JPH0362103B2 - - Google Patents
Info
- Publication number
- JPH0362103B2 JPH0362103B2 JP61216430A JP21643086A JPH0362103B2 JP H0362103 B2 JPH0362103 B2 JP H0362103B2 JP 61216430 A JP61216430 A JP 61216430A JP 21643086 A JP21643086 A JP 21643086A JP H0362103 B2 JPH0362103 B2 JP H0362103B2
- Authority
- JP
- Japan
- Prior art keywords
- polymer chain
- fluorine
- crystalline lens
- elastomeric polymer
- artificial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920000642 polymer Polymers 0.000 claims description 26
- 210000000695 crystalline len Anatomy 0.000 claims description 22
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 13
- 239000011737 fluorine Substances 0.000 claims description 13
- 229910052731 fluorine Inorganic materials 0.000 claims description 13
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 11
- 239000004033 plastic Substances 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 229920001971 elastomer Polymers 0.000 claims description 2
- 239000005060 rubber Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- -1 iodide compound Chemical class 0.000 description 4
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 4
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000008055 phosphate buffer solution Substances 0.000 description 3
- 208000002177 Cataract Diseases 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000021164 cell adhesion Effects 0.000 description 2
- 210000001508 eye Anatomy 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002985 plastic film Substances 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 239000004945 silicone rubber Substances 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- NDMMKOCNFSTXRU-UHFFFAOYSA-N 1,1,2,3,3-pentafluoroprop-1-ene Chemical group FC(F)C(F)=C(F)F NDMMKOCNFSTXRU-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 206010002945 Aphakia Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- HCDGVLDPFQMKDK-UHFFFAOYSA-N hexafluoropropylene Chemical group FC(F)=C(F)C(F)(F)F HCDGVLDPFQMKDK-UHFFFAOYSA-N 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
- 239000004636 vulcanized rubber Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は含フツ素熱可塑性ゴムからなる人工水
晶体に関する。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to an artificial lens made of fluorine-containing thermoplastic rubber.
（従来の技術）
眼球は構造が非常に複雑であり、これに代わる
ような人工臓器は現われていないが、水晶体、ガ
ラス体、角膜などの各機能を個々に代行する人工
臓器は既に開発されている。(Prior technology) The structure of the eyeball is extremely complex, and no artificial organ has appeared to replace it. However, artificial organs that individually perform the functions of the crystalline lens, vitreous body, and cornea have already been developed. There is.
例えば白内障は水晶体が混濁する病気であり、
老化に伴なつて起こるものが圧倒的に多く視力が
低下する。白内障手術は混濁した水晶体を摘出す
ることにあり、このような無水晶体眼の視力矯正
法としてはメガネ、コンタクトレンズあるいは人
工水晶体がある。 For example, cataract is a disease that clouds the crystalline lens.
Visual acuity deteriorates in overwhelmingly many cases as a result of aging. Cataract surgery involves removing the cloudy crystalline lens, and vision correction methods for such aphakic eyes include glasses, contact lenses, and artificial crystalline lenses.
人工水晶体は他の人工臓器と基体的には同様の
生体適合性、すなわち、安全性と医用機能を有し
ていなければならない。その条件をあげると、
長期間眼内にあつても物理的または化学的に変化
しない、滅菌が可能でそれにより変質しない、
眼組織に有害な反応を与えない、わずかな外
力で破壊しない、などがあげられる。しかし、こ
れまで開発されている各種プラスチツク材料は必
ずしもこれら全ての条件を満たすものではない。 The artificial crystalline lens must have basically the same biocompatibility as other artificial organs, that is, it must have safety and medical functions. Given the conditions,
It does not change physically or chemically even if it remains in the eye for a long period of time, and it can be sterilized and does not deteriorate due to it.
Examples include not causing harmful reactions to eye tissue and not being destroyed by the slightest external force. However, the various plastic materials that have been developed so far do not necessarily satisfy all of these conditions.
（発明が解決しようとする問題点）
本発明の目的は生体適合性を有し、生体内劣化
を起こさず、水晶体の機能を果たす人工水晶体を
提供することにある。(Problems to be Solved by the Invention) An object of the present invention is to provide an artificial crystalline lens that is biocompatible, does not deteriorate in vivo, and performs the function of a crystalline lens.
（問題点を解決するための手段）
本発明は含フツ素熱可塑性ゴムからなる人工水
晶体に係る。(Means for Solving the Problems) The present invention relates to an artificial lens made of fluorine-containing thermoplastic rubber.
本発明において含フツ素熱可塑性ゴムとは、比
較的低温（例えば常温付近）では加硫したゴム弾
性を有し、加熱により塑性流動を示すゴムをい
う。 In the present invention, the fluorine-containing thermoplastic rubber refers to a rubber that has vulcanized rubber elasticity at a relatively low temperature (for example, around room temperature) and exhibits plastic flow when heated.
含フツ素熱可塑性ゴムは、好ましくは少なくと
も１種のエラストマー性ポリマー鎖セグメントお
よび少なくとも１種の非エラストマー性ポリマー
鎖セグメントから成り、そのうち少なくとも１つ
は含フツ素ポリマー鎖セグメントである。特に、
エラストマー性ポリマー鎖セグメントと非エラス
トマー性ポリマー鎖セグメントの重量比が40〜
95：５〜60であるものが好ましい。 The fluorine-containing thermoplastic rubber preferably consists of at least one elastomeric polymer chain segment and at least one non-elastomeric polymer chain segment, at least one of which is a fluorine-containing polymer chain segment. especially,
The weight ratio of elastomeric polymer chain segments to non-elastomeric polymer chain segments is from 40 to
95:5 to 60 is preferred.
含フツ素熱可塑性ゴムとして特に好ましい具体
例を示せば２種または３種のポリマー鎖セグメン
トから成る連鎖と、該連鎖の一端に存在するヨウ
素原子ならびに該連鎖の他端に存在するアイオダ
イド化合物から少なくとも１個のヨウ素原子を除
いた残基から成り、
前記ポリマー鎖セグメントの１種（連鎖が２種
のポリマー鎖セグメントから成る場合）もしくは
１種または２種（連鎖が３種のポリマー鎖セグメ
ントから成る場合）は(1)ビニリデンフルオライ
ド／ヘキサフルオロプロピレンまたはペンタフル
オロプロピレン／テトラフルオロエチレン（モル
比45〜90：５〜50：０〜35）ポリマーおよび(2)パ
ーフルオロ（C1〜C3アルキルビニルエーテル）
〔複数個のエーテル結合を含むものも包含する。
以下同様。〕／テトラフルオロエチレン／ビニリ
デンフルオライド（モル比15〜75：０〜85：０〜
85）ポリマーから選択された、分子量30000〜
1200000のエラストマー性ポリマー鎖セグメント
であり、
前記ポリマー鎖セグメントの残余は(3)ビニリデ
ンフルオライド／テトラフルオロエチレン（モル
比０〜100：０〜100）ポリマーおよび(4)エチレ
ン／テトラフルオロエチレン／ヘキサフルオロプ
ロピレン、３，３，３−トリフルオロプロピレン
−１、２−トリフルオロメチル−３，３，３−ト
リフルオロプロピレン−１またはパーフルオロ
（C1〜C3アルキルビニルエーテル）（モル比40〜
60：60〜40：０〜30）ポリマーから選択された、
分子量3000〜400000の非エラストマー性ポリマー
鎖セグメントであり、
エラストマー性ポリマー鎖セグメントと非エラ
ストマー性ポリマー鎖セグメントの重量比が40〜
95：５〜60である、
含フツ素熱可塑性ゴムが挙げられる。 A particularly preferred example of the fluorine-containing thermoplastic rubber is a chain consisting of two or three types of polymer chain segments, an iodine atom present at one end of the chain, and an iodide compound present at the other end of the chain. one of the polymer chain segments (if the chain consists of two polymer chain segments) or one or two (if the chain consists of three polymer chain segments) case) is (1) vinylidene fluoride/hexafluoropropylene or pentafluoropropylene/tetrafluoroethylene (molar ratio 45-90:5-50:0-35) polymer and (2) perfluoro( C1 - C3 alkyl) vinyl ether)
[Includes those containing multiple ether bonds.]
Same below. ]/tetrafluoroethylene/vinylidene fluoride (molar ratio 15-75:0-85:0-
85) Selected from polymers, molecular weight 30000 ~
1200000 elastomeric polymer chain segments, the remainder of said polymer chain segments being (3) vinylidene fluoride/tetrafluoroethylene (molar ratio 0-100:0-100) polymer and (4) ethylene/tetrafluoroethylene/hexafluoride. Fluoropropylene, 3,3,3-trifluoropropylene-1, 2-trifluoromethyl-3,3,3-trifluoropropylene-1 or perfluoro( C1 - C3 alkyl vinyl ether) (mole ratio 40~
60:60~40:0~30) polymers selected from
A non-elastomeric polymer chain segment with a molecular weight of 3,000 to 400,000, and a weight ratio of elastomeric polymer chain segments to non-elastomeric polymer chain segments of 40 to 400,000.
Examples include fluorine-containing thermoplastic rubbers having a ratio of 95:5 to 60.
本発明で使用する上記の好ましい含フツ素熱可
塑性ゴムは特公昭58−4728号公報に記載されてい
る。 The preferred fluorine-containing thermoplastic rubber used in the present invention is described in Japanese Patent Publication No. 58-4728.
このポリマーは各種の鉱酸、有機酸、アルカ
リ、アルコール類等に対して高い耐性を有し、ま
た耐水性及び生体内劣化に対する耐性においても
優れている。具体例としては例えばダイキン工業
(株)製のダイエルサーモプラスチツクＴ−530、Ｔ
−630を挙げるこをができる。 This polymer has high resistance to various mineral acids, organic acids, alkalis, alcohols, etc., and is also excellent in water resistance and resistance to in-vivo deterioration. For example, Daikin Industries
Daiel Thermoplastic T-530, T manufactured by Co., Ltd.
-630 can be raised.
本発明の人工水晶体は例えば上記のポリマーを
加熱圧縮成形等により水晶体の形状に成形するこ
とにより得られる。人工水晶体に固定用環、支持
ループ等を設けることは任意である。 The artificial crystalline lens of the present invention can be obtained, for example, by molding the above polymer into the shape of a crystalline lens by heat compression molding or the like. It is optional to provide a fixing ring, a support loop, etc. to the artificial crystalline lens.
人工水晶体の型式、固定方法はその手術方法の
多様さとあいまつて非常に多く、例えば混濁した
水晶体を除去した水晶体のう内すなわち解剖学的
に正しい位置に挿入するのが好ましいが、その他
各種の公知の方法により固定することもできる。 There are many types of artificial crystalline lenses and fixation methods, as well as the variety of surgical methods.For example, it is preferable to insert the cloudy crystalline lens into the lens capsule from which it has been removed, i.e. in an anatomically correct position, but there are various other well-known methods. It can also be fixed by the following method.
（実施例） 以下に実施例を挙げて詳しく説明する。(Example) A detailed explanation will be given below with reference to examples.
実施例 １
含フツ素熱可塑性ゴムとしてダイエルサーモプ
ラスチツクＴ−530〔ダイキン工業(株)製〕を用い、
これを金型中で230〜260℃の温度で圧縮成形を行
い、直径約４mm、厚み約１mmの凸レンズ状の本発
明人工水晶体を得た。Example 1 Daiel Thermoplastic T-530 (manufactured by Daikin Industries, Ltd.) was used as the fluorine-containing thermoplastic rubber,
This was compression molded in a mold at a temperature of 230 to 260°C to obtain a convex lens-shaped artificial lens of the present invention with a diameter of about 4 mm and a thickness of about 1 mm.
試験例 １
本発明の人工水晶体の生体適合性を調べるため
に、実施例１のポリマーを圧縮溶融成形して約
100μｍの厚さを有するプラスチツクシートを作
成し、このシートを用いて培養テストを行つた。Test Example 1 In order to examine the biocompatibility of the artificial crystalline lens of the present invention, the polymer of Example 1 was compression-melted and
A plastic sheet having a thickness of 100 μm was prepared, and a culture test was conducted using this sheet.
即ち上記プラスチツクシートを70％エタノール
中に24時間浸漬した後、リン酸緩衝液（PBS）
で洗浄し、これを牛胎児血清を10％添加したイー
グルのミニマルエシエンシヤルメデイウム
（MEM）中に入れ、更にマウスの繊維芽細胞3T3
（１×104）を加えて、フアルコンプラスチツクシ
ヤーレ中で37℃で24時間、５％CO2含有空気中で
培養する。培養後PBSで洗浄し、100％エタノー
ルで５分間固定後、ギムザ（Giemsa）試薬で染
色し、シート上における細胞の付着状況を調べ
る。 That is, after immersing the above plastic sheet in 70% ethanol for 24 hours, it was soaked in phosphate buffer solution (PBS).
This was then washed with mouse fibroblasts 3T3 and placed in Eagle's minimal institutional medium (MEM) supplemented with 10% fetal bovine serum.
(1×10 4 ) and incubated in a falcon plastic jar at 37° C. for 24 hours in air containing 5% CO 2 . After culturing, the cells are washed with PBS, fixed with 100% ethanol for 5 minutes, and stained with Giemsa reagent to examine the state of cell attachment on the sheet.
その結果、細胞付着状況は均一であり、生体適
合性は良好であつた。 As a result, the cell adhesion was uniform and the biocompatibility was good.
試験例 ２
比較のためシリコンゴム（表面無処理）、シリ
コンゴム（表面粗化）、シリコンレンズ用素材、
PHEMA（ポリ−２−ヒドロキシエチルメタクリ
レート）、ポリプロピレンのシートを用いて試験
例１と同様に実験を行つたところ、細胞付着状況
は凝集が見られ不均一であつた。Test Example 2 For comparison, silicone rubber (no surface treatment), silicone rubber (surface roughening), silicone lens material,
When an experiment was conducted in the same manner as in Test Example 1 using a sheet of PHEMA (poly-2-hydroxyethyl methacrylate) and polypropylene, the state of cell adhesion was non-uniform with aggregation observed.
Claims (1)
エラストマー性ポリマー鎖セグメントおよび少な
くとも１種の非エラストマー性ポリマー鎖セグメ
ントから成り、そのうちの少なくとも１つは含フ
ツ素ポリマー鎖セグメントである含フツ素熱可塑
性ゴムである特許請求の範囲第１項記載の人工水
晶体。 ３ 含フツ素熱可塑性ゴムが、エラストマー性ポ
リマー鎖セグメント40〜95重量部および非エラス
トマー性ポリマー鎖セグメント５〜60重量部から
成る特許請求の範囲第２項記載の人工水晶体。[Claims] 1. An artificial crystalline lens made of fluorine-containing thermoplastic rubber. 2. Fluorine-containing thermoplastic rubber comprising at least one elastomeric polymer chain segment and at least one non-elastomeric polymer chain segment, at least one of which is a fluorine-containing polymer chain segment. The artificial crystalline lens according to claim 1, which is made of plastic rubber. 3. The artificial crystalline lens according to claim 2, wherein the fluorine-containing thermoplastic rubber comprises 40 to 95 parts by weight of elastomeric polymer chain segments and 5 to 60 parts by weight of non-elastomeric polymer chain segments.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61216430A JPS6371256A (en) | 1986-09-12 | 1986-09-12 | Artificial crystalline lens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61216430A JPS6371256A (en) | 1986-09-12 | 1986-09-12 | Artificial crystalline lens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6371256A JPS6371256A (en) | 1988-03-31 |
| JPH0362103B2 true JPH0362103B2 (en) | 1991-09-24 |
Family
ID=16688430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61216430A Granted JPS6371256A (en) | 1986-09-12 | 1986-09-12 | Artificial crystalline lens |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6371256A (en) |
-
1986
- 1986-09-12 JP JP61216430A patent/JPS6371256A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6371256A (en) | 1988-03-31 |
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