JPH02256608A - Dentifrice composition - Google Patents

Abstract

PURPOSE:To provide a composition such as a tooth wash or tooth paste having high safety and reduced irritation without changing the tastes of foods after the use of the composition by compounding a highly pure N-long chain acylglutamic acid salt containing reduced amounts of higher fatty acid impurities as a foaming agent. CONSTITUTION:A dentifrice composition contains as a foaming agent an N-long chain acylglutamic acid salt having a higher fatty acid content <=1.0wt.% (preferably <=0.5wt.%) in an amount of 0.1-5.0wt.%, preferably 0.3-3.0wt.%, in the case of a tooth paste and in an amount of 0.05-10wt.% in the case of a tooth wash. The dentifrice composition permits to dissolve 'juice effect' and 'dusty taste' wherein the taste of a highly acidic food, typically orange juice, is remarkably changed after the use of the composition. The glutamic acid composing the N-long chain acylglutamic acid salt is preferably the L-isomer and the salt thereof includes alkali metal salts and basic amino acid salts.

Description

Detailed Description of the Invention [Industrial Field of Application] The present invention relates to a dentifrice composition, more specifically, to improve the taste of foods eroded by dentifrice when using a safer N-long chain acylglutamate as a foaming agent. The present invention relates to a dentifrice composition that does not change the dentifrice composition.

[Prior art and its problems 1 A foaming agent is blended into a dentifrice composition in order to impart a cleaning effect, a dispersing emulsification effect, a foaming effect, etc., and a surfactant is used for this purpose.

Surfactants used as foaming agents increase the cleaning effect of toothpaste by lowering the interfacial tension of the toothpaste during use, promote the dispersion and penetration of the medicinal agents contained in the toothpaste, and increase its effectiveness. It can be said to be an essential ingredient as it plays a role such as providing a sense of stability through foaming.

These surfactants must not only have good performance such as interfacial tension lowering ability and foaming properties, but also satisfy aspects such as taste and odor since toothpaste is something that is put in the mouth. , conventionally, sodium alkyl sulfate, sodium acylsarcosine.

Anionic surfactants such as α-olefin sulfonate and coconut monoglyceride sodium sulfate are used. In particular, sodium alkyl sulfate has excellent performance and taste, and is commonly used. It has the major disadvantage of changing the taste of food after use, which is thought to occur when it is adsorbed to the taste buds and oral mucosa of the mouth, and is also a slight irritant to the oral mucosa and inactivates enzymes added as medicinal agents to toothpaste. There are problems such as

On the other hand, recently, the safety of these surfactants has become a problem, and various studies have been conducted to use safer surfactants as blowing agents.One of them is N-long chain acyl. It has been proposed to incorporate glutamate into toothpaste (Japanese Patent Publication No. 45-24480). N-long chain acylglutamate is non-toxic, has very mild irritation to the skin and mucous membranes, has good cleaning power, foaming power, emulsifying power, and has excellent hard water resistance. It is said to have the following characteristics and is very effective as a foaming agent for dentifrice compositions.

Regarding the taste of N-long chain acyl glutamate, it has been reported that when a large amount of N-long chain acyl glutamate containing a relatively low-grade acyl group (e.g. coconut oil fatty acid acyl) is contained, the taste becomes stronger. (Tokuko Showa 58-
45402), but nothing was known about the influence of impurities in N-long chain acylglutamate.

[Problems to be Solved by the Invention] An object of the present invention is to improve the taste of toothpaste containing N-long chain acylglutamate.

Here, the toothpaste includes paste toothpaste, water toothpaste, etc.

Means for Solving Problem E] The present inventor conducted a detailed study on the effect on taste when N-long chain acyl glutamate is added to toothpaste, and found that impurities were found in H-long chain acyl glutamate. Contains 1.0% higher fatty acids (free and/or salt form)
Below, when using a long-chain acyl glutamate with a high purity of preferably 0.5% by weight or less, the ``stickyness'' and ``juice effect'' of toothpaste (after using toothpaste, acidic foods, etc.) Specifically, we have discovered that it is possible to eliminate the phenomenon in which the taste of orange juice feels very different when drinking it (see Japanese Patent Publication No. 47-43830), and have completed the present invention.

That is, in the present invention, the content length of higher fatty acids as a blowing agent is 1.
．． Highly purified N-long chain acyl glutamate with a concentration of 0% or less, for example 0.1 to 5.0% in the case of paste toothpaste
This is a dentifrice composition characterized in that it is blended in an amount of 0.3 to 3.0% by weight, preferably 0.3 to 3.0% by weight.

The amount of N-long chain acyl glutamate is 0.1% by weight.
If it is not swirled, the foaming properties will decrease, and if it exceeds 5.0%, the appropriate softness necessary for the paste-like dentifrice composition will be lost, which is not preferable.

In the case of water toothpaste, it may be added, for example, from 0.05 to 10%. In the case of a water toothpaste that is applied directly into the oral cavity, preferably 5% by weight of O,OS is blended, and in the case of a water dentifrice that is diluted about 10 times and then applied into the oral cavity, it is preferably 1 to 10% by weight.
Mix 11%. If the amount of N-long chain acyl glutamate is less than 0.05%, flavor separation may occur, which is undesirable, and if it exceeds 10% by weight, it may be difficult to design a water toothpaste formulation. This is not desirable because it makes it difficult to

A method for obtaining highly pure N-long chain acyl glutamate is to react glutamic acid and higher fatty acid chloride in the presence of an alkali, using 1.1 to 1.3 times the molar amount of glutamic acid to the higher fatty acid chloride. , a method for suppressing the decomposition of higher fatty acid chlorides, or after drying impure N-long chain acyl glutamate containing several percent higher fatty acids, n-hexa22 petroleum ether, petroleum benzine.

Examples include a method of extracting and purifying higher fatty acids with a hydrophobic organic solvent such as toluene. Glutamic acid may be an L-monomer, a D-monomer, or a mixture of these in arbitrary proportions, but from the viewpoint of biocompatibility, an L-monomer is preferable.

The highly purified N-long chain acylglutamic acid thus obtained is incorporated into dentifrice compositions in the form of alkali metal salts such as sodium salts and potassium salts, or in the form of basic amino acid salts such as lysine. However, the foamability, safety, etc. that should originally be provided are not impaired.

N-long chain acylglutamic acid salts have 8 to 8 carbon atoms.
A water-soluble salt of glutamic acid N-substituted with 20 saturated or unsaturated acyl groups is used.

The above acyl groups include cabrinoyl, lauroyl, tridecanoyl, 2-methyllauroyl, myristoyl,
Pentadecanoyl, valmitoil.

Examples include stearoyl, isostearoyl, and oleoyl. It may also be a mixture of coconut oil fatty acid residues, palm oil fatty acid residues, hydrogenated beef tallow fatty acid residues, or mixed fatty acid residues of coconut oil and hydrogenated beef tallow.

The higher fatty acids to be removed from N-long chain acylglutamic acid in the present invention are unreacted higher fatty acids during the acylation reaction, and include not only the free form but also the salt form.

Dentifrice compositions generally contain calcium diphosphate.
Calcium carbonate, dihydrate and anhydride.

Calcium birophosphate, insoluble sodium metaphosphate,
Abrasives such as anhydrous silicic acid, hydrated silicic acid, aluminosilicate, alumina, and aluminum hydroxide, glycerin, sorbitol, and propylene glycol.

Thickeners such as poly(1-ethylene glycol), binders such as carboxymethylcellulostrium, Veegum, hydroxyethylcellulose, polyvinyl alcohol, saccharin sodium, glycyrrhizin salts, stevioside, neohesveridine dihydrochalcone, paramethoxycinnamic aldehyde, perilartine.

Sweeteners such as aspartame, flavoring agents such as menthol, carvone, and anethole are used, as well as fluorides such as sodium monofluorophosphate, tin fluoride, and sodium fluoride, bactericidal agents such as chlorhexacin salts, and sodium phosphate. Phosphate compound builders such as dextranase,
Enzymes such as amylase, ε-aminocaproic acid, tranexamic acid.

Active ingredients such as anti-inflammatory agents such as allantoinate and gingival astringents such as sodium chloride are used as appropriate.

In the case of a paste-like dentifrice composition, it can be manufactured by kneading these components with an appropriate amount of water. In the case of water toothpaste, it is produced by stirring and mixing these ingredients with an appropriate amount of water and/or alcohol. Ethanol is preferable as the alcohol.

Foaming agent and abrasive agent in the dentifrice composition of the present invention. thickening agent,
Binder, sweetener, bactericide. There is no particular restriction on the mixing ratio of the builder, anti-inflammatory agent, gingival astringent, etc., and it may be the same as that of conventionally known paste dentifrice compositions (toothpaste) and water dentifrices.

As the foaming agent of the present invention, an N-long chain acyl glutamate having a higher fatty acid content of 1.0% or less is used as a blowing agent.
By incorporating 0% by weight, the taste of the base-like dentifrice composition was improved. In the case of water toothpaste, the taste of the dentifrice composition is improved by incorporating 0.05 to 10% of high purity N-long chain acylglutamic acid. However, since the degree of taste and flavor varies greatly from person to person, there is no problem in adding various flavor components to the dentifrice composition of the present invention. These flavor components include the aforementioned sweeteners.

You can use fragrances etc. In particular, aspartame is weakly acidic and stable, and it is effective to incorporate it into a weakly acidic aS composition for the purpose of imparting sweetness.

As a blowing agent, in addition to the pure long-chain acylglutamate used in the present invention, commonly used surfactants such as sodium lauryl sulfate, sodium lauroyl sarcosine, etc. may be used in combination.

Next, examples will be shown to specifically explain the features of the present invention.

A paste toothpaste was prepared according to the conventional method according to the formulation shown in Table 1.

Table 1 Composition - (wt%) 40.0 2.0 20.0 0.1 0.1 2.0 Calcium carbonate Carboxymethyl cellulose Glycerin Sodium saccharin Sterilizer N-Wow 0 Illu L-Sodium glutamate For comparison Paste toothpastes were prepared using N-lauroyl-[-glutamate (sodium salt) with different lauric acid contents according to the formulation in Example 1, and a taste test was conducted by a panel of 10 experts when using the toothpaste. I did this. The results are shown in Table 2.

However, the rating in the table is 3: It has a strong taste.

2: Slightly dusty taste. 1: means no strong taste.

As shown in Table 2 and Table 4, various N-
A paste toothpaste was prepared using long-chain acyl-[-glutamate according to the formulation shown in Table 3 below, and a taste test was conducted.

As is clear from Table 3 and Table 2, the dentifrice composition of the present invention in which the content of lauric acid in the tauyl-[-glutamate is 1.0 wt 1% or less does not have an unpleasant taste. .

Calcium diphosphate dihydrate Carboxymethyl cellulose Glycerin Sorbitol Sodium saccharin Fungicide Long chain acyl-[-45,0 1,0 10,0 10°0 0.1 0.1 Glutamate 1.0 Taste test is an example The same expert panel as in 1 conducted a taste test of orange juice after brushing teeth. The results are also shown in Table 4.

However, the rating in the table is 5: The flavor changes significantly.

4: Flavor changes considerably. 3: Flavor changes slightly.

2: Almost no change in flavor, 1: No change in flavor.

Table 4 From the results in Table 4, it is clear that the paste toothpaste of the present invention, in which the content of higher fatty acids in N-long chain acyl-glutamate is 1.01 m% or less, has almost no taste of orange juice after use. It is clear that there is no change.

Example 7 Using high purity N-lauroyl-glutamate (lauric acid content: 0.2% by weight) and aspartame as a sweetener, a weakly acidic (DH6
, 8) was prepared and a taste test was conducted.

Table 5 Ingredients Blend m (% by weight) Calcium diphosphate dihydrate 40. O Carboxymethyl cellulose 1.0 Glycerin
10.0 Sorbitol 10, O Aspartame 0.1 Bactericide 0.1 As in Example 1, a panel of experts conducted a taste test of orange juice during and after tooth brushing.

As a result, no change in the flavor or taste of orange juice was noticed.

Example 8 A paste toothpaste was prepared using high purity N-lauroyl-[-glutamate (lauric acid content: 0.2% by weight) and sodium chloride according to the formulation shown in Table 6, and a taste test was conducted. .

Table 6 Ingredients Calcium Carbonate Carboxymethyl Cellulose Glycerin Sorbitol Sodium Chloride Bactericidal Amount (wt%) 35, 0 1, 0 10, 0 10, 0 0, 1 Sodium Lauryl Sulfate 0.3 Taste test was as in Example 1. A panel of experts also taste-tested orange juice while brushing and after brushing.

As a result, no change in the flavor or taste of orange juice was noticed.

A paste toothpaste was prepared using the formula shown in Table 7 using high-purity fIIN-lauroyl-[-glutamine R salt (lauric acid content is 0.141%) and sodium chloride, and a taste test was conducted. Ta.

Table 7 Proportion m (wt%) 40.0 1.0 10.0 10.0 10.0 0.1 Calcium carbonate carboxymethyl cellulose Glycerin Sorbitol Sodium chloride Disinfectant Taste test was conducted as in Example 1. A panel of experts also taste-tested orange juice while brushing and after brushing.

As a result, no change in the flavor or taste of orange juice was noticed.

Example 10 Water toothpaste was prepared with the composition shown in Table 8 below.

Table 8 Ingredients Amount (wt%) Saccharin Sodium Menthol Hydrochloride Chlorhexidine Glycerin Paraben Ethanol Water Total 0, 05 0, 05 0, 01 3, 0 0, 05 30, 0 Balance 100, 0 [Effects of the Invention] The present invention As a result, we were able to develop a paste-like dentifrice composition with improved taste, ``Hakoribasa'' and ``Juice Effect J,'' and which can be added with various flavor components to suit individual tastes.

Kuse Suhi 4 no'marinori. 7 company

Claims (4)

[Claims] (1) Content of higher fatty acid as blowing agent is 1.0% by weight
A dentifrice composition comprising the following N-long chain acyl glutamate. (2) N-long chain acyl glutamate from 0.1 to 5.0
The dentifrice composition according to claim 1, which is in the form of a paste containing % by weight. (3) N-long chain acyl glutamate from 0.05 to 10
Claim 1 characterized in that it is a water toothpaste containing % by weight.
The dentifrice composition described in . (4) The dentifrice composition according to any one of claims 1 to 3, wherein the N-long chain acyl glutamate is an N-long chain acyl-L-glutamate.