JPH0225428A - Reduction of bitterness and bitterness reducing composition - Google Patents

Abstract

PURPOSE:To selectively reduce bitterness without damaging medicinal effects of drug and taste of food by adding sodium sulfate to a bitter substance. CONSTITUTION:A bitter substance is incorporated with 0.0001-25 times as much anhydrous sodium sulfate or sodium sulfate hydrate as the substance to selectively alleviate bitterness. When a target substance is a drug, the amount of anhydrous sodium sulfate or sodium sulfate hydrate is preferably 0.5-25 times as much as the substance and when the target substance is a food, the amount is preferably 0.0005-0.1 as much as the substance in the case of a solid food and 0.0001-0.1 as much as the substance in the case of a liquid food.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a composition in which sodium sulfate is added to a bitter substance and a method for reducing the bitterness of a bitter substance.

An object of the present invention is to provide a method for selectively reducing bitterness without impairing the medicinal efficacy of pharmaceuticals and the taste of foods, and a bitterness-reducing composition containing a bitter substance and sodium sulfate.

[Prior Art] Conventionally, in the fields of pharmaceuticals and foods, a method of reducing bitterness by adding a so-called bitterness masking agent to a substance having bitterness is known. For example,
A method of adding uridylic acid or cytidylic acid and a mixture of two or more of them to a bitter-tasting medicine (Japanese Patent Publication No. 17044/1983), a method of adding uridylic acid or cytidylic acid and a mixture of two or more thereof to a bitter-tasting medicine or food, and a method of adding one or more constituent amino acids to a bitter-tasting medicine or food. −
Method of adding glutamic acid-containing peptide or aspartic acid-containing peptide (JP-A-50-121449
No. 51-73113), a method of adding citric acid and an alkali metal citric salt to an aqueous solution containing a bitter component (Japanese Patent Application Laid-open No. 60-246325), a method of reducing the bitterness of potassium chloride with sugar alcohol ( Jikaisu 1986-32855 @) is known.

However, it is completely unknown that sodium sulfate has the effect of reducing bitterness.

[Problems to be Solved by the Invention] For example, although conventionally known bitterness masking agents can reduce the bitterness of bitter foods, they may impair the taste, which may impair the medicinal efficacy of pharmaceuticals or food products. It has been desired to develop a method for selectively reducing bitterness without impairing taste.

[Means for Solving the Problem] Under these circumstances, the inventors of the present invention have conducted extensive research into methods for reducing the bitterness of bitter substances, and have found that sodium sulfate can achieve the intended purpose. This discovery led to the completion of the present invention.

The present invention will be explained in detail below.

Examples of bitter substances used in the present invention include alkaloids such as quinine hydrochloride, quinine sulfate, rescinamine, and caffeine; glycosides such as Scutellaria japonica, gentian, zabonin, and tannin; Antibiotics such as ramphenicol and cephalexin; chemical synthetics such as dextromethorphan hydrobromide, oxapium iodide, metallofenoxate hydrochloride and hydralazine hydrochloride;
Amino acids or their hydrochlorides such as L-tryptophan, leucine, 1-methionine and l-lysine; cyclanderate; aminopyrine; inorganic substances such as potassium chloride and magnesium sulfate; terpenes such as limonene; casein; soy protein Examples include decomposition products of , as well as pharmaceuticals and foods containing these.

Moreover, examples of the sodium sulfate used in the present invention include hydrates of anhydrous sodium sulfate and sodium sulfate, specifically hydrates such as sodium sulfate decahydrate.

In addition, the amount of sodium sulfate added to a substance having a bitter taste is usually o, oooi for a substance having a bitter taste.
~25 times (weight ratio); for example, in the case of a bitter medicine, it varies depending on the intensity of bitterness exhibited by the target medicine, but it is 0.1 times or more (weight ratio) of the target medicine, preferably 0.5 It is sufficient if it is ~25 times (weight ratio).

In addition, in the case of a food with a bitter taste, it is preferable to use a solid powder that is at least o, oooi times (weight ratio) of the target food, although it depends on the strength of the bitterness exhibited by the target food or whether some bitterness remains. 0.00 for applicable foods.
0.05 to 0.1 times (weight ratio), and o,oooi to 0.1 times (weight ratio) for liquid target foods.

Further, the substance having a bitter taste according to the method of the present invention may be in any form such as solid, powder, or liquid.

In addition, sodium sulfate may be added in a conventional manner, for example, to powdered pharmaceuticals or foods before or after drying the powder, or to liquid pharmaceuticals or foods. , may be directly added in an effective amount by a conventional method.

Furthermore, for solid pharmaceuticals or foods, sodium sulfate may be mixed before molding to form tablets or granules, or a film containing sodium sulfate may be formed on the surface of the tablets or granules.

[Effects of the invention] 1. Effect of reducing bitterness on bitter-tasting pharmaceuticals Panelists have found that aqueous solutions or suspensions of bitter-tasting pharmaceuticals and aqueous solutions or suspensions of bitter-tasting pharmaceuticals with addition of sulfuric anhydride or 1 d of suspension for about 5 seconds each.
A sensory test was conducted by putting it in the mouth.

Each symbol in the table indicates the meaning below.

I don't feel any bitterness at all.

±　° does not taste bitter at all.

10: Feels a weak bitter taste.

+10: I feel a strong bitterness.

+10; Extremely strong bitterness.

The table below shows the results of the evaluation of the effect of reducing the bitterness of bitter-tasting pharmaceuticals by adding sodium to lithium sulfate anhydride.
Shown in 1.

Table 1 2.Bitterness reduction effect panel for bitter foods
A sensory test was conducted by holding a food with a bitter taste and a food with anhydrous sodium sulfate added to the bitter food in the mouth.

Each symbol in the table indicates the meaning below.

; I don't feel any bitterness at all.

+; Feels a weak bitterness.

10: I feel a strong bitter taste.

Table 2 shows the results of the evaluation of the bitterness reducing effect of adding sulfuric anhydride to bitter foods.
Shown below.

Table-2 *]: Suspended in Bo *; Percentage indicates weight percentage.

As is clear from the results in Tables 1 and 2, sodium sulfate has the effect of reducing the bitterness of bitter substances.

[Examples] Next, the present invention will be explained with reference to Examples and formulation examples, but the present invention is not limited thereto.

Hey, all percentages are by weight.

In Examples and Formulation Examples, the following methylcellulose, polyvinylpyrrolidone, carboxymethylcellulose calcium salt, and microcrystalline cellulose were used, respectively.

○Methylcellulose (SR400: manufactured by Shin-Etsu Chemical Co., Ltd.) ○Polyvinylpyrrolidone (PVP-30; manufactured by Basfu Corporation) ○Carboxymethylcellulose calcium salt (ECG
505; manufactured by Nichirin Kagaku Co., Ltd.) ○ Microcrystalline cellulose (Avicel P former 01. manufactured by Asahi Kasei Co., Ltd.) Example 1 100 m3 of assembly powder was suspended in 100 m3 of distilled water,
Then, 600 #Ig of anhydrous sodium sulfate is added to obtain a 0.1% suspension of the assembly.

Example 2 50 m3 of oxapium iodide is dissolved in 100 d of distilled water, and then anhydrous sodium 5A acid eoomg is added to obtain a 0.05% aqueous solution of oxapium iodide.

Example 3 200 mg of dextromethorphan hydrobromide was dissolved in 100 g of distilled water, and then 60 g of anhydrous sodium sulfate was dissolved in 100 g of distilled water.
0 my is added to obtain a 0.2% aqueous solution of dextromethorphan hydrobromide.

Example 4 L-1 - 1 g of L-tryptophan hydrochloride is dissolved in 100 d of distilled water, and then 600 mg of anhydrous sodium sulfate is added to obtain a 1% aqueous solution of L-tryptophan hydrochloride.

Example 5 25 mg of quinine sulfate was dissolved in 100 ml of distilled water,
Then, 600//iJ of anhydrous sodium sulfate was added,
A 0.025% aqueous solution of quinine sulfate is obtained.

Example 6 50 mg of chloramphenicol is dissolved in 10 parts (7 parts) of distilled water, and then 19 parts of anhydrous sodium sulfate is added to obtain a 0.05% aqueous solution of chloramphenicol.

Example 7 A grapefruit was cut in half and the juice was squeezed to obtain approximately 260 m of fruit juice from each grapefruit. This fruit juice 107 is weighed out and 100 #IJ of anhydrous sodium sulfate is added to obtain grapefruit juice.

Example 8 Coarse grinding] - Extract 40 g of coffee powder with 400 d of hot water, weigh out 10 d of the extract, and add 25 mg of anhydrous sodium sulfate to obtain a coffee extract.

Formulation example 1. Syrup Dextromethorphan hydrobromide 1oomg, refined white sugar 300rw), citric acid 300mg, glycine 360mg
Powders of 300 mg of anhydrous FANsu1~Thulium 00/IIj9 and methyl cellulose are dissolved in distilled water and adjusted to a total weight of 100 d to obtain a syrup.

Formulation Example 29 Tablets 10 mg of oxapium iodide, 30 mg of lactose, 80 mg of corn starch, 5 omg of microcrystalline cellulose, and iomg of anhydrous sodium sulfate (pulverized product) were kneaded with 5 mg of polyvinylpyrrolidone (10% aqueous solution), and air-dried at 40°C. do. To this, 20 mg of carboxymethyl cellulose calcium salt and 5 mg of magnesium stearate were added, and each tablet was compressed to 210 mg.
Get the tablets.

Formulation example 3. Herbal medicine powder (daily dose): 60 mg of cinnamon powder, 30 mg of bittern powder, 30 m1 of ginger powder, 30 m3 of fennel powder, 30 m3 of powdered fenugreek
, 300m7 of licorice powder, 620mg of Sodula powder, 50m3 of Japanese sagebrush powder, 900m7 of lactose, 550m of microcrystalline cellulose! J and anhydrous sodium sulfate (pulverized product > 2
50 mg was mixed with 150 mg of polyvinylpyrrolidone (10% ethanol solution) and air-dried at 40°C. Then, the particles are sized using a sizing machine equipped with a 32-mesh screen to obtain a powder.

Formulation example 4. Herbal medicine powder (daily dose): cinnamon powder 80ml, bittersweet powder 30mg, ginger powder 30m3, fennel powder 30mg, fenugreek powder 30#I
9. Licorice powder 300771F, licorice powder 620#
lJ, 5 omg of assembly powder, 900 my of lactose, 55 h+g of microcrystalline cellulose, and 570 m3 of sodium sulfate decahydrate (pulverized product) to polyvinylpyrrolidone (1
0% ethanol solution) 150m! Knead using 4
Air dry at 0'C. Then, the particles are sized using a sizing machine equipped with a 32-mesh screen to obtain a powder.

Claims (4)

[Claims] (1) A method for reducing the bitterness of a bitter substance, which comprises adding sodium sulfate to the bitter substance. (2) The method for reducing the bitterness of a substance having a bitter taste according to claim (1), wherein the substance having a bitter taste is a pharmaceutical. (3) The method for reducing the bitterness of a substance having a bitter taste according to claim (1), wherein the substance having a bitter taste is a food. (4) A bitterness reducing composition comprising a bitter substance and sodium sulfate.