JPH02255148A - Double chamber container - Google Patents

Abstract

PURPOSE:To facilitate the mixing of components and preparations at the time of use by forming a double chamber container of radiation crosslinkable plastic, irradiating at least a part of a partition part to form a part irradiated with an electron beam and adhering this part by heating or press welding the same by clamping. CONSTITUTION:Two sheets of, for example, low-density polyethylene 1 which is the material crosslinkable by irradiation of radiations are superposed and the circumference thereof exclusive of liquid introducing ports 3 and 3' is sealed by thermal welding and thereafter, the central part of this container is irradiated with the electron beam to cause the crosslinking reaction of the polyethylene and to form the part 4 irradiated with the electron beam. The center of this part 4 irradiated with the electron beam is adhered by heating to provide the partition part 5. The double chamber container for transfusion is thus produced. A saccharoelectrolysis liquid is introduced from the introducing port 3 into the chamber A if this container and an amino acid liquid is introduced from the introducing port 3' into the chamber B. After the ports 3 apd 3' are sealed, the container is heated to execute a sterilization treatment. The partition part 5 is peeled when either of the chamber A or the chamber is pushed by hand. The chamber A and the chamber B are then communicated with each other and the liquids in both the chambers are easily mixed with each other.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to containers for infusions or tube feedings used primarily in medical applications, particularly for storing infusions and/or nutrients. In order to prevent quality changes, it relates to a multi-chamber container in which each component or preparation is divided into two or more types and stored so that they can be easily mixed at the time of use.

[Conventional technology]

Conventionally, nutritional infusions and other liquid nutritional supplements are formulated by incorporating at least 211I, an ingredient selected from the group consisting of sugars, fats, amino acids, electrolytes, and vitamins.

However, depending on the selection of the above-mentioned ingredients, for example, when glucose and amino acids are combined into a single agent, a so-called Maillard reaction occurs, resulting in coloring. Furthermore, when a fat emulsified liquid is mixed with an electrolyte and/or an amino acid to form a single agent, it has the disadvantage that the emulsified oil coagulates and separates.

For this reason, components or preparations that cannot be manufactured or stored as a component or a part thereof are stored and supplied in separate containers, and these components or preparations are mixed at the time of use.

In order to mix these separate containers at the time of use to make a partial preparation, it is necessary to transfer them to one container and mix them. Therefore, before mixing, multiple containers containing each component or each preparation, Not only do they require a large number of containers and equipment, such as bottles or bags, for mixing, but they also require extremely careful handling to ensure that the transfer and mixing operations are carried out aseptically.

As a means to solve this drawback, we divided a plastic bag-like container into two chambers, leaving a part of the communication area. , prevent the components or preparations in each chamber from mixing (for example, JP-A-51-132692), or
A ball or a tube with one end closed is inserted into the communication part to keep one and both chambers in a discontinuous state (Japanese Patent Application Laid-Open No. 57-52455
It has been proposed that the communication section be opened during use so that the components or preparations in both chambers can be mixed.

[Problem to be solved by the invention]

In these conventional multi-chamber containers, in order to separate and communicate each chamber, in addition to fusing to form a liquid-tight cut, a communicating part is left and the communication is prevented when this part is not in use. In order to
It is necessary to provide equipment or parts such as special lamps as described above.

In addition, as materials for forming multi-chamber containers, the Japanese Pharmacopoeia allows polyvinyl chloride, polypropylene, and polyethylene for plastic containers for infusions; When sterilization is performed with the above-mentioned means such as a clamp provided to prevent communication between the parts, the above-mentioned material has poor heat resistance, so the part where the means to prevent communication such as a clamp is installed is fused. During use, that is, when trying to mix the components or preparations contained in each chamber, the communication part does not open, making it impossible to mix, which has the disadvantage of making it unusable.

Therefore, the object of the present invention is to construct a multi-chambered container house divided into multiple chambers by liquid-tight partitions, use inexpensive plastic materials approved by the Japanese Pharmacopoeia, and even after sufficient sterilization, each chamber will not be damaged. To provide a multi-chamber container for an infusion solution or a nutrient, which allows easy communication during use and allows mixing of components or preparations in each chamber by creating a fusion at a communicating part between the two chambers.

[Means to solve the problem]

The present invention provides a multi-chambered plastic container divided into multiple compartments by a liquid-tight partition, wherein the plastic is a radiation-crosslinkable plastic, at least a part of the partition is irradiated with radiation, and the radiation irradiated part is heated. A multi-chamber container that is glued or crimped with a clamp.

The plastic material that can be used in manufacturing the multi-chamber container according to the present invention is a material that can be cross-linked by irradiation with radiation, and the non-irradiated parts can be fused by heat compression bonding. Any material that can be used can be used, such as polyethylene,
There are polyvinyl chloride, ethylene-vinyl acetate copolymer, polyvinylidene chloride, and polyethylene terephthalate.
These sheets or films can be used.

When manufacturing the multi-chamber container of the present invention using these materials, sheets or films made of the above materials are stacked,
The surrounding portions are fused by heat and pressure bonding using a known method. In addition, in order to prevent the heat draft of the present invention, a liquid-tight partition is provided by fusion in a straight line or a curved line in order to divide the container into two parts depending on the desired number of chambers. When using a mixture of each component or preparation, the parts where communication is to be created between the chambers, that is, the parts corresponding to the communication parts, are irradiated in advance with radiation appropriate for the plastic material used, and the monthly charge is When a liquid-tight partition is formed by causing a cross-linking reaction, as described above, the non-irradiated area will be fused, or the irradiated area will not be fused. Pressure with means to prevent communication. ゛When the non-irradiated areas are fused together, the irradiated areas will not be fused, but external force (this may cause adhesion to the extent that it can be peeled off). In such cases, there is no need to hold it with a clamp or the like.

The non-irradiated area is fused and the irradiated area is fused (adhered) (for example, polyethylene, ethylene, etc.).
In the case of vinyl acetate copolymer and polyethylene terephthalate, heat fusion is performed, and in the case of polyvinyl chloride and polyvinylidene chloride, high frequency fusion is performed.

Radiation that can be used includes, for example, electron beams or gamma rays, the intensity of which is usually between 1 and 100 MRad for polyethylene.
, 0 for polyvinyl chloride and polyvinyritine chloride
, 1 to 50 MRad, 1 to 30 MRad for ethylene-vinyl acetate copolymer, and 1 to 30 MRad for polyethylene terephthalate G.

[For production]

In the multi-chamber container of the present invention, at least a portion of the liquid-tight cut portion is irradiated with radiation in advance to form the cut portion G, so that this portion is fused and has a peelable level of adhesion. Alternatively, if not bonded, communication between the chambers can be prevented by holding with a clamp or the like. In addition, since those parts are crosslinked by radiation irradiation, even if components or preparations are sealed in each chamber and then sterilized, that is, subjected to high temperature treatment, the parts will not fuse together. Therefore, when trying to mix components or preparations in each chamber, simply pressing one chamber by hand or removing the clamp will release the adhesive in the radiation irradiated area, allowing the chambers to communicate and mixing. .

〔Example〕

The present invention will be described below with reference to Examples and drawings.

1 and 2 are plan views of each embodiment.

Example 1 As shown in Figure 1, the length is 30 cm, the width is 18 cm, and the thickness is 20 cm.
Two low-density polyethylene sheets 1 of 0 μm are stacked, and the peripheral part 2 is heat-sealed to a width of 1 m (1 m) at about 120° C., except for the liquid inlet ports 3 and 3'. Next, as shown in the figure, the central part of this container (vertical width: 3 cm, width: 18 cm) was irradiated with an electron beam (absorbed dose: 20 cm).
MRad) was performed to cause a crosslinking reaction of the polyethylene to form the electron beam irradiation part 4. Next descendant here electron beam irradiation section 4
A partition 5 was provided in the center of the container by heating and bonding at a temperature of 180° C. with a width of 1 degree as shown in the figure, thereby creating a multi-chamber container for infusion divided into chambers A and B.

Pour the sugar-weighted decomposition solution into chamber A of this container from inlet 3, and
(This amino acid solution was put into the infusion chamber from the inlet 3', and the inlets 3 and 3' were sealed.Then, the container containing this infusion solution was placed in the 115
The mixture was heated at ℃ for 30 minutes, sterilized, and cooled. The fluid in the compartment could be stored without being mixed.

Next, when trying to mix both the liquids in chambers A and B, if either chamber A or chamber B is pressed by hand, the electron beam irradiation heating adhesive partition 5 will peel off, and chambers A and B will be separated. It is connected to the art room,
The liquids inside could be mixed easily.

Example 2 As shown in Fig. 2, length 30cIrL1 width 18σ, thickness 2
00 μm soft polyvinyl chloride sheets 1 are stacked together,
The peripheral part 2 is heated to a width of about 12 mm using a high frequency heating device.
The liquid inlets 3 and 3' were fused and sealed at 5°C. Next, as shown in the figure, the container has a vertical width of 2α and a width of 4c on the right side of the center, in contact with the surrounding area 2! Electron beam irradiation (absorbed dose 10 MRad) was performed using IL to cause a crosslinking reaction and form the electron beam irradiated portion 4. Next, this electron beam irradiation part 4 and its extension part 6 are subjected to high frequency heating (approximately 135°C) with a width of approximately 1 cIrL.
L. The extension part 6 was fused to form a partition and the heating partition part 5 in the irradiation part 4 was adhered to create a multi-chamber container for infusion divided into a chamber A and a chamber B.

Pour the sugar electrolyte solution into chamber A of this container from inlet 3, and
Pour the amino acid solution into the chamber from the inlet 3', and
' was sealed. Next, the container containing this infusion solution was heat sterilized at 121° C. for 30 minutes and cooled. The fluid in the compartment could be stored without being mixed.

Next, when trying to mix the liquids in chambers A and B, if either chamber A or chamber B is pressed down by hand, the adhesive partition 5 in the electron beam irradiation section 4 will peel off, and the liquids in chamber A and B will be separated. The chambers were in communication and the liquid in both chambers could be mixed easily.

Example 3 In Example 2, the electron beam irradiation section 4 was made to have both a vertical width and a width of 2 cm, and only its extension section 6 was heated with high frequency fluid and fused to form a partition section, and the electron beam irradiation section 4 was High frequency heating was not performed. Instead, this electron beam irradiation unit 4 was suppressed with a clamp to prevent communication between chambers A and B, thereby creating a partitioned multi-chamber container.

A sugar electrolyte solution and an amino acid solution were placed in chambers A and B in the same manner as in Example 2, respectively, and heat sterilization was performed in the same manner as in Example 2.

The fluid in the compartment could be stored without being mixed. Next, when the liquids in chambers A and B are to be mixed, the clamp that suppresses and seals the electron beam irradiation section 4 is removed, and the electron beam irradiation section 4 opens.
Both solutions were easily mixed.

(Effects of the Invention) In the multi-chamber container of the present invention, at least a part of the liquid-tight partition is irradiated with radiation in advance, so even after high-temperature treatment such as heat sterilization, this part is simply glued or pressed with a clamp. By doing so, it can be kept liquid-tight, and when in use, it can be easily peeled off or opened to allow communication between the compartments.

[Brief explanation of drawings]

1 and 2 are plan views of an embodiment of the multi-chamber container of the present invention. DESCRIPTION OF SYMBOLS 1... Sheet, 2... Surrounding part, 3, 3'... Liquid inlet, 4... Electron beam irradiation part, 5... Partition part, 6...
・Extension partition.

Claims (1)

[Claims] 1. In a plastic multi-chamber container divided into a plurality of chambers by a liquid-tight partition, the plastic is a radiation crosslinkable plastic, at least a part of the partition is irradiated with radiation, and the radiation irradiated part is heated. Multi-chamber containers that are glued or crimped together.