JPH03128352A - Granular cysteamine hydrochloride - Google Patents
Granular cysteamine hydrochlorideInfo
- Publication number
- JPH03128352A JPH03128352A JP20960189A JP20960189A JPH03128352A JP H03128352 A JPH03128352 A JP H03128352A JP 20960189 A JP20960189 A JP 20960189A JP 20960189 A JP20960189 A JP 20960189A JP H03128352 A JPH03128352 A JP H03128352A
- Authority
- JP
- Japan
- Prior art keywords
- cysteamine hydrochloride
- granular
- hydrochloride
- cysteamine
- corrosion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OGMADIBCHLQMIP-UHFFFAOYSA-N 2-aminoethanethiol;hydron;chloride Chemical compound Cl.NCCS OGMADIBCHLQMIP-UHFFFAOYSA-N 0.000 title claims abstract description 50
- 229940097265 cysteamine hydrochloride Drugs 0.000 title claims abstract description 50
- 238000001816 cooling Methods 0.000 claims abstract description 7
- 230000007797 corrosion Effects 0.000 claims abstract description 6
- 238000005260 corrosion Methods 0.000 claims abstract description 6
- 239000000758 substrate Substances 0.000 claims abstract description 5
- 230000008018 melting Effects 0.000 claims description 8
- 238000002844 melting Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 abstract description 10
- 239000000843 powder Substances 0.000 abstract description 9
- 239000012299 nitrogen atmosphere Substances 0.000 abstract description 6
- 239000004809 Teflon Substances 0.000 abstract description 5
- 229920006362 Teflon® Polymers 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 abstract description 5
- 150000007522 mineralic acids Chemical class 0.000 abstract description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract description 2
- 229920001971 elastomer Polymers 0.000 abstract description 2
- 229910052751 metal Inorganic materials 0.000 abstract description 2
- 239000002184 metal Substances 0.000 abstract description 2
- 150000002739 metals Chemical class 0.000 abstract description 2
- 229920001084 poly(chloroprene) Polymers 0.000 abstract description 2
- 239000011347 resin Substances 0.000 abstract description 2
- 229920005989 resin Polymers 0.000 abstract description 2
- 239000005060 rubber Substances 0.000 abstract description 2
- 229910001220 stainless steel Inorganic materials 0.000 abstract description 2
- 239000010935 stainless steel Substances 0.000 abstract description 2
- 239000010936 titanium Substances 0.000 abstract description 2
- 229910052719 titanium Inorganic materials 0.000 abstract description 2
- 229920002449 FKM Polymers 0.000 abstract 1
- 230000001112 coagulating effect Effects 0.000 abstract 1
- 239000012768 molten material Substances 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000000243 solution Substances 0.000 description 4
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 3
- 229960003151 mercaptamine Drugs 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229910000856 hastalloy Inorganic materials 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明は粒状システアミン塩酸塩に関するものである。[Detailed description of the invention] [Industrial application field] The present invention relates to granular cysteamine hydrochloride.
システアミン塩酸塩は、医薬、農薬などの原料として有
用な化合物であるが、本発明は微粉未発生が少なく粒径
のよくそろった、貯蔵中においても塊状化しないなどき
わめて取扱い上の作業性に優れ、しかも無機酸および有
＠液体への溶解性に優れた粒状のシステアミン塩酸塩及
びそのｌ！！造する方法を提供するものである。Cysteamine hydrochloride is a compound useful as a raw material for medicines, agricultural chemicals, etc., and the present invention has excellent workability in handling, with little generation of fine powder, uniform particle size, and no clumping during storage. Moreover, granular cysteamine hydrochloride with excellent solubility in inorganic acids and liquids and its l! ! It provides a method for creating
［従来の技術］
従来、シスアミン塩酸塩は一般的につぎのようにして製
造される。[Prior Art] Conventionally, cisamine hydrochloride is generally produced as follows.
（１）エチレイミンと硫化水素とからシステアミンを生
成させ、塩化水素を用いてシステアミン塩酸塩を生成さ
せる方法。(1) A method in which cysteamine is produced from ethyleimine and hydrogen sulfide, and cysteamine hydrochloride is produced using hydrogen chloride.
（２）２−ジメチル−チアゾリジンに塩酸を加えてシス
テアミン塩酸塩を生成させる方法（特公昭５０−２９４
４４号）
（３）モノエタノールアミンを出発原料としてシステア
ミン塩酸塩を生成させる方法（特開昭５７−８８１７１
号、特開昭５７−１４４２５２号、特公昭５５−１７０
１９号、特開昭５７−６４６８４号、特開昭５７−５３
４５８号、特開昭５７一６７５５５号、特開昭５７−６
４６６１号）従来、システアミン塩酸塩は粉体の形状で
取扱われているのが一般的である。しかしながら、シス
テアミン塩酸塩そのものは、人体に対して刺激性かあり
、特に微粉末を吸入すると鼻腔、咽頭を刺激し、咳、く
しゃみがで、また皮膚に付着した１１放置すると炎症を
おこすなど好ましくない性質を有している。したかって
、このような微粉末を多量に含有している粉体状のシス
テアミン塩酸塩を取扱うに際しては、出来る限り皮膚へ
の接触をさけるよう厳重な注意を払う必要がある。(2) Method for producing cysteamine hydrochloride by adding hydrochloric acid to 2-dimethyl-thiazolidine (Japanese Patent Publication No. 50-294
(No. 44) (3) Method for producing cysteamine hydrochloride using monoethanolamine as a starting material (JP-A-57-88171
No., JP-A-57-144252, JP-A-55-170
No. 19, JP-A-57-64684, JP-A-57-53
No. 458, JP-A-57-67555, JP-A-57-6
No. 4661) Conventionally, cysteamine hydrochloride has generally been handled in the form of powder. However, cysteamine hydrochloride itself is irritating to the human body, and inhaling the fine powder can irritate the nasal passages and pharynx, causing coughing and sneezing, and leaving it on the skin can cause inflammation, which is undesirable. It has properties. Therefore, when handling powdered cysteamine hydrochloride containing a large amount of such fine powder, strict care must be taken to avoid contact with the skin as much as possible.
また、粉体状のシステアミン塩酸塩は、貯蔵中に容器の
中で経時的に塊状化してしまい使用するにあたり、容器
から取り出すことができなくなったり、たとえ取り出し
なとしても再度、粉砕しなければ使用することができな
いなどの問題も有している。また塊状化したシステアミ
ン塩酸塩は溶解に長い時間を要するという問題をも有し
ている。In addition, powdered cysteamine hydrochloride may become agglomerated in a container over time during storage, making it impossible to take it out of the container, or even if it cannot be taken out, it must be crushed again before use. There are also problems such as not being able to do so. In addition, clumped cysteamine hydrochloride has the problem that it takes a long time to dissolve.
この様に、粉体のシステアミン塩酸塩は極めて問題の多
い製品の形態であるといわざるをえない。Thus, it must be said that powdered cysteamine hydrochloride is an extremely problematic product form.
［発明が解決しようとする問題点〕
このように、現存するシステアミン塩酸塩の粉状形態は
多くの問題点を有しており、特に工業的に多量に取扱う
に際して種々の不都合を生じている。そこで、本発明の
目的は、微粉末の発生が少なく、しかも貯蔵中において
も塊状化することなく長期間安定しな製品形態を有する
システアミン塩酸塩を提供することにある。[Problems to be Solved by the Invention] As described above, the existing powdered form of cysteamine hydrochloride has many problems, especially when it is handled industrially in large quantities, causing various inconveniences. SUMMARY OF THE INVENTION Therefore, an object of the present invention is to provide cysteamine hydrochloride which has a product form that is stable for a long period of time without generating a small amount of fine powder and does not form agglomerates even during storage.
かかる目的を達成するために、本発明者等は鋭意検討し
た結果、極めて粒径のよくそろった粒状システアミン塩
酸塩類かえられ、このものは微粉末の発生も少なく、貯
蔵安定性及び溶解性にも潰れていることを見い出し、本
発明を完成するにいたったのである。In order to achieve this objective, the inventors of the present invention have made intensive studies and have developed a granular cysteamine hydrochloride with extremely uniform particle sizes, which generates less fine powder and has excellent storage stability and solubility. They discovered that this was the case and completed the present invention.
［問題点を解決するための手段コ
本発明は粉末のシステアミン塩酸塩を溶融して得た溶融
システアミン塩酸塩を冷却、凝固せしめたことを特徴と
する粒状システアミン塩酸塩に関するものである。また
、粉末のシステアミン塩酸塩を溶融して得た溶融システ
アミン塩酸塩を、温度６５゛Ｃ以下に保持された耐蝕性
の基材上に滴下し、冷却、凝固せしめることを特徴とす
る直径０゜１〜２０ｍｍ、好ましくは直径１〜１５ｍｍ
の粒状システアミン塩酸塩に関するものである。[Means for Solving the Problems] The present invention relates to granular cysteamine hydrochloride, which is obtained by cooling and solidifying molten cysteamine hydrochloride obtained by melting powdered cysteamine hydrochloride. In addition, the molten cysteamine hydrochloride obtained by melting powdered cysteamine hydrochloride is dropped onto a corrosion-resistant substrate kept at a temperature of 65°C or less, and is cooled and solidified. 1-20mm, preferably 1-15mm in diameter
granular cysteamine hydrochloride.
本発明は各種の方法によって得られた粉体のシステアミ
ン塩酸塩に適用でき、その方法を限定するものではない
。The present invention can be applied to powdered cysteamine hydrochloride obtained by various methods, and is not limited to these methods.
本発明の方法により粒化できるシステアミン塩酸塩は常
温で固体であり、その融点は約６８℃である。Cysteamine hydrochloride, which can be granulated by the method of the present invention, is solid at room temperature and has a melting point of about 68°C.
システアミン塩酸塩の融解は、融点より高い温度、好ま
しくは６８〜１５０℃、さらに好ましくは７０〜１００
℃の温度が採用される。Cysteamine hydrochloride is melted at a temperature higher than its melting point, preferably from 68 to 150°C, more preferably from 70 to 100°C.
The temperature in °C is adopted.
またシステアミン塩酸塩は吸湿力が強く、高温で酸化を
受けやすいので窒素雰囲気中で加温するのが好ましい。Furthermore, cysteamine hydrochloride has strong hygroscopicity and is easily oxidized at high temperatures, so it is preferable to heat it in a nitrogen atmosphere.
固化させるにあたり、溶融液は６５℃以下に冷却された
平滑な耐蝕性の基材上に滴下し、急冷、固化させるのが
好ましく、通常、凝固点以下、２３０分以内で冷却され
る。耐蝕性の基材として、たとえばステンレス、チタン
、ハステロイ等の金属類、テフロン、ポリプロピレン、
ポリエチレン等の樹脂類、ネオプレン、パイトン等のゴ
ム類が挙げられる。For solidification, the molten liquid is preferably dropped onto a smooth, corrosion-resistant substrate cooled to 65° C. or below, rapidly cooled and solidified, and is usually cooled to below the freezing point within 230 minutes. Corrosion-resistant base materials include metals such as stainless steel, titanium, and Hastelloy, Teflon, polypropylene,
Examples include resins such as polyethylene, and rubbers such as neoprene and pyton.
冷却させる方法は、滴下面の反対側を冷却する方法、た
とえば、冷却水を循環させる方法が採用される。システ
アミン塩酸塩を融解し、冷却凝固せしめる方法は、通常
常圧下に実施されるが、場合により、減圧または加圧下
に行うこともできる。As a cooling method, a method of cooling the opposite side of the dropping surface, for example, a method of circulating cooling water is adopted. The method of melting cysteamine hydrochloride and cooling and solidifying it is usually carried out under normal pressure, but depending on the case, it can also be carried out under reduced pressure or increased pressure.
［実 施 例コ
以下、実施例及び比較例で本発明を更に詳しく説明する
。[Example] The present invention will be explained in more detail below using Examples and Comparative Examples.
［溶解性テスト方法］
粒状システアミン塩酸塩３０ｇを２００ｃｃ広口のガラ
ス製サンプルビン４本にとり、窒素置換後それぞれ密封
下、２０℃で０日、７日、１４日、３０日経過後開封し
た。[Solubility test method] 30 g of granular cysteamine hydrochloride was placed in four 200 cc wide-mouth glass sample bottles, and the bottles were opened after 0 days, 7 days, 14 days, and 30 days had elapsed at 20° C. under nitrogen purging and sealed.
■ 窒素雰囲気下で１００ｍＪビーカー内の３５重量％
塩酸水溶液４０ｍ、Ｑに粒状システアミン塩酸塩を１０
ｇ入れて、スターシーで２００ｒｐｍの回転数で混合し
て、２５℃での溶解時間を測定した。■ 35% by weight in a 100mJ beaker under nitrogen atmosphere
40ml of hydrochloric acid aqueous solution, 10ml of granular cysteamine hydrochloride in Q
g, and mixed at a rotation speed of 200 rpm using Starsea, and the dissolution time at 25° C. was measured.
■ 窒素雰囲気下で１００ｍｊビーカー内のエタノール
２５ｍＪに粒状システアミン塩酸塩を８ｇ入れて、スタ
ーシーで２００ｒｐｍの回転数で混合して、２５℃で溶
解時間を測定した。(2) Under a nitrogen atmosphere, 8 g of granular cysteamine hydrochloride was added to 25 mJ of ethanol in a 100 mJ beaker, mixed at a rotation speed of 200 rpm using a Starsea, and the dissolution time was measured at 25°C.
［塊状化テスト方法］
粒状システアミン塩酸塩３０ｇを２００ｃｃ広口のガラ
ス製サンプルビン４本にとり、窒素置換後でそれぞれ密
封下３０℃で０日、７日、１４日、３０日経過後、ビン
を１８０゛回転して上下を逆さにした時の粒子の移動状
態を肉眼で観察した。[Agglomeration test method] Place 30 g of granular cysteamine hydrochloride in four 200 cc wide-mouth glass sample bottles, and after 0 days, 7 days, 14 days, and 30 days have elapsed at 30°C under nitrogen purging, the bottles were heated to 180°. The movement of the particles was observed with the naked eye when it was rotated and turned upside down.
実施例 １
容量ＩＪのオートクレーブ中にメタノール２０ＯＣＣを
仕込み、系内を窒素置換した。この系の温度を０〜５℃
の範囲内に調節し、撹拌下に硫化水素１３６＋ｒ（４モ
ル）を仕込んだところ、系の圧力は８．６ｋｇ／ｃｄＧ
となった。系の温度を０〜５℃の範囲内に保ち、エチレ
ンイミン８６ｇ（２モル）をメタノール１００ｍｊに溶
解した溶液を撹拌下に２時間かけて連続添加し、反応さ
せた。反応終了後の系の圧力は３．６ｋｇ／ｃＪＧであ
った。Example 1 20 OCC of methanol was charged into an autoclave having a capacity of IJ, and the inside of the system was purged with nitrogen. The temperature of this system is 0-5℃
When hydrogen sulfide 136+r (4 mol) was charged under stirring, the pressure of the system was 8.6 kg/cdG.
It became. The temperature of the system was maintained within the range of 0 to 5° C., and a solution of 86 g (2 mol) of ethyleneimine dissolved in 100 mj of methanol was continuously added over 2 hours with stirring to cause a reaction. The pressure of the system after the completion of the reaction was 3.6 kg/cJG.
得られた反応混合物を窒素シール下にてメタノールが少
量留去されるまで加熱して硫化水素を追い出した。さら
に５℃に冷却して析出した結晶を窒素雰囲気下でろ別、
乾燥させて白色結晶性のシステアミンを得た。The resulting reaction mixture was heated under a nitrogen blanket until a small amount of methanol was distilled off to drive off hydrogen sulfide. After further cooling to 5°C, the precipitated crystals were filtered out under a nitrogen atmosphere.
After drying, white crystalline cysteamine was obtained.
得られたシステアミンをガラス性セパラグルフラスコに
移し、６００ｍＮのイソプロピルアルコールに溶解した
後、７３ｇの塩化水素ガスを吹き込みシステアミン塩酸
塩！８液を得た。該溶液を５℃に冷却して析出した結晶
を窒素雰囲気下でろ別、乾燥させて白色結晶性のシステ
アミン塩酸塩を得た。The obtained cysteamine was transferred to a glass separaglu flask and dissolved in 600 mN isopropyl alcohol, and then 73 g of hydrogen chloride gas was blown into it to form cysteamine hydrochloride! Eight liquids were obtained. The solution was cooled to 5° C., and the precipitated crystals were filtered and dried under a nitrogen atmosphere to obtain white crystalline cysteamine hydrochloride.
得られた白色結晶性の粉末システアミン塩酸塩を８０℃
に加温して溶融させた後、口径２ｍｍのパスツールピペ
ットに吸い取り、水で反対面が冷却されて３０℃に保持
されているテフロン板上に滴下した。テフロン板上で固
化したシステアミン塩酸塩の白色固体は直径３〜５ｍｍ
、高さ２〜３ｍｍの半球状であった。The obtained white crystalline powder cysteamine hydrochloride was heated at 80°C.
After melting by heating, the mixture was sucked into a Pasteur pipette with a diameter of 2 mm, and dropped onto a Teflon plate whose opposite side had been cooled with water and maintained at 30°C. The white solid of cysteamine hydrochloride solidified on the Teflon plate has a diameter of 3 to 5 mm.
, and had a hemispherical shape with a height of 2 to 3 mm.
得られた粒状システアミン塩酸塩について、３０℃でＯ
〜３０日間保存後、３５重量％塩酸水溶液とエタノール
に対する溶解性テストおよび塊状化テストをした。The obtained granular cysteamine hydrochloride was treated with O at 30°C.
After storage for ~30 days, a solubility test in a 35% by weight aqueous hydrochloric acid solution and ethanol and a clumping test were conducted.
溶解性テストの結果を表−１に示す、また塊状化テスト
の結果を表−２に示す。The results of the solubility test are shown in Table 1, and the results of the agglomeration test are shown in Table 2.
表
表
比較例１
実施例１において得られた白色結晶性の粉末のシステア
ミン塩酸塩について、窒素置換後、３０℃でＯ〜３０日
間保存後、溶融せずにその状態で３５重量％塩酸水溶液
とヱタノールに対する溶解性テストおよび塊状化テスト
をしな。Table Comparative Example 1 Cysteamine hydrochloride, a white crystalline powder obtained in Example 1, was stored at 30°C for 30 days after purging with nitrogen. Perform solubility test and clumping test for ethanol.
溶解性テストの結果を表−３に示す。また塊状化テスト
の結果を表−４に示す。The results of the solubility test are shown in Table 3. Table 4 shows the results of the clumping test.
表 ３
表
実施例２
実施例１においてテフロン板上で固化した直径１０〜１
５ｍｍ、高さ５〜６ｍｍの半球状システアミン塩酸塩の
白色固体を用いる以外は実施例１と同様に行ない、３５
重量％塩酸水溶液に対する溶解性テストおよび塊状（ヒ
テストをした。Table 3 Table Example 2 Diameter 10 to 1 solidified on the Teflon plate in Example 1
The same procedure as in Example 1 was carried out except that a hemispherical white solid of cysteamine hydrochloride having a size of 5 mm and a height of 5 to 6 mm was used.
A solubility test in a wt% aqueous hydrochloric acid solution and a mass test were conducted.
溶解性テストの結果を表−５に示す。また塊状化テスト
の結果を表−６に示す。The results of the solubility test are shown in Table-5. Table 6 shows the results of the clumping test.
表
［効 果］
表−１から明らかな通り本発明の粒状システアミン塩酸
塩は従来の粉末システアミン塩酸塩に比較し、貯蔵中に
容器の中で塊状化することがなく、また無機酸および有
機液体への溶解性に優れた効果を発揮するものである。Table [Effects] As is clear from Table 1, the granular cysteamine hydrochloride of the present invention does not form lumps in a container during storage, compared to the conventional powdered cysteamine hydrochloride, and is effective against inorganic acids and organic liquids. It exhibits excellent solubility in
Claims (2)
ステアミン塩酸塩を冷却、凝固せしめたことを特徴とす
る粒状システアミン塩酸塩。(1) Granular cysteamine hydrochloride, which is obtained by cooling and solidifying molten cysteamine hydrochloride obtained by melting powdered cysteamine hydrochloride.
ステアミン塩酸塩を、温度６５℃以下に保持された耐蝕
性の基材上に滴下し、冷却、凝固せしめたことを特徴と
する請求項１記載の粒状システアミン塩酸塩。(2) A claim characterized in that molten cysteamine hydrochloride obtained by melting powdered cysteamine hydrochloride is dropped onto a corrosion-resistant substrate kept at a temperature of 65° C. or less, and then cooled and solidified. 1. The granular cysteamine hydrochloride according to 1.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019900010687A KR0154328B1 (en) | 1989-07-14 | 1990-07-13 | Method for production of granular cysteamine hidrochloride |
| IE257290A IE67043B1 (en) | 1989-07-14 | 1990-07-13 | Granular cysteamine hydrochloride and method for production thereof |
| CN90107077A CN1031997C (en) | 1989-07-14 | 1990-07-14 | Granular cysteamine hydrochloride and method for production thereof |
| TW079105848A TW198696B (en) | 1989-07-14 | 1990-07-14 | |
| ES90307742T ES2070280T3 (en) | 1989-07-14 | 1990-07-16 | GRANULAR CISTEAMINE CHLORIDE AND METHOD FOR ITS PRODUCTION. |
| DE69018327T DE69018327D1 (en) | 1989-07-14 | 1990-07-16 | Granulated cysteamine hydrochloride and process for its preparation. |
| EP90307742A EP0408398B1 (en) | 1989-07-14 | 1990-07-16 | Granular cysteamine hydrochloride and method for production thereof |
| US07/703,744 US5256362A (en) | 1989-07-14 | 1991-05-21 | Method for production of granular cysteamine hydrochloride |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1-180181 | 1989-07-14 | ||
| JP18018189 | 1989-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03128352A true JPH03128352A (en) | 1991-05-31 |
Family
ID=16078804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20960189A Pending JPH03128352A (en) | 1989-07-14 | 1989-08-15 | Granular cysteamine hydrochloride |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03128352A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8979513B2 (en) | 2010-10-07 | 2015-03-17 | Sanyo Denki Co., Ltd. | Lead wire engaging structure and electric apparatus |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4839414A (en) * | 1971-09-30 | 1973-06-09 | ||
| JPS5781454A (en) * | 1980-11-10 | 1982-05-21 | Sogo Yatsukou Kk | Preparation of cysteamine mineral acid salt |
-
1989
- 1989-08-15 JP JP20960189A patent/JPH03128352A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4839414A (en) * | 1971-09-30 | 1973-06-09 | ||
| JPS5781454A (en) * | 1980-11-10 | 1982-05-21 | Sogo Yatsukou Kk | Preparation of cysteamine mineral acid salt |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8979513B2 (en) | 2010-10-07 | 2015-03-17 | Sanyo Denki Co., Ltd. | Lead wire engaging structure and electric apparatus |
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