JPH0443046B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to Reishi
Ganodema, Ganodema,
The present invention relates to a hair-nourishing cosmetic containing as an active ingredient an extract (extract component) of C. Lucidum with water and/or a lower alcohol having 1 to 3 carbon atoms. Many drugs have been applied to treat male pattern baldness. Its mechanism of action includes combinations of drugs that promote blood circulation in the scalp, activate hair matrix cells, and inhibit lipid secretion in the scalp, as well as amino acids and vitamins that are nutrients for hair. There are many examples of this. JP-A No. 50-76214 discloses an extract from the Tsuriganetake subtribe of the Acernocoscomaceae family that is included in a carrier (base) for deodorizing cosmetics. Ungulina officinalis, Ungulina fuomentaria, Ungulina nigricanans, Ungulina marginata, Ungulina fraxinea, Ungulina ulmaria, Ungulina anosa, Ungulina rosea, Ungulina frichinosa, Ungulina corgisa, Ungulina vetulina, Ungulina quercina, Ungulina soloniensis, etc. of A deodorizing cosmetic composition using an extract from the thatch of Polyporus sulfureus, which belongs to the Tachiyoreitake subtribe of the Sarunokoshikake family, is disclosed. However, these extracts of Fuki and deodorizing skin cosmetics containing the same do not substantially have a hair nourishing effect (hair growth promoting effect). Reishi has been attracting a lot of attention in recent years as a health food, but it has traditionally been used as a Chinese herbal medicine to smooth blood flow, prevent congestion, eliminate blood clots, and treat high blood pressure, arteriosclerosis, and heart disease. It is said to have a significant effect on adult diseases such as stroke. As a result of extensive research into the application of Ganoderma to cosmetics, the present inventors found that when the extract component of Reishi with water and/or aliphatic lower monohydric alcohol having 1 to 3 carbon atoms is applied to the skin of humans or animals. , has been found to have an extremely significant hair growth promoting effect,
The invention has been completed. That is, the present invention is a hair-nourishing cosmetic composition characterized by containing an extract of Ganoderma lucidum using water and/or an aliphatic lower monohydric alcohol having 1 to 3 carbon atoms. The extract with water and/or aliphatic lower monohydric alcohol having 1 to 3 carbon atoms of the present invention is preferably 0.01 to 10% by weight based on the total weight of the hair nourishing cosmetic composition (prescription ingredients) as a dry product. is blended in an amount of 0.1 to 5% by weight. The solvent used for the extraction of Ganoderma in the present invention is water or aliphatic lower monohydric alcohol having 1 to 3 carbon atoms (methyl, ethyl, n-propyl, isopropyl alcohol) alone or a mixture thereof. The extraction temperature (temperature of the extraction solvent) may be cold, room temperature, or high temperature. The Ganoderma lucidum extract to be incorporated into the base of hair nourishing cosmetics may be the extract itself or may be in a dry state. The Ganoderma extract (extract component) of the present invention is in the form of a powder, is safe for the human body, and does not cause skin irritation. As a result of conducting a skin irritation test according to the method of ), both the animal skin irritation score and the human skin irritation score were 0.
It has been confirmed that the extract does not cause skin irritation. [Draize, J.H., Association of Food and
Drugoffcials of the United States Appraisal
of the Safety of Chemicals in Foods Drugs
and Cosmetics, 46 (1959), Texas State
Department of Health, Austin) The hair nourishing cosmetics of the present invention can be applied to hair tonics, hair lotions, hair creams, hair creams, etc. according to conventional methods.
It can be made into formulations such as shampoo and rinse. Examples of the base in the hair-growth cosmetic of the present invention include water, alcohols such as ethanol, polyhydric alcohols such as glycerin, liquid paraffin, higher fatty acids (stearic acid, etc.), fatty acid glycerides (glycerin monostearate, etc.) , higher alcohols, animal and vegetable oils, oily substances such as waxes, surfactants (emulsifiers, solubilizers), disinfectants,
A keratolytic agent or the like may be added as appropriate. The hair growth cosmetic of the present invention exhibits a markedly good hair growth promoting effect (hair growth effect) when applied to human or animal skin, is stable even after long-term storage, and has extremely high commercial value. . Examples will be described below. In the examples, parts mean parts by weight, and % means weight %. Example 1 100g of dried Reishi powder was cut into small pieces, soaked in water from Step 2, and heated at 100°C for 1 hour. After that, it is cooled and filtered with suction, and the residue is further soaked in 500 ml of water, heated to 50°C for 2 hours, and filtered with suction again. This operation is repeated twice, and finally about 3 ml of filtrate is obtained. This filtrate was dried under reduced pressure to obtain 14g of dark brown extract.
I got it. Next, 5 g of this extract was dissolved in 495 g of a 50% ethyl alcohol aqueous solution (50% ethanol) to prepare a lotion (hair nourishing cosmetic) of the present invention. Next, the hair growth effect of this lotion on white mice was investigated. DDY white mouse (male, 6 weeks old, average weight 35
g) After cutting the dorsal skin from the tail with electric clippers, remove the hair completely with hair removal cream, and from the next day apply the lotion of the present invention to the skin of the subject area 2 mornings and evenings every day.
0.1 ml per animal was applied twice. A group of 10 animals
Animals in the control group were treated with 50% alcohol water. The hair growth effect was determined by comparing the visual evaluation score, hair length, and hair weight with the control group. Table 1 shows the criteria for determining the hair growth effect.

[Table] On the 15th day after the start of the experiment, the animals were sacrificed and evaluated visually according to the criteria shown in Table 1. The evaluation scores were totaled to determine the average evaluation score per animal. moreover,
Excise the skin from the test area, punch out a certain area of the skin with a punch with a diameter of 12 mm, measure the weight of the hair after drying, and measure the length of 20 hairs, and compare the average value and standard. The deviation was calculated. The hair growth promoting effect of white mice coated with the lotion of the present invention was as follows: hair length was 6.41 ± 1.23 mm, hair weight was
The amount was 5.93±1.25 mg, the evaluation score was 3.4, and an excellent hair-nourishing effect was expressed. In comparison, when a lotion (base) that did not contain Reishi extract was applied, the hair length was 5.23 ± 0.83 mm, the hair weight was 4.67 ± 0.66 mg, and the evaluation score was 2.6. The hair length without lotion was 5.45±95 mm, the hair weight was 5.46±0.79 mg, and the evaluation score was 2.8. Example 2 100g of dried Reishi powder was soaked in alcohol 2, the extraction solvent shown in Table 2, and heated to reflux temperature with a condenser for extraction for 2 hours, filtered with suction, and 500ml was added to the residue. of said alcohol;
Reflux extraction is further carried out for 2 hours, followed by suction filtration again.
This operation is repeated two more times to obtain about 3 filtrates. The filtrate is concentrated under reduced pressure and dried to obtain an extract. Each lotion of the present invention was prepared by dissolving 5 g of the obtained extract in 495 g of a 50% aqueous ethyl alcohol solution. Next, the hair growth effect of each lotion on white mice was investigated in the same manner as in Example 1. The results are shown in Table 2. As is clear from the results in Table 2, the hair growth promoting effect of the lotion containing various alcoholic extracts of Ganoderma lucidum of the present invention on mice was remarkable, and both the hair length and hair weight of the sample-applied groups were lower than that of the control group. In addition, the sample-applied group showed a higher evaluation score based on visual judgment, confirming the hair-growth effect of the sample of the present invention.

[Table] Example 3 The hair-nourishing effect of the cream containing the extract of Ganoderma lucidum of the present invention in various solvents on mice was investigated.
The application sample was prepared by adding 1% by weight of Reishi mushroom extract to a cream having the following formulation. [Formulation] Liquid paraffin 10 parts Stearic acid 5 parts Glyceryl monostearate 6 parts Triethanolamine 1.5 parts Reishi mushroom extract 1.0 parts Purified water 76.5 parts The hair growth effect evaluation experiment was carried out in exactly the same manner as in Example 1, using DDY. The experiment was carried out using white-skinned mice. The results of this experiment are shown in Table 3. The hair growth promoting effect of the cream containing the extract of Ganoderma lucidum in various solvents of the present invention is remarkable, and the hair length and hair weight of the sample-applied group were both greater than those of the control group, and the evaluation score was high. A hair effect was observed.

[Table] Example 4 The hair-nourishing effect of lotions containing extracts of Reishi mushrooms in various solvents was examined by applying them to the scalps of healthy men. A lotion containing an extract of Ganoderma lucidum was prepared according to the following formulation. [Formulation] 95% ethanol 70 parts Reishi extract 1.0 parts Glycerin 1.0 parts Fragrance 1.0 parts Purified water 27.0 parts In the evaluation experiment, the panelists' hair was shaved 1 cm in diameter from two places on the left and right, 5 cm above the ears. Apply about 3 ml of the lotion containing the extract of Ganoderma lucidum of the present invention in various solvents to the left side twice a day in the morning and evening.
This was done by comparing with the untreated right side. In addition, 10 panelists were used for each sample. The effectiveness was determined by cutting 20 hairs from the test area on the 28th day after the start of the experiment and measuring their length. The results of the experiment are shown in Table 4. It was found that the hair growth promoting effect of the lotion containing the extract of Ganoderma lucidum of the present invention using various solvents was remarkable, and the hair length in the sample application area was more effective than the control area. did.

[Table] Extract

Claims (1)

[Scope of Claims] 1. A hair nourishing cosmetic containing an extract of Ganoderma lucidum using water and/or an aliphatic lower monohydric alcohol having 1 to 3 carbon atoms. 2. The hair nourishing cosmetic according to claim 1, wherein the extract of Reishi mushroom with water and/or lower alcohol having 1 to 3 carbon atoms is contained in an amount of 0.01 to 10% by weight based on the total weight of the composition. fee.