JPH0372205B2 - - Google Patents

Info

Publication number: JPH0372205B2
Authority: JP; Japan
Prior art keywords: compound; mycoplasma; infection; animals; tylosin
Prior art date: 1984-03-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP4003384A

Other languages

English (en)

Japanese (ja)

Other versions

JPS60184014A (ja

Inventor

Masahiro Kato

Toshihiro Takahata

Akira Kuwano

Masakazu Takei

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Daiichi Pharmaceutical Co Ltd

Original Assignee

Daiichi Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-02

Filing date

1984-03-02

Publication date

1991-11-18

1984-03-02 Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd

1984-03-02 Priority to JP4003384A priority Critical patent/JPS60184014A/ja

1985-09-19 Publication of JPS60184014A publication Critical patent/JPS60184014A/ja

1991-11-18 Publication of JPH0372205B2 publication Critical patent/JPH0372205B2/ja

Status Granted legal-status Critical Current

Links

241001465754 Metazoa Species 0.000 claims description 14
241000287828 Gallus gallus Species 0.000 claims description 13
235000013330 chicken meat Nutrition 0.000 claims description 13
206010028470 Mycoplasma infections Diseases 0.000 claims description 10
239000003814 drug Substances 0.000 claims description 9
230000003449 preventive effect Effects 0.000 claims description 6
229940124597 therapeutic agent Drugs 0.000 claims description 6
241000283690 Bos taurus Species 0.000 claims description 5
241000282887 Suidae Species 0.000 claims description 5
206010035664 Pneumonia Diseases 0.000 claims description 4
125000000217 alkyl group Chemical group 0.000 claims description 4
230000000069 prophylactic effect Effects 0.000 claims description 4
208000014085 Chronic respiratory disease Diseases 0.000 claims description 3
239000004480 active ingredient Substances 0.000 claims description 3
230000002265 prevention Effects 0.000 claims description 3
150000003839 salts Chemical class 0.000 claims description 3
208000001572 Mycoplasma Pneumonia Diseases 0.000 claims description 2
201000008235 Mycoplasma pneumoniae pneumonia Diseases 0.000 claims description 2
125000005843 halogen group Chemical group 0.000 claims description 2
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
241000204003 Mycoplasmatales Species 0.000 claims 3
150000001875 compounds Chemical class 0.000 description 28
241000204031 Mycoplasma Species 0.000 description 23
229930194936 Tylosin Natural products 0.000 description 18
239000004182 Tylosin Substances 0.000 description 18
238000012360 testing method Methods 0.000 description 18
WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 18
229960004059 tylosin Drugs 0.000 description 18
235000019375 tylosin Nutrition 0.000 description 18
229940126062 Compound A Drugs 0.000 description 17
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 17
208000015181 infectious disease Diseases 0.000 description 15
239000002609 medium Substances 0.000 description 14
241000894006 Bacteria Species 0.000 description 9
208000003322 Coinfection Diseases 0.000 description 9
239000003651 drinking water Substances 0.000 description 9
235000020188 drinking water Nutrition 0.000 description 9
241000588724 Escherichia coli Species 0.000 description 7
230000000844 anti-bacterial effect Effects 0.000 description 5
244000144972 livestock Species 0.000 description 5
241000271566 Aves Species 0.000 description 4
BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 4
238000000034 method Methods 0.000 description 4
210000002966 serum Anatomy 0.000 description 4
230000001225 therapeutic effect Effects 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
108020004414 DNA Proteins 0.000 description 3
206010003246 arthritis Diseases 0.000 description 3
230000001580 bacterial effect Effects 0.000 description 3
229940079593 drug Drugs 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
244000144977 poultry Species 0.000 description 3
235000013594 poultry meat Nutrition 0.000 description 3
210000003437 trachea Anatomy 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
229920001817 Agar Polymers 0.000 description 2
208000035473 Communicable disease Diseases 0.000 description 2
239000008272 agar Substances 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
238000011888 autopsy Methods 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
208000004396 mastitis Diseases 0.000 description 2
239000013028 medium composition Substances 0.000 description 2
LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 2
239000000243 solution Substances 0.000 description 2
241000894007 species Species 0.000 description 2
-1 10-(4-ethyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid Chemical compound 0.000 description 1
TZSXJUSNOOBBOP-ZETCQYMHSA-N 106939-34-8 Chemical compound C([C@@H]1C)OC2=C(F)C(F)=CC3=C2N1C=C(C(=O)OCC)C3=O TZSXJUSNOOBBOP-ZETCQYMHSA-N 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
102000053602 DNA Human genes 0.000 description 1
206010015719 Exsanguination Diseases 0.000 description 1
241000606768 Haemophilus influenzae Species 0.000 description 1
208000004575 Infectious Arthritis Diseases 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
229930182816 L-glutamine Natural products 0.000 description 1
241000204022 Mycoplasma gallisepticum Species 0.000 description 1
BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
241000191940 Staphylococcus Species 0.000 description 1
210000004712 air sac Anatomy 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
229960003589 arginine hydrochloride Drugs 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
210000002421 cell wall Anatomy 0.000 description 1
230000034994 death Effects 0.000 description 1
231100000517 death Toxicity 0.000 description 1
RTWRSOHWLYXRRX-UHFFFAOYSA-N desmethylofloxacin Chemical compound C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCOC1=C32 RTWRSOHWLYXRRX-UHFFFAOYSA-N 0.000 description 1
238000003113 dilution method Methods 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000000832 effect on mycoplasma Effects 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000003902 lesion Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000009304 pastoral farming Methods 0.000 description 1
150000007965 phenolic acids Chemical class 0.000 description 1
229960003531 phenolsulfonphthalein Drugs 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000008213 purified water Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
208000023504 respiratory system disease Diseases 0.000 description 1
201000001223 septic arthritis Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
239000001974 tryptic soy broth Substances 0.000 description 1
108010050327 trypticase-soy broth Proteins 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Landscapes

Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP4003384A 1984-03-02 1984-03-02 動物のマイコプラズマ感染症の予防・治療剤 Granted JPS60184014A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP4003384A JPS60184014A (ja)	1984-03-02	1984-03-02	動物のマイコプラズマ感染症の予防・治療剤

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4003384A JPS60184014A (ja)	1984-03-02	1984-03-02	動物のマイコプラズマ感染症の予防・治療剤

Publications (2)

Publication Number	Publication Date
JPS60184014A JPS60184014A (ja)	1985-09-19
JPH0372205B2 true JPH0372205B2 (es)	1991-11-18

Family

ID=12569597

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP4003384A Granted JPS60184014A (ja)	1984-03-02	1984-03-02	動物のマイコプラズマ感染症の予防・治療剤

Country Status (1)

Country	Link
JP (1)	JPS60184014A (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2709604B2 (ja) *	1988-06-29	1998-02-04	大日本製薬株式会社	マイコプラズマ汚染の防止または除去
US5175160A (en) *	1988-08-09	1992-12-29	Daiichi Pharmaceutical Co., Ltd.	Antimicrobial agent for animals

1984
- 1984-03-02 JP JP4003384A patent/JPS60184014A/ja active Granted

Also Published As

Publication number	Publication date
JPS60184014A (ja)	1985-09-19

Legal Events

Date	Code	Title	Description
2004-03-02	EXPY	Cancellation because of completion of term

Publication	Publication Date	Title
HU198840B (en)	1989-12-28	Process for producing premixes with antibacterial effect, mixable into the drinking water of poultry
Hoflack et al.	2001	Efficacy of Tilmicosin Phosphate (Pulmotil® Premix) in Feed for the Treatment of a Clinical Outbreak of Actinobacilluspleuropneumoniae Infection in Growing–Finishing Pigs
Randall et al.	2006	Modification of enrofloxacin treatment regimens for poultry experimentally infected with Salmonella enterica serovar Typhimurium DT104 to minimize selection of resistance
Schroder	1989	Enrofloxacin: a new antimicrobial agent
US4749568A (en)	1988-06-07	Rubradirin treatment of methicillin-resistant staph
JPH0372205B2 (es)	1991-11-18
Haq et al.	2015	Comparative efficacy of Norfloxacin, Clarithromycin and Cefpodoxime against experimentally induced colibacillosis in pigeons
US6761911B2 (en)	2004-07-13	Use of chlorate ion or preparations thereof for reduction of food borne pathogens
KR20030046491A (ko)	2003-06-12	돼지와 가금의 질병 및 감염 치료 및 예방
Girard et al.	1976	Influence of subtherapeutic levels of a combination of neomycin and oxytetracycline on Salmonella typhimurium in swine, calves, and chickens
EP1121940A1 (en)	2001-08-08	Pharmaceutical compositions comprising an antibiotic and bromhexine, and process for their preparation
EP0354453B1 (en)	1995-01-25	Antimicrobial agent for animals
Vernimb et al.	1976	Effect of gentamicin on early mortality and later performance of broiler and Leghorn chickens
CN106727576B (zh)	2020-08-04	喹噁啉-1，4-二氧化物衍生物作为硫酸粘杆菌素增效剂的应用
US6103716A (en)	2000-08-15	Pyrido(3,2,1-ij)-1,3,4-benzoxadiazine
CN100515425C (zh)	2009-07-22	一种防治畜禽呼吸道和消化道疾病的药物组合物
Anjum et al.	1998	Use of second generation quinolones in Poultry
Goren et al.	1988	Therapeutic efficacy of medicating drinking water with spectinomycin and lincomycinspectinomycin in experimental Escherichia coli infection in poultry
JP2821912B2 (ja)	1998-11-05	動物用抗菌剤
KR20220010798A (ko)	2022-01-27	암페니콜계 항균제 및 아미노글리코시드계 항균제를 유효성분으로 함유하는 동물용 복합항균제 조성물
Wegener et al.	2003	Veterinary use of quinolones and impact on human infections
IE47574B1 (en)	1984-05-02	Inhibiting growth of mycoplasmas
Fulford	1961	The nitrofurans in veterinary medicine
Petrichev	2021	acute per oral toxicity of tilmicosin-substance" Biovet" ad in white rats (Fischer-344).
Zwijnenberg et al.	1992	Evaluation of antibiotics for racing pigeons (Columba livia var. domestica) available in The Netherlands