JPH0224548A - 免疫反応の電気的検出 - Google Patents

免疫反応の電気的検出

Info

Publication number
JPH0224548A
JPH0224548A JP1124617A JP12461789A JPH0224548A JP H0224548 A JPH0224548 A JP H0224548A JP 1124617 A JP1124617 A JP 1124617A JP 12461789 A JP12461789 A JP 12461789A JP H0224548 A JPH0224548 A JP H0224548A
Authority
JP
Japan
Prior art keywords
immunoactive substance
substance
immunoactive
electrode
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1124617A
Other languages
English (en)
Japanese (ja)
Inventor
Ivar Giaever
アイバー・ギアエバー
Charles R Keese
チャールズ・リチャード・キース
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of JPH0224548A publication Critical patent/JPH0224548A/ja
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP1124617A 1988-05-20 1989-05-19 免疫反応の電気的検出 Pending JPH0224548A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/196,718 US4920047A (en) 1988-05-20 1988-05-20 Electrical detection of the immune reaction
US196,718 1988-05-20

Publications (1)

Publication Number Publication Date
JPH0224548A true JPH0224548A (ja) 1990-01-26

Family

ID=22726568

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1124617A Pending JPH0224548A (ja) 1988-05-20 1989-05-19 免疫反応の電気的検出

Country Status (5)

Country Link
US (1) US4920047A (fr)
EP (1) EP0342382A3 (fr)
JP (1) JPH0224548A (fr)
IL (1) IL89719A0 (fr)
NO (1) NO892020L (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
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WO1994023287A1 (fr) * 1993-03-31 1994-10-13 Dkk Corporation Procede et cellule de dosage immunologique
US6508803B1 (en) 1998-11-06 2003-01-21 Furukawa Techno Material Co., Ltd. Niti-type medical guide wire and method of producing the same

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US5218312A (en) * 1988-07-20 1993-06-08 Ricardo Moro Measurement apparatus for measuring a biological substance within a fluid substrate
CA2027694C (fr) * 1989-10-20 2002-03-05 Tadashi Matsunaga Procede et appareil permettant de deceler les leucocytes ou les antigenes sensibilises
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
GB2276724A (en) * 1993-03-31 1994-10-05 Cambridge Life Sciences Electrochemical detection of specific binding species
EP0700520B1 (fr) * 1993-05-29 1997-07-30 Cambridge Life Sciences Plc Capteurs bases sur la transformation de polymeres
WO1995029395A1 (fr) * 1994-04-26 1995-11-02 The Regents Of University Of Michigan Cassette de dosage par methode immunoenzymatique en sandwich unitaire, dispositif a cet effet et mode d'utilisation
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
AUPM950094A0 (en) 1994-11-16 1994-12-08 Australian Membrane And Biotechnology Research Institute Detection device and method
WO1997025616A1 (fr) * 1996-01-11 1997-07-17 Australian Membrane And Biotechnology Research Institute Groupage sanguin par capteur a canal ionique
EP0879412A4 (fr) * 1996-02-08 2004-08-11 Ambri Ltd Biocapteurs de detection des enzymes
AUPN980796A0 (en) * 1996-05-13 1996-06-06 Australian Membrane And Biotechnology Research Institute Improved reservoir components
US7393645B2 (en) * 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US5981268A (en) * 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
DK0988534T3 (da) 1997-06-12 2011-05-23 Clinical Micro Sensors Inc Elektroniske fremgangsmåder og apparat til detektering af analytter
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6852525B1 (en) 1999-11-02 2005-02-08 Advanced Sensor Technologies Mammalian cell culture chamber
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
WO2002012558A1 (fr) * 2000-08-07 2002-02-14 Azur Environmental Ltd. Procede et appareil pour la detection d'analytes
US6835552B2 (en) * 2000-12-14 2004-12-28 The Regents Of The University Of California Impedance measurements for detecting pathogens attached to antibodies
US7435384B2 (en) * 2001-01-08 2008-10-14 Leonard Fish Diagnostic instrument with movable electrode mounting member and methods for detecting analytes
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US7470533B2 (en) * 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
CA2493101C (fr) * 2002-07-20 2012-05-08 Acea Biosciences, Inc. Appareils a base d'impedance et procedes d'analyse de cellules et de particules
US7468255B2 (en) * 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US8206903B2 (en) 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US7732127B2 (en) * 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US7560269B2 (en) * 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US20040011650A1 (en) * 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
US20040018611A1 (en) * 2002-07-23 2004-01-29 Ward Michael Dennis Microfluidic devices for high gradient magnetic separation
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
EP1692258A4 (fr) * 2003-11-12 2007-03-21 Xiao Xu Systemes de detection de cellules electroniques en temps reel pour des epreuves a base de cellules
DE102005019191A1 (de) 2005-04-26 2006-11-09 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Detektion der Abdichtung mittels Rauschanalyse
US8041515B2 (en) * 2006-09-20 2011-10-18 Acea Biosciences, Inc. Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
CN101038284B (zh) 2007-04-25 2011-04-27 博奥生物有限公司 一种提高电阻抗检测装置的电阻抗检测灵敏度的方法
CN101556273B (zh) * 2008-04-08 2013-03-20 博奥生物有限公司 利用电阻抗传感技术分析细胞迁移的方法及其专用装置
WO2009137440A1 (fr) 2008-05-05 2009-11-12 Acea Biosciences, Inc. Surveillance sans marqueur d’un couplage excitation-contraction et cellules pouvant être excitées utilisant des systèmes fondés sur l'impédance avec une résolution dans le temps de l'ordre de la milliseconde
CN101614729B (zh) * 2008-06-27 2013-04-24 博奥生物有限公司 用于细胞操作及电生理信号检测的微电极阵列器件及专用装置
US12066428B2 (en) 2015-11-20 2024-08-20 Agilent Technologies, Inc. Cell-substrate impedance monitoring of cancer cells
EP3589299B1 (fr) 2017-03-03 2025-04-09 Agilent Technologies, Inc. Procédés et systèmes pour la maturation fonctionnelle de cardiomyocytes dérivés de cspi et de cellule se
US10830724B2 (en) * 2017-12-22 2020-11-10 International Business Machines Corporation Micro-capacitance sensor array containing spaced apart first and second overlapping and parallel electrode plates for sensing analytes
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
US20210301245A1 (en) 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples

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US4054646A (en) * 1973-07-30 1977-10-18 General Electric Method and apparatus for detection of antibodies and antigens
SE407115B (sv) * 1975-10-06 1979-03-12 Kabi Ab Forfarande och metelektroder for studium av enzymatiska och andra biokemiska reaktioner
DE2711270A1 (de) * 1976-03-16 1977-09-22 Ici Ltd Organische materialien mit spezifisch reaktiven gruppen
EP0085276A1 (fr) * 1981-12-10 1983-08-10 Greiner Electronics Ag Procédé de détection immuno-chimique de substances
US4490216A (en) * 1983-02-03 1984-12-25 Molecular Devices Corporation Lipid membrane electroanalytical elements and method of analysis therewith
GB2136130B (en) * 1983-02-28 1987-02-11 Theodore Henry Krueger Chemical assay systems and methods
FR2598227B1 (fr) * 1986-04-30 1989-07-28 Bio Merieux Procede de detection et/ou d'identification d'une substance biologique dans un milieu liquide a l'aide de mesures electriques, et dispositif destine a la mise en oeuvre de ce procede

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023287A1 (fr) * 1993-03-31 1994-10-13 Dkk Corporation Procede et cellule de dosage immunologique
US6508803B1 (en) 1998-11-06 2003-01-21 Furukawa Techno Material Co., Ltd. Niti-type medical guide wire and method of producing the same

Also Published As

Publication number Publication date
US4920047A (en) 1990-04-24
IL89719A0 (en) 1989-09-28
NO892020L (no) 1989-11-21
NO892020D0 (no) 1989-05-19
EP0342382A3 (fr) 1990-10-31
EP0342382A2 (fr) 1989-11-23

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