JPH045004B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a novel emulsified skin preparation that maintains the medicinal effects of the skin preparation, improves its applicability to the skin and absorbability, and can also provide skin moisture retaining function. Since ancient times, dangki has been widely used in Chinese medicine as a tonic, sedative, and emmenagogue; baiji as an analgesic, hemostasis, purulent, and purifying agent; and purple root as a detoxifying and antipyretic agent. The usual method for using these substances was to make a decoction, extract them with hot water, and then take the extract internally. However, in China, there are some cases of extracting white root, danggui, etc. with oil and using it as an ointment, and on the other hand, in Japan, there are also cases of extracting white root and danggui with oil and using it as an ointment. There was something called. However, since all of these known ointments are extracted with fats and oils, research by the present inventors has shown that although there are components in the extracted components that have antibacterial and anti-inflammatory properties, there are no residual effects, such as It has been determined that there are no ingredients that have skin moisture retaining or moisturizing effects. On the other hand, since the above-mentioned Chinese herbal therapy was mainly applied internally, the actual efficacy of its ingredients externally (particularly on the skin) has hardly been studied. Therefore, the present inventors developed the above-mentioned three methods for this skin.
A detailed study of the efficacy of the herbal medicine from the species revealed that a fractionated extract using 50-80% ethanol as the extraction solvent contains components that retain moisture and moisturize the skin. Furthermore, in order to further demonstrate the effectiveness of the topical skin preparation, the three herbal medicines mentioned above were extracted with an organic solvent that has little compatibility with water, and the components were added to the oil phase and the 50-80% ethanol fraction mentioned above. The present invention was completed based on the knowledge that an excellent external preparation for skin can be obtained by incorporating each extract into an aqueous phase and mixing and emulsifying these. The present invention provides an oil phase containing a viscous extract obtained by extracting one or more herbal medicines selected from Toki, Shiro, and Shikon with a low polar organic solvent, and This invention relates to an emulsified skin preparation prepared by mixing and emulsifying an aqueous phase containing a powdered extract obtained by extraction with 50 to 80% ethanol. In the present invention, the viscous extract contained in the oil phase is prepared by the following method. That is, first, one or two or more of the three herbal medicines, Toki, Shiro, and Shikon, are arbitrarily selected depending on the purpose, and these are mixed with benzene, n-hexane, chloroform, etc., which have little compatibility with water. Digestion extraction in a low polar organic solvent such as ether or a mixed solvent,
The filtered filtrate is concentrated to dryness using an appropriate method. This is dissolved in ethers, esters, and hydrocarbons used as the oil phase during normal emulsification,
This is used as the oil phase of the emulsion. Further, the method for preparing the powdered extract contained in the aqueous phase is as follows. 50 to 80 doses of the above three herbal medicines
% ethanol at room temperature or digestion treatment,
When the filtered filtrate is concentrated, it contains ingredients that retain and moisturize the skin. but,
From an economic (cost) perspective, it is more advantageous to use the extraction residue after extraction with the organic solvent with low polarity than to extract 50 to 80% ethanol from herbal medicines alone. In order to further increase efficiency, it is more practical to follow the following alternative method. That is, the crude drug is extracted with a less polar organic solvent, and after filtration, the residue is sufficiently re-extracted with water or hot water. It is then filtered and the filtrate is concentrated to an operationally convenient degree. Next, add alcohol to this and adjust the alcohol concentration to 50-80%. Then, insoluble matter (which has almost no water retention ability) precipitates, which is filtered, and the filtrate is collected and concentrated to dryness to obtain a product containing the same components as mentioned above. In order to evaluate the water retention function of the extract obtained as described above, the present inventors used the stratum corneum exfoliated from human feet to test its effectiveness according to methods 1) and 2) below. Tables 1 and 2 for the results.
Shown below. 1) Measurement using extract Γ sample: A Water soluble, 75% EtOH insoluble part (precipitate) B Water and 75% EtOH soluble part C Urea (control) D Water (control) Γ method: Thickness 0.5 The shell layer pressed into tablets with a diameter of 1 cm and 5% of the above A, B, and C
Immerse it in the aqueous solution and D for 30 minutes, then wipe off the excess liquid with tissue paper, and store it at 20℃ and 93%
After 5 days, moisture remains (retention) per 100mg of stratum corneum after leaving it under constant temperature and humidity.
The amount was measured. n=5. 2) Measurement using cream containing extract Γ sample: 2wt% a n-hexane extract
Cream B containing 5wt% of water soluble and 75% EtOH insoluble portion (precipitate) Cream C containing 5wt% of water and 75% EtOH soluble portion
Contains both ingredients A and C (7 wt.
%) cream (product of the present invention) Γ method: This was carried out in the same manner as in 1). n
=5.

【table】

【table】

[Table] As the results in Tables 1 and 2 show, white
It can be seen that the water and 75% EtOH soluble extract of purple root has a clear skin moisture retention effect. Also table-
Even in Cream d (product of the present invention) of No. 2, no decrease in the moisture retention effect was observed, and an excellent external skin preparation could be provided by taking into account the expected effects of Chinese herbal ointments. As a precaution, we compared the wound healing effects (healing rate, healing days) of commercially available Shiun Gypsum and Cream d of the present invention using rabbits, and found that it was as effective as or even more effective than Shiun Gypsum. It was done. The emulsified skin preparation obtained by the present invention further has the following advantages and characteristics. (1) Traditional Chinese herbal ointments are hard and difficult to take in the right amount.
Although it was difficult to apply it uniformly to the skin surface, this drawback was overcome by emulsification. (2) Extraction of Chinese herbal ointments with fats and oils at high temperatures promotes oxidation of the fats and oils, leading to an increase in the POV value, which has a negative effect on the skin, but this problem has been resolved. (3) By emulsifying it, the amount of herbal medicines whose medicinal ingredients are poorly absorbed can be reduced compared to when using ointments. Examples of the present invention are shown below. Incidentally, the proportions in the formulation are in parts by weight. Example 1 Mix 100g of cream and 100g of white cream, add 1 part of hexane
The filtrated filtrate was concentrated to dryness and used as Extract 1. Next, pour the filtered residue into 1.5 liters of hot water.
The filtrate is extracted twice and the filtrate is appropriately concentrated, and alcohol is added to adjust the concentration to 80%. Next, the precipitate is filtered, and the filtrate is concentrated to dryness to obtain Extract 2. These Extract 1 and Extract 2 are each blended into the following cream formulation and emulsified. Oil phase Beeswax 9.0 Liquid paraffin 20.0 Lanolin 3.0 Semi-hardened vegetable oil 25.0 Sorbitan stearate 5.0 Sorbitan stearate-polyoxyethylene-ether 2.0 Extract 1 2.0 Aqueous phase Water 28.0 Extract 2 5.0 Borax 0.7 Preservatives Appropriate amount Fragrance Appropriate amount Example 2 Milk Lotion Take 70g each of Toki, Shiro, and Shikon and mix. The mixture is digested twice with ether 1, filtered and the filtrate is concentrated to dryness to obtain extract 1. Then soak the residue in hot water
Extract twice with 1.5, concentrate the filtrate appropriately, and add alcohol to adjust the concentration to 70%. This is filtered, and the filtrate is concentrated to dryness to obtain Extract 2. These extracts 1 and 2 are blended into the emulsion formulation shown below and emulsified. Oil phase Stearic acid 3.2 Extract 1 1.0 Aqueous phase Glycerin 6.0 Amino acids 0.3 Water 75.5 Alcohol 8.5 Gum tragacanth 2.0 Extract 2 3.0 Preservatives Appropriate amount Flavoring Appropriate amount

Claims (1)

[Scope of Claims] 1. An oil phase containing a viscous extract obtained by extracting one or more crude drugs selected from Toki, Shiro, and Shikon with a low polar organic solvent; An emulsified skin preparation prepared by mixing and emulsifying the crude drug with an aqueous phase containing a powdered extract obtained by extracting the crude drug with 50 to 80% ethanol. 2 The organic solvent with low polarity is selected from benzene, n-hexane, chloroform, ether, etc. 1
The emulsified skin preparation for external use according to claim 1, which is a species or a mixture of two or more species. 3. The powdered extract is obtained by re-extracting the extraction residue obtained by extracting the crude drug with a low polarity organic solvent with 50 to 80% ethanol. Emulsified skin preparation.