JPH0363207A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin cosmetic capable of simultaneously developing and providing excellent beautifying effects and inhibitory effects on skin aging, containing phosphoric ester magnesium salt of L-ascorbic acid and/or sulfuric ester sodium salt of L-ascorbic acid and gamma-aminobutyric acid. CONSTITUTION:A skin cosmetic which comprises one or more compounds selected from phosphoric ester magnesium salt of L-ascorbic acid and sulfuric ester sodium salt of L-ascorbic acid and (B) gamma-aminobutyric acid as essential components in the ratio of usually 0.01-30wt.% component A and 0.01-10wt.% component B, preferably 0.1-10wt.% component A and 1-5wt.% component B based on the total amounts of prescription components of cosmetic, has neither side effects not suitable to human body nor skin irritation, is stable even by long-term preservation and can simultaneously develop and provide chapped skin preventing effects, inhibitory effects on skin aging and beautifying effects by synergistic effects of both the components.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention provides at least one compound selected from L-ascorbic acid phosphate magnesium salt and L-ascorbic acid sulfate sodium salt, and γ-
Regarding skin cosmetics containing aminobutyric acid, more specifically, skin cosmetics containing aminobutyric acid, which have undesirable side effects and skin irritation on the human body,
Stable even after long-term storage, with excellent skin roughness prevention effect.
The present invention relates to a skin cosmetic that can simultaneously express and provide skin anti-aging effects and excellent whitening effects.

[Conventional techniques and inventions try to solve the problem! 1id) Conventionally, in order to restore sunburned skin to a healthy complexion, it has been thought that it is necessary to lighten the increasing amount of melanin pigment formed and to inhibit tyrosinase activity during the melanin production process.

Ascorbic acid has these effects, skin whitening,
It is well known that this compound is effective in improving the treatment of age spots, freckles, melasma, etc. However, when applied to cosmetics, it may have problems with oral stability or easily cause discoloration and odor. Therefore, in order to stabilize ascorbic acid, it has been proposed to blend ascorbic acid as an ester with higher fatty acids or phosphoric acid, or to add antioxidants and reducing agents. There was a problem that the more you use it, the more the whitening effect will fade.

In addition, T-aminobutyric acid has been found to enhance skin functions by activating skin tissue VA and has anti-aging effects on the skin (Japanese Unexamined Patent Publication No. 148041/1989), and proposed that ) Skin cosmetics containing only butyric acid have delayed effects such as anti-aging; for example, in the case of cream,
In the case of the lotion, the effect appeared after 3 months, which was not completely satisfactory and left room for improvement.

An object of the present invention is to provide an excellent skin cosmetic that can simultaneously exhibit and provide an excellent whitening effect and an anti-aging effect on the skin.

[X1! Means for Solving the Problems] The present invention provides a compound containing at least one compound selected from L-ascorbic acid phosphate magnesium salt and L-ascorbic acid sulfate sodium salt, and γ-acnobutyric acid. It is a skin cosmetic.

Mono-ascorbic acid phosphate magnesium salt and L-ascorbic acid sulfate sodium salt (hereinafter abbreviated as L-ascorbic acid t'A iX form) used in the present invention are known substances, and their formulation Iffl is always 0.0 based on the total amount of prescription ingredients (hereinafter the same)
It is in the range of 1 to 30% by weight, preferably 0.1 to 10% by weight.

γ-Aminobutyric acid (hereinafter abbreviated as GABA) used in the present invention is a known substance, and its amount is in the range of 0.01 to 10% by weight, preferably 1 to 5% by weight.

Even if the upper limit of each of these amounts is exceeded, no effect commensurate with the exceeded amount can be expected, and if the amount is less than the lower limit, the object of the present invention cannot be achieved.

Forms of the skin cosmetics of the present invention include creams, emulsions, lotions, punctures, powders, etc. In addition to the above raw materials, pigments, fragrances, preservatives, surfactants, pigments, antioxidants, etc. They can be blended as appropriate within the range that achieves the purpose of the invention.

〔Example〕

Examples will be described below. Note that the percentages shown in the examples are percentages by weight. The methods for measuring the turnover rate of the stratum corneum, the test method for measuring the rough skin improvement effect, the test method for measuring the corneum improvement effect, the sensory test, and the skin color brightness recovery test method described in the Examples are as follows.

(1) Method for measuring the turnover rate of the stratum corneum Add 5 vyt% of the fluorescent dye danzyl chloride to white petrolatum.
A blended ointment is made and applied to the skin of the subject's forearm with a lid closed for 24 hours to allow danzyl chloride to penetrate and bind to the stratum corneum. Thereafter, the test sample was applied to the same area twice a day (morning and evening), the fluorescence of danzyl chloride was monitored every day, and the number of days until the fluorescence disappeared was defined as the turnover rate of the skin stratum corneum. Note that the normal turnover rate of the skin's stratum corneum is 14 to 16 days, but in aged skin it increases to around 18 days. On the other hand, if the anti-aging effect appears, the time will be shortened to around 12 days.

(2) Test method for measuring the effect of improving rough skin The effect of continuous application for 4 weeks was investigated on 20 middle-aged and elderly subjects with rough skin on their lower legs. Approximately 1 g of the sample was applied to the test site of the left lower leg of the subject twice a day, and the condition of the skin before and after the test was judged according to the following criteria. No sample was applied to the right lower leg, which served as a control.

Judgment criteria for skin dryness: Normal±: Slight dryness, no flaking+: Mild dryness, flaking++: Moderate dryness, flaking+++: Significant dryness, flaking Comparing the judgment results of the test site and control site before and after the test, skin If the dryness has improved by two or more steps (e.g. +→-2)
++→±) is considered “effective,” one level of improvement is considered “somewhat effective,” and no change is considered “ineffective.” The number of subjects whose test results were “effective” or “slightly effective.” It was shown in

(3) Test method for measuring the effect of improving keratin (increasing the anti-exfoliation property of keratinocytes) Scotch tape was applied to the skin of the test area before and after the above-mentioned rough skin improvement measurement test.
When the tape was separated by 1y111, the state of the corneocytes attached to the tape was examined in detail using a scanning electron microscope. 1IIj
ll properties were separated and the keratin improving effect was determined.

Judgment criteria for keratin improving effect (increased anti-desquamation property of keratinocytes) Evaluation points: 1 No two scales observed 2: Small scales dotted 3: Small to medium scales noticeable 4: Large scales noticeable on test areas after 4 weeks of continuous application A case where the difference between the evaluation score and that of the control site was 2 or more points was considered "effective," a case where the difference was 2 points or more was considered "somewhat effective," and a case where the difference was 0 points was "ineffective." The test results were ``effective'' and ``slightly effective''.

(4) Sensory test (skin beautification effect test) 20 female subjects (35 to 55 years old) complaining of rough skin, fine wrinkles, dry skin, etc.
The sample was applied to a person 182 times (morning and evening) for three consecutive months.
, the effects were evaluated after 2.3 months. The test results showed that the skin felt moisturized, the skin became smoother, and the skin became taut in response to skin moisturization, smoothness, and elasticity. Shown in number of people.

Furthermore, the M period until the effect appears is also shown.

(5) Skin color brightness recovery test method: The back skin of 20 subjects was irradiated with ultraviolet rays in the UV-B region twice the minimum amount of erythema, and sample application areas and non-application areas were set, and each skin 7H standard was determined. The brightness (Vo value, Vo' value) was measured. Subsequently, the sample was VC applied to the application site twice a day for 3 months, and the skin brightness (Vn value, Vn' value) of the application site and non-application site was measured after 3, 8 and 13 weeks. The recovery of skin color was evaluated using the following criteria.

In addition, the brightness of the skin (Munsell color system V value) was calculated from the xyz values obtained by measurement with a high-speed spectrocolorimeter. In addition, the evaluation was conducted after 13a of 20 subjects +l) Mi Precept Examples 1 to 5. Comparative Examples 1 to 3 Co/w type skin cream] Each O/w type skin cream was prepared by blending an L-ascorbic acid derivative and GABA in the following composition, and the various tests described above were conducted.

In addition, L-ascorbic acid phosphate ester magnesium salt is abbreviated as VCPMg, and L-ascorbic acid sulfate ester sodium salt is abbreviated as VC5Na.

(2) Adjustment method: Dissolve (A) uniformly at 70°C (B) at 50°C (A)
The mixture is prepared by pouring (B) into (A) while stirring to emulsify and disperse, and then cooling to a temperature of 30°C while stirring.

(3) Characteristics Table 1 shows the results of various tests conducted on each 0/w type skin cream.

As shown in Table 1, the O/W type skin creams of Comparative Examples 1 to 3 containing L-ascorbic acid derivatives or GABA alone or containing neither of them did not have sufficient effects in terms of various properties; O containing L-ascorbine 61 derivatives and GABA of Examples 1 to 5 of the invention
/ The W-type skin cream showed remarkable effects in various properties, and in the sensory test, it showed excellent skin beautification effects 1 to 2 months after applying the sample.Examples 6 to 8. Comparative Examples 4 to 6 (W10 Skin Cream) Similarly to Example 1, W10 type skin creams having the following compositions were prepared and various tests were conducted.

flll & [lwei Cool and prepare.

(3) Characteristics Table 2 shows the results of various tests conducted on each W10 type skin cream.

As shown in Table 2, sufficient effects were not obtained in the properties of the W/○ type ski skin creams in Comparative Examples 6 to 8, in which L-ascorbic acid derivatives or GABA were blended alone or in which neither of them were blended. Examples 4 to 6 of the invention
-Ascorbine rJ1. The w/O type skin cream containing derivatives and GABA has remarkable effects on various properties, and in a sensory test, it showed excellent skin beautification effects (2111 skin care method (A) at 70℃ (B) 1 to 2 months after applying the sample. ) at 50℃ to uniformly dissolve A
) is poured into (A) while stirring to emulsify and disperse it, and then cooled to a temperature of 30° C. while stirring.

(3) Characteristics The obtained emulsion showed good results in the various tests mentioned above.

Example 10 [Lotion] (1) Prescription (2) Preparation method (A) to be uniformly dissolved at 70°C (B) at 50°C A)
Pour (B) into (A) while stirring and emulsify and disperse, then add fraction (C) and without stirring (2) Preparation method (A) Mix and dissolve (B) at room temperature. )
Prepare by adding (A) to and stirring.

(3) Characteristics The obtained lotion showed good results in the various tests mentioned above.

〔Effect of the invention〕

Since the present invention is configured as described above, it produces the effects described below.

L-ascorbic acid phosphate ester magnesium salt, L
- When cosmetics contain at least one compound derived from ascorbic acid sulfate sodium salt and γ-aminobutyric acid, the whitening effect increases due to the synergistic effect of the two, and the skin aging prevention effect increases from 1 to 10 days after the start of use. It is clear that the disease appears in a very short period of time, such as the second month, and that it persists.

Claims (1)

[Claims] A skin cosmetic comprising at least one compound selected from L-ascorbic acid phosphate magnesium salt and L-ascorbic acid sulfate sodium salt, and γ-aminobutyric acid.