JPH03504718A - 抗体活性及び広い作用スペクトルを有する調製物 - Google Patents
抗体活性及び広い作用スペクトルを有する調製物Info
- Publication number
- JPH03504718A JPH03504718A JP1504068A JP50406889A JPH03504718A JP H03504718 A JPH03504718 A JP H03504718A JP 1504068 A JP1504068 A JP 1504068A JP 50406889 A JP50406889 A JP 50406889A JP H03504718 A JPH03504718 A JP H03504718A
- Authority
- JP
- Japan
- Prior art keywords
- preparation according
- preparation
- colostrum
- agent
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims description 90
- 230000000694 effects Effects 0.000 title claims description 24
- 230000009471 action Effects 0.000 title description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 36
- 235000021277 colostrum Nutrition 0.000 claims description 36
- 210000003022 colostrum Anatomy 0.000 claims description 36
- 102000018358 immunoglobulin Human genes 0.000 claims description 36
- 239000003795 chemical substances by application Substances 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 19
- 206010012735 Diarrhoea Diseases 0.000 claims description 17
- 241000283690 Bos taurus Species 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 12
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 9
- 230000006641 stabilisation Effects 0.000 claims description 9
- 238000011105 stabilization Methods 0.000 claims description 9
- 206010061598 Immunodeficiency Diseases 0.000 claims description 8
- 208000025865 Ulcer Diseases 0.000 claims description 8
- 208000025079 Yersinia infectious disease Diseases 0.000 claims description 8
- 231100000397 ulcer Toxicity 0.000 claims description 8
- 208000030507 AIDS Diseases 0.000 claims description 6
- 208000019637 Infantile Diarrhea Diseases 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 6
- 201000006549 dyspepsia Diseases 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 5
- 230000001154 acute effect Effects 0.000 claims description 5
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 5
- 239000005018 casein Substances 0.000 claims description 5
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 5
- 235000021240 caseins Nutrition 0.000 claims description 5
- 208000029462 Immunodeficiency disease Diseases 0.000 claims description 4
- 206010022714 Intestinal ulcer Diseases 0.000 claims description 4
- 208000007107 Stomach Ulcer Diseases 0.000 claims description 4
- 230000001684 chronic effect Effects 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 4
- 230000007813 immunodeficiency Effects 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 230000008029 eradication Effects 0.000 claims description 3
- 238000001990 intravenous administration Methods 0.000 claims description 3
- 238000010306 acid treatment Methods 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 210000000936 intestine Anatomy 0.000 claims 1
- 230000032696 parturition Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 description 26
- 231100000765 toxin Toxicity 0.000 description 26
- 108700012359 toxins Proteins 0.000 description 26
- 239000000243 solution Substances 0.000 description 19
- 235000013336 milk Nutrition 0.000 description 11
- 210000004080 milk Anatomy 0.000 description 11
- 239000008267 milk Substances 0.000 description 11
- 238000006386 neutralization reaction Methods 0.000 description 11
- 206010018910 Haemolysis Diseases 0.000 description 10
- 239000000427 antigen Substances 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 108091007433 antigens Proteins 0.000 description 9
- 102000036639 antigens Human genes 0.000 description 9
- 238000001694 spray drying Methods 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 230000002391 anti-complement effect Effects 0.000 description 8
- 108010008730 anticomplement Proteins 0.000 description 8
- 238000010790 dilution Methods 0.000 description 8
- 239000012895 dilution Substances 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 238000001914 filtration Methods 0.000 description 8
- 230000008588 hemolysis Effects 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 229940072221 immunoglobulins Drugs 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 231100000699 Bacterial toxin Toxicity 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 239000000688 bacterial toxin Substances 0.000 description 4
- 239000002095 exotoxin Substances 0.000 description 4
- 231100000776 exotoxin Toxicity 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 241000590002 Helicobacter pylori Species 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 239000005862 Whey Substances 0.000 description 3
- 102000007544 Whey Proteins Human genes 0.000 description 3
- 108010046377 Whey Proteins Proteins 0.000 description 3
- 206010048249 Yersinia infections Diseases 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000011026 diafiltration Methods 0.000 description 3
- 102000018146 globin Human genes 0.000 description 3
- 108060003196 globin Proteins 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000011146 sterile filtration Methods 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 2
- 241001522296 Erithacus rubecula Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 108010040721 Flagellin Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 108010046334 Urease Proteins 0.000 description 2
- 241000607734 Yersinia <bacteria> Species 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000001147 anti-toxic effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 238000003119 immunoblot Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 208000026775 severe diarrhea Diseases 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 1
- 240000001592 Amaranthus caudatus Species 0.000 description 1
- 241000352320 Amegilla aeruginosa Species 0.000 description 1
- 241000589876 Campylobacter Species 0.000 description 1
- 241000205707 Cystoisospora belli Species 0.000 description 1
- 206010012742 Diarrhoea infectious Diseases 0.000 description 1
- 101500023984 Drosophila melanogaster Synapsin-1 Proteins 0.000 description 1
- -1 ETEC Substances 0.000 description 1
- 241000257465 Echinoidea Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 206010015226 Erythema nodosum Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 206010022678 Intestinal infections Diseases 0.000 description 1
- 206010023076 Isosporiasis Diseases 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 102100031953 Protein 4.2 Human genes 0.000 description 1
- 101710196267 Protein 4.2 Proteins 0.000 description 1
- 206010037075 Protozoal infections Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 108010017898 Shiga Toxins Proteins 0.000 description 1
- 241000256215 Spongomorpha aeruginosa Species 0.000 description 1
- 241000223997 Toxoplasma gondii Species 0.000 description 1
- 206010046851 Uveitis Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000003916 acid precipitation Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 201000009840 acute diarrhea Diseases 0.000 description 1
- 235000012735 amaranth Nutrition 0.000 description 1
- 239000004178 amaranth Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 150000001621 bismuth Chemical class 0.000 description 1
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 208000021735 chronic enteritis Diseases 0.000 description 1
- 239000011362 coarse particle Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000000369 enteropathogenic effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000024033 toxin binding Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3813043 | 1988-04-19 | ||
| DE3813043.2 | 1988-04-19 | ||
| EP88118243.0 | 1988-11-02 | ||
| EP88118243 | 1988-11-02 | ||
| EP88121678 | 1988-12-24 | ||
| EP88121678.2 | 1988-12-24 | ||
| EP89104016A EP0338229B1 (de) | 1988-04-19 | 1989-03-07 | Präparat mit Antikörperaktivität und breitem Wirkungsspektrum, daraus bestehende oder diese enthaltende Mittel und deren Verwendung zur Behandlung von bakteriell oder toxin-bedingten Erkrankungen und zur Bekämpfung von Protozoen |
| EP89104016.4 | 1989-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03504718A true JPH03504718A (ja) | 1991-10-17 |
Family
ID=27434187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1504068A Pending JPH03504718A (ja) | 1988-04-19 | 1989-04-18 | 抗体活性及び広い作用スペクトルを有する調製物 |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPH03504718A (pt) |
| AT (1) | ATE90569T1 (pt) |
| AU (1) | AU637045B2 (pt) |
| BR (1) | BR8907385A (pt) |
| DK (1) | DK251990D0 (pt) |
| HU (1) | HU208089B (pt) |
| NO (1) | NO904440D0 (pt) |
| NZ (1) | NZ228595A (pt) |
| PT (1) | PT90318A (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE234855T1 (de) * | 1993-09-20 | 2003-04-15 | Anadis Ltd | Verfahren zur herstellung von immunoglobulinen aus colostrum und deren verwendung in pharmazeutischen zusammensetzungen |
| PL185442B1 (pl) | 1996-10-03 | 2003-05-30 | Georgiades Biotech Ltd | Środek farmaceutyczny o działaniu immunologicznym i psychotropowym, jego postać terapeutyczna oraz zastosowanie |
| NL1033696C2 (nl) * | 2007-04-16 | 2008-10-20 | Friesland Brands Bv | Aan melk ontleende antigeen-specifieke antilichamen, werkwijzen voor het bereiden en gebruik ervan. |
| WO2022148549A1 (en) | 2020-01-14 | 2022-07-14 | Babylat Gmbh | Apparatus and method for obtaining protein-enriched fractions from breast milk |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4051235A (en) * | 1976-04-22 | 1977-09-27 | Plymate Robert R | Method of preparing bovine colostrum for use in treating livestock |
| DE3432718C1 (de) * | 1984-09-06 | 1986-05-22 | Biotest Pharma GmbH, 6000 Frankfurt | Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen |
-
1989
- 1989-03-07 AT AT89104016T patent/ATE90569T1/de not_active IP Right Cessation
- 1989-04-04 NZ NZ228595A patent/NZ228595A/xx unknown
- 1989-04-18 AU AU34171/89A patent/AU637045B2/en not_active Expired - Fee Related
- 1989-04-18 HU HU892524A patent/HU208089B/hu not_active IP Right Cessation
- 1989-04-18 BR BR898907385A patent/BR8907385A/pt not_active Application Discontinuation
- 1989-04-18 JP JP1504068A patent/JPH03504718A/ja active Pending
- 1989-04-19 PT PT90318A patent/PT90318A/pt not_active Application Discontinuation
-
1990
- 1990-10-15 NO NO904440A patent/NO904440D0/no unknown
- 1990-10-18 DK DK251990A patent/DK251990D0/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK251990A (da) | 1990-10-18 |
| NZ228595A (en) | 1991-11-26 |
| NO904440L (no) | 1990-10-15 |
| AU637045B2 (en) | 1993-05-20 |
| HU892524D0 (en) | 1991-04-29 |
| PT90318A (pt) | 1989-11-10 |
| AU3417189A (en) | 1989-11-24 |
| ATE90569T1 (de) | 1993-07-15 |
| BR8907385A (pt) | 1991-05-21 |
| NO904440D0 (no) | 1990-10-15 |
| DK251990D0 (da) | 1990-10-18 |
| HU208089B (en) | 1993-08-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Rump et al. | Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum | |
| Mehra et al. | Milk immunoglobulins for health promotion | |
| EP0338229B1 (de) | Präparat mit Antikörperaktivität und breitem Wirkungsspektrum, daraus bestehende oder diese enthaltende Mittel und deren Verwendung zur Behandlung von bakteriell oder toxin-bedingten Erkrankungen und zur Bekämpfung von Protozoen | |
| US20050220894A1 (en) | Colostrum-based composition | |
| KR20000048855A (ko) | 닭의 난황 항체를 경구 투여하여 질병을 치료하는 방법 | |
| JP2002501526A (ja) | 乳汁における免疫グロブリンaの生成方法 | |
| NZ535195A (en) | Compositions containing labile bioactive materials and mammalian colostrum, methods of preparation and treatment | |
| EP0484148A1 (en) | A method for producing a new medicine for both treating and preventing peptic ulcer diseases and gastritis and thus formulated medicines | |
| CN106075436B (zh) | 一种不含抗生素的抗幽门螺杆菌口服制剂 | |
| US20220267419A1 (en) | Human Immunoglobulin Against Methicillin-Resistant Staphylococcus Aureus, Preparation Method Therefor, And Use Thereof | |
| JPH03504718A (ja) | 抗体活性及び広い作用スペクトルを有する調製物 | |
| WO1999002188A1 (en) | Hen egg yolk antibodies to clostridium difficile antigens and use in therapy for pseudomembranous colitis | |
| JPH11512746A (ja) | 乳漿中の免疫グロブリンの単離方法 | |
| Jadhav et al. | Antivenin production in India | |
| AU696237B1 (en) | Prevention and treatment of enterohemorrhagic E.Coli infection | |
| ES2221705T3 (es) | Utilizacion de anticuerpos aviares. | |
| US5336490A (en) | Haemophilus influenzae pilus vaccines | |
| JPH04275232A (ja) | 胃炎,胃または十二指腸潰瘍予防食品 | |
| RU2264229C2 (ru) | Препарат секреторного иммуноглобулина а, обладающий противовирусным и антибактериальным действием | |
| CN114073765A (zh) | 一种抑制幽门螺杆菌的组合物及其应用 | |
| Selim et al. | Development of IgY antibodies for control of tetanus | |
| RU2453336C1 (ru) | Средство, содержащее иммуноглобулины и обладающее антибактериальной и антивирусной активностью | |
| RU2599029C1 (ru) | Химерный иммуноглобулиновый препарат, обладающий специфическим противовирусным или антибактериальным действием | |
| RU2647369C2 (ru) | Способ лечения острой ожоговой токсемии организма и способ получения противоожоговой сыворотки реконвалесцентов для лечения ожоговой токсемии организма | |
| DD283937A5 (de) | Praeparat mit antikoerperaktivitaet und breitem wiekungsspektrum, daraus bestehende ode4 diese enthaltende mittel und deren verwendung zur behandlung von bakteriellen oder toxin-bedingten erkrankungen und zur bekaempfung von protozen |