JPH0331172B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a sheet-shaped external treatment member. More specifically, the present invention relates to a sheet-shaped external treatment member containing aloe or aloe extract. Aloe has been used as a medicinal herb for thousands of years, and was listed as Ashika in the Japanese Pharmacopoeia in 1899, and has been used as a folk medicine since ancient times. The effects of aloe are as follows: For internal use, it has a stomachic effect on gastrointestinal diseases, an anti-inflammatory agent for gastrointestinal diseases, and duodenal diseases.
Laxative for constipation, prevention of complications for high blood pressure, improving blood circulation for low blood pressure, inactivating viruses for colds, improving constitution for colds, activating metabolism for diabetes, detoxifying effect for liver disease, calming for motion sickness. action,
For external use, such as detoxification for hangovers,
Sterilizing effect and tissue recovery effect on burns, abrasions, and cuts, sterilizing effect and toxin neutralizing effect on insect bites, sterilizing effect on athlete's foot, keratin softening effect on corns, anti-inflammatory effect on tooth decay and pyorrhea, sterilizing effect on stomatitis, It has an anti-inflammatory effect on bruises and stiff shoulders, and an anti-inflammatory analgesic and hemostatic effect on hemorrhoids. As mentioned above, aloe has various medicinal effects, and depending on the purpose, it is used by taking or applying raw aloe, juice, juice, ointment, tablet, etc. By the way, when using aloe for the treatment of burns, cuts, and abrasions, which is expected to be most effective externally and has a large effect, the sooner the initial treatment, the better. Particularly in the case of treatment for burns, it is urgent, and therefore it is preferable to keep and use commercially available ointments. In addition to treating burns as quickly as possible, it is important to cool the affected area, and the degree of initial cooling determines the speed of recovery. In this respect, ointments have the disadvantage of not providing an initial cooling effect. Another treatment is to soak aloe grown at home in boiling water to sterilize it, then remove the outer skin and apply the jelly-like part of the leaf to the affected area. It has the advantage of being effective and allowing the medicinal components of aloe to be applied directly to the affected area, and is a well-known method of use, but it has the disadvantage of being cumbersome and time-consuming. The purpose of the present invention is to obtain an aloe preparation that has a large initial cooling effect without impairing the medicinal efficacy of aloe,
Its gist is that it is an external treatment material made by blending aloe or aloe extract with a hydrophilic hydrogel base and forming it into a sheet shape. Regarding the present invention, as the hydrophilic hydrogel base, those commonly used in the past are generally used. It may be synthetic or natural, and any of those conventionally used for hydrophilic gel bases can be used. Typical examples include saccharides and their derivatives, such as sodium alginate, gum arabic, dextrin, pullulan, amylose, gelatin, curdline, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and carboxymethylcellulose, polyacrylic acid and its salts. (e.g., sodium salt, ammonium salt, alkanolamine salt, etc.), acrylic acid copolymers and their salts (e.g., acrylic acid/ethyl acrylate copolymer, potassium salt of acrylic acid/ethyl acrylate copolymer, etc.) , acrylic acid alkyl ester polymers (e.g., polyethyl acrylate, polyhydroxyethyl acrylate, polyethoxyethyl acrylate), maleic anhydride copolymers (e.g., methyl vinyl ether/maleic anhydride copolymer, isobutylene/anhydride) maleic acid copolymers, etc.) and their salts (e.g., sodium salts,
ammonium salts, etc.), polyvinyl alcohol and its derivatives (e.g., partially saponified polyvinyl alcohol, carboxylated polyvinyl alcohol, etc.), acrylamide polymers and their copolymers (e.g., acrylamide/acrylic acid copolymers, acrylamide/acrylonitrile,
(acrylic acid copolymer, acrylamide/acrylonitrile/acrylic acid ester copolymer, etc.),
Examples include polyvinylpyrrolidone. Such polymeric materials include cross-linking agents (e.g. polyisocyanates, polyepoxides, benzoyl peroxide, etc.)
It may be crosslinked using. The blending amount of the polymeric substance in the hydrophilic hydrogel base varies depending on the strength of the base and the setting of the cooling capacity, but is usually about 3 to 30% by weight.
If it is less than 3% by weight, the hydrogel strength will be insufficient even if it is used in a cross-linked state, and if it is more than 30% by weight, the viscosity during production will be too high and workability will be poor, and the solubility of the polymeric substance will be affected. Therefore, the amount of water that can be blended decreases, and the cooling ability tends to deteriorate. In addition, it is preferable to use polyhydric alcohols such as ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, and glycerin in combination in the base for the purpose of tackification and improving solubility during manufacturing. , usually 5 to 80% by weight.
If it is less than 5% by weight, no significant effect can be obtained by adding it, and if it is more than 80% by weight, the hydrogel strength and cooling ability will be poor. If the water content in the hydrophilic hydrogel base is 10% by weight or more, a cooling effect can be expected, but if it is less than 20% by weight, the cooling effect disappears quickly, and if it is 95% by weight or more,
Due to insufficient hydrogel strength, it is difficult to use depending on the shape and size. Therefore, the preferred water content is 25 to 70% by weight, more preferably 30 to 60% by weight, although it varies slightly depending on the polymer material used. Aloe or aloe extract is blended as a medicinal ingredient, but known bactericides, anti-inflammatory agents, preservatives, fillers, primary alcohols, etc. may be added depending on the purpose. As the aloe, it is preferable to use those listed in the pharmacopoeia (Cape aloe, Socotra aloe, and Aloe cylindrica), but of course other aloe species such as Natal aloe, Sambar aloe, Jafa aloe aloe, etc. can also be used. good. Aloe may be added in the form of its powder, aloe juice, or aloe extract. As the aloe extract, those prepared by extraction with water, alcohol such as ethanol, water-alcohol mixed solvent, etc. are used. Effects can be expected if the amount of aloe or aloe extract is 2% or more as aloe or aloe powder, and 0.8% or more as the above extract, but the extract content is preferably 1 to 15%. The therapeutic member of the present invention is manufactured by uniformly dispersing or dissolving aloe in a hydrophilic hydrogel base and spreading the same on a carrier. As the carrier, conventionally known materials such as cloth and plastic may be used. EXAMPLES The present invention will be described in more detail below with reference to Examples and Experimental Examples, but the present invention is not limited thereto. In the following description, "parts" means "parts by weight." Example 1 6 parts of sodium polyacrylate having an average degree of polymerization of 20,000 and 15 parts of glycerin are dissolved in 80 parts of water. Separately, 0.3 parts of triglycidyl isocyanurate is dissolved in 10 parts of water. Next, an aqueous solution of triglycidyl isocyanurate is added to the aqueous solution of sodium polyacrylate and glycerin while stirring, heated at about 70° C. for 1 hour and then cooled, and 50 parts of juice obtained by squeezing the herbal medicine of aloe are added and mixed. This mixture is applied to a rayon nonwoven fabric to a thickness of 1.0 mm to obtain a treatment member of the present invention. Example 2 90 parts of acrylic acid, 10 parts of butyl acrylate, 50 parts of polyoxypropylated sorbitol, and 2 parts of ammonium persulfate were dissolved in 350 parts of water, and polymerized at 60° C. for 8 hours in an inert gas stream. The resulting viscous liquid
60 parts of polyoxypropylated sorbitol to 100 parts,
After adding 30 parts of a 20% potassium hydroxide aqueous solution and 10 parts of a 10% triglycidyl isocyanurate aqueous solution and mixing them uniformly, 40 parts of an aqueous extract of pharmacopoeial aloe was added and mixed, and the mixture was spread on a 100μ thick rayon non-woven fabric. It is spread to a thickness of about 1 mm to obtain a sheet-like treatment member. Example 3 Maleic anhydride/methyl vinyl ether copolymer (maleic anhydride content 50% by weight) 20% aqueous solution
To 100 parts, 15 parts of diethylene glycol and 1 part of triethanolamine were added and mixed. After uniformly mixing, 20 parts of a 10% aqueous solution of glycerin diglycidyl ether and 50 parts of pharmacopoeial aloe powder were added to make a rayon nonwoven fabric with a thickness of 1.0 parts. mm and cross-linked at room temperature to obtain the treatment member of the present invention. Experimental Example 1 The preparations obtained in Examples 1 to 3 were applied to the burns shown in Table 1, the effectiveness was determined, and the results were
Shown in the table. As is clear from the above results, the treatment member of the present invention had a better therapeutic effect than commercially available aloe ointment.

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Claims (1)

[Scope of Claims] 1. An external treatment member prepared by blending aloe or aloe extract with a hydrophilic hydrogel base and molding it into a sheet. 2. The external treatment member according to claim 1, wherein the water content in the hydrophilic hydrogel base is 10 to 95% by weight. 3. The hydrophilic hydrogel base is made of polyacrylic acid and its salts, acrylic acid copolymers and their salts, maleic anhydride copolymers and their salts, water-soluble polyamides, polovinyl alcohols and their derivatives, and saccharides and their derivatives. The external treatment member according to claim 1, which is made of at least one selected hydrophilic polymer substance. 4. The external treatment member according to claim 1 or 2, wherein the hydrophilic hydrogel base contains 3 to 30% by weight of a hydrophilic polymeric substance.