JPH03209309A - Alopecia-preventing agent - Google Patents

Abstract

PURPOSE:To obtain a alopecia-preventing agent containing Horsetail extract as an active ingredient, exhibiting remarkable depletion-preventing effect to various kind of alopecia such as telogen alopecia or alopecia in growth period and capable of maintaining normal conditions to normal hair. CONSTITUTION:The objective alopecia-preventing agent containing 1.0-10wt.% Horsetail extract as a blend amount of dried weight. The Horsetail extract is produced by drying leaf, stem, vegetative stem spore stem or whole grass (preferably vegetative stem) of Equisetum arvense L. harvested in summer season and full of energy and then extracting with water, 2-5C alcohol (e.g. ethanol, propylene glycol or glycerin), glyceride (e.g. sunflower oil), etc. The Morsetail extract is used directly as the undiluted solution of dipped liquid, boiled liquid, etc., or by concentrating the extract solution or as dried Horsetail extract. The above-mentioned alopecia-preventing agent is used as health care product in each form of liquid, cream, powder, emulsion, aerosol, etc.

Description

[Detailed Description of the Invention] <Industrial Application Field> This invention relates to an agent for preventing hair loss (head hair, eyebrows, beards, hair, etc.). More specifically, the present invention relates to a hair loss prevention agent that exhibits a remarkable hair loss prevention effect on a wide variety of alopecias such as telogen epigenetic alopecia and anagen epigenetic alopecia. Background> It has long been known that body hair has a hair cycle. In other words, when the early anagen hair (down hair stage), in which a short, thin hair shaft begins to emerge from the dermal papilla, begins to grow, the hair bulb (hair root) gradually becomes larger and the hair shaft becomes thicker, leading to the middle anagen stage. Create hair. Furthermore, as this mid-anagen hair progresses, late anagen hair is formed, and the roots of this late anagen hair reach the subcutaneous tissue, and the hair shaft becomes the hair we see every day. This late anagen hair grows over several years (it is said that the lifespan of hair in boat fishing is about 2 to 5 years for men, and about 4 to 6 years for women, but some people continue to grow longer). At the end of its lifespan, the hair bulb (hair root) begins to keratinize.9 The first stage of keratinization is called transitional hair, and this transitional hair has not yet completely keratinized and in about 2 weeks, the next hair begins to keratinate. The hair has become telogen (
Then, the hair bulb (hair root) of this telogen hair becomes completely keratinized, and the hair shaft is gradually pushed up to the surface and hair is removed. At this time, the connective tissue that was in the dermal papilla becomes smaller but still attaches to the hair follicle, and this becomes the new early growth hair [the downy hair mentioned above].
It is said that all changes in the hair root during the hair cycle, which lead to the formation of connective tissue dermal papillae, take place in the fluctuating part of the hair, and that the area above the sebaceous gland opening remains unchanged.

Although alopecia is simply called alopecia, it can be caused by many diseases, both endogenous and extrinsic.Furthermore, even if the cause is endogenous, hair loss may be the main complaint, or hair loss may be a symptom of the underlying disease. There are cases where it appears.

Alopecia can be broadly divided into ■ Telogen epigenetic alopecia (a disease in which a large amount of telogen hair, in which the root of the anagen hair begins to keratinate, falls out as hair) and ■ Anagen hair loss It can be distinguished from the disease (basically a disease in which atrophied hairs in which the roots of hair in the growth stage are destroyed and a large number of hairs fall out). Of course, even in the above-mentioned telogen effluvium, atrophic hairs may be mixed in with the plucked hairs, and in the above-mentioned anagen alopecia, telogen hairs may also be mixed in with the plucked hairs. However, it is not possible to clearly distinguish between (1) telogen epigenetic alopecia and (2) anagen alopecia simply by the type of hair that is pulled out.

Furthermore, no established theory has been established regarding the causes of these various types of alopecia.

By the way, according to one theory, typical examples of telogen effluvium include postpartum (after childbirth) alopecia, post-viral alopecia, androgenetic alopecia (juvenile alopecia, middle-age alopecia). Other examples include inflammatory alopecia, diet/starvation alopecia, and traction alopecia.

For example, the aforementioned postpartum (postpartum) alopecia and post-viral alopecia are said to be closely related to the state of female hormone secretion, and hair that should normally have finished its growth phase is due to an increase in female hormone secretion. It is thought that this causes the growth phase to be further extended and the hair does not become telogen, and when normal hormone conditions are reached, the hair that had been in the growth phase begins to fall out all at once.

Furthermore, it has been well known for a long time that genetics are a major factor in the occurrence of androgenetic alopecia (juvenile alopecia, middle age alopecia, and premature baldness). Another cause is male hormones, which act particularly on hair matrix cells, and it is also said that male hormones act on dermal papillae. In any case, in normal cases, as mentioned earlier regarding the hair cycle, the newly formed early anagen hair grows a little and becomes the middle anagen hair, the hair gets a little thicker and the hair bulb gets bigger, and then hair loss occurs. Hair that grows long without doing so becomes late anagen hair and becomes normal human hair. However, in the early stages of "androgenetic alopecia," a lot of late anagen hair falls out, but when the pores that have fallen out revert to early anagen hair and the hair begins to thicken a little, male hormones act and cause late anagen hair to fall out. Instead of growing into thick hair called stage hair, it passes through transition stage hair and then becomes resting stage hair and falls out. In other words, it is thought that the rate of regression of hair from the growth phase to the resting phase is accelerated, and the hair becomes thinner and thinner without growing thicker, making the hair look thinner and hair in the resting phase being removed.

Therefore, hair tonics and hair restorers for male pattern baldness have traditionally been formulated with vasodilators such as vitamin E, carobronium chloride, and Oriental chinensis extract. It aims to improve the uptake of nutrients in the bulb and thereby promote hair growth, and it also contains vitamins and amino acids that are considered necessary for hair nutrition, and contains female hormones that counteract male hormones. Those containing the following are recognized.

On the other hand, the anagen alopecia include alopecia areata, drug-induced alopecia (anticancer drugs, thiamphenicol, fungicides, 5-boric acid, thallium, etc.), alopecia associated with collagen disease, etc. There are many different types, and it is said that the cause of the disease cannot be definitively identified.

For example, among the above-mentioned anagen alopecia, various theories have been proposed regarding the etiology of alopecia areata, including the ``autoimmune theory'', ``peripheral nerve abnormality theory'', and ``stress theory/nerve baldness theory''. Also, injecting medical drugs.

Alopecia caused by anti-cancer drugs is widely known as a representative example of drug-induced alopecia, which can cause hair loss while taking drugs orally.

In this way, although the cause of anagen epigenetic alopecia cannot be definitively identified, the result is that the hair matrix cells (hair roots) are destroyed for some reason, resulting in atrophic hair. It has been proposed that this results in hair loss due to rapid growth.

As mentioned above, the causes of alopecia are various and cannot be discussed uniformly, but the common causes of alopecia are:
An abnormality occurs in the hair root and the hair does not live up to its original lifespan, resulting in (a) the hair root entering a resting phase, where growth stops or it is atrophied, or (b) the hair root falling into a pathological atrophy state. It is believed that

<Problems to be solved by the invention> As described above, regarding the mechanism of action for preventing hair loss, there are various etiologies depending on the type of alopecia, and anti-hair loss agents have been used depending on the etiology. . Regardless of the mechanism of action of the hair loss prevention effect, it is true that plant herbal extracts or crude drugs have been used as hair loss prevention agents for a long time.

Herbal extracts or herbal medicines that have traditionally been used as anti-hair loss agents include ``Western linden'', ``salvia'', ``
"Chamomile" etc. However, these herbal extracts or herbal medicines have a problem in that they are specific in their effects on the type of alopecia or the cause of alopecia.

Therefore, there is a strong demand for the development of a hair loss prevention agent that is effective against a wide variety of alopecias and is highly safe.

By the way, conventionally, among various herbal extracts, the actions and effects of horsetail extract (water extract and/or oil extract) include "anti-inflammatory action,""skin metabolism promotion action,""blood circulation promotion action," It is known for its "antibacterial action,""preservativeaction,""increasing connective tissue resistance," and "cell activating action."Based on the above actions and effects, horsetail has historically been used in folk medicine and cosmetics. It is used as an effective medicine (cosmetics), for example, as a diuretic agent, for external use to stop bleeding, and as a cleansing agent for purulent ulcers, old wounds, and skin eruptions.
It has also been used as a bath additive for chronic eczema, neurodermatitis, local blood circulation disorders, etc., and as a body odor remover due to its ability to promote systemic metabolism.

However, among the various actions and effects that horsetail extract has, the "cell activating action" is completely unrelated to the hair loss prevention effect, although its relationship with the hair-nourishing effect cannot be denied. Furthermore, it is not well known that the horsetail extract has a "hair loss prevention effect" like that of the linden tree, salvia, chamomile, and the like.

As a result of searches and research to solve the above problems, it was found that horsetail extract (horsetail water extract, horsetail solvent extract and/or horsetail oil extract) can be used to treat a wide range of alopecias (that is, hair loss caused by a wide range of etiologies). The present invention was completed based on the discovery that it can be effectively applied to patients with cancer and has extremely high stability and safety.

The present invention is a hair loss prevention agent that has remarkable effects on a wide variety of alopecias caused by the various etiologies mentioned above,
Moreover, the object is to provide a safe and stable anti-hair loss agent.

Means for Solving the Problems> In order to achieve the above object, the present invention provides a hair loss prevention agent characterized by containing horsetail extract as an active ingredient for hair loss prevention. And so.

The hair loss prevention agent according to the present invention is a hair loss prevention agent that exhibits remarkable effects on a wide range of various types of alopecia caused by various etiologies, as briefly explained in the section of <Problems to be solved by the invention>. be. That is, the following are examples of various alopecias to which the anti-hair loss agent according to the present invention can be applied.

Note that the various types of alopecia mentioned above are described based on the classification of alopecia according to a certain theory.

A) Example of telogen epigenetic alopecia.

(a) Androgenetic alopecia (b) Alopecia due to inflammatory alopecia/dandruff/seborrheic alopecia/contact dermatitis (C) Postpartum (after childbirth) alopecia (d) Pill use Post-alopecia (e) Diet/starvation alopecia (f) Traction alopecia (6) Compression alopecia (c) Hypothyroidism (i) Advanced thyroid function 0) Hypopituitarism (b) Hypoparathyroidism (1) Drug alopecia, hypervitaminosis A, anticoagulants - heparin, heparinoids, etc., antipsychotics - tribalanol, etc., antithyroid drugs - thiouracil, etc., etc. B) Growth alopecia ( a) Alopecia areata (b) Alopecia areata, anticancer drugs, thiamphenicol (111 drugs), boric acid, thallium, etc., others (C) Alopecia due to digital dermatitis (d) Collagen disease ( Alopecia associated with SLE, DLE, open scleroderma lateralis, etc.) (e) Mucin deposition alopecia (f) @ Scarring alopecia (g)! J [Bu Bai Liao - Alopecia due to fungal infections, etc.
The anti-hair loss agent according to the present invention can be widely applied to the various alopecias mentioned above. However, among (A) telogen alopecia, the horsetail extract according to the present invention has a particularly excellent effect on (b) inflammatory alopecia. In addition to the ``hair loss prevention effect'', it is presumed that the effect is even more pronounced due to the synergistic effect with the ``anti-inflammatory effect'' and ``antibacterial effect'' of the horsetail extract.

The anti-hair loss agent of this invention, that is, horsetail extract, is derived from horsetail (EquiseLU), which is a medicinal plant of the horsetail family.
The leaves, stems, vegetative shoots, and one or more selected from the entire army are used as extraction raw materials, and from this raw material, a single solution or two or more selected from water and organic solvents are used as extraction solvents. It is obtained by extraction using a mixture of solvents.

The harvest season of the horsetail plant used as a raw material is not particularly limited, but it is particularly preferable to have vigorous horsetail harvested in the summer. A vegetative stem is particularly preferred, and when preparing a horsetail extract, from the viewpoint of preserving the raw material, it is preferable to dry the raw material horsetail plant and then extract with the water or/and organic solvent.

Next, the solvent used to prepare the horsetail extract from the raw horsetail plant will be described.

The water is preferably purified water or distilled water. As the organic solvent, a monohydric alcohol or a polyhydric alcohol having 2 to 5 carbon atoms can be used, and particularly preferred examples of the alcohol include ethanol, propylene glycol, 1,3-butylene glycol, and glycerin. Furthermore, various glycerides such as vegetable oils can be used as extraction solvents, with sunflower oil and the like being preferred.

Raw material horsetail (Equisetum arvense)
The method for preparing the horsetail extract according to the present invention from L, ) is performed by any known method.

For example, in the case of extraction with water, finely powdered dried horsetail (Equjsetum arvense L.
About 5 to 200 parts by weight of purified water is added to 1 part by weight of , ) and leached at room temperature (leaching conditions: about 10°C to 35°C, about 5 to 10 days, preferably 6 to 8 days). and exudate,
or heating (heating conditions: approx. 80-100°C9 approx. 30
minutes to 3 hours) to obtain a decoction. The exudate and decoction thus obtained are of course the horsetail extract according to the present invention.

Therefore, the exudate and decoction can be used in their original form as the horsetail extract according to the present invention. Furthermore, the exudate and decoction can be concentrated to an appropriate concentration as necessary and used as the horsetail extract according to the present invention. Furthermore, the extraction solvent (water in this example) of the exudate and decoction is distilled off,
It goes without saying that the dried horsetail extract according to the present invention can be used after evaporation or transpiration. For example, as an example of preparing a horsetail extract, one having a concentration of about 101 to 502 (undiluted solution or concentrated solution) is obtained from 10 kg of dried horsetail. The properties of this horsetail extract are as follows: - It is a clear liquid with a pale yellowish green to brown appearance and a distinctive odor when used for boat fishing.

The horsetail extract thus obtained (undiluted solution).

Concentrated solution or dried product) is used as a undiluted solution, I! Either the condensed liquid or dried product can be used as it is according to the formulation examples described below, or a single solution or a mixture of solvents such as water, ethanol, diluted ethanol, propylene glycol, 1,3-butylene glycol, or glycerin can be used. , or/and used by dissolving or diluting it in various cosmetic base materials.

Also, horsetail extract! As another preparation example of (dry powder extraction @ff), the raw material horsetail
ense L, ) with water at 60° C. or lower for 1 to 2 weeks to extract the extract. This extract was extracted under reduced pressure (approximately 2
Concentrate at a temperature of QssiHg~30■KuHg) without exceeding 60°C until it becomes a honey-like viscous state. Next, to increase solubility, it is dissolved in water and filtered and purified. The filtrate is concentrated and dried under reduced pressure at a temperature below 60°C. The solid substance obtained is crushed and sieved to form a powder (brown powder). The horsetail extract (dried form of water extract) is about 10 to 13% of the raw horsetail horsetail, and the horsetail extract (dried form of water extract) is prepared using a suitable solvent such as water, ethanol, diluted ethanol, propylene glycol.

1. It is used by dissolving or diluting it in a solvent such as 3-butylene glycol or glycerin and/or a cosmetic base material.

As another example, when an organic solvent is used as an extraction solvent to prepare a horsetail extract, taking ethanol as an example, dry horsetail (Equisetua) as a raw material is used.
Approximately 5 to 200 parts by weight of 5% to 99.9% ethanol is added to 1 part by weight of the whole plant of P. arvense L.), and the mixture is cooled for about 1 to 3 weeks and then filtered. This filtrate was concentrated under reduced pressure on a water bath, and about 1/10 of the concentrated liquid (1st
Concentrate). Approximately 2 parts by volume of purified water is added to 1 part by volume of this first concentrate, the resulting precipitate is filtered off, the filtrate is further concentrated under reduced pressure on a water bath to reduce the liquid volume to about half, and ethanol is added to the concentrate. Then, add an appropriate amount of purified water and make the total volume about 2 to 5 times the volume of the first concentrated liquid to an alcohol concentration of 50.
Adjust to %. Leave this in a cool place for about 20 to 30 days.

Filter if necessary to obtain about 2 to 8 parts by volume of the first concentrate as the final horsetail extract. When using the final horsetail extract thus obtained, as in the case of the water extract of horsetail, the final solution of the horsetail extract can be used as it is according to the recipe (method of use) described below, or it can be used in a suitable solvent such as water. , ethanol, diluted ethanol, propylene glycol, 1,3-butylene glycol, or other organic solvents such as glycerin or/and cosmetic base materials.

Furthermore, the horsetail extract according to the present invention, as a horsetail extract or an oil-soluble horsetail extract, has conventionally known effects and effects, that is, the above-mentioned "anti-inflammatory action,""skin metabolism promoting action,""blood circulation promoting action," It is listed in the Cosmetic Type Permission Criteria (■) based on the usage examples that have the known actions and effects of "antibacterial action,""preservativeaction,""increase of connective tissue resistance," and "cell activating action." Also,
The horsetail extract according to the present invention is a variety of commercially available horsetail extracts (Hor
setatl Extract) and various oil-soluble horsetail extracts (04l-Soluble Hors
etailExtract) (regardless of liquid or dry powder form), etc.The horsetail extract and oil-soluble horsetail extract listed in the above-mentioned Cosmetic Type Permission Criteria (■), as well as the various commercially available horsetail extracts, are subject to the present invention. Of course, it can also be used as a hair loss prevention agent.

Next, the usage of the antihair loss agent according to the present invention will be described. Horsetail extracts (various horsetail water extracts, various horsetail solvent extracts and horsetail oil extracts prepared by the above-mentioned preparation methods, various horsetail extracts in the form of commercially available liquids or dry powders, and various horsetails extracts in the form of commercially available liquids or dry powders) (including various oil-soluble horsetail extracts, hereinafter referred to as "horsetail extracts"; hereinafter the same shall apply) may be used as a undiluted solution or in a suitable solvent (water, organic solvent or/and various cosmetic base materials). , including all of these below [
It is diluted or mixed with a solvent (hereinafter referred to as "A") to an appropriate concentration and applied or rubbed onto the affected area.

The hair loss prevention agent according to the present invention, that is, the appropriate concentration of the stock solution of horsetail extract and the dilution concentration of various solutions for use, should be in principle an effective amount that does not cause side effects such as dermatitis, and should not be uniform. Therefore, it is difficult to discuss the concentration of the antihair loss agent according to the present invention. This is because the affected area varies depending on the individual differences of the user (presence of autoimmunity, gender, physical condition, etc.), the etiology of alopecia and the degree of progression of the hair loss symptoms, the distribution and ratio of hair related to hair loss in the hair cycle, etc. Concentration of horsetail extract applied/rubbed, number of application/rubbing per -day,
This is because the application/scrubbing period and the like are determined. It is important to determine the usage conditions of the antihair loss agent according to the present invention based on specific examples and empirically to suit each case. Furthermore, it goes without saying that the amount of the horsetail extract according to the present invention incorporated into various products should be changed as appropriate depending on the variety of the product.

As a general guideline for the amount of horsetail extract incorporated into various products, the practical concentration range of horsetail extract is based on the dry weight of horsetail extract (including crude extract and/or purified extract). It can be used in practical formulations in a blending amount of about 0.1% to 40% by weight, preferably 0.5% to 20% by weight, more preferably 1.0% by weight.
The optimum practical amount is between 10% and 10% by weight.

The anti-hair loss agent according to the present invention is effective as long as it contains at least the horsetail extract as a constituent component, and horsetail extract may be used in combination with other known anti-hair loss agents. Needless to say.

The anti-hair loss agent according to the present invention can be incorporated into various cosmetics to provide general hair care products (particularly hair cosmetics, etc.), quasi-drugs, and the like. Examples of the various hair care products (hair cosmetics) include hair tonics, hair essences, hair shampoos, hair rinses, hair treatments (hair conditioners), hair creams, hair styling products, and other hair cosmetics. On the other hand, examples of quasi-drugs include medicated lotions for hair growth, medicated hair tonics and other permanent wave liquids, hair dyes (hair dyes and others), hair creams, and other hair cosmetics. can be exemplified. The common forms of the various cosmetics (including cosmetics and/or quasi-drugs) include liquid, cream, jelly, powder, solid, emulsion, sol and/or gel, There is no limit to its common form, such as spray form (aerosol form), and it can be used in almost all forms.

<Action> This invention provides nutrients to the hair roots of horsetail extract,
In particular, based on the hair loss prevention effect by promoting the growth of body hair such as scalp hair, delaying the rate of degeneration from the growth phase to the telogen phase, or preventing the transition to the telogen phase, and the hair loss prevention effect by preventing hair root atrophy. Although it is possible to achieve extremely excellent prevention of telogen hair loss and prevention of anagen hair loss, the hair loss prevention agent according to the present invention has no adverse effect on normal hair of humans without symptoms of hair loss. It has an excellent effect of maintaining its normal state without any problems.

<Example> (1) Example of preparation of horsetail extract.

50% ethanol 2.00% for 100g of dried horsetail
After mixing 0g and extracting at room temperature (about 20°C) for about 7 days,
Filter to obtain 500 g of horsetail extract.

In this specification, the amount (weight%<wt%>) of the horsetail extract according to the present invention blended into various products such as cosmetics illustrated as examples is the amount of the horsetail extract as a dried horsetail extract. (wt%).

Furthermore, when obtaining a horsetail oil extract, extraction is performed using sunflower oil instead of 50% ethanol in the preparation example. This horsetail oil extract is suitable for use when incorporated into water-free products such as pomades.

(2) Effect test examples for each case of the antihair loss agent according to the present invention.

This effectiveness test example was conducted using a known method of measuring the number of hairs pulled out over time by test subjects complaining of various hair loss symptoms.

(a) Test Materials The product used in this effect test example was a hair tonic containing the hair loss preventing agent according to the present invention and having the following formulation composition, which was used by each subject.

☆Formulation composition of the hair tonic used in the test [All blending amounts are in weight% (wt%)] (IIT%) ・Ethanol - - - - - - - - - ~ - - - - - - −−−・−11−−−・・−・・50.0・Equisetum extract・・・・−・・−・−・・−・=・・・−・・−
・－・・・・・・ 0.6・Glycerin－－－－－・
・−・−・−・−・・−・−・−・−・・・・・−1,0
・T-men)-ru・・・・・・・・・・・・・・・・・・・・
......
・～ 0.5・Fragrance・Pigment・・・・・・・・・・・・・・−・
−・・−１−−−−・・・・−・・−・・・−・−Appropriate amount of purified water−・−・・−１−−−−−−−−−−−−・−
--------------------Total amount 100 ■) Administration method and administration period.

Apply the above test hair tonic twice a day (morning and evening) in an appropriate amount (1
1.5 to 2 m) was rubbed onto the hair removal site. The administration period was 12 weeks in total, and the test hair tonic was distributed for 3 weeks in principle; 10 vials (1 vial for 7 people). Furthermore, during the implementation period of this efficacy test, subjects were prohibited from using any drug for the purpose of treating alopecia.

(C) Observation items and test method ☆Observation port and measurement items At the observation port, the number of hairs pulled out when the test subject was washing their hair was measured before the start of the test, 8 weeks later, and 12 weeks later.

☆ Test method for determining the number of hairs removed during hair washing Before the start of the test, 8 weeks later, and 12 weeks later, the hairs that were removed during hair washing were collected, dried thoroughly in the shade, and the number of removed hairs was measured.

The test method was to wash the hair at one-day intervals in each of the above periods. For example, to measure plucked hair before starting the test, 1
The odd numbered days of the week (1st, 3rd, 5th, 7th) are designated as hair washing days, and the hair washing on the 3rd, 5th, and 7th day of the week is designated as the hair collection day. The total number was counted. Regarding the number of hairs removed after 8 weeks and 12 weeks, each following week, that is, the 9th week day and the 13th week day, is the hair removal measurement week, and the 1st 3.5. The 7th day is designated as a hair washing day, and the 3rd, 5th, and 7th days of the week are designated as hair removal and hair collection days. (inner diameter 35c
(m) was covered with two very fine mesh nonwoven fabrics, and the hair was washed on top of that. The hair jump and hair rinse used during this test period were the same as the products each subject had been using before the start of the test.

During the test period, the subjects kept a diary to record the usage status of the hair tonic, whether or not they washed their hair, the number of days they wore their hair, and the presence or absence of any side effects. And "cutting due to haircut" and "hair removal"
Since it is difficult to distinguish between
Haircuts within the previous week were prohibited.

Side effects were investigated using observation ports and diaries recorded by the subjects. When side effects occurred, the severity was categorized into three levels: mild, moderate, and severe, and recorded. Severe condition was defined as a degree to which the test could not be continued due to dermatitis or other symptoms. Of the 23 subjects tested this time, none complained of moderate or higher side effects. This result suggests that the antihair loss agent (horsetail extract) according to the present invention is extremely safe.

Furthermore, since there was no similar adverse effect on normal humans who do not exhibit alopecia, it is suggested that the anti-hair loss agent according to the present invention is extremely safe.

☆The results of this effect test, ie, "Example results of the number of hairs removed during hair washing" are shown in Table 1.

From the results in Table 1, ■ the hair loss prevention agent according to the present invention is
It has been suggested that it is extremely effective against a wide variety of alopecias. ■The hair loss prevention agent of this invention for various types of alopecia has a risk rate of 5% after 8 weeks of use.
A significant difference was observed, and after 12 weeks of use, a significant difference was observed with a risk rate of 1%. This suggests that the hair loss preventing agent according to the present invention exhibits an extremely excellent hair loss prevention effect even when used for a short period of time.

c) Margins below this page] Electricity 1 Harm: Number of hairs removed at the time of the earthquake 1 Lie 0 [List the total of 3 times / t) Mi:: ” 1405/
Axis AOD (3) Examples of prescriptions for various other hair cosmetics are illustrated below. It goes without saying that the formulation is not limited to this example. (All compounding ratios in Examples are weight % (wt%). (A) Hair essence, ethanol, castor oil, horsetail extract, fragrance 1 pigment, purified water (wt%) 65.0% 5.0 1. 0 Appropriate amount total amount 100 (B) Hair shampoo sodium alkyl ether sulfate ------
-・・Ethanollauric acid jetanolamide・−・−Propylene glycol・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・· −・・−１−−−
--・・～・(wt%) 16.0% 7.5 4.0 2.0 0.3 Appropriate amount output*: p<f105. Kimoto: p<0.01, so 8 weeks barley is 5%, and 14th grade is l9 and Gae Sanori.

・Purified water total amount 100 (C) Hair rinse (wt%)
・Stearyldimethylbenzyl ammonium chloride--------1,4%--Ethanol------------------------------------ −・・・−7,5 Stearyl alcohol・−Shinichi・−・・−・−・・−0,6 Glyceryl monostearate−−−−1,5 Squalane−・・・・・・−・−・・−・・・・・−1−
−3,0・Equisetum extract−・・−・−・−・−・=・−
・ ・ -----------0, 3 ・ Preservatory, pigment / fragrance - ・ 一 — 1 ---------------------------------------- −・−・−・−１−−−−−−−−−−・−
・----1-----・--1-----・-Total amount 100 (
D) Hair treatment・Stearyldimethylbenzyl ammonium chloride・・・−・−・・Ethanol・Stearyl alcohol・・・・・・・・・・−
・−・−・Glyceryl monostearate/squalane (wt %) 1.5% 10.0 4.0 3.0 10.0 ・Horsetail extract−・・−・−・−・・−・・
−−−−−0,4・Preservatives・Pigments・Fragrance・・・・・−−
−−−・・・−・・・−・・Appropriate amount/Purified water−・・
〜・−・−・・・・・−・・−・・−・−・−
・---Total 1100 (E) Hair conditioner (a) (vegetable) Pomade, Japanese oak, castor oil-------------------
・・・−・・・−・・Sunflower oil, hydrogenated oil, horsetail extract −・・・・・・・−・−・・−・・・・・・・
・・・−・−・Fragrances, pigments, antioxidants−−−−−m−・−・−・−・・
−−1−−(b) (Mineral) Pomade/Vaseline/Fluid Halafine−−1−−−−・−・−・・・−・・
・・・−・−・・Sunflower oil, paraffin, horsetail extract−・−・−・・・・・−・・−・・
-・(wt%) 10-13% 58-53 0 2-1 0.6 Appropriate amount (gt%) 39% 5 0 5 0.4 ・Fragrance-・-・-・・・・・・・・・・...------m-
−−・・−・−−−m−・−・・Appropriate amount・Pigment, antioxidant・−・−−−−−・−1−−−・−・Appropriate amount・Fragrance・Purified water Appropriate amount Total amount 100 (C) Hair cream (0/W type) (wt%
)・White beeswax・−・・−・・−−−−−−−−−
−・・−−−−−−・3%・Liquid lanolin−・−・・
・−・−・−・−・−−−1−・・−1・Liquid paraffin (355 seconds)−−−−−−−−30・Polyoxyethylene cetyl ether (20E, O,)−・-・1.5・Polyoxyethylene cetyl ether (5E, O,) −・−2,5・Sorbitan monostearate... 1.5・Ethanol-1−−1−−・・−・−・-7,5・Horsetail extract・・・・−1−−−−−−・・−0,3・Propyl roseoxybenzoate−・−・−・−−・−・−・−・Adequate amount・Paraoxy Methyl benzoate --- Appropriate amount/Borax ---
−−−−・−・−・−・・・−・・・・・・・−・
・−・−・−・ 0.3・Tetrasodium edetate・・・
・−・−・−・・Adequate amount・Flopylene gelicol・−・−
−−1−−−−−・〜・−3 (Yu Hair Liquid
(wt%)・Polyoxypropylene butyl ether・−・−・−15 to 25%・Ethanol−・−−−−−・−・・−・〜・・−m−−−
・−・−・−・−50～40・Horsetail extract---
1－－－－－・・−・−・・−１１１〜−・−0,4
・Edetate disodium---1---1---...
・−・Appropriate amount・Fragrance 1 pigment−・−・−・−・−−−−1・
−・・−1−−−−・・−・−Appropriate amount・Purified water・・
・・・・・・−・−−−−−・−・・−・−Total amount 100
(e) Set lotion, polyvinylpyrrolidone, polyoxyethylene cholesterol (24E, 0.), ethanol, glycerin, horsetail extract, etc.・・・－・－・－
・・−・−1−−−・・Fragrance 1 Dye (wt%) 2% 37.5 0.3 Appropriate amount・Paraoxybenzoic acid ester−・−・−・・−・・・Quantity・Purification Water－－－－－・−・・−・・・・−−−１−・−・・・・−
・−・・−・・・−Total amount io.

hair) Resin transparent gel carboxy (wt%) (turbid hair solid (wt%)
Liquid paraffin--111...-------1-----5,0% ethanol-1--
１・−・−−−−−１・・・・−・−・−・・−・−
・・－・5.0・Lanolin alcohol・−−1−−・
・−−−m−−・−・−−−−−2, tlauric acid jetanolamide−−−−1−−・・−・−・2
．． 0. Polyoxyethylene lauryl ether phosphoric acid...--7.0. Horsetail extract------------------...
−−−−−−・0.2・Purified water−・・−−1−−−・−
・・・−・−・・−１−−−・・・−−−〜−＝−
---～・-100% effect in total> This invention provides nutrition to the hair roots of horsetail extract,
In particular, it promotes the growth of body hair such as scalp hair, delays the rate of degeneration from the growth phase to the telogen phase, and prevents the entry into the telogen phase, and has a remarkable hair loss prevention effect by preventing hair root atrophy. Based on this, it is possible to achieve extremely excellent prevention of quiescent hair loss and growth hair loss, and to achieve the purpose of the invention, such as having an outstanding hair loss prevention effect on a wide variety of alopecias. It has a remarkable effect.

Moreover, the anti-hair loss agent according to the present invention has an excellent action and effect of maintaining the normal state of hair without any adverse effect on normal human hair without any symptoms of hair loss, and also has side effects. The present invention has a remarkable effect of achieving the object of the invention.

Claims (1)

[Claims] (1) A hair loss prevention agent characterized by containing horsetail extract as an active ingredient for hair loss prevention.