JPH0414992B2 - - Google Patents

Info

Publication number
JPH0414992B2
JPH0414992B2 JP62171721A JP17172187A JPH0414992B2 JP H0414992 B2 JPH0414992 B2 JP H0414992B2 JP 62171721 A JP62171721 A JP 62171721A JP 17172187 A JP17172187 A JP 17172187A JP H0414992 B2 JPH0414992 B2 JP H0414992B2
Authority
JP
Japan
Prior art keywords
catheter
tube
antibacterial composition
antibacterial
indwelling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP62171721A
Other languages
English (en)
Other versions
JPS6415056A (en
Inventor
Hanao Maeda
Satoshi Ando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP62171721A priority Critical patent/JPS6415056A/ja
Priority to US07/213,898 priority patent/US4923450A/en
Priority to EP88306165A priority patent/EP0301717B1/en
Priority to DE8888306165T priority patent/DE3866048D1/de
Priority to CA000571545A priority patent/CA1295554C/en
Publication of JPS6415056A publication Critical patent/JPS6415056A/ja
Publication of JPH0414992B2 publication Critical patent/JPH0414992B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)

Description

【発明の詳細な説明】 （産業上の利用分野） 本発明は、体内留置用チユーブに関し、詳しく
は抗菌（緑膿菌、黄色ブドウ状球菌、大腸菌、及
び真菌）を目的とした体内留置用チユーブ、即ち
カテーテル、又はカニユーレに関するものであ
る。
（従来の技術） 従来、この種の体内留置用チユーブは体内に挿
入、かつ留置する目的で使用するが、その装着期
間は使用目的で異なるが、約２日から１週間ぐら
いである。これは、カテーテル等の周囲に各種細
菌が発生して膀胱炎を発症するからである。その
ため従来は必要に応じて、新規殺菌済みカテーテ
ル等に取り替えなければならず、その手段が煩わ
しく、又患者に苦痛を与える等の不具合があつ
た。
（発明が解決しようとする課題） ところで、従来抗菌剤としては有機金属化合
物、有機系化合物が知られたいるが、これらは融
点が低く、揮発性が高いため抗菌剤として使用す
る場合には、熱に対して不安定で、かつ効果の持
続性が頗る悪いという不具合がある。そのため、
カテーテルなどに使用することが出来ないという
問題点があつた。一方、工業用、あるいは建築用
の製品に使用される抗菌剤として、例えば特開昭
60−181002号公報に示すように、ゼオライト中に
含有するイオン交換可能な金属が銀、銅、及び亜
鉛からなる群から選択された少なくとも１種の金
属から置換されてなる結晶水含有状態、又は無水
状態の粒子状抗菌性組成物が知られている。
しかしながら、この抗菌性組成物が医療分野に
応用できるか否かは不明であつた。
そこで、本発明者は、前記抗菌性組成物が医療
分野において有効に活用できるか否かについて、
鋭意努力研究した結果、前記抗菌性組成物は湿
気、液体に接すると長期に渡つて抗菌効果を持続
することを発見した。
（問題点を解決すべき手段） 本発明は、かかる目的に着目してなされたもの
であり、その要旨とするところはカテーテル等の
本体の少なくとも体内に挿入、かつ留置される部
分に、ゼオライト中に含有するイオン交換可能な
金属が銀、銅及び亜鉛からなる群から選択された
少なくとも１種の金属から置換されてなる結晶水
含有状態又は無水状態の粒子状抗菌性組成物を付
着、若しくは混入してなることである。
従つて、体内の分泌物などに前記抗菌性組成物
が接するため、銀イオン、銅イオン、銅、又は亜
鉛イオンが長期に渡つて出現し、その触媒作用に
よつて抗菌（例えば緑膿菌、黄色ブドウ状球菌、
大腸菌、真菌）効果が持続する。また、熱（体
温）に対しても安定し、しかも無機材につき安定
性も高く、カテーテル等として、極めて有効なも
のを提供しうる。
（実施例） 以下、本発明の一実施例を図面に基づいて説明
する。
説明を具体的にするため、本実施例においては
長期間使用できる膀胱内留置カテーテル（自然導
尿）に使用されるものを示す。
第１図は本発明にかかるカテーテルを示し、図
中ａは、患者の体内に挿入、かつ留置される部分
に付着した抗菌性組成物を示し、かかる抗菌組性
成物は、接着剤などの止着手段によつて、プラス
チツク製外套管１１の内外表面に付着されてい
る。
前述の抗菌性組成物は、天然ゼオライト、若し
くは合成ゼオライト、又はこの両者を担体とし、
該ゼオライト中に含有されるイオン交換可能な金
属の一部分、又は実質上全部が銀、銅及び亜鉛か
らなる群から選択された少なくとも１種の金属に
より置換されてなる結晶水含有状態、又は無水状
態のものである。
又、カテーテル本体は、従来周知の構造のもの
であり、図示するカテーテル本体は、カニユーレ
とその材質を同じくする硬質性、又は半硬質性プ
ラスチツク製チユーブ管１１の先端に硬質部材か
らなる排液口１５を設け、この排液口１５に先端
を連通し、かつ前記管１１内を挿通する小径のプ
ラスチツク管１２を配設し、前記管１２の基端に
取付け部材１３を介して、水、又は空気の注入口
１４を設けたものであり、該管１１が体内に挿
入、かつ留置される構造のものである。
そして、図示するものは、カテーテル本体の外
周面に、前記抗菌性組成物ａを付着したものであ
る。しかし、本発明は、外套たる管１１の内周
面、注入用プラスチツク管１２の内外周面に前記
抗菌性組成物ａを付着してもよいことは勿論であ
る。
さらに、かかる抗菌性組成物ａを前記外套管１
１の成形時に、その成形溶液中に混入して、成形
するも任意である。
かくして、前記抗菌性組成物ａを付着した、又
は混入したカテーテル本体を構成する外套管１
１、及び小径の管１２を患者の体内に挿入、かつ
留置して長期間に渉る自然導尿（寝たきり老人、
又は下半身麻酔患者）の目的、又は腹膜潅流にお
いて、復腔内に溜まつた老廃物を体外へ導くため
に使用すると、前記抗菌性組成物ａによつて、体
内のカテーテル本体周囲に緑膿菌、黄色ブドウ状
球菌、大腸菌、及び真菌が発生しない。特に、前
記抗菌性組成物ａは、緑膿菌に対して強い抗菌作
用を呈する。加えて、前記抗菌性組成物ａは、毒
性もない。尚、各種のカテーテル、カニユーレに
本発明のものが摘用可能なることは勿論である。
（効果） 本発明にかかる体内留置用チユーブ、即ち、カ
テーテル、カニユーレは前述のごとく、カテーテ
ル、又はカニユーレ本体の少なくとも体内に挿
入、かつ留置される部分に、ゼオライト中に含有
するイオン交換可能な金属が銀、銅及び亜鉛から
なる群から選択された少なくとも１種の金属から
置換されてなる結晶水含有状態、又は無水状態の
粒子状抗菌性組成物を付着、若しくは混入してな
るから、緑膿菌に対して、極めて強い抗菌作用を
有し、又黄色ブドウ状球菌、大腸菌、及び真菌に
対しても有効である。そのため、前述の従来品に
比べ、患者の体内への挿入、留置期間を大幅に延
長することが可能となる。従つて、新規なカテー
テルに交換する回数が減少するため、カテーテル
交換のための手数と、それに伴う患者の苦痛を大
幅に軽減でき、初期の目的を達成しうる。
【図面の簡単な説明】
図面は、本発明の１実施例を示し、第１図はそ
の斜視図にして、小径の管１２の先端部にあるバ
ルーン内に水、又は空気が入り膨らんだ状態を示
す。第２図は、第１図における−線断面図で
ある。 図中、ａは抗菌性組成物。１１，１２，１３，
１４，１５はカテーテル本体の構成部品をそれぞ
れ示す。

Claims (1)

    【特許請求の範囲】
  1. １ 体内留置用チユーブ本体の少なくとも体内に
    挿入、かつ留置される部分に、イオン交換可能な
    金属部分が銀、銅、及び亜鉛からなる群から選択
    された少なくとも１種の金属で一部分、又は実質
    上全量置換されてなる微粒状のゼオライトを付
    着、もしくは混入してなることを特徴とする体内
    留置用チユーブ。
JP62171721A 1987-07-09 1987-07-09 Body indwelling tube Granted JPS6415056A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP62171721A JPS6415056A (en) 1987-07-09 1987-07-09 Body indwelling tube
US07/213,898 US4923450A (en) 1987-07-09 1988-06-30 Medical tubes for placement into the body of a patient
EP88306165A EP0301717B1 (en) 1987-07-09 1988-07-06 Medical tubes for placement into the body of a patient
DE8888306165T DE3866048D1 (de) 1987-07-09 1988-07-06 Medizinische schlaeuche zur plazierung in den koerper eines patienten.
CA000571545A CA1295554C (en) 1987-07-09 1988-07-08 Medical tubes for placement into the body of a patient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62171721A JPS6415056A (en) 1987-07-09 1987-07-09 Body indwelling tube

Publications (2)

Publication Number Publication Date
JPS6415056A JPS6415056A (en) 1989-01-19
JPH0414992B2 true JPH0414992B2 (ja) 1992-03-16

Family

ID=15928438

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62171721A Granted JPS6415056A (en) 1987-07-09 1987-07-09 Body indwelling tube

Country Status (5)

Country Link
US (1) US4923450A (ja)
EP (1) EP0301717B1 (ja)
JP (1) JPS6415056A (ja)
CA (1) CA1295554C (ja)
DE (1) DE3866048D1 (ja)

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US4923450A (en) 1990-05-08
EP0301717B1 (en) 1991-11-06
CA1295554C (en) 1992-02-11

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