JPH022067B2 - - Google Patents

Description

[Detailed description of the invention]

[Technical Field of the Invention] The present invention relates to a freeze-drying apparatus used in the fields of living organisms, medicine, food, etc. [Technical Background of the Invention] The basic principle of a freeze-drying device is a sublimation process in a vacuum. Therefore, the target product is frozen on a shelf in a drying room, and then heated and dehydrated in a vacuum as a frozen product. The energy required for freezing and drying is applied to a single heat medium by a refrigerator and a heater, and the freezing and drying processes are achieved by circulating this heat medium. A known technique will be explained with reference to FIG. Heat medium flow paths 3 and 8 are connected before and after a hollow shelf 2 provided inside the freeze-drying chamber 1, and the flow paths 6 and 7 form a heat medium circulation path. This circulation path is provided with an evaporator 12 of the main refrigeration cycle A, an evaporator 16 of the supplementary refrigeration cycle B, a heater 5, and a pump 4. The main refrigeration cycle A has a compressor 9, a condenser 10,
It is composed of an expansion valve 11, an evaporator 12, and a refrigerant path 17 connecting these. The supplementary refrigeration cycle B includes a compressor 13, a condenser 14, an expansion valve 15, and an evaporator 1.
6 and a refrigerant path 18 that freezes them. In addition to the evaporator 12, the main refrigeration cycle A has an evaporator 19 in a cold trap chamber 29. The condensers 10 and 14 have a cooling water inflow path 21,
23 and the outflow passages 20 and 22 are connected to an external cooler such as a cooling tower. Flow paths 3, 6, 7, 8 for circulating the heat medium to the freeze-drying chamber 1
The circulation path formed by this is filled with trichlorethylene, silicone oil, etc., the refrigerant path 17 of the main refrigeration cycle A is filled with R-22, R-502, etc., and the refrigerant path 18 of the supplementary refrigeration cycle B is filled with R-22, R-502, etc.
-12 etc. are filled. Next, a publicly known freeze-drying process will be described. First, the target product is placed on the hollow shelf 2 in the freeze-drying chamber 1. The heat medium filling the heat medium flow paths 3, 6, 7, and 8 is cooled by an evaporator 12 and sent to the hollow shelf 2 by a pump 4, where the target product is frozen on the shelf. When the freeze-drying chamber 1 and the cold trap chamber 29 are evacuated to a set temperature of, for example, -40°C, the vacuum is evacuated to, for example, 10 ^-3 mmHg, and at the same time, the main refrigeration cycle A operates the three-way valves 25 and 26. Therefore, the condenser 10, refrigerant path 27, and expansion valve 2
4, the path is switched to the evaporator 19, refrigerant path 28, and compressor 9, and cooling operation of the cold trap chamber 29 is performed. On the other hand, the low temperature heat medium being circulated by the pump 4 is gradually heated by the heater 5. The heated heat medium is heated to a set temperature e.g. 50
℃ and circulates through the shelves 2, supplying latent heat of sublimation to the frozen products on the shelves, while the sublimated water vapor is sent to the evaporator 19 (cold) cooled to -65℃ in the main refrigeration cycle A. A sublimation drying process in vacuum is accomplished. It is not uncommon for such freeze-drying processes, particularly drying processes, to last from half a day and a night to a few days and nights. The supplementary refrigeration cycle B works as a control refrigeration cycle to maintain the heat medium temperature at a set value during heating (works when the heat medium temperature rises too much), and
If the main refrigeration cycle A fails during drying, the heat medium in the circulation path consisting of flow paths 3, 6, 7, and 8 is cooled instead of the main refrigeration cycle A to prevent the target product from melting during drying, thereby freezing the product. It has the function of cooling the inside of the drying chamber 1 and backing up the main refrigeration cycle A. [Problems with the background technology] The known technology shown in Figure 1 is equipped with a main supplementary refrigeration cycle and uses a single heat medium to achieve the freeze-drying process, so the energy consumption is greater than that of other drying methods. Quite a lot compared to that. The reason why freeze-dried products are expensive is because of the high cost of the equipment itself and the huge amount of energy consumed, but the energy used to accomplish the freeze-drying process is mainly (i.e. )Freezing energy by refrigerator,
(b) sublimation energy from the heater, and (c) water vapor condensation energy from the refrigerator. All of these are consumed and are not recovered. In particular, the energy consumption of (b) and (c) in the drying process, which requires a long time, is large (therefore, the effect of saving energy in this drying process is significant). Furthermore, in the freeze-drying apparatus such as the above-mentioned known technology, only a single heating medium is used, and in order to switch the process from freezing to drying, the entire temperature of the heating medium at -40°C must be raised to +50°C. In addition, switching from drying to freezing requires lowering the temperature.
This energy consumption during heating and cooling also results in wasted energy. In addition, the supplementary refrigeration cycle works to control the temperature of the heat medium during drying, but since its operation involves frequent ON-OFF operations in areas where the refrigerant evaporation temperature is high, it is difficult to suppress hunting even as a control system. Moreover, frequent ON-OFF operations can cause refrigerator failures, and the reliability of functioning as a backup device in the event of a failure of the main refrigeration cycle is also poor. [Object of the Invention] An object of the present invention is to provide a freeze-drying apparatus that solves the problems of the above-mentioned known techniques, achieves energy saving, and is capable of stable and highly reliable operation. [Summary of the invention] An attached refrigeration cycle is formed by a main refrigeration cycle used for the freezing process and cold trap cooling, and an auxiliary refrigeration cycle used for the drying process and for auxiliary cooling when the main refrigeration cycle fails,
In addition, a flow path is formed that interconnects the evaporator, condenser, freeze-drying chamber, and heat medium cooler (cooling tower, etc.) of the main supplementary refrigeration cycle and has a pump and a switching valve at an appropriate position. is a device that performs freeze-drying by filling and circulating a single heating medium, and during the freezing process,
A main refrigeration circulation path for the heat medium flowing through the evaporator and freeze-drying chamber of the main refrigeration cycle is formed, and a main condensation heat removal circuit for the heat medium flowing through the condenser and heat medium cooler of the main refrigeration cycle is formed. During the drying process, a drying circuit is formed for the heating medium that flows through the condenser of the supplementary refrigeration cycle and the freeze-drying chamber, and the condenser of the main refrigeration cycle and the supplementary refrigeration cycle that cool the cold trap are formed. During the freezing process, a condensation heat utilization circuit is formed for the heat medium flowing through the evaporator of the main refrigeration cycle, so that the heat released from the condenser of the main refrigeration cycle can be switched to be used as a heat source for the evaporator of the supplementary refrigeration cycle. The present invention relates to a freeze-drying apparatus in which the flow path for the heat medium is formed during the drying process and during the drying process.
(First invention) In addition, during the freezing process in the apparatus of the first invention, a sub-refrigeration circulation path for a heat medium flowing through the evaporator and the freeze-drying chamber of the supplementary refrigeration cycle is formed, and a The present invention relates to a freeze drying apparatus that can be used for auxiliary cooling when the main refrigeration cycle fails, etc. by forming a sub-condensation heat removal circuit for the heat medium flowing through the condenser and the heat medium cooler. Yes (second invention). Furthermore, during the freezing process in the apparatus of the first invention, the following three systems are used: (a) the main refrigeration circulation path for the heat medium flowing through the evaporator and freeze-drying chamber of the main refrigeration cycle; (b) A first system in which a main condensation heat removal circuit for the heat medium flowing through the condenser and the heat medium cooler is formed; A second system in which a refrigeration circuit and a sub-condensation heat removal circuit for the heat medium flowing through the condenser and heat medium cooler of the auxiliary refrigeration cycle are formed; (c) the evaporator and freeze drying of the main auxiliary refrigeration cycle; Alternative switching between a refrigeration circuit for the heat medium flowing through the room and a third system in which a condensation heat removal circuit for the heat medium flowing through the condenser of the main supplementary refrigeration cycle and the heat medium cooler is formed. The present invention relates to a freeze-drying apparatus that can perform this (third invention). The first system and the second system correspond to the freezing cycles of the first invention and the second invention, respectively. [Embodiment of the Invention] A first embodiment of the invention will be described with reference to FIG. In the figure, A is the main refrigeration cycle, B is the supplementary refrigeration cycle, 1 is the freeze-drying chamber, and 29 is the cold trap chamber, and the parts denoted by numerals 1 to 29 are the same parts as those in the prior art shown in FIG. ing. Next, the configuration of this embodiment added to the known technique shown in FIG. 1 will be explained. Four-way valves 33 and 34 are installed at appropriate positions in the circulation path formed by the heat medium flow paths 3, 6, 7, and 8, for example, two four-way valves 33 and 34 are installed in the flow path 7, and four-way valves 34 are installed in the flow path 8.
5 will be provided. Forms a heat medium flow path connecting the condenser 10 of the main refrigeration cycle A and the cooling tower 41 as a heat medium cooler, and includes a flow path 38 for inflow into the condenser 10 and a flow path 37 for outflow. It will be done. A three-way valve 36 is provided at an appropriate position in the flow path 37. 39 is a pump, and 40 is a tank. Heat medium flow paths 42 and 43 are provided between the four-way valves 35 and 34 and between the four-way valve 34 and the flow path 37, respectively. A flow path 44 for inflowing the heat medium into the condenser 14 of the supplementary refrigeration cycle B and a flow path 45 for the outflow of the heat medium are provided.The flow path 44 has one end connected to the four-way valve 33, and the flow path 45 has one end connected to the four-way valve Connected to valve 35.
A flow path 49 connects the four-way valve 33 and the three-way valve 36. 46 and 47 are tanks, and 48 is a pump. In this embodiment, all flow passages are filled with the same heat medium, such as brine. Next, the operation of this embodiment will be explained. () In the case of freezing process, place the target product on the hollow shelf 2 in the freeze-drying chamber 1,
Freezing operation begins, but in this case, (a) of the third invention
There are three systems as shown in (b) and (c). The four-way valves 33, 34, 35 and the three-way valve 36 are switched as appropriate depending on the system, and the pumps 4, 39, 48 are operated. (a) During the first system (freezing operation according to the first invention and the third invention (a)), (a) Main refrigeration circuit for brine The brine cooled in the evaporator 12 of the main refrigeration cycle A is as follows. It circulates through the flow path and performs a freezing action in the freeze-drying chamber 1. Evaporator 12 → Distribution path 8 → Freeze-drying chamber 1 →
Distribution path 3 → Tank 47 → Distribution path 6 → Four-way valve 33 → Evaporator 16 → Four-way valve 34 → Distribution path 7
→ Pump 4 → Evaporator 12 Note that the evaporator 16 can be bypassed. (B) Main condensation heat removal circuit for brine The heat generated in the condenser 10 of the main refrigeration cycle A is circulated in the flow path by brine as follows, and the heat is released to the outside in the cooling tower. Condenser 10 → Flow path 37 → Three-way valve 36 →
Cooling tower 41 → Tank 40 → Pump 39 → Distribution path 38 → Condenser 10 (b) In the case of the second system (freezing operation of the second invention and third invention (b)), (a) Brine sub-refrigeration circuit drying Main refrigeration cycle A during process operation
When a failure occurs in the supplementary freezing cycle B, the four-way valves 33, 34, and 35 are switched to refreeze the target product that is being dried in the supplementary freezing cycle B, and the brine cooled in the evaporator 16 of the supplementary freezing cycle B is processed as follows. It circulates within the flow path and performs a freezing action within the freeze-drying chamber 1. Evaporator 16 → Four-way valve 34 → Pump 4 → Evaporator 12 → Distribution path 8 → Four-way valve 35 → Freeze-drying chamber 1 → Distribution path 3 → Tank 47 → Distribution path 6
→ Four-way valve 33 → Evaporator 16 (b) Brine sub-condensation heat removal circulation path The heat generated in the condenser 14 of the supplementary refrigeration cycle B is circulated in the flow path by brine as follows, and then transferred to the cooling tower 41. is released to the outside. Condenser 14→Flow passage 45→Four-way valve 35→
Distribution passage 42 → four-way valve 34 → distribution passage 43 → cooling tower 41 → tank 40 → pump 39 → distribution passage 38 → condenser 10 → distribution passage 3
7→Three-way valve 36→Flow path 49→Four-way valve 33
→Flow path 44→Tank 46→Pump 48→
Flow path 44 → condenser 14 (c) When the third system (freezing operation according to (c) of the third invention), (a) Brine refrigeration circulation path When performing the freezing process rapidly, main auxiliary refrigeration cycle A ,B to operate the evaporator 1
The brine cooled in steps 2 and 16 circulates through the flow path and performs a freezing action in the freeze-drying chamber 1 as described below. Evaporator 16 → Four-way valve 34 → Pump 4 → Evaporator 12 → Distribution path 8 → Four-way valve 35 → Freeze-drying chamber 1 → Distribution path 3 → Tank 47 → Distribution path 6
→ Four-way valve 33 → Evaporator 16 (b) Brine condensation heat removal circuit Condenser 10 of main auxiliary refrigeration cycle A, B,
The heat generated in the cooling tower 14 is circulated in the flow path by brine as follows, and is released to the outside in the cooling tower 41. Condenser 10 → Flow path 37 → Three-way valve 36 →
Distribution passage 49 → Four-way valve 33 → Distribution passage 44 → Tank 46 → Pump 48 → Distribution passage 44 → Condenser 14 → Distribution passage 45 → Four-way valve 35 → Distribution passage 42 → Four-way valve 34 → Distribution passage 43 → Cooling tower 41 → Tank 40→Pump 39→
Flow path 38 → condenser 10 Instead of connecting the condensers 10 and 14 in series to the cooling tower 41 as described above, each condenser 10 and 14 may be connected to the cooling tower 41 separately, that is, in parallel. can. () In case of drying process When the freezing of the target product is completed, the freeze-drying chamber 1 and the cold trap chamber 29 are evacuated, the hollow shelf 2 of the freeze-drying chamber 1 is heated with heated brine, and the cold trap chamber 29 is heated. is cooled by the evaporator 19 of the main refrigeration cycle A. The heat generated in the condenser 10 of the main refrigeration cycle A is used as an evaporation heat source for the evaporator 16 of the supplementary refrigeration cycle B, which acts as a heater in the drying process. The frozen products on the hollow shelf 2 are given latent heat of sublimation to accelerate drying. The vapor generated from the frozen product condenses in the cold trap chamber 29. (a) Brine drying circulation path Condenser 14 → Distribution passage 45 → Four-way valve 35 → Freeze-drying chamber 1 → Distribution passage 3 → Tank 47 → Distribution passage 6 → Four-way valve 33 → Distribution passage 44 → Tank 46 →
Pump 48 → Distribution path 44 → Condenser 14 (b) Brine condensation heat utilization circulation path Condenser 10 → Distribution path 37 → Three-way valve 36 → Distribution path 49 → Four-way valve 33 → Evaporator 16 → Four-way valve 34 → Distribution path 43→Cooling Tower 41→
Tank 40 → Pump 39 → Flow path 38 → Condenser 10 The heat generated in the condenser 10 of the main refrigeration cycle A is given to the evaporator 16 of the auxiliary refrigeration cycle B, thereby obtaining high-temperature latent heat of condensation from the condenser 14. Can be done. By imparting this large amount of latent heat of condensation to the brine, the drying process can be carried out without using the heater 5 as in the prior art. The temperature of the brine heated in the condenser 14 is adjusted by adjusting the expansion valve 15 and the like. In the first embodiment described above, "(a) main freezing circulation path for brine" in the case of freezing process and "(b) drying circulation path for brine" in case of drying process.
As you can see, when switching from the freezing process to the drying process, the flow paths 3, 6, 7,
Among the brine in the brine circulation path including 8, only the flow paths 3, 6 and the freeze-drying chamber 1 are heated from low temperature brine to high temperature brine, and the flow paths 7, 8 and evaporation The brine in vessels 12, 16 is not heated. In contrast, the first
In the known technique shown in the figure, all the heat medium filled in the heat medium circulation path including the flow paths 3, 6, 7, and 8 must be heated from low temperature to high temperature, resulting in large heat loss. . A second embodiment of the present invention will be explained with reference to FIG. In the figure, A is the main refrigeration cycle, B is the supplementary refrigeration cycle, 1 is the freeze-drying chamber, 29 is the cold trap chamber, and 41 is the cooling tower. The same parts as the example are shown. Next, the configuration of this embodiment added to or modified from the first embodiment shown in FIG. 2 will be explained. Four-way valves 33, 34, 35 of the first embodiment provided in the brine circulation path including the flow paths 3, 6, 7, 8
are replaced by three-way valves 33', 34', and 35' in the second embodiment. In this embodiment, three-way valves 51, 52, 55, and 58 are additionally provided in the brine flow path. The three-way valve 51 is connected to the flow path 3 and the flow path 6, and is also connected to the tank 46 via the flow path 53. The three-way valve 52 connects to the three-way valve 33' via the flow passage 60 and to the three-way valve 36 via the flow passage 49.
and are connected to the flow path 44 via the flow path 54, respectively. The three-way valve 55 connects to the flow path 43 via the flow path 57, and to the three-way valve 35' via the flow path 56.
Each is connected to the condenser 14 via a flow path 45. The three-way valve 58 is provided in the flow path 8 between the pump 4 and the evaporator 12 and connected to the flow path 8 via a flow path 59 . Flow path 59 forms a bypass path for brine to bypass evaporator 12 . Although this embodiment has more valves and more flow passages than the first embodiment, the operation and effect are exactly the same. The brine circulation path for each freeze-drying process will be explained below. For convenience of explanation, drawing symbols are mainly used. () In the case of the freezing process (a) In the case of the first system (freezing operation according to the first invention and the third invention (a)), (a) Main freezing circulation path for brine Evaporator 12 → 8 → 35' → Freeze drying Room 1
→3→51→47→6→33'→16→7
→4→Evaporator 12 (b) Main condensation heat removal circuit for brine Condenser 10→37→Cooling tower 4
1 → 40 → 39 → 38 → Condenser 10 (b) In the case of the second system (freezing operation of the second invention and third invention (b)), (a) Brine sub-refrigeration circuit Evaporator 16 → 34' →7→4→58→5
9→8→35'→Freeze-drying chamber 1→3→51
→47→6→33'→evaporator 16 It is also possible to flow the brine through the evaporator 12 which is not in operation. (b) Brine sub-condensation heat removal circuit Condenser 14→45→55→57→43→
37 → Cooling tower 41 → 40 → 39
→38→10→37→36→49→54→
44→Condenser 14 (c) In the case of the third system (freezing operation according to (c) of the third invention), (a) Brine refrigeration circuit Evaporator 16→34'→7→4→Evaporator 1
2→8→35′→Freeze-drying chamber 1→3→51
→47→6→33'→Evaporator 16 (b) Brine condensation heat removal circuit Condenser 14→45→55→57→43→
37 → Cooling tower 41 → 40 → 39
→38→Condenser 10→37→36→54→
44 → Condenser 14 () For drying process (a) Brine drying circuit Condenser 14 → 45 → 55 → 35' → Freeze drying chamber 1 → 3 → 51 → 53 → 46 → 48 → 44
→ Condenser 14 (b) Brine condensation heat utilization circulation path Condenser 10 → 37 → 36 → 49 → 52 → 3
3' → Evaporator 16 → 34' → 43 → 37 → Cooling tower 41 → 40 → 39 → 38 → Condenser 10 When the freezing process is switched to the drying process, the freeze-drying Only the brine in the flow path 3 leading from the chamber 1 to the three-way valve 51 is heated from a low temperature to a high temperature, resulting in energy loss. [Effects of the Invention] As explained above, the present invention provides high-temperature latent heat of condensation from the condenser of the supplementary refrigeration cycle by giving heat generated in the condenser of the main refrigeration cycle to the evaporator of the supplementary refrigeration cycle during the drying process. Since it is possible to obtain a sufficient amount of sublimation energy, there is no need to provide a separate heater as in the known technology, resulting in a large energy saving effect. By simply adding a heat transfer path and a switching valve to the known technology, the supplementary refrigeration cycle can be used not only for freezing but also for drying, which reduces equipment costs and running costs, making it possible to reduce freeze-dried products. The cost will be reduced. Since it is not necessary to use the supplementary refrigeration cycle to control the temperature of the heat medium in the drying process as in the known technology, stable operation of the supplementary refrigeration cycle is achieved and the reliability of the apparatus is increased. When the process is changed over from a freezing process to a drying process or vice versa, the known technology requires temperature adjustment of all the heat carriers in the heat carrier circuit from a low temperature to a high temperature or vice versa. Although the amount of thermal energy consumed was large, in the present invention, when switching the process, it is sufficient to change the temperature of a part of the heat medium in the circulation path, so there is an energy saving effect. Furthermore, in the present invention, all the heat medium flow paths of the entire device are filled with a single heat medium, and this heat medium is selected to function as a working medium at both low and high temperatures, making the device easy to use. It is also convenient for driving.

[Brief explanation of drawings]

FIG. 1 is a flow sheet diagram of a freeze-drying apparatus which is a known technique, and FIGS. 2 and 3 are flow sheet diagrams of first and second embodiments of the freeze-drying apparatus of the present invention, respectively. A... Main refrigeration cycle, B... Supplementary refrigeration cycle, 1... Freeze-drying chamber, 3... Distribution path, 4... Pump, 6, 7, 8... Distribution path, 10... Condensation of main refrigeration cycle 12...Evaporator of main refrigeration cycle, 14...Condenser of supplementary refrigeration cycle, 16...
Evaporator of supplementary refrigeration cycle, 17, 18... Distribution path, 25, 26... Three-way valve as switching valve, 29
...Cold trap room, 33, 34, 35...
Four-way valve as a switching valve, 33', 34', 35'...
...Three-way valve as a switching valve, 36... Three-way valve as a switching valve, 37, 38... Flow path, 39... Pump, 41... Heat medium cooler, 42, 43, 44,
45...Flow path, 48...Pump, 49...Flow path, 51, 52...Three-way valve as a switching valve, 5
3, 54...Flow passage, 55...Three-way valve as a switching valve, 56, 57...Flow path, 58...Three-way valve as a switching valve.

Claims (1)

[Scope of Claims] 1. An attached refrigeration cycle is formed of a main refrigeration cycle for main cooling and cold trapping and a supplementary refrigeration cycle for drying and supplementary cooling, and the evaporator, condenser, In an apparatus in which a freeze-drying chamber and a heat medium cooler are interconnected to form a flow path having a pump and a switching valve, and a single heat medium is passed through the flow path to perform freeze-drying, when freezing, the main refrigerator A main refrigeration circuit for the heat medium that flows through the evaporator and the freeze-drying chamber of the cycle is formed, and a main condensation heat removal circuit for the heat medium that flows through the condenser and the heat medium cooler of the main refrigeration cycle is formed. ,
Also, during drying, a drying circuit is formed for the heat medium that flows through the condenser of the supplementary refrigeration cycle and the freeze-drying chamber, and it also flows through the condenser of the main refrigeration cycle that cools the cold trap and the evaporator of the supplementary refrigeration cycle. A freeze-drying device capable of switching the flow path for a heat medium during freezing and drying so that a circulation path for utilizing condensation heat of the heat medium is formed. 2. The attached refrigeration cycle is formed of a main refrigeration cycle for main cooling and cold traps and a supplementary refrigeration cycle for drying and auxiliary cooling, and the evaporator, condenser, freeze-drying chamber, and heat medium of the main auxiliary refrigeration cycle are In an apparatus that performs freeze-drying by interconnecting coolers and forming a flow path having a pump and a switching valve, and passing a single heat medium through the flow path, when freezing, the evaporator of the supplementary refrigeration cycle and the freeze-drying A sub-refrigeration circulation path for the heat medium that flows through the drying chamber is formed, and a sub-condensation heat removal circuit for the heat medium that flows through the condenser and heat medium cooler of the supplementary refrigeration cycle is formed,
Also, during drying, a drying circuit is formed for the heat medium that flows through the condenser of the supplementary refrigeration cycle and the freeze-drying chamber, and it also flows through the condenser of the main refrigeration cycle that cools the cold trap and the evaporator of the supplementary refrigeration cycle. A freeze-drying device capable of switching the flow path for a heat medium during freezing and drying so that a circulation path for utilizing condensation heat of the heat medium is formed. 3. The attached refrigeration cycle is formed of a main refrigeration cycle for main cooling and cold traps and a supplementary refrigeration cycle for drying and auxiliary cooling, and the evaporator, condenser, freeze-drying chamber, and heat medium of the main auxiliary refrigeration cycle are In an apparatus that performs freeze-drying by interconnecting coolers and forming a flow path having a pump and a switching valve, and flowing a single heat medium through the flow path, during freezing, the following three systems are used: a) A main refrigeration circuit for the heat medium that flows through the evaporator and freeze-drying chamber of the main refrigeration cycle, and a main condensation heat removal circuit for the heat medium that flows through the condenser and heat medium cooler of the main refrigeration cycle are formed. (b) A sub-refrigeration circuit for the heat medium flowing through the evaporator and freeze-drying chamber of the supplementary refrigeration cycle, and a sub-condensation circuit for the heat medium flowing through the condenser and heat medium cooler of the supplementary refrigeration cycle. (c) A refrigeration circuit for the heat medium flowing through the evaporator and freeze-drying chamber of the main auxiliary refrigeration cycle, and a condenser and heat medium cooler of the main auxiliary refrigeration cycle. A third system is formed in which a condensation heat removal circuit is formed for the heat medium flowing through the condenser of the supplementary refrigeration cycle and a freeze-drying chamber. During freezing and drying, a drying circulation path is formed, and a circulation path is formed that utilizes the condensation heat of the heating medium flowing through the condenser of the main refrigeration cycle that cools the cold trap and the evaporator of the supplementary refrigeration cycle. A freeze-drying device capable of switching the flow path of the heat medium at any time.