is also possible to use a method in which the gypsum powder is dissolved in a volatile solvent (approximately twice the volume) and then sprayed or directly added to the gypsum powder, and after the solvent has volatilized, the gypsum powder is stirred and mixed. In addition, in order to uniformly disperse benzethonium chloride and/or henzalkonium chloride in these formulations, first mix this with a small amount of gypsum powder, and then add gypsum powder to this mixture in several portions. It is best to stir and mix the ingredients to make a final gypsum material with the required amount of benzethonium chloride and/or henzalkonium chloride.Also, if agglomeration occurs when adding it as a solution, use a pulverizer to crush it.
That's fine.

Thus, plaster materials for dental models containing benzethonium chloride and/or Handel's chloride are superior to conventional dental molds that do not contain antibacterial agents in terms of properties such as hardenability, volume change during curing, and strength of the cured product. It is equivalent to plaster for modeling.Its use is similar to conventional ones, when mixed with water,
Apply this mixture to the concave mold of the hardened impression material after taking the impression.
All you have to do is put it in, release it after curing, and apply the necessary techniques, and you can obtain a tooth model with perfect molding accuracy and strength (no problems).

(Example) Hereinafter, examples of the present invention will be described, including a performance comparison LK experiment (Explanation-4). In addition, in the following, "part" means 9 parts by weight.

Actuallyll1I! Example 1 Mixture with 5 parts of gypsum powder↑chloride in the machine)
・After adding 0.1 part of lithium powder and mixing and stirring, add 15 parts of gypsum powder and mix and stir, then add 30 parts and 50 parts of gypsum powder one after another and mix and stir in the same way to obtain gypsum powder. A gypsum material containing an antibacterial agent was prepared by uniformly mixing 0.1 part of benzethonium chloride per 100 parts.

On the other hand, an impression covering the entire lower tooth of a 50-year-old man was taken on a sterilized tray using a combination of agar for Indo-Australian materials and ruginate for impression materials. was divided into two approximately along the midline using a metal plate. Then, ζ, the four halves of this impression material were injected with JJ1 regular model plaster mixed with water, and the left half was filled with the above antibacterial agent-containing plaster material mixed with water. Each wear 1 - After curing at room temperature in a bath, these are removed to obtain a plaster model! Teeth number on the plaster model in Part 11? , 6, 5.4.3, and tooth number 3, 4, 5.6.7 of the left half-body stone bird model in the jaw part of each tooth and jaw] and bar C-11ζ, Mark 1 each
! Type M was added to the agar medium. Then, each of the M types of culture media was left in a thermostatic chamber at 36±l'c to check for bacterial growth, and the results shown in Table 1 were obtained. In addition, the symbol (+) in the table means that there is bacterial propagation, and the symbol (-) means that there is no bacterial propagation.

Table Example 2 Henzalkonium chloride 0.0% instead of benzethonium chloride.
A plaster material containing an antibacterial agent was obtained in the same manner as in Example 1 except that 1 part was used. Then, using this plaster material and ordinary plaster for modeling, it was carried out in the same manner as in Example 1.
When a plaster model was prepared and a bacterial propagation test was conducted on the impression material prepared in accordance with Example 1, results were shown in Table 2 below.
The results were obtained.

Fruitful &! Example 3 Example! , 2, to 100 parts of gypsum powder, 0.0125 part, 0.025 part, and 0.7 zethonium chloride powder and 0.025 part of henzalkonium chloride powder were added, respectively.
Antibacterial agent-containing plaster materials containing 0.05 parts and 0.1 parts were prepared. For each gypsum material and gypsum powder without antibacterial agents,
On the other hand, the garbage receptacle in the kitchen sink has a bacterial count of 5 XIO'li1/ml of bacteria water (standard agar medium 36℃, viable bacteria count measured at 48 hrl) 1-
Kneading water 24-1 to which 1 was added, and the same N bacterial water IQ
Kneading water 24-1 containing mj was used to knead each of B for 1 minute, immediately after kneading (J) and after 10 minutes after kneading (I
I)? :! Pour 2 to 3 g of kneaded gypsum into two Petri dishes, and immediately add 20% of standard agar medium at about 50°C to each Petri dish.
After the medium was injected and the medium solidified, it was left in a thermostat at 36°C ± 1°C, and the presence or absence of bacterial growth near the plaster and in the medium was examined for each number of days it was left in Tables 3-1 to 3-3. Results expressed as 4 were obtained. In addition, the symbol (+) in the table means that there is bacterial propagation, and the symbol (-) means that there is no bacterial propagation.

From the results in Tables 3-1 to 3-4, it is clear that both benzethonium chloride and benzalkonium chloride have a sufficient anti-2g content when mixed at 0,025 parts or more per 100 parts of stone lif powder.
It is clear that the effect is reduced by 1η.

Example 4 99.5% of 3 times the volume of 0.1 part of Henze I.Nium chloride
Dissolve in ethyl alcohol, add this solution to 6 parts of gypsum powder at 40°C by spraying with stirring, and after the ethyl alcohol has evaporated, add 14 parts of gypsum powder and mix and stir! 1! Next, add 30 parts and 50 parts of gypsum powder one by one and mix and stir 11! A gypsum material formula with anti-dusting agent was obtained.

For this plaster material formula and plaster material B with anti-oxidant obtained in Example 2, +41 soh, ? jl water II 24ml/1
00g Toshite, gypsum properties JIS-T6605
The results shown in Table 4 were obtained.

From the results in Table 4, it is clear that the plaster material of the present invention has no problems in hardenability, volume change upon hardening, strength, etc., and has sufficient suitability as plaster for dental models.

(Effects unique to the invention) According to the plaster material for dental models of the present invention, since the plaster material itself has an excellent antibacterial effect, it is effective against body fluids and dirt in the patient's oral cavity during the creation of tooth molds. Prevents the transfer of bacteria and viruses from contaminated impression materials to plaster tooth models, and prevents LRF staining.
This avoids various infection risks in dental techniques. In addition, this stone ingot has sufficient permeability as a plaster for dental models in terms of stone-green properties such as hardening properties, volume change upon hardening, and strength.

Claims (1)

[Claims] Benzethonium chloride or/and benzalkonium chloride is 0.025 to 1.0 per 100 parts by weight of gypsum powder.
Plaster material for dental models containing parts by weight.