JPH0484770A - Method for controlling line of instrument for analysis - Google Patents

Abstract

PURPOSE:To improve analyzing accuracy by expediting a synchronization between an electrolyte measuring apparatus and a biochemical analyzer by increasing the sample suction time of the electrolyte measuring apparatus by integral times of the analyzing cycle of the biochemical analyzer. CONSTITUTION:Existences of an electrolyte measurement and a biochemical analysis are investigated when a sample is carried into a prescribed position. A sample in a suction position of a sample suction mechanism 400 of an electro lyte measuring apparatus 300 and a sample in a suction position of a sample suction mechanism 600 of a biochemical analyzer 500 can be recognized from a label information read by a sample carrying measure 200 and a sample- carrying hysteresis by the measure 200 in a controlling element 100 at this time. The analyzing cycle can be prolonged by integral times of the analyzing cycle of the biochemical analyzer 500 in the same time when the sample suction time is increased by integral times of the analyzing cycle of the biochemical analyzer 500 in the electrolyte measuring apparatus 300. The synchronism can be obtained even if the analyzing time in the electrolyte measurement is pro longed by this.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention has a first analyzer with a single analysis line and a plurality of analysis lines, and can process samples in a cycle shorter than the analysis cycle of the first analyzer. The present invention relates to a line control method for an analyzer that continuously supplies samples, and a second analyzer that aspirates and analyzes multiple analysis lines.

[Conventional technology]

Generally, in an automatic biochemical analyzer, a test sample is analyzed by reacting a test sample liquid with a predetermined reagent in a reactor and performing colorimetric measurements.

Figure 5 is a flow path system diagram of a conventional biochemical automatic analyzer using a rotary reactor (Japanese Patent Publication No. 53-34079), in which 31 is a sample supply section, 35 is a sampling head, and 40
is a measuring valve, and 49 is a rotating reactor.

The sample supply unit 31 includes a turntable 32, a large number of sample tubes 33 provided around the circumference thereof, and a turntable driving device 34, and a sample liquid to be tested is injected into each of the sample tubes 33.

The sampling head 35 includes a suction pipe 36 and a suction pipe 36 .
The distal end of the suction tube 36 is inserted into a sample tube at a predetermined position among the plurality of sample tubes on the turntable 32, and the sample liquid is sucked up. The sampling head 35 can also be inserted into the cleaning tank 38 as shown by the dotted line, and in this state, the tip of the suction pipe 36 is cleaned by jetting water, for example, from the nozzle 39.

The sample liquid measurement valve 40 consists of a fixed member 41, 42 and a rotating member 43 placed closely between them, the rotating member having at least two holes 44a, 4 with equal volume.
4b is drilled. The sampling head 35 is connected to the fixing member 41, and the switching valve 45 is connected to the fixing member 42. This switching valve 45 is connected to a pump 46, which in turn returns to the switching valve 45.
It is connected to the cleaning liquid tank 47 through.

The rotary reactor 49 includes a rotating body 50 and a plurality of reaction tubes 51 on the same circumference held by the rotating body 50. The rotating body 50 is driven by a driving device and rotates intermittently. The symbols A, B, C, . . . , L in the figure indicate specific positions of the reaction tube 51. Valves are provided above and below the rotating reactor 49, and a light source 52 is provided substantially at the center of the rotating body, and a detector 53 is placed opposite the light source 52. Note that the positions of the light source 52 and the detector 53 may be reversed.

The position of the reaction tube 51 (the specified first position) is the position where the sample and the first reagent are introduced into the reaction tube. The fixed member 41 of the measurement valve has a pipe 61 passing through the preheating chamber 60.
is connected, and a pump 62 is provided in the middle of the piping,
Moreover, the lower end is inserted into a container 64 filled with a first reagent 63.

Two further pipes 65 and 66 pass through the preheating chamber 60, one of which 65 carries the second reagent, and the other 66 carries the cleaning fluid.

When the pump 62 is operated, the first reagent 63 is heated and then introduced into the measurement valve 40, and the sample liquid is pushed out into the hole 44b of the rotating member 43 having a fixed volume.
It is introduced into the reaction tube 51 at position A. A means for stirring the sample-first reagent mixture is placed at a position intermediate between position A and position B. In this position, the top of the reaction tube is evacuated and air (or any other desired gas) is introduced into the reaction tube. Since the air becomes bubbles in the liquid and moves upward, the sample liquid and the first reagent introduced at position A are thereby well stirred and the reaction is promoted.

The position H is the introduction position of the second reagent. When the pump 71 is operated, the second reagent is sucked up, heated to a predetermined temperature in the preheating chamber 60, and then introduced into the reaction tube 51.

The intermediate position between H and I is a stirring means position similar to that placed between A and B, where air is introduced through the resistance tube 74 and the air bubbles cause the reaction with the first reagent to finish or react. Stirring of the process sample and the second reagent is performed.

The position J indicates the measurement position, and the light from the lamp 52 placed practically at the center of the rotating body is irradiated onto the reaction solution through the reaction tube, and the transmitted light is detected by the detector 53.

The output signal from the detector 53 is sent to a recorder or display device 76 via an amplifier 75, and the absorbance during the reaction between the sample and the reagent is recorded or displayed with respect to the time axis. A portion of the output signal from the amplifier 75 is sent to an A-D converter 77 and digitized, and the signal is sent to a data analysis device 78 such as an electronic computer where a predetermined calculation is performed.

K and L are cleaning positions, and a cleaning liquid such as water is introduced from a pipe 66. The pipe 66 is connected to an air mixing section 79 and a pump 8.
0 into the cleaning liquid tank 47. A compressor 81 is inserted into the air mixing section 79 into the cleaning liquid tank 44 via a valve 82 . Compressed air is sent from a compressor 81 to the air mixing section 79 via a valve 82, and air is mixed into the cleaning liquid from the pump 80.

As a result, the cleaning liquid containing bubbles is introduced into the reactor 51, and the cleaning effect can be enhanced.

The middle between J and K, the middle between K and L, and the middle between L and A are the positions where the liquid in the reaction tube is discharged, and compressed air is introduced from the compressor 81 to the upper part of the reaction tube via the valve 83 and piping 84. The pressure pushes out the liquid in the reaction tube,
The liquid is sent to the drainage reservoir through piping 85.

In contrast to the automatic biochemistry analyzer, which measures the amount of GOT, GPT, etc. in serum and plasma by colorimetric measurement by reacting them with reagents as described above, electrolyte measuring devices measure the amount of GOT and GPT in serum and plasma using, for example, the ion-selective electrode method. It measures Na'', K'', and Cl-1 degree in plasma.

Electrolyte measuring instruments generally employ a method of diluting a sample to a certain ratio with a diluent for the following reasons. That is, in an electrolyte analyzer, since the sample has a high concentration, if the sample is introduced and measured at the same concentration, the electrodes will be contaminated and deteriorate to a large degree. Therefore, it is necessary to perform thorough cleaning. Furthermore, the longer the entire channel system is, the larger the amount of sample used will be.

Furthermore, since semi-solid components such as proteins and lipids are included and volume errors occur, measurement errors become large. For this reason, diluted samples are used.

Both automatic biochemistry analyzers and electrolyte measuring machines analyze and measure components of blood, urine, etc., and there are also automatic biochemical analyzers that incorporate an electrolyte measuring machine into a single device as an attachment.

[Problem to be solved by the invention]

However, when attempting to combine an electrolyte measuring device and an automatic biochemical analyzer into a single device to configure a series of sample aspiration systems, an electrolyte measuring device has only a single analysis line, whereas an automatic biochemical analyzer has only a single analysis line. Since the analyzer has multiple analysis lines, it is necessary to synchronize them, which causes various problems.

FIG. 6 is a diagram for explaining the analysis cycle of each analyzer.

In the case of a certain electrolyte measuring machine, there is only a single analysis line, so if the sample is aspirated, diluted, measured, and washed as shown in Figure 6 (al), the analysis time is 54 seconds.
This becomes the analysis cycle.

In general, with electrolyte measuring instruments, it is customary to increase the measurement accuracy by measuring the electrode potential multiple times, and in this case, the difference between the first and second values from the two measurements is the set value. The measurement ends when the value is within the range.

On the other hand, for example, in the case of a biochemical automatic analyzer having 96 analysis lines, if each analysis line is sampled for 6 seconds as shown in FIG. 6(b), the analysis time is 576 seconds. The analysis cycle will be 6 seconds.

If the electrolyte measuring device and automatic biochemical analyzer described above are to be integrated into a single device and analysis is to be performed using a series of sample supply systems, the analysis cycles of both must be synchronized. Therefore, conventionally, in the case of the example shown in FIG. 6, the analysis time of the electrolyte measuring device was fixed at 54 seconds for synchronization. For this reason, it was not possible to increase the accuracy of analysis by increasing the number of measurements with an electrolyte measuring device, instead of limiting it to two measurements, until the difference between the previous measurement value and the current measurement value was within the set value. . If the difference between the first and second values is greater than the set value, you can repeat the measurement three or four times until the difference from the previous measurement falls within the set value. There is a problem that it becomes necessary to make the length longer, resulting in a lot of wasted time.

Another problem is that it is difficult to perform the same processing when the sample is blood or urine because the latter has a higher concentration. Therefore, electrolyte measuring instruments are prepared according to each sample. Therefore, there is a problem in that the equipment cost also increases.

The present invention solves the above problems, and facilitates synchronization between an electrolyte measuring device and an automatic biochemical analyzer.
The object of the present invention is to provide a line control method for an analyzer that can improve analysis accuracy even when configured with a single device. Another object of the invention is to make it equally applicable to different samples such as blood and urine.

[Means to solve the problem]

To this end, the present invention provides a first analyzer with a single analysis line, and a second analyzer with a plurality of analysis lines, which aspirates a sample in a cycle shorter than the analysis cycle of the first analyzer and analyzes the plurality of analysis lines. A line control system for an analyzer that includes a second analyzer and continuously supplies samples,
The sample aspiration time and analysis cycle of the first analyzer are made an integral multiple of the sample aspiration cycle of the second analyzer, and the analysis cycle of the first analyzer is made an integer multiple of the sample aspiration cycle of the second analyzer. It is characterized by being extendable.

[Effect]

In the analyzer line control system of the present invention, the sample suction time and analysis cycle of the first analyzer are set to be an integral multiple of the sample suction cycle of the second analyzer, and the analysis cycle of the first analyzer is set to the second analyzer. Since the sample aspiration cycle of the first analyzer can be extended by an integral multiple, synchronization can be achieved even if the first analyzer is extended. Therefore, the number of measurements can be increased with the first analyzer, and the number of washing steps can also be increased, which improves measurement accuracy, allows samples with different properties to be analyzed, and sets washing steps according to the sample. be able to.

〔Example〕

Examples will be described below with reference to the drawings.

First, before explaining the line control system of the analyzer of the present invention, the electrolyte measuring instrument applied to the present invention will be explained.

FIG. 3 is a diagram showing a configuration example of an electrolyte measuring device applied to the line control method of the analyzer of the present invention, and FIG. 4 is a diagram showing an outline of the measurement flow.

In FIG. 3, a sampling cup 1 is a container for storing collected samples such as blood and urine. The sampling pipette 2 moves a sampling nozzle between the sampling cup 1 and the washing jar 3 to aspirate a sample, discharge a diluted liquid into the washing jar 3, and suck the discharged diluted liquid.

The sampling pump IO weighs and transfers the sample, and the dilution pump 11 dilutes the sample and cleans the dilution cell 5. The drain air valve 6 is a solenoid valve that supplies pressurized air for draining or cleaning the dilution cell 5. The mixing air valve 7 is a solenoid valve that supplies pressurized air for stirring the dilution cell 5. is for adjusting the pressure of pressurized air for stirring.

The ion selective electrode 21 is an electrode for selectively measuring Na, CI ion activities, and the comparison electrode 22 is a reference electrode for extracting the potential of each ion electrode. The flow cell 23 is a cell for guiding a standard solution or sample to each electrode surface. The standard solution pump 27 is a pump for transferring the standard solution from the internal standard solution tank 31 to the bot 29, and the waste solution pump 26 is a pump for transferring the standard solution and sample into the flow cell 23 and draining it to the waste solution tank 32. The comparison outer cylinder liquid pump 25 is a pump for transferring the comparison outer cylinder liquid from the comparison outer cylinder liquid tank 33 to the flow cell 23. The bot 29 is a container that receives the standard solution to be transferred to the flow cell 23, and has a function of blocking the flow path from the standard solution supply system during measurement.

The dilution cell 5 has openings at the top and bottom, and mixes the sample and diluent with pressurized air.The upper opening is opened to the atmosphere, and the sample, diluent, and cleaning solution (diluent) are passed through the lower opening. is introduced, the upper opening is closed, the sample and diluent are stirred with pressurized air from the lower opening, the upper opening is opened to the atmosphere, and the waste liquid pump 26 is operated from the lower opening for dilution. Transfer the sample.

The pump change valve 9 is a rotary type valve consisting of a stator S on the upper side and a rotor R on the lower side in the figure.

Then, by moving (rotating) the rotor R in the horizontal direction in the figure, a switching position is established where the line Y1 is selectively connected to A and BSC on the stator S side, and the sampling pump 10 and the dilution pump 11 are connected to each other. suction,
Switch the discharge. Dilution valve 4 also
Similarly, it is a rotary type valve consisting of a stator S on the upper side and a rotor R on the lower side in the figure. By moving (rotating) the rotor R in the left-right direction in the figure, the lower opening of the dilution cell 5 connected to the stator S side is opened at A on the rotor R side.
It has a switching position that is selectively connected to the BSC, and switches between stirring, transferring, draining, etc. of the diluted liquid. The four-way change valve 13 connects the dilution system and the measurement system,
It performs switching, and is configured to cut off the flow path from the dilution system during measurement.

Next, the measurement flow will be explained.

Weighing of the sample starts with the dilution system filled with diluent, so the operation for setting the initial state will be explained. In the illustrated position of the pump change valve 9, the diluent tank 30 communicates with the sampling pump IO and the dilution pump 11, and the other line Bl of the dilution pump 11 is blocked, so that the sampling pump IO1! The diluent is sucked from the diluent tank 30 by the suction operation of the illusion pump 11 . Therefore, after suctioning the diluted liquid, the rotor R of the pump change valve 9 is shifted to the left in the figure, and the line Yl on the rotor R side is connected to the line Y3 of the stator S. In this state, the line Yl connected to the other side of the sampling pump IO is closed on the stator S side of the pump change valve 9. Therefore, the diluent is discharged from the line Y3 to the sampling pipette 2 side through the dilution valve 4 by the discharge operation of the sampling pump IO. Thereafter, the pump change valve 9 is returned to its original position and a suction operation and a similar discharge operation are performed again, so that the dilution system is evacuated and filled with diluent, which is further discharged from the sampling pipette 2. Therefore, by setting the sampling pipette 2 to the cleaning jar 3 side, the cleaning jar 3 is also filled with the diluent.

From the above state, proceed to weighing the sample, replacing the internal standard solution, and measuring as follows. Note that the dilution valve 4, pump change valve 9, and four-way change valve I3 start in the illustrated state.

First, the sampling pump 10 performs a predetermined stroke suction operation with the sampling pipette 2 positioned in the space, and then performs a similar suction operation in the order of the sampling cup 1, the space, and the cleaning jar 3. As a result, the line from the sampling pipette 2 to the dilution valve 4 contains diluent-air-sample-air-diluent at a volume corresponding to the suction stroke of the sampling pump IO. The reason why both sides of the weighed sample are insulated from the diluent with air is to prevent the sample from diffusing into the diluent due to direct contact between the sample and the diluent.

On the other hand, during this time, the standard solution pump 27 is activated to transfer the standard solution to the bot 29, while the waste liquid pump 26 and the comparative external cylinder liquid pump 25 transfer the standard liquid and the comparative external cylinder liquid to the flow cell 23.

Next, the dilution valve 4 moves the rotor to the right in the figure and connects the line on the stator side to which the sampling pipette 2 is connected to the line Y2 on the rotor side, and the pump change valve 9 moves the rotor to the right side in the figure. Move to the right in the figure and connect the rotor line Y1 and the stator line Y2. Then, the sample is set in the line Y2 between the dilution valve 4 and the pump change valve 9 by the suction operation of the sampling pump 10.

Thereafter, the dilution valve 4 is moved to the illustrated position, and the pump change valve 9 moves the rotor to the left in the figure to connect line B1 on the rotor side and line Y2 on the stator side, and the dilution pump The sample and the diluent are introduced into the dilution cell 5 by the discharge operation of step 11. In this case, since the amount of diluent introduced into the dilution cell 5 is determined by the discharge stroke of the dilution pump 11, for example, when diluting 20 times, the sampling pump 10
Assuming that 10 ml of diluent is weighed in step 1, the discharge stroke of the dilution pump 11 is determined so as to introduce 190 ml of diluent into the dilution cell 5.

When the sample and diluent are introduced into the dilution cell 5, the dilution valve 4 moves the rotor to the left in the figure, opens the mixing air valve 7, and agitates the inside of the dilution cell 5 with pressurized air. In this case, since the upper line of the dilution cell 5 is closed on the rotor side of the illusion valve 4, pressurized air is supplied and stirred until the pressure within the dilution cell 5 is balanced.

When the stirring is finished, the dilution valve 4 moves the rotor further to the left in the figure and connects the bottom line of the dilution cell 5 to the four-way change valve 13 side. The diluted sample is connected to four lines, and the waste liquid pump 26 is operated to transfer the diluted sample to the flow cell 23 and introduce it into the ion-selective electrode 21. In this case, the upper opening of the dilution cell 5 is connected to a drain air valve 6 and is opened to the atmosphere.

It goes without saying that the internal standard solution is measured after the internal standard solution is replaced and after the stabilization time has elapsed and before the diluted sample is introduced into the electrode.

After the diluted sample is introduced into the electrode and the stabilization time has elapsed, the four-way change valve 13 is returned to the illustrated state to shut off the flow system and the sample is measured, followed by cleaning using the internal standard solution. Execute.

On the other hand, after the diluted sample is transferred to the flow cell 23, the dilution cell 5 is cleaned in the cleaning mode. in this case,
Using, for example, a diluent as the washing water, switch the dilution valve 4 and introduce it from the lower opening in the same way as the sample, then introduce pressurized air from the drain air valve 6 through the upper opening and through the lower opening. Drain water from the four-way change valve 13 to the drain.

Next, an embodiment of the present invention in which the electrolyte measuring device described above is incorporated into a conventional automatic biochemical analyzer will be described.

FIG. 1 is a diagram for explaining one embodiment of a line control system for an analyzer according to the present invention, and FIG. 2 is a diagram for explaining the entire line control.

In FIG. 1, the sample conveyance means 200 has a reading mechanism and a conveyance line driving mechanism, and controls the sample conveyance line 700 while reading the ID and test information of each label attached to the sampling cup. The control unit 100 controls the sample transport means 200 and analyzes the electrolyte measuring device 300 and biochemical analyzer 500 based on the ID and test information of each sampling cup read by the sample transport means 200. The electrolyte measuring device 300 and the biochemical analyzer 500 have a sample suction mechanism 40
0.600, from the sampling cup 800 on the sample conveyance line 700 that has been conveyed to the control unit 100.
The sample is aspirated based on the instructions given and a predetermined analysis is performed.

Next, the overall line control by the control section will be explained with reference to FIG.

First, once the sample is transported to a predetermined location, it is checked for electrolyte measurement and biochemical analysis. At this time, the control unit 100 controls the sample suction mechanism 400 of the electrolyte measuring device 300 based on the information on the label read by the sample transport means 200 and the sample transport history by the sample transport means 200.
The sample at the suction position of the biochemical analyzer 500 and the sample at the suction position of the sample suction mechanism 600 of the biochemical analyzer 500 can be recognized. Therefore, if both of the IDs and analysis items are "present," the electrolyte measuring device 300 and the biochemical analyzer 500 are respectively instructed to start the analysis along with the analysis items. Based on this instruction, the electrolyte measuring device 300. Each biochemical analyzer 500 has a sampling cup 80.
Perform predetermined sample aspiration from 0 and perform analysis. Then, wait for the completion of electrolyte measurement and biochemical analysis before moving on to transporting the next sample.

Note that the electrolyte measurement is completed when the suction of the sample into a single analysis line is completed, which is an integral multiple of the analysis cycle of the biochemical analyzer 500. Furthermore, the biochemical analysis is completed when the suction of the sample to the analysis line corresponding to each analysis item is completed. Therefore, if the sample suction time of the electrolyte measuring device 300 is 12 seconds, then the sample will be taken after 12 seconds, and if the analysis cycle of the biochemical analyzer is 6 seconds and there are 10 analysis items, then the sample will be taken after 60 seconds. After determining the completion of the electrolyte measurement, the completion of the biochemical analysis is determined, so for example, if the analysis item of the biochemical analyzer is 1, the next sample is transferred 12 seconds later, and if it is 3, the next sample is transferred 18 seconds later. Move.

If only electrolyte measurement or biochemical analysis is required, instruct the start of electrolyte measurement and biochemical analysis, respectively.
Wait for completion and move on to the next sample transfer.

However, electrolyte measurements begin after the analysis for the previous sample is completed. This is because, as mentioned earlier, the electrolyte measuring machine does not have a single analysis line, so if the analysis time, that is, the analysis cycle, is, for example, 54 seconds, the sample cannot be aspirated until this cycle is completed. be.

Therefore, when electrolyte measurements are performed continuously, it takes 54 seconds to transfer the next sample even when there are few analysis items for biochemical analysis.

In an electrolyte measuring device, the present invention makes the sample suction time an integral multiple of the analysis cycle of the biochemical analyzer as described above, and extends the analysis cycle (analysis time) by an integral multiple of the analysis cycle of the biochemical analyzer. This makes it possible to maintain synchronization even if the analysis time in electrolyte measurement is extended.

For example, the analysis time in the electrolyte measuring device is extended in the following cases.

The first case is when the number of measurements is increased in order to improve measurement accuracy. In electrolyte measurement using the ion-selective electrode method, it is customary to measure the electrode potential multiple times to improve the quality of the data. In order to obtain the minimum analysis time of 54 seconds, for example, two measurements are performed, and the measurement is terminated when the difference between the first and second values is within the set value. However, if the difference is greater than the set value, the measurement is repeated a third and fourth time until the difference between the two successive values falls within the set value.

If the maximum set number of times is exceeded, the measurement ends as a measurement error.

The second case is when measuring the internal standard solution as well, comparing it with the previous measured value and repeating it until the difference falls within the set value.

The third case is when measuring an external standard solution. In this case,
Above 1. Unlike the second case, the possibility of sampling errors makes it necessary to repeat the basic analysis cycle again, and the sample is transferred in a 54-second cycle instead of a 12-second cycle. The conditions for this repetition are determined based on whether the measured value is within a set value by comparing it with the previous measured value.

Therefore, measurements will be repeated in 54 second cycles until the value falls within the set value. However, the above 1st and 2nd
- If the repeating conditions are the same, repeat the same measurements. Note that the measurement of the external standard solution is usually performed every day prior to the measurement of the sample.

Furthermore, since the concentration of urine is higher than that of blood, there is a problem in performing a mixed analysis of urine and blood when considering electrode sensitivity calibration and line cleaning. In the present invention,
Since the analysis time can be extended, it is now possible to perform a mixed analysis by increasing the number of washes for blood, and by doubling the washing cycle when the sample is urine compared to, for example, blood. With the electrolyte measuring device that uses the 54-second blood analysis cycle described above, by extending the analysis time by 12 seconds to 66 seconds, it is possible to use the device that normally measures blood to handle urine as a sample as well. becomes.

〔Effect of the invention〕

As is clear from the above description, according to the present invention, the analysis cycle of the electrolyte measuring device is extended by an integral multiple of the analysis cycle of the automatic biochemistry analyzer, so that the electrolyte measuring device and the automatic biochemistry analyzer can be continuously connected. This makes it easy to synchronize sample supply, and it is also easy to increase the number of measurements to improve analysis accuracy. Furthermore, even if the number of times the electrolyte measuring device is washed is increased, the analysis cycle corresponding to that time can be extended, so blood and urine can be processed in the same system by increasing the number of times the electrolyte measuring device is washed.

[Brief explanation of drawings]

Fig. 1 is a diagram for explaining an embodiment of the line control method of the analyzer according to the present invention, Fig. 2 is a diagram for explaining the overall line control, and Fig. 3 is a diagram for explaining the line control method of the analyzer according to the present invention. Diagram 4 showing a configuration example of an electrolyte measuring device applied to a line control method.
The figure shows an overview of the measurement flow, Figure 5 is a flow path diagram of a conventional biochemical automatic analyzer using a rotary reactor, and Figure 6 is a diagram explaining the analysis cycle of each analyzer. be. 100...control unit, 200...sample transport means,
300... Electrolyte measuring device, 400 and 600... Sample suction mechanism, 500... Biochemical analyzer. Applicant: JEOL Co., Ltd. Agent, Patent Attorney: Ryukichi Abe (7 others) Fig. Sampling and dilution section II variable section detection section Fig. 6 (a) 6 seconds 6 seconds 6 seconds analysis cycle

Claims (4)

[Claims] (1) A first analyzer with a single analysis line, and a second analysis that has multiple analysis lines and aspirates a sample in a cycle shorter than the analysis cycle of the first analyzer and analyzes the multiple analysis lines. A line control method for an analyzer that continuously supplies samples, the method comprising: making the sample suction time and analysis cycle of the first analyzer an integral multiple of the sample suction cycle of the second analyzer; and A line control system for an analyzer, characterized in that the analysis cycle of a first analyzer can be extended by an integral multiple of the sample suction cycle of a second analyzer. (2) An electrolyte measuring device is used as the first analyzer, and an automatic biochemistry analyzer is used as the second analyzer. 2. The line control system for an analyzer according to claim 1, wherein the line control method for an analyzer is configured to terminate the measurement when the line control method is executed. (3) In the measurement of the external standard solution of the electrolyte measuring device, the sample is transferred during the analysis cycle, so that it is possible to repeatedly extend the analysis cycle in the event of a measurement error.
Line control method of the analyzer described. (4) The line control system for an analyzer according to claim 2, characterized in that the number of sample cleaning steps is increased or decreased depending on the sample in the electrolyte measuring device.