JPH0443047B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to Reishi
Ganoderma, Ganoderma,
Lucidum) with organic solvents such as alcohols with 4 to 5 carbon atoms, hydrocarbons, halogenated hydrocarbons, ethers, and esters (extract components)
The present invention relates to a hair nourishing cosmetic containing as an active ingredient. Many drugs have been applied to treat male pattern baldness. Its mechanism of action includes combining drugs that promote blood circulation in the scalp, activate hair matrix cells, and suppress the secretion of lipids in the scalp, as well as other amino acids and vitamins that are nutritious for hair. There are many examples. JP-A No. 50-76214 discloses an extract from the Tsuriganetake subtribe of the Acernocoscomaceae family that is included in a carrier (base) for deodorizing cosmetics. Ungulina officinalis, Ungulina fuomentaria, Ungulina nigricanans, Ungulina marginata, Ungulina fraxinea, Ungulina ulmaria, Ungulina anosa, Ungulina rosea, Ungulina frichinosa, Ungulina corgisa, Ungulina vetulina, Ungulina quercina, Ungulina soloniensis, etc. of A deodorizing cosmetic composition using an extract from the thatch of Polyporus sulfureus, which belongs to the Tachiyoreitake subtribe of the Sarunokoshikake family, is disclosed. However, these extracts of Fuki and deodorizing skin cosmetics containing the same do not substantially have a hair nourishing effect (hair growth promoting effect). Reishi has been attracting a lot of attention in recent years as a health food, but it has traditionally been used as a Chinese herbal medicine to smooth blood flow, prevent congestion, eliminate blood clots, and treat high blood pressure, arteriosclerosis, and heart disease. It is said to have a significant effect on adult diseases such as stroke. As a result of intensive research into the application of Reishi to cosmetics, the present inventors found that Reishi can be used in organic solvents such as alcohols with 4 to 5 carbon atoms, hydrocarbons, halogenated hydrocarbons, ethers, and esters. When the extract (extract ingredients) is applied to human or animal skin,
The present invention was completed based on the discovery that the hair growth promoting effect is extremely significant. That is, the present invention contains an extract of Reishi mushroom extracted with at least one solvent selected from the group consisting of alcohols having 4 to 5 carbon atoms, hydrocarbons, halogenated hydrocarbons, ethers, and esters. The present invention relates to hair nourishing cosmetics characterized by: The extract using organic solvents such as alcohols having 4 to 5 carbon atoms, hydrocarbons, halogenated hydrocarbons, ethers, esters, etc. of the present invention is the total amount of the composition (prescription ingredients) of the hair nourishing cosmetic as a dry product. The amount is usually 0.01 to 10% by weight, preferably 0.1 to 5% by weight. The solvent used for extracting Ganoderma of the present invention has a carbon number of 4
or 5 alcohols, hydrocarbons, halogenated hydrocarbons, ethers, and esters, each alone or a mixture thereof. Examples of the solvent in the present invention include alcohols having 4 to 5 carbon atoms such as n-butyl alcohol, isobutyl alcohol, sec-butyl alcohol, tertiary-butyl alcohol, n-amyl alcohol, isoamyl alcohol, and sec-amyl alcohol; pentane, hexane, heptane, octane,
Hydrocarbons such as cyclohexane, benzene, toluene, xylene, ethylbenzene, petroleum ether, halogenated hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride, ethylene chloride, trichlorethylene, perchloroethylene, ethyl ether, isopropyl ether , methyl cellosolve, cellosolve, diethyl cellosolve, dioxane, ethers such as tetrahydrofuran, ketones such as acetone, methyl ethyl ketone, methyl acetate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, sec-butyl acetate, amyl acetate and esters such as isoamyl acetate. The extraction temperature (temperature of the extraction solvent) may be cold, room temperature, or high temperature. The Ganoderma lucidum extract to be incorporated into the base of hair nourishing cosmetics may be the extract itself or may be in a dry state. The Ganoderma extract (extract component) of the present invention is in the form of a powder, is safe for the human body, and does not cause skin irritation. As a result of conducting a skin irritation test according to the method of ), both the animal skin irritation score and the human skin irritation score were 0.
It has been confirmed that the extract does not cause skin irritation. [Draize, J.H., Association of Food and
Drugoffcials of the United States Appraisal
of the Safety of Chemicals in Foods Drugs
and Cosmetics, 46 (1959), Texas State
Department of Health Austin) The hair nourishing cosmetics of the present invention can be applied to hair tonics, hair lotions, hair creams, hair creams, etc. according to conventional methods.
It can be made into formulations such as shampoo and rinse. Examples of the base in the hair-growth cosmetic of the present invention include water, alcohols such as ethanol, polyhydric alcohols such as glycerin, liquid paraffin, higher fatty acids (stearic acid, etc.), fatty acid glycerides (glycerin monostearate, etc.) , higher alcohols, animal and vegetable oils, oily substances such as waxes, surfactants (emulsifiers, solubilizers), disinfectants,
A keratolytic agent or the like may be added as appropriate. The hair growth cosmetic of the present invention exhibits a markedly good hair growth promoting effect (hair growth effect) when applied to human or animal skin, and is stable even after long-term storage, and has extremely high commercial value. . Examples will be described below. In the examples, parts mean parts by weight, and % means weight %. Example 1 100g of dried Ganoderma powder was immersed in various solvents (extraction solvents) 2 shown in Table 2, heated to reflux temperature with a condenser, extracted for 2 hours, filtered with suction, and extracted. Add 0.5 of the same solvent to the residue, perform further reflux extraction for 2 hours, and filter again. This operation is repeated two more times to obtain about 3 filtrates. The filtration is concentrated under reduced pressure and dried to obtain each extract. Each lotion (hair nourishing cosmetic) of the present invention was prepared by dissolving 5 g of the obtained extract in 45 g of 50% ethyl alcohol aqueous solution (50% ethanol). Next, the hair growth effect of this lotion on white mice was investigated. DDY white mouse (male, 6 weeks old, average weight 36
g) After cutting the dorsal skin from the tail with electric clippers, remove the hair completely with hair removal cream, and from the next day apply the lotion of the present invention to the skin of the subject area 2 mornings and evenings every day.
0.1 ml per animal was applied twice. A group of 10 animals
Animals in the control group were treated with 50% alcohol water. The hair growth effect was determined by comparing the visual evaluation score, hair length, and hair weight with the control group. Table 1 shows the criteria for determining the hair growth effect.

[Table] On the 15th day after the start of the experiment, the animals were sacrificed and evaluated visually according to the criteria shown in Table 1. The evaluation scores were totaled to determine the average evaluation score per animal. moreover,
Excise the skin from the test area, punch out a certain area of the skin with a punch with a diameter of 12 mm, measure the weight of the hair after drying, and measure the length of 20 hairs, and compare the average value and standard. The deviation was calculated. The results of this experiment are shown in Table 2. As is clear from the results in Table 2, the hair growth promoting effect of the lotion containing the extract of Ganoderma lucidum of the present invention in various organic solvents on mice was remarkable, and both the hair length and hair weight of the sample-applied groups were The value was higher than that of the control group, and the sample-applied group also showed a higher evaluation score by visual evaluation, which confirms the hair-nourishing effect of the sample of the present invention. Example 2 The hair-nourishing effect of the cream containing the extract of Reishi mushroom of the present invention in various solvents on mice was investigated.
The application sample is a cream with the following formula and Reishi extract.

[Table] Things

It was prepared by blending 1% by weight of [Table]. [Formulation] Liquid paraffin 10 parts Stearic acid 5 parts Glyceryl monostearate 6 parts Triethanolamine 1.5 parts Reishi mushroom extract 1.0 parts Purified water 76.5 parts The hair growth effect evaluation experiment was carried out in the same manner as in Example 1, using DDY. The experiment was carried out using white-skinned mice. The results of this experiment are shown in Table 3. As is clear from the results in Table 3, the hair growth promoting effect of the cream containing the extract of Ganoderma lucidum of the present invention in various solvents is remarkable, and both the hair length and hair weight of the sample application group were greater than those of the control group. , the evaluation score was high, and the hair-nourishing effect of Reishi mushroom extract was recognized.

[Table] Example 3 The hair-nourishing effect of a lotion containing extracts of Ganoderma lucidum in various solvents was examined by applying it to the scalps of healthy men. A lotion containing an extract of Ganoderma lucidum was prepared according to the following formulation. [Formulation] 95% ethanol 70 parts Reishi extract 1.0 parts Glycerin 1.0 parts Fragrance 1.0 parts Purified water 27.0 parts In the evaluation experiment, the panelists' hair was shaved 1 cm in diameter from two places on the left and right, 5 cm above the ears. Apply about 3 ml of the lotion containing the extract of Ganoderma lucidum of the present invention in various solvents to the left side twice a day in the morning and evening.
This was done by comparing with the untreated right side. In addition, 10 panelists were used for each sample. The effectiveness was determined by cutting 20 hairs from the test area on the 28th day after the start of the experiment and measuring their length. The results of the experiment are shown in Table 4. As is clear from the results in Table 4, the hair growth promoting effect of the lotion containing extracts of Ganoderma lucidum of the present invention using various solvents is remarkable, and the length of the hair in the sample application area is significantly higher than that in the control area. It turns out that both are effective.

[Table] Extract

Claims (1)

[Scope of Claims] 1. An extract of Reishi mushroom extracted with at least one solvent selected from the group consisting of alcohols having 4 to 5 carbon atoms, hydrocarbons, halogenated hydrocarbons, ethers, and esters. A hair nourishing cosmetic characterized by containing. 2 Reishi mushroom extract is based on the total weight of the composition.
Claim 1 containing 0.01 to 10% by weight
Hair nourishing cosmetics as described in section.