JPH03210156A - Feed reducing accumulated amount of body fat - Google Patents
Feed reducing accumulated amount of body fatInfo
- Publication number
- JPH03210156A JPH03210156A JP2003568A JP356890A JPH03210156A JP H03210156 A JPH03210156 A JP H03210156A JP 2003568 A JP2003568 A JP 2003568A JP 356890 A JP356890 A JP 356890A JP H03210156 A JPH03210156 A JP H03210156A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- body fat
- feed
- accumulated amount
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、家畜の脂肪代謝を改善し、体脂肪の蓄積量を
減少させる飼料に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a feed that improves fat metabolism and reduces body fat accumulation in livestock.
近年、畜産動物において、発育促進の目的のために、エ
ネルギー摂取量が多くなってきており、体脂肪の蓄積量
が増大する傾向にある。In recent years, livestock animals have been increasing their energy intake for the purpose of promoting growth, and there is a tendency for body fat accumulation to increase.
しかし、最近の健康食ブームにより、動物性脂肪を食べ
ないようにする人々が増大し、体脂肪の少ない畜産物を
生産する方法や飼料の開発が広く要望されていた。However, with the recent health food boom, an increasing number of people are avoiding eating animal fat, and there has been a wide demand for the development of methods and feed for producing livestock products with low body fat.
〔発明が解決しようとする課題］
しかしながら、このような体脂肪の少ない畜産物を生産
する飼料は、広く要望されているにもかかわらず、有効
なものはほとんど開発されていなかった。わずかに、本
出願人が 、蛋白質の構成成分であるある種のアミノ酸
を飼料に強化することにより、体脂肪蓄積量を減少させ
る飼料を提案している（特願平１−２８７３９５号明細
書）。[Problems to be Solved by the Invention] However, although feeds that produce livestock products with low body fat are widely desired, few effective feeds have been developed. The present applicant has proposed a feed that reduces body fat accumulation by fortifying the feed with certain amino acids that are constituents of protein (Japanese Patent Application No. 1-287395). .
〔問題を解決するための手段］
ところで、ビタミンＤ、はＣａ代謝にとって重要な役割
をもつ物質であることはよく知られている。[Means for solving the problem] By the way, it is well known that vitamin D is a substance that plays an important role in Ca metabolism.
ビタミンＤ、が小腸でＣａの吸収を促進する働きを持つ
には、ビタミンＤ、が肝臓において２５位が水酸化され
て２５（ＯＨ）Ｄ、となり、次に腎臓においてｌα位が
水酸化されて、ｌα、２５ （ＯＨ） ｚ Ｄ ３とな
る必要がある。このｌα、２５ （ＯＨ） ｚ Ｄ ３
は小腸でのＣａの吸収促進作用が最も高く、活性型ビタ
ミンＤ３と呼ばれている。In order for vitamin D to have the function of promoting Ca absorption in the small intestine, vitamin D must be hydroxylated at position 25 in the liver to become 25(OH)D, and then hydroxylated at position lα in the kidney. , lα, 25 (OH) z D 3. This lα, 25 (OH) z D 3
Vitamin D3 has the highest Ca absorption promotion effect in the small intestine and is called active vitamin D3.
他方、近年、ビタミンＤ３と脂肪代謝に関する研究が開
始されており、ビタミンＤ１、特に１α、２５（ＯＨ）
２Ｄ３が、前脂肪細胞の脂肪細胞への分化を阻害する
働きを持つことや、肝臓での脂肪分解に関与することが
試験管内（インビトロ）の実験で報告されている。すな
わち、ｌα、２５ （ＯＨ） ｚ Ｄ ３は、脂肪細胞
の数を減少させ、体脂肪の蓄積量を減少させる働きがあ
るものと推測される。On the other hand, in recent years, research on vitamin D3 and fat metabolism has begun, and vitamin D1, especially 1α, 25(OH)
In vitro experiments have reported that 2D3 has the function of inhibiting the differentiation of preadipocytes into adipocytes and is involved in lipolysis in the liver. That is, lα,25 (OH) z D 3 is presumed to have the function of reducing the number of adipocytes and the amount of accumulated body fat.
しかし、この点について動物を用いた生体（インビボ）
での試験は実施されておらず、実際に動物に対して体脂
肪の蓄積量を減少させる働きが有るか否か不明である。However, in this regard, in vivo studies using animals
No tests have been conducted on this drug, and it is unclear whether it actually works to reduce body fat accumulation in animals.
本発明者らは、この点を明らかにするため、ビタミンＤ
３および１α（ＯＨ）Ｄ３（本物質は、肝臓ですみやか
に２５位が水酸化され、１α、２５ （ＯＨ） ｚ Ｄ
３となる）をブロイラーに給与して、体脂肪蓄積量に
与える影響を検討した。In order to clarify this point, the present inventors investigated vitamin D
3 and 1α(OH)D3 (This substance is quickly hydroxylated at the 25th position in the liver, and 1α, 25(OH) z D
3) was fed to broilers to examine its effect on body fat accumulation.
その結果、ビタミンＤ、および１α（ＯＨ）Ｄ３は、と
もに体脂肪蓄積量を抑制することを見い出した。As a result, it was found that both vitamin D and 1α(OH)D3 suppress body fat accumulation.
また、我々は、体脂肪の蓄積量を減少させる好適な添加
量を見い出し、本発明を完成させた。Furthermore, we have found a suitable addition amount to reduce the amount of body fat accumulated, and have completed the present invention.
すなわち、本発明の体脂肪蓄積量を減少させる飼料は、
飼料眩当りビタミンＤ３を２５０〜２５００１１ｇおよ
び／または１α（ＯＨ）Ｄ：ｌを０．２５〜４．ＯＩ！
ｇの範囲に強化することを特徴として構成されている。That is, the feed that reduces body fat accumulation of the present invention is
250 to 250011 g of vitamin D3 and/or 0.25 to 4.0 g of 1α(OH)D:l per feed. OI!
The structure is characterized by strengthening to a range of g.
ビタミンＤ３および１α（ＯＨ）Ｄ３の添加量が、それ
ぞれ２５０Ｉ！ｇおよび０．２５ｘ未満であると、体脂
肪蓄積の抑制効果はない。ビタミンＤ３および１α（Ｏ
Ｈ）Ｄ３の添加量が、それぞれ２５００ μｇおよび４
眉を越えると、ビタミンＤ３およびｌα（ＯＨ）Ｄ３の
過剰摂取による副作用が出現し増体面で好ましくない。The added amount of vitamin D3 and 1α(OH)D3 is 250I each! g and less than 0.25x, there is no effect of suppressing body fat accumulation. Vitamin D3 and 1α (O
H) The amount of D3 added is 2500 μg and 4
When the amount exceeds the eyebrows, side effects due to excessive intake of vitamin D3 and lα(OH)D3 appear, which is not desirable in terms of weight gain.
なお、ビタミンＤと１α（ＯＨ）Ｄ３は、それぞれ単独
で強化しても、混合して強化してもよい。Note that vitamin D and 1α(OH)D3 may be enriched individually or in combination.
その他の飼料成分は家畜用の公知の飼料でよく、蛋白質
、エネルギー源、カルシウム源、リン源、ビタミン類、
ミネラル等を含み、ＮＲＣ要求量を満足する配合のもの
である。蛋白質としては、魚粉、大豆粕、菜種粕、フェ
ザ−ミール、ミートボーンミル等であり、アミノ酸イン
バランスを補うためにＤＬ−メチオニン、Ｌ−）リプト
ファン、Ｌ−スレオニン等のアミノ酸を加えてもよい。Other feed ingredients may be known feeds for livestock, such as protein, energy source, calcium source, phosphorus source, vitamins, etc.
It contains minerals, etc., and is formulated to meet NRC requirements. Examples of protein include fish meal, soybean meal, rapeseed meal, feather meal, meat bone meal, etc. Amino acids such as DL-methionine, L-)liptophan, and L-threonine may be added to compensate for amino acid imbalances. good.
エネルギー源としては、とうもろこし、マイロ、小麦粉
等の穀類と、飼料用油脂、大豆油、粉末油脂等がある。Energy sources include grains such as corn, milo, and wheat flour, as well as feed oils, soybean oil, powdered oils, and the like.
その他、リン源、ビタミン類、ミネラル等を公知飼料と
同様に含有させる必要がある。In addition, it is necessary to contain phosphorus sources, vitamins, minerals, etc. in the same way as known feeds.
成分の含有率は、粗蛋白質１２〜２５％、粗脂肪３〜１
０％程度、カルシウム０．８〜２．０％程度、ＭＥ２７
００〜３３００Ｋｃａ ｌ／ ｋｇ程度でよい。The content of ingredients is 12-25% crude protein, 3-1% crude fat.
About 0%, calcium about 0.8-2.0%, ME27
It may be about 00 to 3300 Kcal/kg.
本発明の体脂肪の蓄積量を減少させる飼料は、ビタミン
Ｄ３および１α（ＯＨ）Ｄ：＋が体内で１α、２５（Ｏ
Ｈ）ＺＤ３となり、この１α、２５ （ＯＲ） ｚ Ｄ
３が前脂肪細胞を脂肪細胞へ分化させる作用を阻害す
るとともに、脂肪の分解を促進し、体脂肪の蓄積量を減
少させる。The feed for reducing body fat accumulation of the present invention contains vitamin D3 and 1α(OH)D:+ in the body.
H) ZD3, and this 1α, 25 (OR) z D
3 inhibits the differentiation of preadipocytes into adipocytes, promotes fat decomposition, and reduces body fat accumulation.
市販のブロイラー飼料（プロエースＳおよびプロエース
Ｇ、伊藤忠飼料■製品）に、ビタミンＤ３または１α（
ＯＨ）Ｄ３を添加し、試験を実施した。Vitamin D3 or 1α (
OH)D3 was added and the test was carried out.
試験は５グループを設定し、ブロイラー初生雛１８０羽
（雄９０羽、雌９０羽）を用い、ｌグルー１１１１１８
羽（６羽×３反復）、雌１８羽（６羽×３反復）の５グ
ループで４９日齢まで試験を実施した。The test consisted of 5 groups, using 180 day-old broiler chicks (90 males, 90 females), and using l glue 111118.
The test was conducted in 5 groups of feathers (6 birds x 3 replicates) and 18 females (6 birds x 3 replicates) until the age of 49 days.
試験区分を以下に示す。The test categories are shown below.
１区 対照区 ２区 ビタミン Ｄ３ 強化区 ３区 ビタミン Ｄ３ 強化区 ４区 １α（ＯＨ） Ｄｓ強化区 ５区１α（ＯＨ）０３強化区 （無添加） （プロエース３３７５■／ｋｇ プロエースＧ １５０μｇ／ｋｇ） （プロエース５２５００Ｉ！ｇ／ｋｇ プロエースＧ ５０００尾／ｋｇ） （プロエース５Ｏ０８眉／ｋｇ プロエースＧ１．６■／ｋｇ） （プロエース８４．０尾／ｋｇ プロエース０８．０尾／ｋｇ） 結果を下表に示す。Ward 1: Control area Ward 2 Vitamin D3 Enriched Ward Ward 3 Vitamin D3 Reinforcement area 4th ward 1α (OH) Ds reinforcement area 5th Ward 1α (OH) 03 Strengthened Ward (Additive-free) (Proace 3375■/kg Proace G 150μg/kg) (Proace 52500I!g/kg Proace G 5000 fish/kg) (Proace 5O08 eyebrows/kg Proace G1.6■/kg) (Proace 84.0 fish/kg Proace 08.0 fish/kg) The results are shown in the table below.
ビタミンＤ３および１α（ＯＨ）Ｄ３を強化しない飼料
で育てた１区は、腹脂肪量が、他の区分に比して、雄で
約２５％、雌で約１７％増加している。したがって、ビ
タミンＤ、および１α（ＯＨ）Ｄ、の強化は体脂肪の蓄
積量を減少させることが明らかである。In Group 1, which was raised on feed that was not enriched with vitamin D3 and 1α(OH)D3, the amount of belly fat increased by about 25% in males and by about 17% in females compared to other categories. Therefore, it is clear that fortification of vitamin D and 1α(OH)D reduces the amount of body fat stored.
また、ビタミンＤ３の添加量が多い３区は、体重が、２
区および４区に比して、雄および雌とも約り％少ない。In addition, in the 3rd district where the amount of added vitamin D3 is high, the weight is 2.
Compared to Ward and Ward 4, both males and females are approximately % lower.
さらに、ｌα（ＯＨ）Ｄ、の添加量が多い５区は、体重
が、２区および４区に比して、雄で１４％、雌で約り％
少ない。Furthermore, in Group 5, which had a large amount of added lα(OH)D, the body weight was 14% lower in males and approximately % lower in females than in Groups 2 and 4.
few.
したがって、ビタミンＤ３および１α（ＯＨ）Ｄ３の添
加量を多くすると、増体面で好ましくないことが明らか
である。Therefore, it is clear that increasing the amounts of vitamin D3 and 1α(OH)D3 is not favorable in terms of weight gain.
２区および４区は、体重が減少することなく、腹脂肪量
が減少しており、好適であることが明らかである。It is clear that the 2nd and 4th sections are preferable because the amount of abdominal fat decreased without any decrease in body weight.
本発明は以上のように構成することにより、生体重に影
響を与えることなく体脂肪の蓄積量を減少させることが
できる。By configuring the present invention as described above, it is possible to reduce the amount of accumulated body fat without affecting live weight.
Claims (1)
よび／または１α（ＯＨ）Ｄ＿３を０．２５〜４．０μ
ｇの範囲に強化した体脂肪の蓄積量を減少させる飼料250-2500 μg of vitamin D_3 and/or 0.25-4.0 μg of 1α(OH)D_3 per kg of feed
Feed that reduces body fat accumulation enriched in the g range
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003568A JPH0695892B2 (en) | 1990-01-12 | 1990-01-12 | Feed that reduces body fat storage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003568A JPH0695892B2 (en) | 1990-01-12 | 1990-01-12 | Feed that reduces body fat storage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03210156A true JPH03210156A (en) | 1991-09-13 |
| JPH0695892B2 JPH0695892B2 (en) | 1994-11-30 |
Family
ID=11561043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003568A Expired - Fee Related JPH0695892B2 (en) | 1990-01-12 | 1990-01-12 | Feed that reduces body fat storage |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0695892B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005051396A3 (en) * | 2003-11-25 | 2005-11-17 | Deltanoid Pharmaceuticals Inc | Methods for reducing body fat using vitamin d compounds |
| US8604009B2 (en) | 2010-03-23 | 2013-12-10 | Wisconsin Alumni Research Foundation | (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6356254A (en) * | 1973-01-10 | 1988-03-10 | リサ−チ・インステイチユ−ト・フオア・メデイスン・アンド・ケミストリ−・インコ−ポレイテツド | Feed composition |
-
1990
- 1990-01-12 JP JP2003568A patent/JPH0695892B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6356254A (en) * | 1973-01-10 | 1988-03-10 | リサ−チ・インステイチユ−ト・フオア・メデイスン・アンド・ケミストリ−・インコ−ポレイテツド | Feed composition |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005051396A3 (en) * | 2003-11-25 | 2005-11-17 | Deltanoid Pharmaceuticals Inc | Methods for reducing body fat using vitamin d compounds |
| JP2007512371A (en) * | 2003-11-25 | 2007-05-17 | デルタノイド ファーマシューティカルズ，インコーポレイティド | Method for reducing body fat using vitamin compounds |
| US8604009B2 (en) | 2010-03-23 | 2013-12-10 | Wisconsin Alumni Research Foundation | (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0695892B2 (en) | 1994-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |