JPH04290532A - Method for producing granulated or coated products - Google Patents

Abstract

PURPOSE:To solve such problems of conventional granulation method or coating method using a low melting material that the powder or low-melting material decomposes because of long exposure time to heat or decaying property or dissolving property of the granulated or coated material can not be controlled. CONSTITUTION:A low melting material is mixed and dispersed in a powder, and the mixture is sprayed into a heated atmosphere and cooled to produce the granulate material or coated material of the powder. Any powder, (1) granulated material or coated material can be used to prepare the granulated material, and to prepare coated material, such powder, (2) granulated material or coated material having higher melting point by >=30 deg.C than the low melting material can be used.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing granules and/or coatings.

0002

BACKGROUND OF THE INVENTION Research into granulation or coating methods using low melting point substances has been carried out in the past. for example,
The so-called agitation granulation method involves mixing powder with a low melting point substance as a binder and heating the mixture in a jacketed granulation mixer to granulate the binder [Granulation Handbook (edited by Japan Powder Industry Association)] Ohmsha Shoten Co., Ltd., published S532.10), p301], or by suspending or dissolving the powder in a dissolved low melting point substance, and then spraying and solidifying it using a spray or rotating disk. The so-called melt granulation method (mentioned Granulation Handbook, P1)
99) is known. In addition, a lipid powder with a melting point of 40°C or higher is applied as a coating agent to the water-soluble vitamin powder.
The water-soluble vitamin powder is made to collide with the water-soluble vitamin powder to adhere and coat the lipid powder on the entire peripheral surface of the water-soluble vitamin powder to produce a lipid-coated preparation using the water-soluble vitamins as a core material. Method for producing sex vitamins-coated preparations (Unexamined Japanese Patent Publication No. 6
3-164864) is also known.

0003

[Problems to be Solved by the Invention] However, in conventional granulation and coating methods, the powder or low-melting point substance decomposes due to the long exposure time to heat (about several minutes to several hours). There were problems such as the inability to control the disintegration and dissolution properties of granulated or coated products. An object of the present invention is to provide a method that overcomes the disadvantages of the prior art.

0004

[Means for Solving the Problems] The present invention produces granulated and/or coated powder by mixing and dispersing a low melting point substance in powder, injecting the mixture into a heated atmosphere, and then cooling it. This is the way to do it.

In the present invention, the powder includes (1) all powders and their granules or coatings when producing granules, and (2) low melting point powders when producing coated products. Powder having a melting point 30° C. or more higher than the melting point of the substance, and granules or coatings thereof can be used. In addition, as a low melting point substance, 40 to 150
It is preferable to have a melting point of ℃, for example, hydrocarbons (
(e.g., paraffin, microcrystallin, ceresin, etc.), fats and oils (e.g., hydrogenated oil, wood wax, cocoa butter, etc.), fatty acids (e.g., myristic acid, palmitic acid, stearic acid, etc.), higher alcohols (e.g., cetanol), , stearyl alcohol, etc.), polyhydric alcohols (Macrogol 6000, Macrogol 4000, etc.), waxes (eg, carnauba wax, beeswax, etc.)
, sugar alcohols (e.g. D-glucose, D-sorbitol, etc.), metal soaps (titanium stearate, calcium oleate, etc.), surfactants and fatty acid esters (e.g. sorbitan monostearate, glycerin monostearate) , acetylated glycerin monostearate, Pluronic F68, hexadecyl palmitate, octadecyl stearate, etc.), ibuprofen, trimethadione, and the like.

[0006] The heating atmosphere can be created using hot air, microwaves, or the like. The heating temperature is determined by the relationship with the amount of time the mixture of powder and low melting point substance is left in the heating atmosphere when it is injected (i.e., the total amount of heat), but when manufacturing a coated product, , set so as not to melt the powder. For spraying, the mixture is sprayed with pressurized air using a powder spray nozzle or the like. Cooling is performed by cold air cooling, natural cooling, etc.

In the present invention, the mixing ratio of the powder and the low melting point substance is not particularly limited, and is, for example, 1:99 to 99:1. In this case, in the mixture of powder and low melting point substance, if the content of the low melting point substance is less than 10%, granules will mainly be formed, whereas if the content of the low melting point substance exceeds 30%, Mainly used for coatings. When the content of the low melting point substance is 10% to 30%, both granulated products and coated products can be obtained. In the above case, it is desirable to adjust the pressure of the pressurized air as appropriate depending on the purpose of the product being manufactured (for example, when manufacturing a coated product, the pressure of the pressurized air should be adjusted to 0.5 to 1 .0kg/cm2, etc.)

[0008]

[Effects of the Invention] The present invention has made it possible to provide a granulation and/or coating method that is excellent in the following points. 1) Stirring granulation method, melt granulation method, and JP-A-63-1648
Compared to the technology in Publication No. 64, the time of exposure to heat is shorter (several minutes to
(from several hours to several seconds), making it possible to significantly suppress the decomposition of the powders and low-melting-point substances used. 2) In the present invention, there is no particular restriction on the mixing ratio of the powder and the low melting point substance, so the ratio of the low melting point substance can be lower than in the melt-cooling granulation method, making it easier to control disintegration and dissolution properties. Ta. 3) For example, the stirring granulation method required multiple steps such as mixing → granulation → cooling → crushing → sieving → product, but in the present invention, the process of mixing → granulation or coating → product can be shortened, and therefore the process can be completed in a short time. can now be granulated or coated. 4) Compared to conventional technology, particles with uniform diameter can be produced. 5) In addition to the advantages of 1) to 4), the dissolution properties of the granulated or coated products produced by the present invention are superior to those of conventional methods.

[0009]

[Embodiment] An embodiment of the present invention will be described below with reference to FIG. 4 kg of bisbuthiamine and 1 kg of carnauba wax were mixed for 1 minute in a plastic bag, and the mixture was dried using a spray dryer [manufactured by Okawara Kakoki Co., Ltd., Model L-12].
into the powder injection nozzle 1. The mixture that has entered the powder injection nozzle 1 is injected by pressurized air adjusted to a pressure of 0.5 kg/cm2 and falls, and after coming into contact with the 260°C hot air injected from the hot air injection nozzle 2, during the fall. It was naturally cooled and collected in cyclone 3. As a result, approximately 5 kg of bisbutiamine coated with carnauba wax was obtained.
I got it.

[Brief explanation of the drawing]

[Fig. 1] Fig. 1 is a diagram showing a spray drying apparatus, and in the figure, 1 indicates a powder injection nozzle, 2 indicates a hot air injection nozzle, and 3 indicates a powder injection nozzle.
indicates a cyclone.

Claims (1)

[Claims] 1. A method for producing granulated and/or coated powder by mixing and dispersing a low melting point substance in powder, injecting the mixture into a heated atmosphere, and then cooling the mixture.