JPH0219164A - Gelatin film for stanching and sealing wound and manufacture thereof - Google Patents
Gelatin film for stanching and sealing wound and manufacture thereofInfo
- Publication number
- JPH0219164A JPH0219164A JP63169232A JP16923288A JPH0219164A JP H0219164 A JPH0219164 A JP H0219164A JP 63169232 A JP63169232 A JP 63169232A JP 16923288 A JP16923288 A JP 16923288A JP H0219164 A JPH0219164 A JP H0219164A
- Authority
- JP
- Japan
- Prior art keywords
- gelatin
- film
- gelatin film
- wound
- hemostasis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010025899 gelatin film Proteins 0.000 title claims abstract description 30
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- 238000007789 sealing Methods 0.000 title claims description 10
- 108010010803 Gelatin Proteins 0.000 claims abstract description 38
- 239000008273 gelatin Substances 0.000 claims abstract description 38
- 229920000159 gelatin Polymers 0.000 claims abstract description 38
- 235000019322 gelatine Nutrition 0.000 claims abstract description 38
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 38
- 239000010408 film Substances 0.000 claims abstract description 17
- 239000010409 thin film Substances 0.000 claims abstract description 5
- 230000023597 hemostasis Effects 0.000 claims description 12
- 239000000701 coagulant Substances 0.000 claims description 2
- 239000000645 desinfectant Substances 0.000 claims description 2
- 231100000344 non-irritating Toxicity 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 11
- 238000000034 method Methods 0.000 abstract description 9
- 206010052428 Wound Diseases 0.000 description 14
- 208000027418 Wounds and injury Diseases 0.000 description 14
- 238000000465 moulding Methods 0.000 description 7
- 208000007536 Thrombosis Diseases 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 5
- 239000010839 body fluid Substances 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- IYLLULUTZPKQBW-UHFFFAOYSA-N Acrinol Chemical compound CC(O)C(O)=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 IYLLULUTZPKQBW-UHFFFAOYSA-N 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 230000002439 hemostatic effect Effects 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 208000002847 Surgical Wound Diseases 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 206010065360 Anal prolapse Diseases 0.000 description 1
- 241001269524 Dura Species 0.000 description 1
- 241000406668 Loxodonta cyclotis Species 0.000 description 1
- 206010051077 Post procedural haemorrhage Diseases 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 238000010879 hemorrhoidectomy Methods 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004224 pleura Anatomy 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000011470 radical surgery Methods 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、止血および傷口封止用ゼラチンフィルムとそ
の製造法に関し、更に詳しくは、止血性および傷口封止
性に秀れた極薄の未変性ゼラチンフィルム、並びにその
ようなゼラチンフィルムを簡易かつ経済的に製造するこ
とができる新方法に関し、手術創面の止血、火傷面の被
覆保護、その他救急処置用の止血貼剤として秀れた瞬間
止血作用によって医療活動上に多いに役立つものである
。[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to a gelatin film for hemostasis and wound sealing and a method for producing the same, and more specifically, to an ultra-thin gelatin film with excellent hemostasis and wound sealing properties. Regarding undenatured gelatin films and new methods for producing such gelatin films simply and economically, this moment is an excellent moment for use as hemostatic patches for surgical wound hemostasis, burn protection, and other emergency procedures. It is of great use in medical activities due to its hemostatic effect.
〔従来の技術、および解決すべき技術的課題〕周知のと
おり、手術時における硬膜や胸膜のごとき膜状組織の欠
損を充填保護する手段としてゼラチンフィルムを使用し
ようとする提案は１９５０年のＪ、Ｔ、Ｃｏｒｒｅｌｌ
を１矢とし、翌１９５１年ニ至ってＪ、ＰＪｅｉｎ
Ｍａｎｎが軟化ゼラチンフィルムを大脳硬膜癒着の防止
、および眼科手術の癒着防止に成功したことによって実
用化の途が拓かれたものと云える。そして、その後、ゼ
ラチンフィルムは膜組織の癒着防止用剤として米国のア
ップジョン社によって［ゼルフィルム（商品名）」の名
で大々的に実施され、医学関係者に汎用されて今日に至
っている次第である。[Prior art and technical problems to be solved] As is well known, the proposal to use gelatin film as a means to fill and protect defects in membranous tissues such as the dura and pleura during surgery was published in 1950 in J. , T.Correll
The following year, in 1951, J.P.Jein
Mann's success in using softened gelatin films to prevent cerebral dural adhesions and adhesion in ophthalmic surgery can be said to have paved the way for practical application. After that, gelatin film was widely used as an agent for preventing adhesion of membrane tissue by Upjohn Company in the United States under the name "Zelfilm (product name)" and is widely used by medical professionals to this day. be.
ところで、ゼラチンフィルムを医療用として利用せんと
した従前の提案は、ゼラチンフィルムを創面組織間に介
在させ両組職を遮断して相互癒着を抑制しようとする点
に主眼が置かれてぃて、其処に用いられていたものは豚
の皮革より得たゼラチンを氷酢酸とホルマリンで処理し
たところの所謂「変性ゼラチ刈であって吸水膨潤性は保
有してはいても、粘着性は見られず、細胞組織に対する
所謂［剥離剤［としての分離作用と感触のソフト性とい
う適合作用とを補完する限度でしか考えられていなかっ
たのである。By the way, previous proposals for using gelatin films for medical purposes have focused on interposing gelatin films between wound tissues to block both tissues and suppress mutual adhesions. The gelatin used there was so-called ``denatured gelatin,'' made by treating gelatin obtained from pig skin with glacial acetic acid and formalin, and although it had water absorption and swelling properties, it did not show any stickiness. However, it was only considered to complement the separating action as a so-called exfoliating agent on cell tissues and the compatible action of soft touch.
しかしながら、未変性ゼラチンそのものは、本来、非常
に強い瞬間役水性、溶解硬化性および粘着性を保有して
おり、か−るゼラチンの物性は医療上も利用できる筈で
ある。このような情況から、本発明者は、か＼るゼラチ
ンの物性を医療手段に利用する方途を求めて試行錯誤的
研究を長年重ねてきた次第であり、その結果、未変性ゼ
ラチンを高密度の薄いフィルム状に成形して傷口等に接
触させると、当該ゼラチン成分が体液中の水分を瞬間的
に吸収して溶解し、忽ちの裡に血餅状に硬化して止血作
用と傷口封止作用とを発揮する事実を見出した。However, unmodified gelatin itself inherently has very strong instantaneous water resistance, dissolution hardening properties, and adhesiveness, and such physical properties of gelatin should be useful for medical purposes. Under these circumstances, the present inventor has conducted trial and error research for many years in search of a way to utilize the physical properties of gelatin for medical purposes. When formed into a thin film and brought into contact with a wound, etc., the gelatin component instantaneously absorbs and dissolves water in body fluids, and instantly hardens into a blood clot, providing hemostasis and wound sealing effects. We have discovered a fact that demonstrates this.
本発明は、癒着防止というゼラチンの剥離作用の利用に
主眼を置いた従来の医学的技術思想をコペルニクス的に
転回せしめたものであってその第一の技術的課題は、手
術創面や傷口、あるいは火傷面のごとく血液その他の体
液が漏出する人体部位に粘着させることによって体液中
の水分を吸収し当該水分吸収部分が瞬間的に熔解して血
餅状に付着し創面（傷口）の封鎖保護および秀れた止血
作用を奏する止血および傷口封止用ゼラチンフィルムを
提供することにある。The present invention is a Copernican reversal of the conventional medical technical thought that focused on the use of the peeling action of gelatin to prevent adhesion. By adhering to areas of the human body from which blood and other body fluids leak, such as burnt surfaces, it absorbs the moisture in the body fluids, and the moisture-absorbing portion instantly melts and adheres in the form of a blood clot, sealing and protecting the wound surface. An object of the present invention is to provide a gelatin film for hemostasis and wound sealing that exhibits excellent hemostasis effects.
また、本発明の第二の技術的課題は、止血および傷口封
止作用に秀れたゼラチンフィルムを簡易にして短期間に
、しかも安価に製造することができる新方法を提供する
にある。A second technical object of the present invention is to provide a new method that allows gelatin films with excellent hemostasis and wound sealing properties to be easily produced in a short period of time and at low cost.
さらに本発明の第三の技術的課題は、従来類例を見ない
程に極薄で、しかもゼラチン成分が非常に高密度に硬化
した医療用の未変性ゼラチンフィルムを製造できる方法
を提供するにある。Furthermore, the third technical object of the present invention is to provide a method for producing an unmodified gelatin film for medical use that is extremely thin and has a gelatin component hardened to an extremely high density, which has never been seen before. .
本発明者が上記課題を解決するために採用した手段を説
明すれば、次のとおりである。The means adopted by the present inventor to solve the above problems are as follows.
まず、本発明は、未変性ゼラチンを極薄のフィルム状に
成形するという形態的手段を採用することによって上記
第一の技術的課題を解決することに成功し、また、従来
ゼラチンフィルムの製造に際して定説化され実施されて
いた、低温、低湿下の乾燥方法を改め、本発明者の新知
見に基づく新成形法、つまり無塵雰囲気中で至適の温度
・湿度条件を保ちつつ、乾燥させるという方法を採用す
ることによって、製造工程の顕著な短縮化が実現すると
共に、含水率１６％以下という均質にして高品位のゼラ
チンフィルムを製造するという工程的手段を採用するこ
とによって上記第二の技術的課題と第三の技ｊネｉ的課
題の解決に成功したのである。First, the present invention has succeeded in solving the first technical problem mentioned above by employing a formal means of forming unmodified gelatin into an ultra-thin film. The conventional method of drying at low temperatures and low humidity has been revised, and a new molding method based on the inventor's new knowledge has been developed, in which drying is carried out in a dust-free atmosphere while maintaining optimal temperature and humidity conditions. By adopting this method, the production process can be significantly shortened, and by adopting a process means to produce a homogeneous, high-quality gelatin film with a water content of 16% or less, the above-mentioned second technology can be achieved. We succeeded in solving the technical problem and the third technical problem.
以下、本発明を実施例をもって、更に詳しく説明する。 Hereinafter, the present invention will be explained in more detail with reference to Examples.
ｉ９日本局方の精製ゼラチン １０ｇ１１、蒸留水
３００ ｇｉｉｉ 、アクリノ
ール（膜束消毒剤） ０．１ｇ上記暴留水中、ＩＯＭ
をあらがしめ２０〜３０’Ｃに加温し、其処に未変性ゼ
ラチン１０ｇを注入、充分膨潤せしめた後、残余の蒸留
水２００−を、６０〜７０’Ｃに加熱し、追加注入、充
分に前記ゼラチンを溶解する。更にその時点で０．１ｇ
のアクリノールをゼラチン溶液中に混合溶解せしめ、ア
クリノール加、未変性ゼラチン溶液（ゾル）を得る。こ
の溶液を、ステンレス製の平滑な底面（光輝仕上）を有
する薄い平型成形器（幅２４５鵬×長さ３４５ＩＩＩ１
１×深さ２２市）中に、約１〜４端の深さとなるよう、
水平状態に注入し、ゼラチン溶液のゲル化開始を待って
室温２１〜３０’Ｃ，湿度５０〜６５％の無塵状態のク
リーン乾燥室に静置、乾燥せしめると、約２．５〜３日
で、ゲル化ゼラチンは、淡黄色、透明な硬いフィルム状
となり、成形器の表面に密着する。i9 Japanese Pharmacopoeia purified gelatin 10g11, distilled water 300 giii, acrinol (membrane bundle disinfectant) 0.1g above distilled water, IOM
After heating to 20-30'C and pouring 10g of undenatured gelatin into it and allowing it to swell sufficiently, heat the remaining 200ml of distilled water to 60-70'C and inject additional gelatin. Dissolve the gelatin in the solution. Furthermore, at that point 0.1g
Acrinol is mixed and dissolved in a gelatin solution to obtain an acrinol-added undenatured gelatin solution (sol). This solution was poured into a thin flat molding machine made of stainless steel with a smooth bottom (bright finish) (width 245mm x length 345mm).
1 x depth 22 city), so that it is about 1 to 4 ends deep.
Pour it horizontally, wait for the gelatin solution to start gelling, and then leave it in a dust-free clean drying room at a room temperature of 21-30'C and a humidity of 50-65% for about 2.5-3 days. The gelatin becomes a pale yellow, transparent, hard film that adheres to the surface of the molding machine.
更に、同条件にて乾燥を続行すると、約２〜３日でフィ
ルムは成形品表面より剥離し、淡黄色を帯びた透明で光
沢あるゼラチンフィルムが得られた。Further, when drying was continued under the same conditions, the film was peeled off from the surface of the molded product in about 2 to 3 days, and a transparent and glossy gelatin film with a pale yellow tinge was obtained.
そこで・このゼラチンフィルムを財団法人北陸公衆衛生
研究所（福井型光陽４下目１１番２２号）で試験検査を
依願したところ、下記の如き結果が６ｉ認できた。Therefore, we requested that this gelatin film be tested and inspected at the Hokuriku Public Health Research Institute (Fukui Type Koyo 4, Lower 11-22), and the following results were obtained.
フィルムの大きさ 幅 ２０１ｍＸ長さ８０ａｍフィル
ムの厚す 平均 ０．０６９ｍｍフィルムの含水外
１４．８％
２１り０メーター（−２計）、水 分 カー４フイフシ
ー−ｉｔ、（Ｊ、Ｐ）１次に、１掲１−ｉｉ−ｉｉｉの
成分を前述の重量比で溶解させた６０°Ｃのゼラチン溶
液を平型成形器に流し込んだ後、１０価Ｈｇで５分間減
圧脱泡処理してから室温２１〜３０°Ｃ，湿度５０〜６
５％に保ちつつゲル状態に固形化させ、２〜３１］間ク
リーン・ルームで乾燥に付したこところ全面に亙って泡
粒−つ存しない均一な淡黄色極薄のゼラチンフィルムが
得られた。Film size Width 201m x Length 80am Film thickness Average 0.069mm Excluding water content of film 14.8% 210 meters (-2 total), Moisture Car 4 Fift Sea-it, (J, P) 1st After pouring a gelatin solution at 60°C in which the ingredients listed in Item 1-ii-iii in the above weight ratio were dissolved into a flat molding machine, it was degassed under reduced pressure with 10-valent Hg for 5 minutes, and then heated to room temperature. 21-30°C, humidity 50-6
The gelatin film was solidified into a gel state while maintaining the gelatin concentration at 5%, and dried in a clean room for 2 to 31 days, resulting in a uniform pale yellow, ultra-thin gelatin film with no bubbles remaining over the entire surface. Ta.
更に、１掲ｉ −ｉｉ −ｉｉｉの成分を前述の重量比
で溶解させた６０°Ｃのゼラチン溶液を平型成形器に流
し込んで固形化させたゲル状ゼラチンをクリーンルーム
内で上記と同一条件にて３日間乾燥後、５０℃の温風に
１〜２時間曝したところ成形器からのフィルム剥離速度
が昂進すると共に、高品位の極薄ゼラチンフィルムが４
日間で完成した。Furthermore, a gelatin solution at 60°C in which components 1-i-ii-iii were dissolved in the above-mentioned weight ratio was poured into a flat molding machine to solidify the gelatin, which was then heated in a clean room under the same conditions as above. After drying for 3 days, the film was exposed to hot air at 50°C for 1 to 2 hours, and the peeling speed of the film from the molding device increased, and the high-quality ultra-thin gelatin film was
It was completed in days.
本実施例ゼラチンフィルムは概ね上記のような性状を存
しており、上記のようにして製造されるが、本発明は前
述の実施例に限定されるものでは決してなく、［特許請
求の範囲Ｊの記載内において種々の変更が可能であって
、本発明品を量産するに際しては、その成形器のサイズ
を大型化したり、さらに攪拌などの操作を機械化自動化
する等という設計変更はもとより可能であり、
また更に、例えばアクリノール、血液凝固剤（例えば、
トロンビン）などのほか、各種の水溶性抗菌剤を添加す
ることも本発明の技術的範囲に属することはいうまでも
ない。The gelatin film of this example generally has the above-mentioned properties and is produced as described above, but the present invention is by no means limited to the above-mentioned example. Various changes are possible within the description, and when mass producing the product of the present invention, it is possible to make design changes such as increasing the size of the molding machine and mechanizing and automating operations such as stirring. , still further, e.g. acrinol, blood coagulants (e.g.
It goes without saying that addition of various water-soluble antibacterial agents, such as thrombin), also falls within the technical scope of the present invention.
〔本実施例品の作用］
上記した第一実施例ゼラチンフィルムについて、その止
血および傷口封止作用を実際に治療に試用してみたとこ
ろ、次のとおりであった。[Effects of the Product of this Example] When the gelatin film of the first example described above was actually used for treatment, the hemostasis and wound sealing effects were as follows.
（ａ） 年令１０才の少年の膝苫骨部に生した擦過側
（直径約３ｃ１１）に対し、消毒処置したうぇで直径約
４ｍｍ程度に切り抜いた本実施例ゼラチンフィルムを当
該創傷部に圧接させた。(a) The gelatin film of this example, cut out to a diameter of about 4 mm after disinfection, was applied to the abraded side (about 3 cm in diameter) on the knee bone of a 10-year-old boy. I made pressure contact.
すると、創傷部に触れたゼラチンフィルムは当該創傷部
から漏出する血液中の水分を瞬時に吸収することによっ
て其処に血餅状に粘着して止血せしめると共に、残余の
フィルム部分は傷口周辺のｍ織に粘着して前記血餅造成
部分を外側より堤防状に取り囲み、後出血を抑制し止血
を完成した。Then, the gelatin film that comes into contact with the wound instantly absorbs the water in the blood leaking from the wound, adheres to the wound in the form of a blood clot, and stops the bleeding. The blood clot was adhered to the blood clot and surrounded it from the outside in a bank-like manner, suppressing post-bleeding and completing hemostasis.
（ｂ） ７８才の女 内痔核兼脱肛の診断にて入院、
ミリガン・モーガン氏法にて根治手術施行、痔核切除術
後の、コスモス花杖、手術野に対し、上記ゼラチンフィ
ルムを同大、同型に形成、更に同型の小ガーゼ片にフィ
ルムを一針にて縫着し、上記紡錘形手術側に貼着したと
ころ瞬時に止血したため、その上面に滅菌ガーゼを貼用
、手術を終了した。(b) A 78-year-old woman was hospitalized with a diagnosis of internal hemorrhoids and anal prolapse.
Radical surgery was performed using the Milligan-Morgan method, and after hemorrhoidectomy, the above gelatin film was formed on the surgical field to the same size and shape, and then the film was applied with a single stitch to a small piece of gauze of the same shape. When it was sutured and attached to the spindle-shaped surgery side, the bleeding stopped instantly, so sterile gauze was attached to the upper surface, and the surgery was completed.
以後、後出血もなく経過良好であった。Thereafter, the patient's progress was uneventful with no post-operative bleeding.
（Ｃ） 年令３０才の主婦が手背部に熱湯を浴びて約
５ｃｍ角の火傷を負ったので、消毒処置後、約１ｃｒａ
角の本実施例ゼラチンフィルムを防用したところ、同ゼ
ラチンフィルムは火傷面から滲出する滲出液の水分を吸
収して瞬時溶着し火傷表面にゼラチンのガード被膜を形
成した。(C) A 30-year-old housewife received boiling water on the back of her hand and suffered a burn about 5cm square. After disinfection, the burn was about 1cra.
When the gelatin film of this example was used to protect the burn area, the gelatin film absorbed the moisture of the exudate exuding from the burnt surface and instantly welded to form a gelatin guard coating on the burnt surface.
（ｄ） 皮膚面に粘着可能なビニールシート（適応部
分により幅５〜５０ｍｍ）上に本実施例ゼラチンシート
（幅５〜５０ｍ＋ａ、長さ２０〜７０１ｍ）を貼着して
絆創膏となし、救象、止血創傷処置用絆創膏として使用
したところ効果抜群であった。(d) The gelatin sheet of this example (width 5-50 m+a, length 20-701 m) was pasted on a vinyl sheet (width 5-50 mm depending on the applicable part) that can be adhered to the skin surface to make a bandage, and the elephant was saved. When used as a bandage for hemostatic wound treatment, it was extremely effective.
以上実施例をもって説明したとおり、本発明ゼラチンフ
ィルムは、血液０体液に接触することによって瞬時に水
分を吸収して傷口面に血餅状に融合して当該部位を防護
すると共に、出血や体液の漏出を速やかに阻止できるの
で手術創面の止血、火傷面の被覆保護剤として、さらに
救２、処置用の止血防剤として医療上極めて有用である
。As explained above with the examples, the gelatin film of the present invention instantly absorbs moisture when it comes into contact with blood or body fluids, fuses to the wound surface in the form of a blood clot, and protects the site, as well as prevents bleeding and body fluids. Since it can quickly prevent leakage, it is extremely useful medically as a hemostasis agent for surgical wounds, as a protective agent for covering burnt surfaces, and as a hemostasis preventive agent for rescue and treatment purposes.
また、本発明方法によれば、従来類例を見ないほど極薄
で、非常に高品質の未変性ゼラチンフィルムが得られ、
そのことが治療上の高い効能と施用上の利点を保障でき
るなど、その効果は頗る大と云える。Furthermore, according to the method of the present invention, an unmodified gelatin film that is extremely thin and of extremely high quality, unprecedented in the past, can be obtained.
This can be said to be extremely effective, as it guarantees high therapeutic efficacy and application advantages.
Claims (4)
を特徴とする止血および傷口封止用ゼラチンフィルム。(1) A gelatin film for hemostasis and wound sealing, characterized by forming undenatured gelatin into a thin film.
チン溶液を平滑な底面を有する型内に浅く水平状態に注
入した後、無塵雰囲気中で乾燥硬化させてフィルム化せ
しめ、 含水率１６％以下の薄膜状ゼラチンフィルムを得ること
を特徴とした止血および傷口封止用ゼラチンフィルムの
製造法。(2) A gelatin solution containing 5 to 2.5 w% of unmodified gelatin is injected horizontally into a mold with a smooth bottom, and then dried and hardened in a dust-free atmosphere to form a film. A method for producing a gelatin film for hemostasis and wound sealing, characterized by obtaining a thin gelatin film with a thickness of 16% or less.
および血液凝固剤を添加混入してフィルム化せしめる請
求項（２）記載の、 ゼラチンフィルムの製造法。(3) The method for producing a gelatin film according to claim (2), wherein a non-irritating, water-soluble sterilizing disinfectant and a blood coagulant are added and mixed into the gelatin solution to form a film.
チン溶液を平滑底面の型内に１〜４ｍｍ厚に流し込み、
クリーン・ルーム内で室温２１〜３０℃、湿度５０〜６
５％に保ちつつ固化させた後、乾燥して厚さ０．０６９
ｍｍ前後のゼラチンフィルムに硬化せしめる請求項（１
）または（２）記載の、ゼラチンフィルムの製造法。(4) Pour an undenatured gelatin solution containing 5 to 2.5 w% gelatin component into a mold with a smooth bottom to a thickness of 1 to 4 mm,
In a clean room, room temperature 21-30℃, humidity 50-6
After solidifying while maintaining the concentration at 5%, it is dried to a thickness of 0.069.
Claim (1) wherein the gelatin film is hardened into a gelatin film with a diameter of around mm.
) or (2), the method for producing a gelatin film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63169232A JPH0219164A (en) | 1988-07-06 | 1988-07-06 | Gelatin film for stanching and sealing wound and manufacture thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63169232A JPH0219164A (en) | 1988-07-06 | 1988-07-06 | Gelatin film for stanching and sealing wound and manufacture thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0219164A true JPH0219164A (en) | 1990-01-23 |
| JPH0444551B2 JPH0444551B2 (en) | 1992-07-22 |
Family
ID=15882682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63169232A Granted JPH0219164A (en) | 1988-07-06 | 1988-07-06 | Gelatin film for stanching and sealing wound and manufacture thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0219164A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0959795A4 (en) * | 1996-10-16 | 2000-01-19 | Fusion Medical Technologies | Films having improved characteristics and methods for their preparation and use |
| KR100766280B1 (en) * | 2006-06-12 | 2007-10-17 | 남동산업주식회사 | Screw Type Recycled Water Filtration Treatment System Using Multiple Discs |
-
1988
- 1988-07-06 JP JP63169232A patent/JPH0219164A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0959795A4 (en) * | 1996-10-16 | 2000-01-19 | Fusion Medical Technologies | Films having improved characteristics and methods for their preparation and use |
| KR100766280B1 (en) * | 2006-06-12 | 2007-10-17 | 남동산업주식회사 | Screw Type Recycled Water Filtration Treatment System Using Multiple Discs |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0444551B2 (en) | 1992-07-22 |
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