JPH0440664B2 - - Google Patents

Info

Publication number
JPH0440664B2
JPH0440664B2 JP26398784A JP26398784A JPH0440664B2 JP H0440664 B2 JPH0440664 B2 JP H0440664B2 JP 26398784 A JP26398784 A JP 26398784A JP 26398784 A JP26398784 A JP 26398784A JP H0440664 B2 JPH0440664 B2 JP H0440664B2
Authority
JP
Japan
Prior art keywords
reagent
valve
openings
switching valve
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP26398784A
Other languages
Japanese (ja)
Other versions
JPS61140868A (en
Inventor
Masaaki Saito
Keiichi Ikeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jeol Ltd
Original Assignee
Nihon Denshi KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Denshi KK filed Critical Nihon Denshi KK
Priority to JP26398784A priority Critical patent/JPS61140868A/en
Publication of JPS61140868A publication Critical patent/JPS61140868A/en
Publication of JPH0440664B2 publication Critical patent/JPH0440664B2/ja
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Multiple-Way Valves (AREA)

Description

【発明の詳細な説明】 ［産業上の利用分野］ 本発明はコンパクト化した自動化学分析装置に
関する。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a compact automatic chemical analyzer.

［従来の技術］ 自動化学分析装置では血液や尿等のサンプルに
試薬を反応させ、該反応液の濃度に対応したもの
を検出して、サンプルを分析している。[Prior Art] An automatic chemical analyzer analyzes a sample by reacting a sample such as blood or urine with a reagent and detecting a concentration corresponding to the concentration of the reaction solution.

さて、斯くの如き自動化学分析装置においてサ
ンプルを分析する場合、多数の項目について分析
するのが一般的である。 Now, when a sample is analyzed using such an automatic chemical analyzer, it is common to analyze a large number of items.

第４図はサンプルを多数（例えば８項目）の項
目について連続的に分析する自動化学分析装置の
一概略図を示したものである。図中１は試薬通路
体で、該通路体は第５図に示すように、内部に共
通通路２が設けけられており、該共通通路から底
面に放射状に分散するように、８本の試薬通路
L1，L2，L3，L4，L5，L6，L7，L8が設けられて
いる。該試薬通路L1，L2，L3，L4，L5，L6，L7，
L8の開口には夫々チユーブを介して第１、第２、
第３、第４、第５、第６、第７、第８試薬バルブ
R1，R2，R3，R4，R5，R6，R7，R8が繋がつて
いる。該各試薬バルブは１つのパスの切換えによ
り、３つの流路の内何れかの流路を切換える事の
出来る流路切換えバルブである。該８つのバルブ
の内、何れか１つのバルブにおいて、パスがａの
如く切換つた時、何れの流路も繋がらず、ｂの如
く切換つた時、前記試薬通路の内、前記選択され
たバルブと繋がつている通路と試薬ポンプ３を繋
ぎ、ｃの如く切換つた時、第１、第２、第３、第
４、第５、第６、第７、第８試薬容器C1，C2，
C3，C4，C5，C6，C7，C8の内、前記選択された
バルブと繋がつている試薬容器と前記試薬ポンプ
３を繋ぐ。前記試薬通路体１の共通通路２の開口
には試薬共通チユーブ４及びサンプリング系５を
介して反応系６が繋がつている。該反応系は、例
えば、特公昭55−16270号公報に示す如き回転反
応器から成り、回転体７と該回転体に保持された
複数の反応管８ａ，８ｂ，８ｃ，８ｄ，８ｅ，８
ｆ，８ｇ，８ｈとから構成され、駆動装置（図示
せず）により回転体は間歇的に回転させられる。
図中Ａ，Ｂ，Ｃ，Ｄ，Ｅ，Ｆ，Ｇ，Ｈは各反応管
の特定位置を示している。Ａの位置はサンプルと
試薬を反応管内に導入する位置、Ｂの位置はガス
導入によるサンプルと試薬の混合液の気泡撹拌位
置、Ｆの位置は吸光度測定位置で、光源９からの
光を反応管に照射し、その透過光を検出器１０に
より検出する位置である。尚、前記試薬バルブの
切換え、試薬ポンプ、サンプリング系及び反応系
の動作等は全て制御系の指令に基づいて行なわれ
る。 FIG. 4 shows a schematic diagram of an automatic chemical analyzer that continuously analyzes a sample for a large number of items (for example, 8 items). In the figure, reference numeral 1 denotes a reagent passage body, which, as shown in FIG. aisle
L 1 , L 2 , L 3 , L 4 , L 5 , L 6 , L 7 , and L 8 are provided. The reagent passages L 1 , L 2 , L 3 , L 4 , L 5 , L 6 , L 7 ,
The first , second, and
3rd, 4th, 5th, 6th, 7th, 8th reagent valve
R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are connected. Each of the reagent valves is a flow path switching valve that can switch any one of the three flow paths by switching one path. In any one of the eight valves, when the path is switched as shown in a, none of the channels are connected, and when it is switched as shown in b, the reagent passage is connected to the selected valve. When the connected passage and the reagent pump 3 are connected and switched as shown in c, the first, second, third, fourth, fifth, sixth, seventh, and eighth reagent containers C 1 , C 2 ,
The reagent pump 3 is connected to the reagent container connected to the selected valve among C 3 , C 4 , C 5 , C 6 , C 7 , and C 8 . A reaction system 6 is connected to the opening of the common passage 2 of the reagent passage body 1 via a reagent common tube 4 and a sampling system 5. The reaction system consists of a rotating reactor as shown in, for example, Japanese Patent Publication No. 55-16270, and includes a rotating body 7 and a plurality of reaction tubes 8a, 8b, 8c, 8d, 8e, 8 held by the rotating body.
f, 8g, and 8h, and the rotating body is intermittently rotated by a drive device (not shown).
In the figure, A, B, C, D, E, F, G, and H indicate specific positions of each reaction tube. Position A is the position where the sample and reagent are introduced into the reaction tube, position B is the position where bubbles are stirred in the sample and reagent mixture by introducing gas, and position F is the position where the absorbance is measured. This is the position where the transmitted light is detected by the detector 10. The switching of the reagent valves, the operation of the reagent pump, the sampling system, the reaction system, etc. are all performed based on commands from the control system.

斯くの如き装置において、試薬通路体１と反応
系６を結ぶ流路には、サンプリング系５により或
るサンプルが供給される。先ず、第１試薬バルブ
R1のみのパスがｃのように切換る。そして、試
薬ポンプ３の作動により、第１項目の分析に必要
な試薬を収容した第１試薬容器C1から所定量の
第１試薬を該バルブと該ポンプ間のチユーブ内に
吸引する。次に、前記第１試薬バルブのパスをｂ
の如く切換え、前記試薬ポンプ３の作動により、
前記チユーブ内の試薬を該バルブのパス、試薬通
路L1、試薬共通チユーブ４を通じて、サンプリ
ング系５により通路に供給されたサンプルと共に
反応系６のＡの位置にある反応管８ａに送込む。
該反応系においては、回転体７が右に１ステツプ
回転し、反応管８ａは反応管８ｂがあつた位置
へ、反応管８ｈは８ａがあつた位置に来る。この
間に、次の如き動作が行なわれている。即ち、試
薬通路体１と反応系６を結ぶ流路には、サンプリ
ング系５により前記と同じサンプルが供給され、
第２試薬バルブR2のみのパスがｃのように切換
り、試薬ポンプ３の作動により、第２項目の分析
に必要な試薬を収容した第２試薬容器C2から所
定量の第２試薬を該バルブと該ポンプ間のチユー
ブ内に吸引する。そして、前記第２試薬バルブの
パスをｂの如く切換え、前記試薬ポンプ３の作動
により、前記チユーブ内の試薬を該バルブのパ
ス、試薬通路L2、試薬共通チユーブ４を通じて、
サンプリング系５により通路に供給されたサンプ
ルと共に反応系６のＡの位置にある反応管８ｈに
送込む。この様にして、反応系においては、回転
体７が右に間歇的に１ステツプ回転し、この間
に、前記の如きサンプルを第３、第４、…、第８
試薬により順次Ａの位置にある反応管に送り込む
動作が繰返えされる。そして、この間、反応系６
のＦの位置において、順次、サンプルと第１試
薬、第２試薬、第３試薬、第４試薬、…、第８試
薬との各反応液の濃度が検出され、第１項目、第
２項目、第３項目、第４項目、…、第８項目の分
析がなされる。尚、特に説明しなかつたが、反応
系６のＡの位置において、サンプルと試薬が送り
込まれる直前に、前記共通通路２、試薬共通チユ
ーブ４及びサンプリング系５の流路を結ぶライン
と、該Ａの位置に来た反応管が洗浄系（図示せ
ず）により洗浄され、更に、ライン内に残つた洗
浄液を吹き飛す為に圧縮空気供給手段（図示せ
ず）から圧縮空気が供給される。 In such an apparatus, a certain sample is supplied by a sampling system 5 to a channel connecting the reagent passage body 1 and the reaction system 6. First, the first reagent valve
The path of only R1 switches as shown in c. Then, by operating the reagent pump 3, a predetermined amount of the first reagent is sucked into the tube between the valve and the pump from the first reagent container C1 containing the reagent necessary for the analysis of the first item. Next, change the path of the first reagent valve to b
By switching the reagent pump 3 as shown in FIG.
The reagent in the tube is sent to the reaction tube 8a at position A of the reaction system 6 through the path of the valve, the reagent passage L 1 and the reagent common tube 4 together with the sample supplied to the passage by the sampling system 5.
In this reaction system, the rotating body 7 rotates one step to the right, and the reaction tube 8a comes to the position where the reaction tube 8b was placed, and the reaction tube 8h comes to the position where the reaction tube 8a was placed. During this time, the following operations are performed. That is, the same sample as described above is supplied by the sampling system 5 to the channel connecting the reagent passage body 1 and the reaction system 6,
The path of only the second reagent valve R2 is switched as shown in c, and the reagent pump 3 is operated to pump a predetermined amount of the second reagent from the second reagent container C2 containing the reagents necessary for the analysis of the second item. Suction is drawn into the tube between the valve and the pump. Then, the path of the second reagent valve is switched as shown in b, and by operating the reagent pump 3, the reagent in the tube is transferred through the path of the valve, the reagent passage L2 , and the reagent common tube 4.
The sample is sent to the reaction tube 8h at position A of the reaction system 6 together with the sample supplied to the passage by the sampling system 5. In this way, in the reaction system, the rotating body 7 rotates one step to the right intermittently, and during this period, the above-mentioned samples are transferred to the third, fourth, ..., eighth sample.
The operation of sequentially feeding reagents into the reaction tube at position A is repeated. During this time, reaction system 6
At position F, the concentrations of the reaction solutions of the sample and the first reagent, the second reagent, the third reagent, the fourth reagent, ..., the eighth reagent are sequentially detected, and the concentrations of the first item, second item, The third item, fourth item, ..., eighth item are analyzed. Although not specifically explained, at the position A of the reaction system 6, immediately before the sample and reagent are sent, a line connecting the common passage 2, the reagent common tube 4, and the flow path of the sampling system 5, and the A The reaction tube that has arrived at the position is cleaned by a cleaning system (not shown), and compressed air is supplied from a compressed air supply means (not shown) to blow away the cleaning liquid remaining in the line.

［発明が解決しようとする問題点］ さて、このような自動化学分析装置の試薬供給
系において、分析項目数に対応した数の試薬容器
が用意されるが、又、該試薬バルブも同じ数設け
ねばならない。しかし、一般に分析項目は10個以
上あり、このように多数の試薬バルブを設ける
と、コストが著しく高くなる。又、該バルブの数
が多くなると、装置全体が大きくなるばかりでな
く、装置の他のユニツトが理想的位置に配置出来
なくなる。[Problems to be Solved by the Invention] Now, in the reagent supply system of such an automatic chemical analyzer, the number of reagent containers corresponding to the number of analysis items is prepared, and the same number of reagent valves are also provided. Must be. However, there are generally 10 or more analysis items, and providing such a large number of reagent valves significantly increases costs. Furthermore, when the number of valves increases, not only does the entire device become larger, but other units of the device cannot be placed in ideal positions.

［問題点を解決するための手段］ 本発明の自動化学分析装置はバルブ１１と、複
数の流路のうちのいずれかを切換えにより試薬ポ
ンプ１７に接続する第１切換バルブ１４と、反応
系６と、複数の流路のうちのいずれかを切換えに
より該反応系６に接続する第２切換バルブ１４′
と、該第２切換バルブ１４′と前記反応系６との
間に設けられたサンプリング系５と、複数の試薬
容器Ｃとを備え、前記バルブ１１は一方が他方に
対して回転可能な第１、第２の部材１３，１２か
らなり、第１の部材１３は第２の部材１２との接
合面に３つの開口を一組として複数組の開口を有
し、各組の第１の開口の各々は前記各試薬容器Ｃ
に夫々接続され、第２の開口の各々は前記第１切
換バルブ１４の各流路に夫々接続され、第３の開
口の各々は前記第２切換バルブ１４′の各流路に
夫々接続され、第２の部材１２は第１の部材１３
との接合面に該第２の部材１２内を通る流路Ｖに
よつて接続された２つの開口を複数対有し、第
１、第２の部材１３，１２の相対的な回転により
該各組の３つの開口のうちいずれか２つの開口を
接続するようにしたことを特徴としている。[Means for Solving the Problems] The automatic chemical analyzer of the present invention includes a valve 11, a first switching valve 14 that connects one of a plurality of channels to a reagent pump 17 by switching, and a reaction system 6. and a second switching valve 14' that connects to the reaction system 6 by switching one of the plurality of channels.
, a sampling system 5 provided between the second switching valve 14' and the reaction system 6, and a plurality of reagent containers C, one of which is rotatable with respect to the other. , second members 13 and 12, the first member 13 has a plurality of sets of three openings on the joint surface with the second member 12, and each set of first openings has a plurality of openings. Each of the above reagent containers C
each of the second openings is connected to each flow path of the first switching valve 14, and each of the third openings is connected to each flow path of the second switching valve 14', The second member 12 is the first member 13
It has a plurality of pairs of two openings connected by a flow path V passing through the second member 12 on the joint surface thereof, and the relative rotation of the first and second members 13 and 12 causes each of the openings to It is characterized in that any two of the three openings in the set are connected.

［実施例］ 第１図は本発明の自動化学分析装置の要部であ
る試薬系の流系図である。図中１１は回転体１２
と固定体１３とから成るバルブで、第２図に示す
如き形状をしている。固定体１３の回転体１２と
の接触面の同一半径上に24個の開口h11，h12，
h13，h21，h22，h23，h31，h32，h33，……，h71，
h72，h73，h81，h82，h83が等間隔に開けられてい
る。又、該固定体の側面には貫通孔k11，k12，
k13，k21，k22，k23，k31，k32，k33，……，k71，
k72，k73，k81，k82，k83を介して前記各開口h11，
h12，h13，h21，h22，h23，h31，h32，h33，……，
h71，h72，h73，h81，h82，h83に繋がつた開口f11，
f12，f13、f21，f22，f23、f31A，f32，f33、……，
f71，f72，f73、f81，f82，f83が開けられている。前
記回転体１２の内部には８個のＶ字状の貫通孔げ
V1，V2，V3，V4，V5，V6，V7，V8が設けられ
ており、該各貫通孔に対して２つの開口が前記固
定体に開けられた開口と同じ様に、同一半径上に
同一間隔で開けられている。[Example] FIG. 1 is a flow diagram of a reagent system which is a main part of an automatic chemical analyzer of the present invention. In the figure, 11 is a rotating body 12
This valve consists of a fixed body 13 and a fixed body 13, and has a shape as shown in FIG. 24 openings h 11 , h 12 , on the same radius of the contact surface of the fixed body 13 with the rotating body 12
h 13 , h 21 , h 22 , h 23 , h 31 , h 32 , h 33 , ..., h 71 ,
h 72 , h 73 , h 81 , h 82 , and h 83 are equally spaced. In addition, through holes k 11 , k 12 ,
k 13 , k 21 , k 22 , k 23 , k 31 , k 32 , k 33 , ..., k 71 ,
The respective openings h11 , k72 , k73 , k81 , k82, k83 ,
h 12 , h 13 , h 21 , h 22 , h 23 , h 31 , h 32 , h 33 , ...,
Opening f 11 connected to h 71 , h 72 , h 73 , h 81 , h 82 , h 83 ,
f 12 , f 13 , f 21 , f 22 , f 23 , f 31 A, f 32 , f 33 , ...,
f 71 , f 72 , f 73 , f 81 , f 82 , f 83 are opened. There are eight V-shaped through holes inside the rotating body 12.
V 1 , V 2 , V 3 , V 4 , V 5 , V 6 , V 7 , and V 8 are provided, and two openings for each through hole are the same as the openings made in the fixed body. They are opened at the same distance on the same radius.

前記固定体１３の側面に開けられた開口f11，
f21，f31，……，f71，f81にはチユーブを介して
夫々第１、第２、第３、…、第７、第８試薬容器
C1，C2，C3……，C7，C8が繋がつている。開口
f12，f22，f32，f42，……，f72，f82はチユーブを介
して夫々第１切換バルブ１４の固定体１５（第３
図参照）の側面に開けられた開口p1，p2，p3，…
…，p7，p8に繋がつている。該切換バルブ１４は
第３図に示す様に、回転体１６と固定体１５とか
ら成り、固定体の回転体との接触面の同一半径上
には開口q1，q2，q3，……，q7，q8が開けられて
おり、該各開口は貫通孔r1，r2，r3，……，r7，
r8を介して前記側面に開けられた開口p1，p2，
p3，……，p7，p8と繋がつている。前記回転体１
６の内部には貫通孔Ｓが設けられており、前記貫
通孔は前記固定体の接触面に開けられた開口と同
一半径上に開けられた接触面上の開口と上面に開
けられた開口SHに繋がつている。該開口SHはチ
ユーブを介して試薬ポンプ１７と繋がつている。
前記固定体１３の開口f13，f23，f33，……，f7C，
f83は第６図に示す第２切換バルブ１４′の固定体
１５′側面に開けられた開口p1′，p2′，p3′，……，
p7′，p8′に繋がつている。該切換バルブは第３図
に示す前記第１切換バルブと同じ構造を有してお
り、回転体１６′と固定体１５′とから成り、固定
体の回転体との接触面の同一半径上には開口q1′，
q2′q3′，……，q7′，q8′が開けられており、該各開
口は貫通孔r1′，r2′r3′，……，r7′，r8′を介して
前
記側面に開けられた開口p1′，p2′，p3′，……．
p7′，p8′と繋がつている。前記回転体１６′の内部
には貫通孔S′が設けられており、前記貫通孔は前
記固定体の接触面に開けられた開口と同一半径上
に開けられた接触面上の開口と上面に開けられた
開口SH′に繋がつている。該開口SH′はチユーブ
を介して前記第４図の如きサンプリング系及び反
応系に繋がつている。尚、前記第１切換バルブと
第２切換バルブは同期して作動し、該バルブ、前
記バルブ１１及び試薬ポンプは制御装置の指令に
より作動する。 An opening f 11 made in the side surface of the fixed body 13,
f 21 , f 31 , ..., f 71 , f 81 are connected to the first, second, third, ..., seventh, and eighth reagent containers through tubes, respectively.
C 1 , C 2 , C 3 ..., C 7 , C 8 are connected. opening
f 12 , f 22 , f 32 , f 42 , ..., f 72 , f 82 are respectively connected to the fixed body 15 (third
(see figure) openings p 1 , p 2 , p 3 ,...
..., p 7 and p 8 are connected. As shown in FIG. 3, the switching valve 14 consists of a rotating body 16 and a fixed body 15, and openings q 1 , q 2 , q 3 , . . . are formed on the same radius of the contact surface of the fixed body with the rotating body. ..., q 7 , q 8 are opened, and the respective openings are through holes r 1 , r 2 , r 3 , ..., r 7 ,
Openings p 1 , p 2 , made in the side surface through r 8 ,
It is connected to p 3 , ..., p 7 and p 8 . The rotating body 1
6 is provided with a through hole S, and the through hole has an opening on the contact surface that is on the same radius as the opening that is made on the contact surface of the fixed body, and an opening SH that is made on the top surface. is connected to. The opening SH is connected to a reagent pump 17 via a tube.
The openings f 13 , f 23 , f 33 , ..., f 7 C of the fixed body 13,
f 83 are openings p 1 ′, p 2 ′, p 3 ′, ..., made on the side surface of the fixed body 15' of the second switching valve 14' shown in FIG.
It is connected to p 7 ′ and p 8 ′. The switching valve has the same structure as the first switching valve shown in FIG. is the aperture q 1 ′,
q 2 ′q 3 ′, ..., q 7 ′, q 8 ′ are opened, and each opening is a through hole r 1 ′, r 2 ′r 3 ′, ..., r 7 ′, r 8 ′ Openings p 1 ′, p 2 ′, p 3 ′, ....
It is connected to p 7 ′ and p 8 ′. A through hole S' is provided inside the rotating body 16', and the through hole is connected to an opening on the contact surface on the same radius as the opening on the contact surface of the fixed body, and on the upper surface thereof. It is connected to the opened opening SH′. The opening SH' is connected to a sampling system and a reaction system as shown in FIG. 4 through a tube. Note that the first switching valve and the second switching valve operate synchronously, and the valve, the valve 11, and the reagent pump operate according to commands from the control device.

斯くの如き試薬供給系を有する自動化学分析装
置において、第２切換バルブ１４′と反応系６を
結ぶ流路には、サンプリング系５により或るサン
プルが供給される。先ず、第１切換バルブ１４と
第２切換バルブ１４′においては回転体１６，１
６′の貫通孔Ｓ，S′と固定体の開口p1，p1′が繋が
るように回転体１６，１６′は回転する。又、バ
ルブ１１においては回転体１２の貫通孔V1の２
つの開口が夫々固定体１３の貫通孔k11，k12と
夫々繋がるように回転体１２は回転する。そし
て、試薬ポンプ１７の作動により、第１項目の分
析に必要な試薬を収容した第１試薬容器C1から
所定量の第１試薬を該バルブ１１と該第１切換バ
ルブ１４間のチユーブ内に吸引する。次に、前記
バルブ１１において回転体１２の貫通孔V1の２
つの開口が夫々k12，k13に繋がるように回転体１
２は回転する。そして、前記試薬ポンプ１７の作
動により、前記チユーブの試薬内をチユーブ、バ
ルブ１１の固定体１３の貫通孔k12、回転体１２
の貫通孔V1、固定体１３の貫通孔k13、チユー
ブ、第２切換バルブ１４′を介して、サンプルと
共に反応系６のＡの位置にある反応管８ａに送込
む。該反応系においては、回転体７が右に１ステ
ツプ回転し、反応管８ａは反応管８ｂがあつた位
置へ、反応管８ｈは８ａがあつた位置に来る。こ
の間に、次の如き動作が行なわれている。即ち、
第１切換バルブ１４と第２切換バルブ１４′にお
いては回転体１６，１６′の貫通孔Ｓ，S′と固定
体の開口p2，p2′が繋がるように回転体１６，１
６′は回転する。又、バルブ１１においては回転
体の貫通孔V2の２つの開口が夫々固定体１３の
貫通孔k21，k22と夫々繋がるように回転体１２は
回転する。そして、試薬ポンプ１７の作動によ
り、第２項目の分析に必要な試薬を収容した第２
試薬容器C2から所定量の第２試薬を該バルブ１
１と該第１切換バルブ１４間のチユーブ内に吸引
する。次に、前記バルブ１１において回転体１２
の貫通孔V2の２つの開口が夫々k22，k23に繋がる
ように回転体１２は回転する。そして、前記試薬
ポンプ１７の作動により、前記チユーブ内の試薬
をチユーブ、バルブ１１の固定体１３の貫通孔
k22、回転体１２の貫通孔V2、固定体１３の貫通
孔k23、チユーブ、第２切換バルブ１４′を介し
て、サンプリング系５により通路に供給されたサ
ンプルと共に反応系６のＡの位置にある反応管８
ｈに送込む。この様にして、反応系においては、
回転体７が右に間歇的に１ステツプ回転し、この
間に、前記の如きサンプルを第３、第４…、第８
試薬により順次Ａの位置にある反応管に送り込む
動作が繰返えされる。そして、この間、反応系６
のＦの位置において、順次、サンプルと第１試
薬、第２試薬、第３試薬、第４試薬、……、第８
試薬との各反応液の濃度が検出される。 In an automatic chemical analyzer having such a reagent supply system, a certain sample is supplied by the sampling system 5 to the channel connecting the second switching valve 14' and the reaction system 6. First, in the first switching valve 14 and the second switching valve 14', the rotating bodies 16, 1
The rotating bodies 16, 16' are rotated so that the through holes S, S' of the fixing body 6' are connected to the openings p 1 , p 1 ' of the fixed body. In addition, in the valve 11, the through hole V1 of the rotating body 12 is
The rotating body 12 rotates so that the two openings are connected to the through holes k 11 and k 12 of the fixed body 13, respectively. Then, by operating the reagent pump 17, a predetermined amount of the first reagent is pumped into the tube between the valve 11 and the first switching valve 14 from the first reagent container C1 containing the reagent necessary for the analysis of the first item. Suction. Next, in the valve 11, 2 of the through hole V1 of the rotating body 12
Rotating body 1 so that the two openings are connected to k 12 and k 13 respectively.
2 rotates. Then, by the operation of the reagent pump 17, the inside of the reagent in the tube is transferred to the tube, the through hole k 12 of the fixed body 13 of the valve 11, and the rotating body 12.
The sample is sent together with the sample to the reaction tube 8a located at position A of the reaction system 6 through the through hole V 1 of the fixed body 13, the through hole k 13 of the fixed body 13, the tube, and the second switching valve 14'. In this reaction system, the rotating body 7 rotates one step to the right, and the reaction tube 8a comes to the position where the reaction tube 8b was placed, and the reaction tube 8h comes to the position where the reaction tube 8a was placed. During this time, the following operations are performed. That is,
In the first switching valve 14 and the second switching valve 14', the rotating bodies 16, 1 are connected so that the through holes S, S' of the rotating bodies 16, 16' are connected to the openings p 2 , p 2 ' of the fixed body.
6' rotates. Further, in the valve 11, the rotating body 12 rotates so that the two openings of the through hole V2 of the rotating body are connected to the through holes k21 and k22 of the fixed body 13, respectively. Then, by the operation of the reagent pump 17, the second
Pour a predetermined amount of the second reagent from the reagent container C 2 into the valve 1.
1 and the first switching valve 14. Next, in the valve 11, the rotating body 12
The rotating body 12 rotates so that the two openings of the through hole V 2 are connected to k 22 and k 23 , respectively. Then, by the operation of the reagent pump 17, the reagent in the tube is pumped through the through hole of the fixed body 13 of the valve 11.
k 22 , the through hole V 2 of the rotating body 12, the through hole k 23 of the fixed body 13, the tube, and the second switching valve 14', together with the sample supplied to the passage by the sampling system 5 of A of the reaction system 6. Reaction tube 8 in position
Send it to h. In this way, in the reaction system,
The rotating body 7 intermittently rotates one step to the right, and during this period, the above-mentioned samples are transferred to the third, fourth, and eighth samples.
The operation of sequentially feeding reagents into the reaction tube at position A is repeated. During this time, reaction system 6
At position F, the sample and the first reagent, the second reagent, the third reagent, the fourth reagent, ..., the eighth
The concentration of each reaction solution with the reagent is detected.

尚、特に説明しなかつたが、反応系６のＡの位
置において、サンプルと試薬が送り込まれる直前
に、前記第２切換バルブ１４′の貫通孔S′、該バ
ルブと反応系６を結ぶ流路及び該Ａの位置に来た
反応管が洗浄系（図示せず）により洗浄され、更
に、ライン内に残つた洗浄液を吹き飛す為に圧縮
空気供給手段（図示せず）から圧縮空気が供給さ
れる。 Although not specifically explained, at the position A of the reaction system 6, just before the sample and reagent are sent, the through hole S' of the second switching valve 14' and the flow path connecting the valve and the reaction system 6 are connected. The reaction tube that has come to the position A is cleaned by a cleaning system (not shown), and compressed air is supplied from a compressed air supply means (not shown) to blow away the cleaning liquid remaining in the line. be done.

又、上述した実施例においては、貫通孔V1，
V2等を有する部材を回転させるようにしたが、
逆に貫通孔k11，k21等を有する部材を回転させる
ようにしても良い。 Furthermore, in the embodiment described above, the through holes V 1 ,
I tried to rotate a member with V 2 etc., but
Conversely, the members having the through holes k 11 , k 21 , etc. may be rotated.

［発明の効果］ 本発明によれば、自動化学分析装置の試薬供給
系において、分析項目数が如何に多くあつても、
従来の様に、該分析項目数と同じ数の試薬バルブ
を設ける必要は無く、バルブを極めて少なくする
ことができ、コストを著しく低減できる。又、バ
ルブを少なくできるため、従来に比べ装置全体が
小さくなると共に装置の他のユニツトを理想的位
置に配置出来る。[Effects of the Invention] According to the present invention, no matter how many analysis items there are in the reagent supply system of an automatic chemical analyzer,
Unlike the conventional method, it is not necessary to provide the same number of reagent valves as the number of analysis items, and the number of valves can be extremely reduced, resulting in a significant reduction in cost. Furthermore, since the number of valves can be reduced, the entire device can be made smaller than in the past, and other units of the device can be placed in ideal positions.

【図面の簡単な説明】[Brief explanation of drawings]

第１図は本発明の一実施例を示した自動化学分
析装置の概略図、第２図、第３図及び第６図は該
装置の一部詳細図、第４図は従来の自動化学分析
装置の概略図、第５図は該従来装置の一部詳細図
である。 C1，C2……，C7，C8：試薬容器、５：サンプ
リング系、６：反応系、１１：バルブ、１２：回
転体、１３：固定体、１４：第１切換バルブ、１
５：固定体、１６：回転体、h11，h12，h13，h21，
……，h73，h81，h82，h83，f11，f12，f13，f21，…
…，f81，f82，f83，SH，SH′，q1，q2，……，
q7，q8，p1，p2，……，p7，p8：開口、k11，k12，
k13，k21，……，k73，k81，k82，k83，V1，V2，
……，V7，V8，Ｓ，S′，r1，r2，……，r7，r8：
貫通孔、１７：試薬ポンプ。 FIG. 1 is a schematic diagram of an automatic chemical analyzer showing an embodiment of the present invention, FIGS. 2, 3, and 6 are partial detailed views of the device, and FIG. 4 is a conventional automatic chemical analyzer. A schematic diagram of the apparatus, FIG. 5 is a partially detailed view of the conventional apparatus. C 1 , C 2 ..., C 7 , C 8 : Reagent container, 5: Sampling system, 6: Reaction system, 11: Valve, 12: Rotating body, 13: Fixed body, 14: First switching valve, 1
5: Fixed body, 16: Rotating body, h 11 , h 12 , h 13 , h 21 ,
..., h73 , h81 , h82 , h83 , f11 , f12 , f13 , f21 ,...
..., f 81 , f 82 , f 83 , SH, SH', q 1 , q 2 , ...,
q 7 , q 8 , p 1 , p 2 , ..., p 7 , p 8 : opening, k 11 , k 12 ,
k 13 , k 21 , ..., k 73 , k 81 , k 82 , k 83 , V 1 , V 2 ,
..., V 7 , V 8 , S, S', r 1 , r 2 , ..., r 7 , r 8 :
Through hole, 17: Reagent pump.

Claims (1)

【特許請求の範囲】[Claims] １ バルブ１１と、複数の流路のうちのいずれか
を切換えにより試薬ポンプ１７に接続する第１切
換バルブ１４と、反応系６と、複数の流路のうち
のいずれかを切換えにより該反応系６に接続する
第２切換バルブ１４′と、該第２切換バルブ１
４′と前記反応系６との間に設けられたサンプリ
ング系５と、複数ブの試薬容器Ｃとを備え、前記
バルブ１１は一方が他方に対して回転可能な第
１、第２の部材１３，１２からなり、第１の部材
１３は第２の部材１２との接合面に３つの開口を
一組として複数組の開口を有し、各組の第１の開
口の各々は前記各試薬容器Ｃに夫々接続され、第
２の開口の各々は前記第１切換バルブ１４の各流
路に夫々接続され、第３の開口の各々は前記第２
切換バルブ１４′の各流路に夫々接続され、第２
の部材１２は第１の部材１３との接合面に該第２
の部材１２内を通る流路Ｖによつて接続された２
つの開口を複数対有し、第１、第２の部材１３，
１２の相対的な回転により該各組の３つの開口の
うちいずれか２つの開口を接続するようにしたこ
とを特徴とする自動化学分析装置。1. A valve 11, a first switching valve 14 that connects to the reagent pump 17 by switching any one of the plurality of flow paths, a reaction system 6, and a first switching valve 14 that connects the reaction system to the reagent pump 17 by switching one of the plurality of flow paths. a second switching valve 14' connected to the second switching valve 1;
4' and the reaction system 6, and a plurality of reagent containers C, the valve 11 has first and second members 13, one of which is rotatable with respect to the other. , 12, the first member 13 has a plurality of sets of three openings on the joint surface with the second member 12, and each of the first openings of each set is connected to each reagent container. C, each of the second openings is connected to each flow path of the first switching valve 14, and each of the third openings is connected to the second
The second valve is connected to each flow path of the switching valve 14'.
The member 12 has the second member 12 on the joint surface with the first member 13.
2 connected by a flow path V passing through the member 12 of
The first member 13, the second member 13,
An automatic chemical analyzer characterized in that any two of the three openings in each set are connected by twelve relative rotations.
JP26398784A 1984-12-14 1984-12-14 Automatic chemical analysis instrument Granted JPS61140868A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP26398784A JPS61140868A (en) 1984-12-14 1984-12-14 Automatic chemical analysis instrument

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26398784A JPS61140868A (en) 1984-12-14 1984-12-14 Automatic chemical analysis instrument

Publications (2)

Publication Number Publication Date
JPS61140868A JPS61140868A (en) 1986-06-27
JPH0440664B2 true JPH0440664B2 (en) 1992-07-03

Family

ID=17396964

Family Applications (1)

Application Number Title Priority Date Filing Date
JP26398784A Granted JPS61140868A (en) 1984-12-14 1984-12-14 Automatic chemical analysis instrument

Country Status (1)

Country Link
JP (1) JPS61140868A (en)

Also Published As

Publication number Publication date
JPS61140868A (en) 1986-06-27

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