JPH03169Y2 - - Google Patents

Description

[Detailed description of the invention] (Industrial field of application) This invention is applicable to experiments such as administering samples of drugs, foods, or environmental pollutants to experimental animals such as rats and mice to examine their effects on living organisms. The present invention relates to an infusion swivel used to continuously infuse samples such as medicinal solutions into laboratory animals over a certain period of time, or to collect desired body fluids from laboratory animals.

(Prior art) When conducting experiments such as testing by continuously infusing a sample into a laboratory animal for a long period of time, the animal should not be restrained during the infusion of the sample to maintain a physiologically natural state as much as possible. It is important to
To this end, it is necessary to allow experimental animals to move freely during infusion.

However, when injecting infusions while allowing experimental animals to freely move around, the catheter whose tip is inserted into the animal becomes twisted due to the movement of the animal.

Therefore, in order to correct the torsion of this catheter, attempts have been made to use a rotating ring equipped with an infusion passage, that is, an infusion swivel (SWIVEL).

By the way, as a conventional infusion swivel, there is, for example, one shown in FIG. 6 (hereinafter referred to as a conventional product). Hereinafter, this conventional product will be explained with reference to FIG. 6. In the same figure, 1 indicates a fixing part, 2 a fixing body with a screw hole 3 drilled in the upper half in the axial direction, and 4 is a connecting member made of Teflon or the like and having a connecting hole 4a bored in the center in the axial direction, and the connecting member 4 is tightly fitted into the bottom of the screw hole 3. Reference numeral 5 denotes a threaded rod having a center hole vertically arranged in the axial direction, and the threaded rod 5 is screwed into the screw hole 3 and fixed by pressing the connecting member 4 at its tip. Reference numeral 7 denotes an infusion thin tube that penetrates the center hole of the threaded rod 5 and is fixed with a screw or the like.The upper end 7a and lower end 7b of the infusion thin tube 7 are made to protrude from the threaded rod 5, and the lower end 7b is tightly fitted into the connecting hole 4a of the connecting member 4. The upper end 7a is connected to an infusion pipe 8 which is connected to a pump section (not shown).

Reference numeral 9 indicates a rotating part, and reference numeral 10 indicates a rotating body having a central hole facing in the axial direction. It is rotatably mounted. Reference numeral 13 denotes an infusion thin tube that is inserted into the center hole of the rotating body 10 and fixed with a screw or the like.
3a is tightly fitted into the connecting hole 4a of the connecting member 4 to connect both the infusion tubes 7 and 13, and the sample is infused through both the tubes 7 and 13. 1
Reference numeral 4 denotes a fitting tube provided at the lower end peripheral portion of the rotating body 10;
5 is a catheter, and the proximal end of the catheter 15 is connected to the lower end 13b of the infusion thin tube 13 through the fitting tube 15.

Then, the tip of the catheter 15 is inserted into the experimental animal and fixed with appropriate means, and the sample is continuously infused into the animal for a long period of time while the animal is allowed to move freely in the cage. Even when the catheter 15 rotates, the twisting of the catheter 15 is absorbed and corrected by the rotation of the rotating body 10.

The catheter 15 is entirely covered with a protective coating made of a coil spring made of stainless steel or the like to prevent the catheter from being damaged by an animal chewing on it.

According to this conventional product, fluid can be continuously infused while the animal is allowed to move freely within the cage.

(Problems to be solved by the invention) However, conventional infusion swivels, including the conventional products mentioned above, do not have a means to adjust the length of the catheter, and therefore have the following problems. .

(b) In order to allow the animal in the cage to move around freely, the length of the catheter 15 is set to match the longest distance within the activity range of the animal in the cage. Therefore, when the animal stands up in the center of the cage, the catheter becomes loose and gets in the way, causing stress and sometimes causing the catheter to wrap around the animal's head. arise.

(b) Since the catheter 15 is entirely covered with a protective coating (coil spring) as described above,
Small animals such as rats and mice find them quite heavy. Therefore, when the catheter is loosened, the load of the coil spring is applied to the animal, which becomes a burden and causes stress.

The object of the present invention is to provide an infusion swivel that solves the above-mentioned problems.

(Means for Solving the Problem) In the present invention, an adjustment chamber formed in a cylindrical shape with a bottom and located on the peripheral wall side and provided with an inlet/outlet for the catheter is fixed to the lower end of the rotating part of the swivel body,
This adjustment chamber solves the above problem by automatically moving the catheter in and out according to the movement of the animal, such as the position and posture of the animal in the cage, and adjusting the length of the catheter. .

That is, the content of the present invention will be explained using FIG. 1 corresponding to the embodiment.
and a rotating part 29 which has an infusion passage (in the embodiment, the infusion thin tube 34) and is rotatably provided with respect to the fixed part 21, and both the infusion passages communicate with each other even when the rotating part 29 is rotating. The swivel body 20 is configured as shown in FIG. An inlet/outlet 41 for the catheter 42 is provided at a position in the rotation adjustment chamber 38, and the catheter 42, whose proximal end is connected to the lower end of the infusion passageway (in the embodiment, the infusion tube 34) of the rotating section 29, is taken out from the inlet/outlet 41 of the rotation adjustment chamber 38. It is characterized by being configured as follows.

(Embodiments) Hereinafter, embodiments of the present invention will be described with reference to the drawings. Fig. 1 is a longitudinal sectional view showing one embodiment of the infusion swivel according to the present invention, Fig. 2 is an enlarged longitudinal sectional view showing the connecting part of the infusion tube, and Fig. 3 is an enlarged view of the proximal end of the catheter. Fig. 4 is a side view shown in Fig. 1.
It is a sectional view taken along the line - in the figure.

In these figures, 20 indicates a swivel body, and this swivel body 20 includes a fixed part having an infusion passage, and a rotating part having an infusion passage and rotatably provided with respect to the fixed part. The system is configured so that liquid can be transported through both of the above-mentioned infusion passages even when the infusion passage is rotating.
As an example, a swivel body 20 configured as follows
is adopted. That is, 21 indicates a fixing part, 22 is a fixing body formed with an appropriate length, and a screw hole 23 is bored in the upper half of the fixing body 22 in the axial direction. Reference numeral 24 denotes a connecting member formed to tightly fit into the screw hole 23. The connecting member 24 is made of a chemical-resistant and self-lubricating material, such as Teflon, and has an axial direction in the center. A connecting hole 25 is provided vertically. The connecting member 24 is tightly fitted and housed in the bottom of the screw hole 23 and is fixed by being pressed by the tip of a threaded rod 26 screwed into the screw hole 23. A center hole 27 is provided vertically in the center of the threaded rod 26, and an infusion tube 28 (infusion passage) made of stainless steel or the like is passed through the hole 27 and fixed to the threaded rod 26 with a screw or other means. Upper end 28a and lower end 2 of the infusion tube 28
8b is made to protrude from the hole 27 of the threaded rod 26, and the lower end 28b of the thin tube 28 is connected to the connecting hole 2 of the connecting member 24.
It is tightly fitted into the upper half of 5. Further, the upper end 28a of the thin tube is connected to an infusion pipe connected to a pump section, as will be described later.

Reference numeral 29 indicates a rotating part, and 30 is a rotating body having a vertical center hole 31 facing in the axial direction;
is rotatably attached via a bearing 33 to the center of a lid 32 screwed onto the lower end of the fixed body 22. An infusion thin tube 34 (infusion passage) made of stainless steel or the like is passed through the hole 31 of the rotating body 30 and fixed by an appropriate means, and the upper end 34a of the thin tube 34 is made to protrude from the hole 31, and the upper end 34a is inserted into the screw hole 33. The hole 2 of the connecting member 24 is inserted through the through hole 23a formed at the bottom.
Both infusion tubes 28, 34 are tightly fitted into the lower half of 5.
The tubes 28 and 34 are connected to each other so that a sample or the like can be infused through both the thin tubes 28 and 34. Further, the lower end 34b of the infusion thin tube 34 is bent approximately at a right angle, and 35 is an engagement member fitted to the bent lower end 34b. A proximal end of a catheter, which will be described later, is fitted onto this bent lower end 34b for connection. 36 is a nut member screwed onto the fixed body 22;
The swivel body 20 of this embodiment has a nut member 36
The fixed body 2 is held by holding the predetermined portion 37 between the lid body 32 and the lid body 32.
2 is fixedly supported.

Although the swivel body 20 of the embodiment is configured as described above, the structure of the swivel body 20 can be changed arbitrarily, and the key points are the fixing part 21,
A rotating part 29 is rotatably provided with respect to the fixed part 21, and the infusion passage (in the embodiment, the infusion thin tube 28) of the fixed part 21 is provided even when the rotating part 29 is rotating.
and the infusion passage of the rotating part 29 (in the embodiment, the infusion tube 3
4), and the liquid can be transported through both infusion passages.

Reference numeral 38 indicates a rotation adjustment chamber, and the adjustment chamber 38 is formed into a cylindrical shape having an appropriate diameter and height, and its center portion is fixed to the lower end of the rotating body 30. The adjustment chamber 38 of the embodiment is composed of a cylindrical dish body 39 with a bottom and an upper lid 40 that can be fitted onto and removed from the dish body 39. The upper lid 40 is fixed to the rotating body 30, and the dish body 3 is attached to the upper lid 40.
9 is configured to be removably fitted.
A catheter inlet/outlet 41 is provided diagonally downward on the peripheral wall side of the adjustment chamber 38 . Further, in the embodiment, the lower end of the rotating body 30 is brought close to the bottom of the plate body 39, and this lower end is used as a core rod.

42 is a catheter, the proximal end of the catheter 42 is fitted and connected to the lower end 34b of the infusion tube 34;
The distal end side is taken out of the chamber 38 through the entrance/exit 41. 43 is a protective covering made of coil springs,
Catheter 42 is entirely covered with a protective coating 43. Then, the tip of the catheter 42 is inserted into the vein of the experimental animal A and fixed by appropriate means.
It is to be kept in detention. In addition, the catheter 42
The length (same for the protective covering 43) is appropriately set to match the longest distance within the active range of the animal in the cage, depending on the size of the cage, etc., which will be described later.

The infusion swivel of the embodiment is constructed as described above, and next, an example of its usage and function will be explained. FIG. 5 is a longitudinal sectional view showing an example of an infusion setting device for animal experiments employing the infusion swivel of the present invention. In the figure, 50 is a cage made of transparent glass, transparent plastic, etc., and 51 is a sealing lid detachably provided at the upper end opening of the cage 50. This cage 50 is formed in a closed type, but there is also an open type cage,
This should be selected and adopted as appropriate depending on the purpose.

The bottom of the cage 50 is formed into a row shape 52, 53 is a excrement separator attached to the lower end of the funnel 52, 54 is a feces collection bottle, and 55 is a urine collection bottle, in which the excrement and urine excreted by the experimental animal A in the cage 50 are collected. , feces and urine are separated by a separator 53, and the feces is collected in a feces collection bottle 5.
4 and urine is collected into a urine collection bottle 55, respectively. 56 indicates a gas collection tube. The above-mentioned excrement separation and collection mechanism may be provided as desired. In addition, a feeding section and a water supply section are provided in appropriate parts of the cage 50, and the animal A in the cage 50 is provided with a feeding section and a water supply section.
It may also be configured so that it is fed and watered.

Reference numeral 57 denotes a lid that tightly fits into the upper end opening 58 of the sealing lid 51, 59 a lid that fits tightly into the upper end opening 60 of the lid 57, and 61 a gas introduction pipe protruding from the lid 57. shows.

The lid body 59 has a center hole oriented in the axial direction through which the infusion tube 28 is inserted tightly, and a screw member 62 provided at the top is rotated to open the inner rubber packing (not shown). The infusion thin tube inserted into the center hole is tightly sealed within the center hole by pressing the center hole.

Reference numeral 63 indicates a cassette main body configured to be stored in and out of the cage 50, and the cassette main body 6
3 is formed by integrally forming a ceiling body 65 supported by support rods 66 of an appropriate length on top of a floor body 64 in a lattice shape or the like formed corresponding to the shape of the cage 50,
67 is a mounting body fixed to the center of the ceiling body 65;
A mounting hole 68 into which the fixed body 22 of the swivel body 20 is fitted is provided in the center of the mounting body 67. Then, in the swivel according to the present invention, the fixing body 22 of the swivel body 20 is fitted into the mounting hole 68,
The nut member 36 screwed onto the fixed body 22 is tightened to form the nut member 36 and the lid body 32 screwed onto the lower part of the nut member 36.
The mounting body 67 is held between the two and is attached to the mounting body 67. Further, the upper end 28a of the infusion thin tube 28 is made to protrude from the center hole of the lid body 59, and the screw member 62
is rotated to form a tight seal within the center hole. 6
Reference numeral 9 denotes a spreader fixed at the center of the lower part of the floor body 64, and this spreader spreads the excrement and urine excreted by the animal A and causes it to fall onto the inclined wall surface of the funnel 52, thereby allowing the separator 53 to effectively separate the excrement and urine. It was set up for the purpose of clarification.
70 is an arbitrary number of mounting pieces fixed at appropriate intervals around the ceiling body 65; 71 is a threaded cylinder fixed to each mounting piece 70; 72 is a screw screwed into each threaded cylinder 71; The cassette main body 63 is attached to the lid 51 by rotating each screw 72 and engaging the tips of the screws 72 in the engagement recesses or grooves 73 formed in the sealing lid 51 of the cage 50 in correspondence with the screws 72. It is configured to be removably engaged and fixed.

Note that the cage 50 and the swivel body 20
The mounting means may be changed to any structure other than that shown in the drawings.

In FIG. 5, reference numeral 74 indicates a pump section such as a pump or cylinder, 75 indicates a sample such as a drug solution, and 76 indicates an infusion pipe connecting the pump section 74 and the upper end 28a of the infusion tube 28.

Therefore, first, the pump section 74 is activated to drop a few drops of the sample 75 from the tip of the catheter 42, and
And the air inside the catheter 42 is discharged to the outside.

Then, animal A, which had a predetermined section incised under anesthesia, was removed from the cage 50 and placed on the floor body 64 of the cassette body 63 that had been set. Insert it into a vein, fix it with appropriate means, and leave it in place.

Next, in the above state, the lid 51 is attached to the cassette main body 63.
Then, the cassette main body 63 is stored in the cage 50, and the upper end of the opening of the cage 50 is sealed with the sealing lid 51.

The setting is completed as described above, and in this state, sample 75 is infused into animal A to perform various experiments. Then, when the animal A in the cage 50 moves around, the rotation adjustment chamber 38 rotates in accordance with this movement, so the rotating body 30 rotates, thereby correcting the twist of the catheter 42 and allowing the infusion to proceed without any hindrance. It can be sustained smoothly.

On the other hand, since the catheter 42 whose proximal end is connected to the lower end 34b of the infusion tube 34 is taken out from the entrance/exit 41 of the adjustment chamber 38, it can be freely pulled out from the adjustment chamber 38 by pulling it. 42 is entirely covered with a protective cover 43 made of a coil spring, so by pressing this, as shown by the imaginary line in FIG.
The winding ring of the mainspring is stored in the adjustment chamber 38 in such a manner that it is greatly expanded (see FIG. 4).

Therefore, when the animal A moves toward the peripheral wall of the cage 50, the catheter 42 is pulled out from the adjustment chamber 38 according to the amount of movement of the animal A, and conversely moves toward the center. Alternatively, when the animal A stands up, the protective covering 43 is pushed up according to the amount of movement, so it enters the adjustment chamber 38, and in this way, the catheter 42 (protective covering) adjusts the position and posture of the animal A in the cage 50. The length outside the chamber 38 is adjusted by moving in and out of the adjustment chamber 38 according to the situation.

(Effects of the invention) As explained above, the present invention includes a fixed part having an infusion passage, and a rotating part having an infusion passage and rotatably provided with respect to the fixed part, and when the rotating part is rotating. The swivel body is configured such that both of the infusion passages communicate with each other, and a rotation adjustment chamber formed in a cylindrical shape with a bottom and whose center portion is fixed to the lower end of the rotation section. The entrance and exit for the catheter is located on the peripheral wall side.
The catheter, whose proximal end is connected to the lower end of the infusion passage of the rotating section, is configured to be taken out from the entrance/exit of the rotation adjustment chamber. According to the present invention, the following effects can be expected.

(b) Even when the animal moves around in the cage, fluid can be infused smoothly while automatically correcting the twisting of the catheter.

(b) The length of the catheter is automatically adjusted according to the position and posture of the animal, so unlike conventional products, the catheter does not become loose and get in the way.
Prevents wrapping around the animal's jaw.

(c) As mentioned in (b) above, since the catheter does not loosen significantly, it is possible to prevent the load of the coil spring protective covering from being applied to the animal, thus reducing stress on the animal. Can be removed.

[Brief explanation of the drawing]

Fig. 1 is a longitudinal sectional view showing one embodiment of the infusion swivel according to the present invention, Fig. 2 is an enlarged longitudinal sectional view showing the connecting part of the infusion tube, and Fig. 3 is an enlarged view of the proximal end of the catheter. FIG. 4 is a sectional view taken along the line -- in FIG. 1, FIG. 5 is a vertical sectional side view showing one embodiment of the infusion setting device for animal experiments using a swivel according to the present invention, and FIG. 1 is a longitudinal cross-sectional view showing an example of a conventional infusion swivel. 20... Swivel body, 21... Fixed part, 22
... Fixed body, 24 ... Connection member, 25 ... Connection hole, 28 ... Infusion thin tube, 29 ... Rotating part, 30 ...
... Rotating body, 33 ... Bearing, 34 ... Infusion tube, 38 ... Rotation adjustment chamber, 41 ... Entrance/exit, 42
...Catheter, 43...Protective covering.

Claims (1)

[Scope of utility model registration request] a fixed part having an infusion passage; and an infusion passage;
A swivel body is provided with a rotating part that is rotatably provided with respect to the fixed part, and configured so that both the infusion passages communicate with each other even when the rotating part is rotating; a rotation adjustment chamber fixed to the lower end of the rotating section, the rotation adjustment chamber is provided with an inlet/outlet for the catheter located on the peripheral wall side, and the proximal end is the lower end of the infusion passage of the rotating section. 1. A swivel for infusion, characterized in that the catheter connected to the swivel is configured to be taken out from the entrance/exit of the rotation adjustment chamber to the outside of the room.