JPH0419925B2 - - Google Patents
Info
- Publication number
- JPH0419925B2 JPH0419925B2 JP23351083A JP23351083A JPH0419925B2 JP H0419925 B2 JPH0419925 B2 JP H0419925B2 JP 23351083 A JP23351083 A JP 23351083A JP 23351083 A JP23351083 A JP 23351083A JP H0419925 B2 JPH0419925 B2 JP H0419925B2
- Authority
- JP
- Japan
- Prior art keywords
- propylene
- transparency
- random copolymer
- container
- blow molding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/08—Biaxial stretching during blow-moulding
- B29C49/16—Biaxial stretching during blow-moulding using pressure difference for pre-stretching, e.g. pre-blowing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/0005—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor characterised by the material
- B29C49/0006—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor characterised by the material for heating or cooling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/18—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor using several blowing steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/42—Component parts, details or accessories; Auxiliary operations
- B29C49/64—Heating or cooling preforms, parisons or blown articles
- B29C49/6472—Heating or cooling preforms, parisons or blown articles in several stages
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/10—Homopolymers or copolymers of propene
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/42—Component parts, details or accessories; Auxiliary operations
- B29C49/78—Measuring, controlling or regulating
- B29C2049/7879—Stretching, e.g. stretch rod
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C2949/00—Indexing scheme relating to blow-moulding
- B29C2949/07—Preforms or parisons characterised by their configuration
- B29C2949/0715—Preforms or parisons characterised by their configuration the preform having one end closed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/02—Combined blow-moulding and manufacture of the preform or the parison
- B29C49/06—Injection blow-moulding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/08—Biaxial stretching during blow-moulding
- B29C49/087—Means for providing controlled or limited stretch ratio
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
- B29K2023/10—Polymers of propylene
- B29K2023/12—PP, i.e. polypropylene
Landscapes
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Thermal Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Containers Having Bodies Formed In One Piece (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
【発明の詳細な説明】
本発明は透明性、耐熱性に優れたポリプロピレ
ン系樹脂製の医療容器に関する。更に詳しくはリ
ンゲル液、ハルトマン液等の輸液用に適した容器
に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a medical container made of polypropylene resin with excellent transparency and heat resistance. More specifically, the present invention relates to a container suitable for infusions such as Ringer's solution and Hartmann's solution.
輸液用プラスチツク容器の規格については日本
薬局法に定められているが、中でも透明性につい
ては、内容液中の異物を観察するのにできるだけ
高いことが要求されている。ポリプロピレン系樹
脂は機械的性質、滅菌時の耐熱性、安全衛生性に
優れた樹脂としてこの輸液用容器として使用され
ているが、透明性の点で不十分であり、押出成形
式２軸延伸ブロー成形等により透明性の改良が行
なわれているが、未だ不十分である。 Standards for plastic containers for infusions are stipulated by the Japanese Pharmacopoeia Law, and in particular, transparency is required to be as high as possible to allow observation of foreign substances in the liquid content. Polypropylene resin is used for this infusion container because it has excellent mechanical properties, heat resistance during sterilization, and safety and hygiene. Transparency has been improved by molding, etc., but it is still insufficient.
本発明者らはポリプロピレン系樹脂製の輸液容
器の透明性を改良すべく鋭意検討した結果、特定
のポリプロピレン系樹脂を使用して、射出延伸ブ
ロー成形を行なうことにより、透明性の優れた容
器が得られることを見出し、本発明に到達した。 As a result of intensive studies aimed at improving the transparency of infusion containers made of polypropylene resin, the inventors of the present invention found that by using a specific polypropylene resin and performing injection stretch blow molding, a container with excellent transparency was created. The present invention has been achieved based on the discovery that the present invention can be obtained.
即ち、本発明は、メルトフローインデツクスが
４〜20g／10分であるプロピレン−エチレンラン
ダム共重合体を、造核剤を添加することなく、射
出延伸ブロー成形法により成形されたことを特徴
とする医療容器である。 That is, the present invention is characterized in that a propylene-ethylene random copolymer having a melt flow index of 4 to 20 g/10 minutes is molded by injection stretch blow molding without adding a nucleating agent. It is a medical container.
本発明において用いるプロピレン−エチレンラ
ンダム共重合体とは日本工業規格JISK−7210の
条件14に従つて測定したメルトフローインデツク
ス（以下、MFIと略す）が４〜20g／10分のもの
である。MFIが4g／10分以下では得られる容器
の透明性は不十分であり、20g／10分を越えると
容器の偏肉が著しくなる。 The propylene-ethylene random copolymer used in the present invention has a melt flow index (hereinafter abbreviated as MFI) of 4 to 20 g/10 minutes measured according to condition 14 of the Japanese Industrial Standard JISK-7210. If the MFI is less than 4 g/10 minutes, the transparency of the resulting container will be insufficient, and if it exceeds 20 g/10 minutes, the thickness of the container will be significantly uneven.
又、本発明においてはプロピレン−エチレンラ
ンダム共重合体としてはエチレンが少ないものが
望ましく、特にエチレン含量が0.5〜８重量％好
ましくは１〜６重量％であるものが透明性、耐熱
性の上から好適に用いうる。 In addition, in the present invention, the propylene-ethylene random copolymer preferably has a low ethylene content, and in particular, a copolymer with an ethylene content of 0.5 to 8% by weight, preferably 1 to 6% by weight, has good transparency and heat resistance. It can be suitably used.
更に造核剤を用いれば、透明性は向上するので
あるが、本用途においては使用する必要はない程
に良好な透明性が得られる。 Furthermore, the transparency can be improved by using a nucleating agent, but the transparency is so good that it is not necessary to use it in this application.
本発明において用いる射出延伸ブロー成形法と
は、有底パリソンを射出成形によつて成形し、つ
いで予備ブロー、延伸温度調整後、延伸ブローす
ることによつて製品を得る成形法であり、延伸の
方法としてはロツドによる機械的なたて延伸と空
気吹込みによる方法の組合せが普通に行なわれ
る。 The injection stretch blow molding method used in the present invention is a molding method in which a bottomed parison is molded by injection molding, and then a product is obtained by pre-blowing, stretching temperature adjustment, and stretch blowing. A combination of mechanical vertical stretching using a rod and air blowing is commonly used.
これに用いる成形機としては日精ASB機械株
式会社製射出延伸ブロー成形機ASB−50，ASB
−150，ASB−250，ASB−650等をあげることが
できる。 The molding machine used for this is the injection stretch blow molding machine ASB-50 manufactured by Nissei ASB Machinery Co., Ltd.
-150, ASB-250, ASB-650, etc.
本発明の高透明で偏肉の少ないプロピレン−エ
チレンランダム共重合体製の医療容器を成形する
条件としては、例えば射出延伸ブロー成形機
ASB−50を用いた場合、下記条件が望ましい。 Conditions for molding the medical container made of the propylene-ethylene random copolymer which is highly transparent and has less uneven thickness of the present invention include, for example, an injection stretch blow molding machine.
When using ASB-50, the following conditions are desirable.
射出成形温度：200〜260℃
予備ブロー：たて延伸倍率 1.0〜1.8倍
横延伸倍率 1.2〜2.0倍
ブロー圧力 ３〜６Kg／cm
延伸温度調整金型温度：90〜140℃
延伸ブロー：たて延伸倍率 1.2〜3.5倍
横延伸倍率 1.2〜6.0倍
ブロー圧力 ４〜20Kg／cm2
本発明の医療容器は上記プロピレン−エチレン
ランダム共重合体に、必要に応じ、安定剤等の添
加物を極く少量、添加し、上記射出延伸ブロー成
形法により通常胴部の肉厚が0.2〜1.0mmになる様
に成形されたものである。 Injection molding temperature: 200 to 260℃ Preliminary blowing: Vertical stretch ratio 1.0 to 1.8 times Lateral stretch ratio 1.2 to 2.0 times Blow pressure 3 to 6 Kg/cm Stretching temperature adjustment mold temperature: 90 to 140℃ Stretch blowing: Vertical stretching Magnification: 1.2 to 3.5 times Transverse stretching ratio: 1.2 to 6.0 times Blow pressure: 4 to 20 Kg/cm 2 The medical container of the present invention is made of the above-mentioned propylene-ethylene random copolymer with a very small amount of additives such as stabilizers, if necessary. , and is molded by the above-mentioned injection stretch blow molding method so that the wall thickness of the body part is usually 0.2 to 1.0 mm.
本発明の医療容器は透明性、耐熱性に優れてい
るので高温滅菌が可能であり、輸液用容器として
好適に用いうる。 Since the medical container of the present invention has excellent transparency and heat resistance, it can be sterilized at high temperature and can be suitably used as an infusion container.
以下、実施例により本発明を説明する。 The present invention will be explained below with reference to Examples.
実施例 １
MFIが15g／10分で、エチレン含有量が４重量
％であるプロピレン−エチレンランダム共重合体
を日精ASB機械(株)製、射出延伸ブロー成形機
ASB−50にて下記条件で射出延伸ブロー成形を
行ない、胴部直径70mm、容量500c.c.の丸型ボトル
を成形した。Example 1 A propylene-ethylene random copolymer having an MFI of 15 g/10 minutes and an ethylene content of 4% by weight was molded using an injection stretch blow molding machine manufactured by Nissei ASB Machinery Co., Ltd.
Injection stretch blow molding was performed using ASB-50 under the following conditions to form a round bottle with a body diameter of 70 mm and a capacity of 500 c.c.
射出延伸ブロー成形条件
射出成形温度：220℃
射出成形金型温度：15℃
予備ブロー：たて１倍、横1.4倍
予備ブローエアー圧力：５Kg／cm2
延伸温度調節金型温度：100℃
延伸ブロー：たて1.8倍、横1.2倍
延伸ブロー圧力：９Kg／cm2
得られたボトルは重量24gで肉厚の均一性が良
く、透明性の優れた容器であり、特に内容液を入
れた時の透視性は良好で、輸液容器等の医療容器
として好適なものであつた。胴部の肉厚は0.50mm
で、切取つた試験片の霞度を日本電色製のヘーズ
メーターを用い、JISK−6714記載の方法によつ
て測定したところ7.8％であつた。Injection stretch blow molding conditions Injection molding temperature: 220°C Injection mold temperature: 15°C Preliminary blowing: 1x vertically, 1.4x horizontally Preliminary blowing air pressure: 5Kg/cm 2 Stretching temperature control mold temperature: 100°C Stretching blowing : Vertical 1.8 times, Width 1.2 times Stretching blow pressure: 9 Kg/cm 2 The obtained bottle weighs 24 g, has good wall thickness uniformity, and is a container with excellent transparency, especially when filled with liquid. It had good transparency and was suitable for medical containers such as infusion containers. Body wall thickness is 0.50mm
The degree of haze of the cut test piece was measured using a Nippon Denshoku haze meter according to the method described in JISK-6714, and found to be 7.8%.
実施例 ２
実施例１において、プロピレン−エチレンラン
ダム共重合体としてMFIが6g／10分でエチレン
含有量が２重量％のプロピレン−エチレンランダ
ム共重合体を用いた他は、実施例−１と同様にし
て、射出延伸ブロー成形を行ない、容量500c.c.の
丸型ボトルを成形した。得られたボトルは重量
24gで、肉厚の均一性が良く、透明性の優れた容
器であり、特に内容液を入れた時の透視性は良好
で、輸液容器等の医療容器として好適なものであ
つた。胴部の肉厚は0.50mmで、霞度は9.2％であ
つた。Example 2 Same as Example 1 except that in Example 1, a propylene-ethylene random copolymer having an MFI of 6 g/10 minutes and an ethylene content of 2% by weight was used as the propylene-ethylene random copolymer. Then, injection stretch blow molding was performed to mold a round bottle with a capacity of 500 c.c. The resulting bottle weighs
The container weighed 24 g, had good thickness uniformity, and was excellent in transparency.The container had particularly good transparency when filled with liquid, and was suitable as a medical container such as an infusion container. The wall thickness of the body was 0.50 mm, and the degree of haze was 9.2%.
比較例 １
実施例１において、プロピレン−エチレンラン
ダム共重合体としてMFIが2g／10分で、エチレ
ン含有量が２重量％であるプロピレン−エチレン
ランダム共重合体を用いた他は、実施例１と同様
にして、射出延伸ブロー成形を行ない容量500c.c.
の丸型ボトルを得た。Comparative Example 1 The same procedure as Example 1 was used except that a propylene-ethylene random copolymer having an MFI of 2 g/10 min and an ethylene content of 2% by weight was used as the propylene-ethylene random copolymer. In the same way, injection stretch blow molding was performed to obtain a capacity of 500c.c.
A round bottle was obtained.
得られたボトルの透明性は不十分で、胴部の肉
厚0.49mmであり、霞度は19.8％であつた。 The resulting bottle had insufficient transparency, the wall thickness of the body was 0.49 mm, and the degree of haze was 19.8%.
比較例 ２
実施例１において、プロピレン−エチレンラン
ダム共重合体としてMFIが25g／10分で、エチレ
ン含有量が2.0％であるプロピレン−エチレンラ
ンダム共重合体を用いた他は、実施例１と同様に
して、射出延伸ブロー成形を行なつたが、得られ
たボトルはたて方向、横方向いずれの方向でも偏
肉が大きく、使用できないものであつた。Comparative Example 2 Same as Example 1 except that a propylene-ethylene random copolymer having an MFI of 25 g/10 min and an ethylene content of 2.0% was used as the propylene-ethylene random copolymer. Injection stretch blow molding was then carried out, but the resulting bottle had large thickness deviations in both the vertical and horizontal directions, making it unusable.
Claims (1)
であるプロピレン−エチレンランダム共重合体
を、造核剤を添加することなく、射出延伸ブロー
成形法により成形されたことを特徴とする医療容
器。1. A medical container characterized in that a propylene-ethylene random copolymer having a melt flow index of 4 to 20 g/10 minutes is molded by injection stretch blow molding without adding a nucleating agent.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58233510A JPS60125631A (en) | 1983-12-13 | 1983-12-13 | Medical vessel |
| EP84115106A EP0151741A3 (en) | 1983-12-13 | 1984-12-10 | Injection stretch-blow molded container and resin composition therefor |
| EP87110734A EP0251340B1 (en) | 1983-12-13 | 1984-12-10 | Injection stretch-blow molding process |
| DE3486446T DE3486446T2 (en) | 1983-12-13 | 1984-12-10 | Injection blow molding |
| AU36543/84A AU554076B2 (en) | 1983-12-13 | 1984-12-12 | Ethylene-propylene copolymer compositions and containers |
| CA000469959A CA1240446A (en) | 1983-12-13 | 1984-12-12 | Injection stretch-blow molded container and resin composition therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58233510A JPS60125631A (en) | 1983-12-13 | 1983-12-13 | Medical vessel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60125631A JPS60125631A (en) | 1985-07-04 |
| JPH0419925B2 true JPH0419925B2 (en) | 1992-03-31 |
Family
ID=16956154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58233510A Granted JPS60125631A (en) | 1983-12-13 | 1983-12-13 | Medical vessel |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60125631A (en) |
-
1983
- 1983-12-13 JP JP58233510A patent/JPS60125631A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60125631A (en) | 1985-07-04 |
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