JPH03280854A - Biophylaxis system-activating composition - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Fields of Application] The present invention is utilized in fields such as processed foods, beverages, seasonings, functional foods, medical foods, and the restaurant industry.

[Prior Art and Problems] Conventionally, royal jelly has been known as a typical food that activates the biological defense system, but it is not widely used because of its high price.

On the other hand, some herbal medicines are known to have nourishing and tonic effects, and have been eaten as medicinal dishes in China since ancient times. Medicinal terms have recently become popular in Japan, and are sold at restaurants and stores, but there is no scientific data to back up their efficacy, so they are often used to refer to herbal medicines. jEl varies. In other words, in today's Japan, herbal medicines are used as Chinese ingredients, spices, and condiments, and we cannot expect the original efficacy of medicinal dishes.

[Problems to be solved by the present invention] Therefore, we screened crude drugs that are low in price and have the effect of activating the biological defense system, and then blended the selected materials. It is an object of the present invention to find composition amounts and ratios that are free from the above.

[Means to solve the problem]

As a result of our intensive research in order to solve the above-mentioned problems, we found that the same weight to 100 times the weight of lily, bellflower root, and citrus nut were soaked in water at a temperature of 60°C or higher and 100°C or lower for 15 minutes or 60 minutes.
The extract obtained by extraction for 0 minutes or reflux distillation with ethanol, methanol, etc. is concentrated or dried, and then
Expression (1) and expression (2) express one or more of them as dry weight.
), the present invention was completed by blending it into an aqueous medium or molding it into a solid composition, powder, granule, tablet, tablet, or capsule so as to contain it in one serving.

That is, when the weight of the aqueous extract of Nira is x (tg), the weight of the aqueous extract of Kikyo root is y (-g), and the weight of the aqueous extract of Cypress nut is z (mg), x+0.9y+0 .6z≧25--(1) and x+y
+z≦6000 --(2>One serving is the amount that an individual ingests on average. For example, for soups that serve 4 people per bag, formula (1) and formula (2) are used for each bag.
It will be contained in an amount four times the range indicated by .

There are no particular restrictions on the extraction conditions for the extraction of lily, bellflower root, and nutmeg, but to be more specific, if the water is less than the same tffi, the components will not be extracted sufficiently, and if the water is more than 100 times the weight, the extract will dry out. It takes a lot of time. Regarding the extraction temperature, if it is less than 60"C, the components will not be extracted sufficiently, and if it is over 100"C, the operation will be complicated.As for the extraction time, if it is less than 15 minutes, the components will not be extracted sufficiently, and if it is longer than 90 minutes, the ingredients will not be extracted sufficiently. In addition, the extraction efficiency can be improved by reflux distillation with ethanol, methanol, etc.For extract concentration and drying methods, hot air, freezing, reduced pressure, microwave, far infrared rays, etc. You may use the method.The amount of ingredients per serving is x + 0
．． When 9y+0.6z<25, activation of the biological defense system cannot be expected, and when x+y+z>6000, the flavor and medicinal flavor become too strong, which is not sensually preferable. Processing into liquid compositions, solid compositions, powders, granules, tablets, capsules, etc., follows conventional methods used in food and pharmaceutical products, and in some cases, seasoning and halving are performed. Good too. The present invention will be explained below according to examples.

<Example 1> 2 liters of water was added to 100 g of chopped raw salmon (Chiba Terumo), bellflower root, and citrus nut (all manufactured by Rowe Medical Trading Co., Ltd.), and the mixture was boiled for 30 minutes. After cooling, 10
Centrifugation was performed at 0OOG for 10 minutes, the supernatant was concentrated under reduced pressure, and then freeze-dried. The amounts of the extracts obtained were 19.5 g, 22.8 g, and 31.2 g, respectively.

Subsequently, human normal fibroblasts in which interferon-β production was induced by synthetic double-stranded RNA polyinosinic acid: polycytidylic acid were injected with aqueous extracts of lizard, bellflower root, and mandarin root (described above) at the end of the culture medium. The concentration is 0. The amount of interferon-β produced in the culture supernatant was determined by enzyme-labeled immunosorbent assay (EL).
ISA).

The amount of interferon is 39 units without the addition of the extract, and 219 units with the addition of the extract.) (5,
6 times), 195 units (5.0 times) for bellflower root, and 126 units (3.2 times) for bellflower root. This value is 2.7 times higher than that of royal jelly, which is reported to have an activation effect on the biological defense system (Japan Agricultural Chemistry Society 1989).
Annual Conference Abstracts, p. 248), all showed high activity. By the way, if the activity of the water extract of nira is 1,
The water extract of bellflower root is 0.9, and the water extract of bell pepper is 0.9.
6. Royal jelly is 0. It becomes 5. In the case of royal jelly, the daily intake of commercially available products is 50 mg or more ("Challenges and Strategies for Health Foods in the Age of Functional Foods")
Yano Keizai p., 1711987), the amount of intake per meal that can be expected to be effective for the aqueous extracts of Nira, Kikyo root, and Kikko is determined by the amount of aqueous extract of Nira Weight x (+g), l1 of water extract of bellflower root
llffi is y (ag), weight of water extract of Quercus chinensis is z
(IIg), x+0.9y+0.6z≧2
It turned out to be 5. In addition, in terms of price, compared to royal jelly (150 to 200 yen/g), the aqueous extracts of carp, bellflower root, and nutmeg (5 to 10 yen/g) were much cheaper.

<Example 2> Aqueous extracts (lyophilized powder: x (+g) of each of the lizard, bellflower root, and citrus chinensis prepared in Example 1).

A mixture of equal amounts of y (-g) and z (mg)) was adjusted within the range of 1000≦x+y+z≦8000, and 20
We asked a panel of people to drink it and to what extent they could consume it as a single meal without any sensual problems. 6 panel members answered up to 4000 mg, 12 panel members answered up to 5000+ mg, and 2 panel answered up to 6000 mg.
All of them answered 6000+sg or less. From the comments, if x+y+z > 6000, the condiment of nira (spicy, slightly acidic)
・It was shown that the medicine (warm), the seasoning of bellflower root (bitter, spicy) or the seasoning of nutmeg (sweet) were too strong (too strong), and the preferred intake per meal was x + y + z ≦ 6000. Ta.

<Example 3> The water extract (freeze-dried powder) of lizard prepared in Example 1 was
A food containing hard capsules was produced by filling 0 g of gelatin shells. When 10 panelists tasted each of these capsules over a period of one month, 9 panelists said they could not taste the fish flavor at all, and 1 panel member said they could smell a faint smell on their breath after eating. Ta.

<Example 4> Gum was experimentally produced using the water extracts (lyophilized powder) of bellflower root and bellflower root prepared in Example 1. If the aqueous extracts (lyophilized powder) of bellflower root and bellflower root are contained in 1 piece of gum (2.5 g), 10 mg and 20 g, respectively, the above-mentioned frozen amount per meal (1 to 6 pieces) The intake amount of dry powder (Chinese root 1: 枸杞子 2) is 30-180 m
g. The weight ratio is: sugar 294, butyl rubber 100, petrolatan 90, paraffin wax 40,
The above-mentioned freeze-dried powder (1 part of Kikyo root: 2 parts of Kikyo root) and 1 part of fragrance were prepared.

When a trained panel sampled this, it was determined that there was no problem with the taste or flavor.

<Example 5> 10 g each of chopped raw salmon (Kochi Frequency), bellflower root, and mandarin root (all manufactured by Row Medical Trading Co., Ltd.)
1 liter of water was added to the solution and heated at 60"C for 90 minutes. After cooling, centrifugation was performed at 100OOG for 1 degree, and the supernatants were concentrated by heating under reduced pressure to a concentration of 11. 1.8g of water extract of Nira, 2.0g of water extract of Kikyo root, 2.8g of water extract of Mandarin root.
).

3ml of this sample extract, 360g of sugar, 2g of citric M
After adding 1 g of malic acid, 1 g of vitamin C, and 2 g of drink flavor (Ogawa Kaori), the volume was made up to 2 liters with water. Dispense this into 100ml bottles and
When a panel of well-trained men sampled the product, 18 said they could drink it every day, and 2 said they had a strong image of it as an herbal medicine.

[Effects of the present invention]

It is possible to obtain a complex acid that is inexpensive, has a scientifically expected activation effect on the biological defense system, and has a sensually pleasing taste and texture.

Claims (2)

[Claims] (1) A liquid composition characterized by containing one or more selected from the aqueous extracts of lizard, bellflower root, and nutmeg;
Solid compositions, powders, granules, tablets, tablets and capsules. (2) The composition according to claim 1, wherein the content per serving is in the range of formula (1) and formula (2) in terms of dry weight. That is, when the weight of the aqueous extract of Nira is x (mg), the weight of the aqueous extract of Kikyo root is y (mg), and the weight of the aqueous extract of Cypress nut is z (mg), x+0.9y+0. 6z≧25--(1) and x+y+z≦6000--(2)