JPH032533B2 - - Google Patents

Info

Publication number: JPH032533B2
Authority: JP; Japan
Prior art keywords: oxygen; dye; porous; quenching; light
Prior art date: 1982-10-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP57503315A

Other languages

English (en)

Japanese (ja)

Other versions

JPS59500896A (ja

Inventor

Jon Iuan Piitaason

Rafuaeru Uinsento Fuitsujerarudo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

US Department of Energy

Original Assignee

US Department of Energy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-15

Filing date

1982-10-15

Publication date

1991-01-16

1982-10-15 Application filed by US Department of Energy filed Critical US Department of Energy

1982-10-15 Priority claimed from PCT/US1982/001418 external-priority patent/WO1983003344A1/fr

1984-05-24 Publication of JPS59500896A publication Critical patent/JPS59500896A/ja

1991-01-16 Publication of JPH032533B2 publication Critical patent/JPH032533B2/ja

Status Granted legal-status Critical Current

Links

QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 60
229910052760 oxygen Inorganic materials 0.000 description 60
239000001301 oxygen Substances 0.000 description 60
239000000975 dye Substances 0.000 description 42
230000000171 quenching effect Effects 0.000 description 26
230000036961 partial effect Effects 0.000 description 25
238000010791 quenching Methods 0.000 description 24
238000005259 measurement Methods 0.000 description 22
239000000523 sample Substances 0.000 description 20
230000003287 optical effect Effects 0.000 description 16
239000013307 optical fiber Substances 0.000 description 16
238000004020 luminiscence type Methods 0.000 description 14
239000008280 blood Substances 0.000 description 13
210000004369 blood Anatomy 0.000 description 13
238000000576 coating method Methods 0.000 description 11
239000000835 fiber Substances 0.000 description 11
239000011248 coating agent Substances 0.000 description 10
230000035945 sensitivity Effects 0.000 description 9
230000035699 permeability Effects 0.000 description 7
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
229920000642 polymer Polymers 0.000 description 6
238000001179 sorption measurement Methods 0.000 description 6
241001465754 Metazoa Species 0.000 description 5
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
210000004204 blood vessel Anatomy 0.000 description 5
229920003023 plastic Polymers 0.000 description 5
239000013308 plastic optical fiber Substances 0.000 description 5
-1 polypropylene Polymers 0.000 description 5
230000008033 biological extinction Effects 0.000 description 4
239000007789 gas Substances 0.000 description 4
239000000463 material Substances 0.000 description 4
238000012546 transfer Methods 0.000 description 4
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
239000004743 Polypropylene Substances 0.000 description 3
230000004913 activation Effects 0.000 description 3
239000003463 adsorbent Substances 0.000 description 3
125000003118 aryl group Chemical group 0.000 description 3
238000004364 calculation method Methods 0.000 description 3
229910002092 carbon dioxide Inorganic materials 0.000 description 3
229920001429 chelating resin Polymers 0.000 description 3
238000012937 correction Methods 0.000 description 3
238000009792 diffusion process Methods 0.000 description 3
230000005284 excitation Effects 0.000 description 3
230000005281 excited state Effects 0.000 description 3
238000005286 illumination Methods 0.000 description 3
239000007788 liquid Substances 0.000 description 3
230000007246 mechanism Effects 0.000 description 3
238000000034 method Methods 0.000 description 3
238000012544 monitoring process Methods 0.000 description 3
239000004033 plastic Substances 0.000 description 3
229920001155 polypropylene Polymers 0.000 description 3
239000000741 silica gel Substances 0.000 description 3
229910002027 silica gel Inorganic materials 0.000 description 3
238000012360 testing method Methods 0.000 description 3
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
229920013683 Celanese Polymers 0.000 description 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
JMEAFYJXCJNGCX-UHFFFAOYSA-N butanoic acid;perylene Chemical group CCCC(O)=O.CCCC(O)=O.C1=CC(C2=CC=CC=3C2=C2C=CC=3)=C3C2=CC=CC3=C1 JMEAFYJXCJNGCX-UHFFFAOYSA-N 0.000 description 2
239000001569 carbon dioxide Substances 0.000 description 2
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
229910001882 dioxygen Inorganic materials 0.000 description 2
GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthene Chemical compound C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 description 2
150000003278 haem Chemical class 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
239000003456 ion exchange resin Substances 0.000 description 2
229920003303 ion-exchange polymer Polymers 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
239000011148 porous material Substances 0.000 description 2
230000002441 reversible effect Effects 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
XOHUEYCVLUUEJJ-UHFFFAOYSA-I 2,3-Diphosphoglycerate Chemical compound [O-]P(=O)([O-])OC(C(=O)[O-])COP([O-])([O-])=O XOHUEYCVLUUEJJ-UHFFFAOYSA-I 0.000 description 1
KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 description 1
GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
QXYRRCOJHNZVDJ-UHFFFAOYSA-N 4-pyren-1-ylbutanoic acid Chemical compound C1=C2C(CCCC(=O)O)=CC=C(C=C3)C2=C2C3=CC=CC2=C1 QXYRRCOJHNZVDJ-UHFFFAOYSA-N 0.000 description 1
VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
241000195493 Cryptophyta Species 0.000 description 1
108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
108091005886 Hemoglobin subunit gamma Proteins 0.000 description 1
102100038617 Hemoglobin subunit gamma-2 Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
241000282412 Homo Species 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
238000004847 absorption spectroscopy Methods 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 description 1
BGLGAKMTYHWWKW-UHFFFAOYSA-N acridine yellow Chemical compound [H+].[Cl-].CC1=C(N)C=C2N=C(C=C(C(C)=C3)N)C3=CC2=C1 BGLGAKMTYHWWKW-UHFFFAOYSA-N 0.000 description 1
PEJLNXHANOHNSU-UHFFFAOYSA-N acridine-3,6-diamine;10-methylacridin-10-ium-3,6-diamine;chloride Chemical compound [Cl-].C1=CC(N)=CC2=NC3=CC(N)=CC=C3C=C21.C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 PEJLNXHANOHNSU-UHFFFAOYSA-N 0.000 description 1
229920006397 acrylic thermoplastic Polymers 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
230000000274 adsorptive effect Effects 0.000 description 1
DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 1
230000017531 blood circulation Effects 0.000 description 1
238000009530 blood pressure measurement Methods 0.000 description 1
210000000748 cardiovascular system Anatomy 0.000 description 1
230000002860 competitive effect Effects 0.000 description 1
238000011109 contamination Methods 0.000 description 1
229960000956 coumarin Drugs 0.000 description 1
235000001671 coumarin Nutrition 0.000 description 1
VBVAVBCYMYWNOU-UHFFFAOYSA-N coumarin 6 Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 VBVAVBCYMYWNOU-UHFFFAOYSA-N 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
229920006037 cross link polymer Polymers 0.000 description 1
238000013461 design Methods 0.000 description 1
238000010586 diagram Methods 0.000 description 1
NJDNXYGOVLYJHP-UHFFFAOYSA-L disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=CC(=O)C=C2OC2=CC([O-])=CC=C21 NJDNXYGOVLYJHP-UHFFFAOYSA-L 0.000 description 1
238000009826 distribution Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
238000005562 fading Methods 0.000 description 1
229920002457 flexible plastic Polymers 0.000 description 1
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
238000002189 fluorescence spectrum Methods 0.000 description 1
230000004927 fusion Effects 0.000 description 1
230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
102000018146 globin Human genes 0.000 description 1
108060003196 globin Proteins 0.000 description 1
229920001600 hydrophobic polymer Polymers 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000012784 inorganic fiber Substances 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
230000031700 light absorption Effects 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
HYLDLLCHFLSKAG-UHFFFAOYSA-M lissamine flavine FF Chemical compound [Na+].C1=CC(C)=CC=C1N(C1=O)C(=O)C2=C3C1=CC=CC3=C(N)C(S([O-])(=O)=O)=C2 HYLDLLCHFLSKAG-UHFFFAOYSA-M 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000035772 mutation Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000002985 plastic film Substances 0.000 description 1
229920006255 plastic film Polymers 0.000 description 1
229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000002861 polymer material Substances 0.000 description 1
230000008569 process Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
238000006862 quantum yield reaction Methods 0.000 description 1
238000005070 sampling Methods 0.000 description 1
208000007056 sickle cell anemia Diseases 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
241000894007 species Species 0.000 description 1
230000003068 static effect Effects 0.000 description 1
ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
230000000287 tissue oxygenation Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
239000003643 water by type Substances 0.000 description 1

Landscapes

Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

JP57503315A 1982-03-30 1982-10-15 光ファイバーを用いた酸素分圧測定装置 Granted JPS59500896A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US363425		1982-03-30
US396055		1982-07-07
PCT/US1982/001418 WO1983003344A1 (fr)	1982-03-30	1982-10-15	Sonde de p¿o2 en fibre optique

Publications (2)

Publication Number	Publication Date
JPS59500896A JPS59500896A (ja)	1984-05-24
JPH032533B2 true JPH032533B2 (fr)	1991-01-16

Family

ID=22168274

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP57503315A Granted JPS59500896A (ja)	1982-03-30	1982-10-15	光ファイバーを用いた酸素分圧測定装置

Country Status (1)

Country	Link
JP (1)	JPS59500896A (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2976033A4 (fr) *	2013-03-19	2016-12-14	Surgisense Corp	Appareils, systèmes et procédés de détermination de l'oxygénation d'un tissu
CN112932389A (zh)	2014-04-05	2021-06-11	手术感应设备公司	用于解析和绘制生理状况的成像系统

1982
- 1982-10-15 JP JP57503315A patent/JPS59500896A/ja active Granted

Also Published As

Publication number	Publication date
JPS59500896A (ja)	1984-05-24

Publication	Publication Date	Title
US4476870A (en)	1984-10-16	Fiber optic PO.sbsb.2 probe
Peterson et al.	1984	Fiber-optic sensors for biomedical applications
US4785814A (en)	1988-11-22	Optical probe for measuring pH and oxygen in blood and employing a composite membrane
Peterson et al.	1984	Fiber-optic probe for in vivo measurement of oxygen partial pressure
AU711817B2 (en)	1999-10-21	Device and method for measuring tissue oxygenation through the skin using oxygen dependent quenching of phosphorescence
US5624847A (en)	1997-04-29	Method for optically measuring chemical analytes
DE69736300T2 (de)	2007-07-05	Detektionsvorrichtung zur Messung des Sauerstoffgehaltes im Gewebe
US4861727A (en)	1989-08-29	Luminescent oxygen sensor based on a lanthanide complex
US4050450A (en)	1977-09-27	Reflection standard for fiber optic probe
US4200110A (en)	1980-04-29	Fiber optic pH probe
DE68926246T2 (de)	1996-11-21	In vitro photometrisches verfahren zur bestimmung eines blutgasparameters in einer blutprobe
Goldstein et al.	1980	A miniature fiber optic pH sensor for physiological use
US7096053B2 (en)	2006-08-22	Internal biochemical sensing device
US5190729A (en)	1993-03-02	Luminescent oxygen sensor based on a lanthanide complex
KR20070085230A (ko)	2007-08-27	형광 рＨ 검출기 시스템 및 관련 방법
CA2048892A1 (fr)	1992-02-11	Detecteur d'incidents a fibres optiques multiples et methode de fabrication de ce detecteur
CA2095002A1 (fr)	1993-11-23	Stabilisation d'un capteur de bioxyde de carbone
WO2000064492A1 (fr)	2000-11-02	Dispositif de surveillance optique de la concentration d'un bioanalyte dans le sang et procedes associes
JPH0385430A (ja)	1991-04-10	センサ要素及びその製造方法
AU2020267041A1 (en)	2021-12-23	Calibration of a gas sensor
US5155046A (en)	1992-10-13	System and method for measuring oxygen in the presence of halothane
Martin et al.	1987	Fibre-optics and optical sensors in medicine
JPH032533B2 (fr)	1991-01-16
Zhang et al.	1994	Optical pH sensor for physiological pH measurement
JPS63260532A (ja)	1988-10-27	近赤外線無侵襲生体計測装置