JPH04279599A - リボソーム不活性化タンパク質、その不活性前駆体形、作製方法および利用方法 - Google Patents

リボソーム不活性化タンパク質、その不活性前駆体形、作製方法および利用方法

Info

Publication number
JPH04279599A
JPH04279599A JP3139171A JP13917191A JPH04279599A JP H04279599 A JPH04279599 A JP H04279599A JP 3139171 A JP3139171 A JP 3139171A JP 13917191 A JP13917191 A JP 13917191A JP H04279599 A JPH04279599 A JP H04279599A
Authority
JP
Japan
Prior art keywords
rip
protein
sequence
dna
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3139171A
Other languages
English (en)
Japanese (ja)
Inventor
Terence A Walsh
テレンス　エイ．ウォルシュ
Timothy D Hey
ティモシー　ディー．ヘイ
Alice E R Morgan
アリス　イー．アール．モーガン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corteva Agriscience LLC
Original Assignee
DowElanco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DowElanco LLC filed Critical DowElanco LLC
Publication of JPH04279599A publication Critical patent/JPH04279599A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP3139171A 1990-06-11 1991-06-11 リボソーム不活性化タンパク質、その不活性前駆体形、作製方法および利用方法 Pending JPH04279599A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/535,636 US5248606A (en) 1990-06-11 1990-06-11 Dna encoding inactive precursor and active forms of maize ribosome inactivating protein
US535636 1990-06-11

Publications (1)

Publication Number Publication Date
JPH04279599A true JPH04279599A (ja) 1992-10-05

Family

ID=24135102

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3139171A Pending JPH04279599A (ja) 1990-06-11 1991-06-11 リボソーム不活性化タンパク質、その不活性前駆体形、作製方法および利用方法

Country Status (10)

Country Link
US (1) US5248606A (de)
EP (1) EP0466222B1 (de)
JP (1) JPH04279599A (de)
CN (1) CN1062172A (de)
AT (1) ATE184289T1 (de)
AU (1) AU638133B2 (de)
BR (1) BR9102418A (de)
CA (1) CA2044201A1 (de)
DE (1) DE69131589T2 (de)
HU (1) HUT58800A (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672683A (en) * 1989-09-07 1997-09-30 Alkermes, Inc. Transferrin neuropharmaceutical agent fusion protein
US5635384A (en) * 1990-06-11 1997-06-03 Dowelanco Ribosome-inactivating proteins, inactive precursor forms thereof, a process for making and a method of using
DE4040954C2 (de) * 1990-12-20 2001-05-17 Max Planck Gesellschaft Verfahren zur Erzeugung von pathogen-resistenten Pflanzen
JPH07504654A (ja) * 1992-03-11 1995-05-25 ナルヘックス　リミテッド オキソ及びヒドロキシ置換炭化水素のアミン誘導体
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
MXPA93002392A (es) 1992-03-11 2005-02-04 Narhex Ltd Derivados amino de hidrocarburos-oxo e hidroxi-substituidos.
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
GB9304905D0 (en) * 1992-03-16 1993-04-28 Zeneca Ltd Processes
US5916772A (en) * 1992-06-16 1999-06-29 Whittier Institute For Diabetes And Endocrinology Recombinant production of saporin-containing proteins
US5332808A (en) * 1992-09-08 1994-07-26 North Carolina State University DNA encoding a ribosome inactivating protein
KR970001565B1 (ko) * 1993-08-28 1997-02-11 장기하 섬자리공 항바이러스성 단백질(pip) 유전자 및 이를 발현하는 미생물
EG23907A (en) * 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
JPH0856655A (ja) * 1994-08-16 1996-03-05 Frontier:Kk 細胞致死剤および細胞死抑制剤
EP0909322B1 (de) * 1996-04-30 2005-11-16 Twinstrand Therapeutics Inc. Antivirale variante von ricin-proteinen
US7247715B2 (en) 1997-04-30 2007-07-24 Twinstrand Therapeutics Inc. Ricin-like toxin variants for treatment of cancer, viral or parasitic infections
WO2001025267A2 (en) 1999-10-04 2001-04-12 Twinstrand Therapeutics Inc. Improved ricin-like toxins for treatment of cancer
AU7023798A (en) 1997-04-30 1998-11-24 De Novo Enzyme Corporation Ricin-like toxin variants for treatment of cancer, viral or parasitic infections
WO1999003492A1 (en) * 1997-07-16 1999-01-28 Sophie Chen Antiviral and antitumor agents
AU2401800A (en) * 1998-12-31 2000-07-31 Rutgers, The State University Virus-resistant transgenic plants expressing l3
US6531125B1 (en) 1999-03-02 2003-03-11 Twinstrand Therapeutics Inc. Antiviral ricin-like proteins
AU2006201828B2 (en) * 2000-10-14 2009-07-16 British American Tobacco (Investments) Limited Plant cell death system
GB0025217D0 (en) * 2000-10-14 2000-11-29 Cambridge Advanced Tech Plant cell death system
GB0025225D0 (en) * 2000-10-14 2000-11-29 Cambridge Advanced Tech Plant cell death system
US7560424B2 (en) 2001-04-30 2009-07-14 Zystor Therapeutics, Inc. Targeted therapeutic proteins
US7629309B2 (en) 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
EP1394250A1 (de) * 2001-05-11 2004-03-03 Kazunari Taira Verfahren zur bildung eines stabilen komplexes des transkriptionsprodukts einer ein willkürliches peptid codierenden dna mit dem translationsprodukt, in dem verfahren eingesetztes nukleinsäurekonstrukt, durch das verfahren gebildeter komplex sowie screening auf funktionelles protein und das protein codierende mrna oder dna unter verwendung des verfahrens
US20030072761A1 (en) 2001-10-16 2003-04-17 Lebowitz Jonathan Methods and compositions for targeting proteins across the blood brain barrier
CA2553955C (en) 2004-02-10 2012-08-28 Zystor Therapeutics, Inc. Acid alpha-glucosidase and fragments thereof
JP5627571B2 (ja) 2008-05-07 2014-11-19 バイオマリン ファーマシューティカル インコーポレイテッド リソソーム標的化ペプチドおよびその使用
EP3679942A1 (de) 2009-06-17 2020-07-15 BioMarin Pharmaceutical Inc. Formulierungen für lysosomale enzyme
CN102234638B (zh) * 2010-04-27 2013-03-27 香港中文大学 修饰的玉米核糖体失活蛋白前体及其应用和蛋白纯化方法
US10347262B2 (en) 2017-10-18 2019-07-09 The Nielsen Company (Us), Llc Systems and methods to improve timestamp transition resolution
BR112020016884A2 (pt) * 2018-02-26 2020-12-15 R.P. Scherer Technologies, Llc Forma de dosagem farmacêutica para uma emulsão de simeticona e loperamida
CN110455903A (zh) * 2018-05-07 2019-11-15 天士力生物医药股份有限公司 一种注射用重组人尿激酶原杂质分析的梯度电泳检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE68703T1 (de) * 1984-02-08 1991-11-15 Cetus Corp Toxinkonjugate.
NZ218460A (en) * 1985-11-29 1989-07-27 Univ Melbourne Ricin-antibody conjugate
FR2601679B1 (fr) * 1986-07-15 1990-05-25 Sanofi Sa Immunotoxines, procede de preparation et compositions pharmaceutiques en contenant
DE3724323C2 (de) * 1986-07-29 1995-07-20 Erba Farmitalia Ein neuer Inhibitor für die Proteinsynthese
US4869903A (en) * 1987-05-29 1989-09-26 Genelabs Incorporated Method of selectively inhibiting HIV
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IT1229216B (it) * 1989-03-31 1991-07-25 Italfarmaco Spa Proteine inibenti i ribosomi e loro derivati.
AU654563B2 (en) * 1991-07-24 1994-11-10 Imperial Chemical Industries Plc Proteins

Also Published As

Publication number Publication date
HU911944D0 (en) 1991-12-30
CA2044201A1 (en) 1991-12-12
US5248606A (en) 1993-09-28
AU638133B2 (en) 1993-06-17
DE69131589D1 (de) 1999-10-14
EP0466222B1 (de) 1999-09-08
BR9102418A (pt) 1992-01-14
CN1062172A (zh) 1992-06-24
ATE184289T1 (de) 1999-09-15
HUT58800A (en) 1992-03-30
AU7832991A (en) 1991-12-12
DE69131589T2 (de) 2000-05-04
EP0466222A1 (de) 1992-01-15

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