JPH03200712A - Oral composition - Google Patents

Abstract

PURPOSE:To obtain the subject composition for oral cavity application, having excellent aging stability and exhibiting tartar-preventing effect by using aluminum hydroxide having specific shape as an abrasive and compounding a polyphosphoric acid salt thereto. CONSTITUTION:The objective composition contains (A) 5-80wt.% of aluminum hydroxide having an average particle diameter of 5-14mum, substantially free from particles of >=44mum in diameter and having the product (average particle diameter)X(specific surface area) of <=20mum.m<2>/g, (B) 0.1-10wt.% of a straight- chain polyphosphoric acid salt of formula Mn+2PnO3n+1 (M is Na or K; n>=2) and (C) proper additives such as acidic phosphoric acid salt (e.g. sodium dihydrogen phosphate), a binder, a tackifier, a surfactant, a sweetener, an antiseptic, a perfumery, etc. It can be used in the form of tooth paste, moist dentifrice, prophylaxis paste, etc.

Description

Detailed Description of the Invention [Industrial Field of Application] The present invention relates to oral compositions such as toothpastes and profilafsis pastes, and more specifically, the present invention relates to oral compositions such as toothpastes and profilafsis pastes. The present invention relates to oral compositions.

[Conventional technology]

Conventionally, it has been known to incorporate polyphosphates into oral compositions for the purpose of preventing the deposition of tartar on teeth (Japanese Patent Application Laid-open No. 52-108029, 54-80429, 5
No. 9-42311, No. 62-111911, No. 62-
No. 212314, No. 63-5016, No. 63-452
No. 14, Japanese Unexamined Patent Publication No. 1-13015, etc.). Among these, the dentifrice composition described in JP-A No. 63-5016 contains the following formula (1)% formula (1) as a tartar preventive active ingredient (where M is Na or K, n≧2). It is a mixture of linear polyphosphates represented by

On the other hand, the use of aluminum hydroxide as an abrasive for oral compositions has been well known (for example,
No. 650, No. 28-3000, No. 31-5550), and an oral composition containing a polyphosphate and aluminum hydroxide has also been disclosed (Japanese Unexamined Patent Publication No. 61-15).
No. 1113, No. 63-30408, No. 63-1419
Publication No. 20).

[Problem to be solved by the invention]

However, when polyphosphate is blended into an oral composition that uses aluminum hydroxide as an abrasive, the polyphosphate is hydrolyzed by trace amounts of AQ ions released from aluminum hydroxide (particularly easily released at high temperatures). (Chemistry and Utilization of Phosphate J 197 published by Kagaku Kogyosha)
2 3rd edition p.

(See ■65 to ↓67), and therefore the storage stability of the polyphosphate deteriorates. Therefore, when an oral composition containing aluminum hydroxide and a polyphosphate is stored, especially when stored at high temperatures, there is a problem that the tartar inhibiting effect of polyphosphoric acid deteriorates over time.

The present invention was made in view of the above circumstances, and an object of the present invention is to provide an oral composition containing aluminum hydroxide and a polyphosphate in which the stability of the polyphosphate over time is improved. shall be.

[Means and effects for solving the problem] The present inventors,
As a result of intensive studies to achieve the above purpose, we found that aluminum hydroxide has an average particle size of 5 to 14μ, and 44
It does not substantially contain particles larger than p, and the product of average particle diameter and specific surface area is 20p-rr? When aluminum hydroxide with specific physical properties of /g or less is used, and when a specific polyphosphate represented by formula (1) is used in combination with this, surprisingly, compared to the case where conventional aluminum hydroxide is used, The inventors have discovered that the storage stability of the polyphosphate of formula (1), particularly at high temperatures, is improved, and the present invention has been completed.

In other words, conventional aluminum hydroxide abrasives usually precipitate coarse particles of aluminum hydroxide, which are then crushed into 9 classifications and used to achieve the desired average particle size. Even if the average particle diameter is moderate, the specific surface area is large, and the product of the average particle diameter and the specific surface area is usually 237 an-m/g or more. In this case, the conventional aluminum hydroxide abrasive has an average particle size of 7.
Those with a specific surface area of ~9p have a specific surface area of 3 m/g, and those with an average particle size of 110l1 or more contain a considerable amount of coarse particles with a size of 44Im or more.The most commonly used particle size range for toothpaste is 5. For ~10- particles, the content of particles whose particle size is 80% or less of the average particle size is 5.5% of the total particles.
(wt%, the same hereinafter) The content of particles with a particle size of 1.57 rm or less is 3.5% or more of the total particles, and therefore the specific surface area is large, and since it contains coarse particles, the physical It has high chemical activity and releases AQ ions easily.

In contrast, the aluminum hydroxide used in the present invention does not contain coarse particles and has a small specific surface area.

The physical and chemical activity of the particle surface is extremely low.

It does not easily release AQ ions even under high temperatures, has mild abrasive power, and has a good feeling of use. Therefore, when such aluminum hydroxide and the polyphosphate of formula (1) are used together, the polyphosphate The storage stability of this product has been improved, and it shows a stable tartar formation inhibiting effect even after long-term storage.
It is possible to obtain an oral composition with a good feeling of use.

The present invention will be explained in more detail below.

As mentioned above, the oral composition of the present invention has an average particle diameter of 5 to 14 as an abrasive, substantially does not contain particles of 44p or more, and has a product of the average particle diameter and specific surface area of 20 μ·rd.
/g or less of aluminum hydroxide and a linear polyphosphate represented by the following general formula (1) % formula % (1) (where M is Na or K, n≧2). It contains.

In this case, it is preferable to use aluminum hydroxide having an average particle diameter of 5 to 14 M, particularly 7 to 12 μm, and a specific surface area of 2.8%/g or less within the above area range. That is, when the average particle size exceeds 14/ZI11, the polishing force becomes high and excessive roughness may be felt during use, and when the average particle size is smaller than 5 pm, the specific surface area often exceeds 2.8 rrr/g. , the stabilization of polyphosphates may be hindered. In addition, the particle size distribution is better as the part of fine particles is smaller.
For the purpose of the present invention, it is preferable to use aluminum hydroxide in which the content of particles with a particle size of 1.51a or less is 2% or less, particularly 1.5% or less of the total particles.

In addition, in the present invention, the specific surface area is determined by BET using N2.
The average particle diameter is a value determined by a laser light scattering method.

The aluminum hydroxide used in the present invention is produced by crystallizing the primary particles to a size of 20 to 100% of the target average particle diameter in the crystallization stage of aluminum hydroxide production (conventionally, the size of the primary particles is 20 to 100% of the target average particle diameter
If they are crystallized so that they are present in 90% or more of the total water particles, the primary particles do not break during the pulverization stage, and particle agglomerates (secondary particle)
It can be obtained by crushing. That is, according to this method, control by crystallization and -
Since no pulverized pieces are generated due to breakage of the formed particles, aluminum hydroxide with a small proportion of fine particles and low surface activity can be produced satisfactorily. Note that the aluminum hydroxide used in the present invention can also be prepared by removing the fine particle portion of aluminum hydroxide produced by the conventional production method, but the production method described above is better in terms of production cost and production efficiency. It's advantageous.

The amount of aluminum hydroxide mentioned above is selected as appropriate,
Usually 5-80%, in the case of toothpaste 20-60%
It is. In addition, other abrasives can also be blended into the oral cavity composition of the present invention within a range that does not impair the object of the present invention.

In addition, as the polyphosphate represented by the above formula (1),
Sodium pyrophosphate or potassium pyrophosphate with an average degree of polymerization n = 2, sodium tripolyphosphate or potassium tripolyphosphate with n = 3, sodium tetrapolyphosphate or potassium tetrapolyphosphate with n = 4, sodium metaphosphate or metalin with a high degree of polymerization. One or more kinds of potassium acid and the like are used. Note that hexametaphosphate with n≧20 has superior stability over time compared to linear polyphosphate with 19〉n≧2 (Japanese Unexamined Patent Publication No. 151113/1983), but it is difficult to polish aluminum hydroxide. When used as an agent, the above-mentioned hexametaphosphate with N≧20 also deteriorates over time. However, according to the present invention, including this hexametaphosphate with N≧20 (1
) The stability over time of all polyphosphates of N22 represented by the formula is improved.

Although the amount of the polyphosphate is not necessarily limited, it is preferably 0.1 to 10%, particularly 0.5 to 5% of the total composition. If the amount is less than 0.1%, the effect of preventing tartar formation may not be sufficient, and if it is more than 10%, the taste of the composition may be poor.

By incorporating an acidic phosphate into the oral composition of the present invention, the stability of the polyphosphate over time is further improved. In this case, as the acidic phosphate, one or more of sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate, etc. can be used. In addition, the amount added is preferably 0.1 to 10% of the entire composition; if it is less than 0.1%, the effect of addition may not be sufficient, and if it is more than 10%, the taste of the composition is bad. It may happen.

The oral composition of the present invention can be used as a toothpaste or a moist toothpaste.

It can be prepared as Profilafsis paste, etc., but commonly used ingredients can be added depending on its type.For example, when manufacturing toothpaste, in addition to the above ingredients, binders, thickeners, surfactants, etc. Agents, sweeteners, preservatives, fragrances, various active ingredients, etc. may be added.

〔Effect of the invention〕

As explained above, the oral composition of the present invention has excellent temporal stability of the polyphosphate of formula (1), and has a good tartar preventive effect even when stored for a long period of time, especially at high temperatures. It is something that can be demonstrated.

Next, the effects of the present invention will be concretely illustrated through experimental examples.

[Experiment example]

Two types of suspensions were prepared by mixing 50 g of aluminum hydroxide with the properties shown in Table 1 and 50 g of Solution A with the following composition. After storing this at 40°C for 10 days, the suspension was released by hydrolysis of tripolyphosphoric acid. The amount of orthophosphoric acid produced was determined by the vanadomolybdic acid method, and the residual rate of sodium tripolyphosphate was investigated. The results are shown in Table 2.

Table ■ A 2% aqueous solution of sodium tripolyphosphate with a degree of polymerization n = 3 was prepared as a polyphosphate, and p
The one that made H Near.

[Experimental Example 2] Using aluminum hydroxide I and II in Table 1, the following
Toothpaste with the composition shown in the table &1-13 (&3゜4.6,7,
9, 10, 12, and 13 are products of the present invention.

The others are comparative products) were prepared respectively, and 40
The residual rate of polyphosphoric acid after storage at ℃ for 1 month was investigated. The results are shown in Table 3.

Note that the unit of compounding amount in Table 3 is %.

Amount of Polycarbonate After the toothpaste was well dispersed in water, it was centrifuged, and the supernatant liquid was used as the sample solution. The residual rate of polyphosphoric acid was determined by quantifying orthophosphoric acid ions derived from hydrolysis of polyphosphoric acid present in the sample solution using the vanadomolybdic acid method. Samples containing acidic phosphate (sodium dihydrogen phosphate) will have added orthophosphoric acid ions, so quantify the amount of orthophosphoric acid immediately after toothpaste preparation and after storage.
The residual rate of polyphosphoric acid was determined by using the difference as orthophosphoric acid derived from hydrolysis of polyphosphoric acid.

From Tables 2 and 3 above, when conventional aluminum hydroxide is used as a base material, hydrolysis of polyphosphoric acid is promoted when stored at high temperatures, and when n < 20, it is less than 50%, and n ≧ 20 has good stability. Only about 70% of the original remains, compared to 1.
When the aluminum hydroxide of the present invention was used, the residual rate was 80% or more for all polyphosphoric acids with n≧2, and especially 90% or more when n≧20. Furthermore, when acidic phosphate was added to this system, the residual rate of polyphosphoric acid was further improved.

Examples will be shown below. The properties of aluminum hydroxide used in the following examples are as shown in Table 4.

No. table [Example 1] Toothpaste Inventive aluminum hydroxide Silicic anhydride Carboxymethyl cellulose sodium lagenan sorbit Propylene glycol 40% 1.0 0, 2 0 sodium lauryl sulfate saccharin sodium sodium fluoride fragrance Sodium pyrophosphate water total [Example 2] Toothpaste Inventive aluminum hydroxide carrageenan Sodium alginate sorbit Propylene glycol sodium lauryl sulfate Sodium lauroyl sarcosinate saccharin sodium Sodium monofluorophosphate Chlorhexidine Incense Sodium tripolyphosphate Residue 100.0% 50% 0.5 0.5 0 3.0 1.0 0.3 0.2 0.76 0.01 1, 2 1.0 water total [Example 3] Toothpaste Inventive aluminum hydroxide Carboxymethyl cellulose sodium EC glycerin Propylene glycol sodium lauryl sulfate Lauric acid jetanolamide saccharin sodium tin fluoride fragrance Sodium hexametaphosphate total [Example 4] Toothpaste Inventive aluminum hydroxide power lagenan Residue 100° 0% 45% 0.6 0.3 5 3.0 1, 2 0.2 0, 1 0.4 0.9 1.2 100° 0% 35% 0° xanthan gum sorbit glycerin polyethylene glycol sodium lauryl sulfate myristic acid jetanolamide saccharin sodium sodium fluoride dextranase Incense Sodium tripolyphosphate alcohol sodium lauryl sulfate Polyoxyethylene hydrogenated castor oil saccharin sodium Sodium monofluorophosphate tranexamic acid Incense Sodium hexametaphosphate [Example 5] Toothpaste Inventive aluminum hydroxide Silicic anhydride Carboxymethyl cellulose sodium gelatin sorbit polyethylene glycol 30% 0 0.6 0.4 0 2.0

Claims (1)

[Claims] 1. As an abrasive, the average particle diameter is 5 to 14 μm, and 44 μm.
Aluminum hydroxide that does not substantially contain particles larger than m and has a product of average particle diameter and specific surface area of 20 μm m^2/g or less, and the following general formula (1) M_n_+_2P_nO_3_n_+_1...(1) (However, M is An oral cavity composition characterized by containing a linear polyphosphate represented by Na or K, n≧2. 2. The oral composition according to claim 1, which contains an acidic phosphate.