JPH03178667A - Liquid treating device of hollow fiber type and production thereof - Google Patents

Abstract

PURPOSE:To prevent the generation of the stagnation, turbulence, etc., of liquid and to prevent the generation of the damage in the liquid component by providing a liquid guide part which smoothes the flow of the liquid flowing therein in the end part facing to the liquid inflow parts of respective hollow fiber membranes. CONSTITUTION:The porous hollow fiber membranes 2 are disposed in a housing 1 of a hollow fiber type artificial lung and both ends of a hollow fiber bundle 3 are fixed liquid-tightly by a partition wall 4 in the state of opening the ends of the hollow fiber membranes 2. The end face 4a of the partition wall 4 is covered by a flow passage forming member 7 and constitutes a blood outlet/inlet part 7a together with this flow passage forming member 7. The blood guide part 9 continuous by forming a curved surface from the inside wall surface 2a of the hollow part to the end face 4a of the partition wall 4 is provided at the end face facing to the blood outlet/inlet part 7a of the hollow fiber membranes 2. The blood flowing into the blood outlet/inlet part 7a from a blood inflow/outflow port 8 flows smoothly into the hollow part along the curved surface of the liquid guide part 9 without stagnating or generating the turbulence. The generation of a thrombosis, etc., is prevented and the generation of the damage of the blood components is prevented.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a hollow fiber liquid processing device in which hollow fibers such as an artificial kidney, an artificial lung, and a plasma separator are used as an artificial organ or donor pheresis, and the like. Regarding the manufacturing method.

[Prior Art] Conventionally, in this type of liquid processing device, for example, in an oxygenator using hollow fibers, when fixing the eastern end of the hollow fiber to a housing, the eastern end of the hollow fiber is coated with a partition-forming resin such as urethane resin ( By fixing the membrane with a botting agent (botting agent) and cutting the partition wall forming resin together with the east end of the hollow fiber, an opening at the end surface of the partition wall of the hollow fiber membrane was created.

[Problems to be Solved by the Invention] However, in such an oxygenator, the end face of the partition wall is formed through a cutting process after the resin is solidified, so it has a rough structure, and in particular, the end face of the partition wall has a rough structure. Since the end face of the cut surface is left exposed, there is a problem that blood flowing from the blood inflow part does not flow smoothly into the hollow part and stagnates or turbulence occurs, and furthermore, the blood components are damaged.

The present invention has been made in view of such problems, and includes:
A hollow structure that allows the liquid to flow smoothly from the liquid inflow part into the hollow part of the hollow fiber membrane, prevents the occurrence of liquid stagnation, turbulence, etc., and prevents damage to the liquid components. An object of the present invention is to provide a thread-type liquid processing device and a method for manufacturing the same.

[Means for Solving the Problems] In order to solve the above problems, a hollow fiber type liquid processing device according to the present invention is provided with a liquid inflow portion and a liquid outflow portion, and a connection between the liquid inflow portion and the liquid outflow portion. a housing having a fluid inlet and outlet therebetween; a hollow fiber bundle comprising a large number of hollow fiber membranes and housed between a liquid inlet and a liquid outlet of the housing; a hollow fiber type liquid processing device comprising partition walls for fixing both ends of the hollow fiber bundle to the housing in a liquid-tight state, the end of each hollow fiber membrane facing the liquid inflow portion; The membrane is characterized by being provided with a liquid guide part for smoothing the flow of the inflowing liquid, and further characterized in that the liquid guide part is provided at the end of the hollow fiber membrane opposite to the liquid outflow part. It is.

Specifically, the liquid guide portion is a curved surface portion that is continuous from the inner wall surface of the hollow fiber membrane to the end surface of the partition wall,
Alternatively, it is a sloped portion that continues in a straight line from the inner wall surface of the hollow fiber membrane to the end surface of the partition wall.

Further, the method for manufacturing a hollow fiber type liquid treatment device according to the present invention includes:
A step of injecting and solidifying the partition wall forming resin from the fluid inlet/outlet and fixing the vicinity of the end of the hollow fiber bundle to the housing, and cutting the end of the solidified partition wall forming resin together with the hollow fiber bundle to form a hollow fiber bundle. The method is characterized by comprising a step of opening an end of the hollow fiber membrane to form a partition wall, and a step of melting the end of the hollow fiber membrane to form the curved surface portion. Specifically, it is formed by heating the end face of the partition wall or by irradiating the end face of the partition wall with a heat ray such as a light beam.

[Function] According to the hollow fiber type liquid treatment device according to the present invention, since the liquid guide portion consisting of the curved surface portion or the inclined portion is provided at the end of the hollow fiber membrane at the end face of the partition wall, the liquid inflow from the liquid inflow portion is provided. The liquid flows smoothly into the hollow part along the curved or inclined surface of the liquid guide, so that there is no stagnation or turbulence of the liquid, and no damage to the liquid components. .

Further, according to the method for manufacturing a hollow fiber type liquid processing device of the present invention, after the solidified partition wall forming resin is cut together with the hollow fiber bundle, the ends of each hollow fiber membrane are thermally melted by a heat ray such as a light beam. As a result, a curved liquid guiding portion that is continuous from the inner wall surface to the end surface of the partition wall can be easily formed at the end of the hollow fiber membrane.

[Example] Hereinafter, the present invention will be described in detail with reference to the drawings.

FIG. 3 shows a cross-sectional structure of a hollow fiber oxygenator according to an embodiment of the present invention.

In the figure, reference numeral 1 denotes a cylindrical housing, and inside this housing 1, a large number of porous hollow fiber membranes 2 are arranged in parallel and spaced apart from each other along the longitudinal direction of the housing 1. Both ends of a hollow fiber bundle 3 made up of these hollow fiber membranes 2 are fluid-tightly fixed by a partition wall 4 with the ends of each hollow fiber membrane 2 open. Further, these partition walls 4 are connected to the outer peripheral surface of the hollow fiber membrane 2 and the housing l.
Together with the inner surface of the gas chamber 5, it constitutes a gas chamber 5.

Furthermore, an oxygen-containing gas inlet/outlet 6 is provided on the side surface of the housing 1 as a fluid inlet/outlet communicating with the gas chamber 5 .

The end surface 4a of the partition wall 4 is covered with a flow path forming member 7, and together with this flow path forming member 7, constitutes a blood inflow/outflow portion 7a. A blood inlet 8 is provided in the flow path forming member 7 so as to face the end surface 4 a of the partition wall 4 . Although not shown, the other end of the hollow fiber bundle 3 also has a symmetrical structure, so its explanation will be omitted.

The end face of the hollow fiber membrane 2 facing the blood inflow/outflow part 7a has a continuous curved surface from the inner wall face 2a of the hollow part to the end face 4a of the partition wall 4, as shown in an enlarged view in FIG. 1(C). A blood guiding section 9 is provided.

That is, in the artificial lung using the hollow fibers of this embodiment, the blood flowing into the blood inflow/outflow portion 7a from the blood outflow inlet 8 is as follows.
The blood flows smoothly into the hollow part along the curved surface of the liquid guide part 9 provided at the end of the hollow fiber membrane 2, so that blood does not stagnate or create turbulent flow, and the formation of blood clots etc. In addition, it is possible to prevent the occurrence of damage to blood components.

The liquid guide section 9 may be provided at both the ends of the hollow fiber membrane 2 on the blood inflow side and the blood outflow side, or may be provided only at the end on the blood inflow side.

Next, a specific method for manufacturing the hollow fiber oxygenator will be described with reference to FIGS. 1(a) to 1(c).

FIG. 1(a) shows that the resin for forming partition walls in a fluid state is filled from the oxygen-containing gas inlet 6 to a predetermined thickness and solidified, and after the hollow fiber bundle 3 is fixed to the housing 1, the resin is solidified. This figure shows the state after the partition wall forming resin has been cut along with the hollow fiber bundle 3 to form partition walls 4, and is an enlarged view of the vicinity of the end of the hollow fiber membrane 2.

In this embodiment, after the above-mentioned cutting step, the end surface 4a of the partition wall 4 is irradiated with a light beam 10, as shown in FIG. 4(b). By irradiating the light beam 10, the ends of the hollow fiber membranes 2 are heated and melted to form a curved surface as shown in FIG.

As the material for the hollow fiber membrane 2, a thermoplastic polyolefin resin such as polypropylene is suitably used. Furthermore, polyethylene, polyvinylidene fluoride, cuprarayon, etc. may also be used.

Further, as the partition wall forming resin, thermosetting resins such as urethane resin, silicone resin, and epoxy resin are preferably used.

In addition, when the hollow fiber membrane 2 is made of polypropylene, the intensity of the light beam IO is determined so that when the hollow fiber membrane 2 is made of polypropylene, the end portion of the polypropylene starts to melt at about 170°C.
It must be adjusted so that it is heated to

Next, in order to confirm the effects of the present invention, the inventors
The following experiment was conducted.

(Experiment Example 1) Bovine blood was processed with Bevarin to reduce Ht (blood viscosity) to 35%.
The temperature was controlled at 37°C. As samples, an artificial lung treated with a light beam (A) and an artificial lung not treated with a light beam (B) were prepared. These artificial lungs (A) and (B) are each independently pumped with a roller pump.
Circulate at β/min, 0.15 min, 30 min.

Blood was sampled after 60 minutes, 2 hours, 4 hours, and 6 hours. The blood was then centrifuged and separated into plasma and blood cells, and the amount of hemoglobin released in the plasma was measured by the TMB method. The results are shown in Table-1.

The results showed that the amount of free hemoglobin in the artificial lung (A) according to the present invention was significantly reduced compared to the conventional artificial lung (B).

In the above embodiment, the blood guiding section 9 is a curved surface, but the blood guiding section 11 may have a linear inclined surface as shown in FIG. 2. Furthermore, although the present invention has been described with reference to an example in which a hollow fiber is applied to an artificial lung, the present invention is not limited to this, and may be applied to other artificial organs such as a hollow fiber type artificial kidney, a plasma separator, etc.
Of course, it can also be applied to donaphelesis, water purifiers, etc.

Other heat treatment methods include infrared rays, far infrared rays,
This can also be achieved by heating the ends with hot air and high frequency heating.

[Effects of the Invention] As detailed above, according to the hollow fiber type liquid treatment device according to the present invention, since the liquid guide portion is provided at the end of each hollow fiber membrane, the liquid flow path becomes smooth. Therefore, the liquid flowing in from the liquid inflow part flows smoothly into the hollow part along the liquid guide part, so that the liquid does not stagnate or turbulent flow occurs, and the liquid components are not damaged. It disappears.

Further, according to the method for manufacturing a hollow fiber type liquid processing device according to the present invention, the ends of the hollow fiber membranes are melted by a light beam or the like, so that the liquid guide portion can be easily formed.

[Brief explanation of drawings]

FIGS. 1(a) to (c) are enlarged sectional views of main parts showing the manufacturing process of a hollow fiber oxygenator according to one embodiment of the present invention, and FIG. 2 is a main part showing another embodiment of the present invention. Enlarged cross-sectional view, Figure 3 is the first
FIG. 2 is a partial cross-sectional view of an artificial lung made of hollow fibers manufactured by the method shown in the figure. l...Housing, 2...Hollow fiber membrane 3...Hollow fiber bundle, 4...Partition wall 6...Oxygen-containing gas inlet/outlet, 8...Blood outlet port 9...-Blood guide section (Liquid guide part) 10... Light beam

Claims (7)

[Claims] (1) A housing that is provided with a liquid inlet and a liquid outlet, and has a fluid outlet between the liquid inlet and the liquid outlet; and a housing that includes a large number of hollow fiber membranes, A hollow fiber bundle accommodated between the hollow fiber bundle and the liquid outflow portion, and a partition wall that fixes both ends of the hollow fiber bundle to the housing in a fluid-tight manner with the ends of each hollow fiber membrane being open. A hollow fiber type liquid processing device characterized in that a liquid guide portion for smoothing the flow of the inflowing liquid is provided at an end of each of the hollow fiber membranes facing the liquid inflow portion. type liquid processing equipment. (2) The hollow fiber type liquid processing device according to claim 1, wherein the liquid guide section is further provided at an end of the hollow fiber membrane facing the liquid outflow section. (3) The hollow fiber type liquid processing device according to claim 1 or 2, wherein the liquid guide portion is a curved surface portion that is continuous from the inner wall surface of the hollow fiber membrane to the end surface of the partition wall. (4) The hollow fiber type liquid processing device according to claim 1 or 2, wherein the liquid guide portion is a continuous inclined portion in a straight line from the inner wall surface of the hollow fiber membrane to the end surface of the partition wall. (5) A method for manufacturing a hollow fiber type liquid processing device according to claim 3, wherein a partition forming resin is injected from the fluid inlet/outlet and solidified, and the vicinity of the end of the hollow fiber bundle is fixed to the housing. a step of cutting the ends of the solidified partition wall forming resin together with the hollow fiber bundle to open the ends of the hollow fiber membranes to form partition walls, and melting the ends of each of the hollow fiber membranes. A method for manufacturing a hollow fiber liquid processing device, comprising the step of forming the curved surface portion. (6) The method for manufacturing a hollow fiber liquid processing device according to claim 5, wherein the curved surface portion is formed by heating an end face of the partition wall. (7) The method for manufacturing a hollow fiber liquid processing apparatus according to claim 6, wherein the curved surface portion is formed by irradiating the end face of the partition wall with a heat ray such as a light beam.