JPH04500622A - Syringes for dispensing different types of liquid therapeutics - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] A syringe for dispensing different types of liquid treatments This invention relates to a syringe for injecting drugs, especially insulin.

Such a syringe can be used, for example, under the name "OptiPen J" (registered Insulin syringe of Hoechst ()IOEcH5T) sold under trademark) It is.

Other syringes are named “Insujek” by NORDISK. It is sold under the trademark "Inject-X" (registered trademark).

Finally, there are other "NovoPen I (registered trademark)" and "NovoPen (formerly NovoP)" There are two syringes sold under the trademark "EN II) (registered trademark)".

All of these syringes are capable of administering metered doses of insulin. these are, Virtually any conventional type of insulin can be administered. these syringes requires one type of insulin for each injection, e.g. standard insulin, long-term insulin. Only one type of insulin or mixed insulin can be injected. It has the disadvantage of being ugly.

It is an object of the present invention to inject several types of liquid therapeutic agents, in particular of the type mentioned above. Insulin can be administered simultaneously or sequentially with any combination of elements in one injection. The aim is to provide a syringe of the above-mentioned type that can be administered at Ru.

Here, substances or therapeutic agents, especially insulin, are separated or differentiated. Administer immediately or after a period of time (after mixing in a container containing It is not important whether it is done or not.

According to the invention, this object is achieved by the features of claim 1. inventive Further refinements and advantageous embodiments result from the dependent claims.

Other features, details, advantages and applications can be found in the following description of preferred embodiments of the invention and in the appendices. This will become clear from the accompanying drawings.

FIG. 1 includes an injection housing with a needle body attached to one end and a therapeutic agent; A needle device is disposed within the container chamber and communicates with two containers containing liquid therapeutic agents. A length of the syringe according to the invention, which also has counting and metering means and a syringe release device. FIG.

FIG. 2 is a cross-sectional view of the syringe of FIG. 1 taken along the line ■-■.

FIG. 3 is a cross-sectional view of the syringe of FIG. 1 taken along the line ■-■.

Figure 4 has two single chambers separated from each other by a partition, each of which has a cross-sectional a therapeutic agent container chamber having a separate therapeutic agent container (cartridge) having a hemispherical shape; FIG.

FIG. FIG. 3 is a cross-sectional view of the component therapeutic agent container chamber.

Figure 6 shows triangles arranged spatially adjacent, that is, at the same distance from each other. , a first syringe of the invention connected to three containers, each containing a different therapeutic agent. FIG. 2 is an enlarged view of the injection needle device in Example 2;

FIG. 7 shows separate therapeutic reagent containers separated by a septum and having the shape of a third circle in cross section. It has three separate chambers each containing a cartridge (second chamber in Figure 6). FIG. 2 is a cross-sectional view of a therapeutic agent container chamber (corresponding to an example syringe).

FIG. 8 has three separate therapeutic chambers, each having the shape of a third circle in cross section. 6 is a cross-sectional view of a single-piece therapeutic agent container chamber (corresponding to the second embodiment syringe of FIG. 6); It is.

Figure 9 shows squares arranged spatially adjacent, that is, at the same distance from each other. , a first syringe of the invention connected to four containers, each containing a different therapeutic agent. FIG. 3 is an enlarged view of the injection needle device in Example 3;

FIG. 10 shows separate therapeutic agents separated by a septum and having a quadrant shape in cross section. It has four separate chambers each containing a container (cartridge) (see 3 in Figure 9). FIG. 3 is a cross-sectional view of a therapeutic agent container chamber (corresponding to an embodiment of a syringe).

Figure 11 has four separate therapeutic chambers, each having the shape of a quadrant in cross section. Cross-section of a single-piece therapeutic agent container chamber (corresponding to the syringe of the third embodiment of FIG. 9) It is a diagram.

FIG. 12 is a schematic diagram of another embodiment in which the needle body is secured to the container housing with a locking device; and Figure 13 shows a spring clip device (beer bottle lid method) for attaching the needle body to the container housing. FIG. 14 is a schematic view of another embodiment in which the needle body is secured to the container housing. FIG. 5 is a schematic diagram of another embodiment of fixing with a spring ring device; FIG. 15 is a schematic diagram of a refillable liquid/therapeutic container; FIG. 5 is a schematic illustration of a piston of the refillable liquid/therapeutic container of FIG. 5; FIG. 17 shows the movement along the longitudinal axis (in the open position) to interrupt the supply of liquid. 1 is a schematic illustration of the front of a syringe with a movable needle body; Figure 18 is a schematic view of the front part of the syringe (in the closed position) according to Figure 17; , FIG. 19 shows the rotation around the longitudinal axis (in the open position) for interrupting the supply of liquid. 1 is a schematic diagram of the front part of an injection device with a rotatable needle body; FIG. 20 shows the rotation around the longitudinal axis (in the open position) for interrupting the supply of liquid. It can be additionally inserted into the injection needle from the back side of the rotatable needle body and syringe in the direction of arrow X. 1 is a schematic illustration of the front part of a syringe with a closing body that can be closed; FIG.

As shown in FIG. 1, a syringe l of the invention is attached to one end 3 of the syringe. A syringe needle device 5 arranged in the needle body 4 and a liquid therapeutic agent inserted therein. a container (cartridge) 9 containing the IO, and two therapeutic drug containers for receiving and holding the IO respectively. A cup-shaped container housing 6 having a container chamber (cartridge, container chamber) 7.8, and a housing two counting and metering means arranged in and supported by the counting element 11; and these counting and metering means connect release means 14.15 to the other end 16 of the syringe l. Each has its own.

The needle body 4, preferably made of a plastics material or the like, is a substantially completely cylindrical member. Consists of 2. The injection needle device 5 has a needle tip 18 protruding from one end of the front shoulder surface 26, and two needles. The supply channel 19.2o is embedded in the member 2 so as to protrude from the needle body 4 at the other end of the rear shoulder surface 27. It is set up.

The member 2 has an annular extension 2 extending axially on the projecting side of the supply channel 19.2o. 1 is provided.

Preferably two grooves 22 extending axially and arranged diametrically opposite each other. ．． 23 is formed on the inner surface of the extension 21.

An adjustment spring 24.25 is inserted into each of these grooves. Adjustment spring 24.25 is preferably integral with the extension 21 and is correspondingly formed as a projecting member. Good.

The container housing 6 has an outer surface 29 located axially forward and an axially rearwardly located outer surface 29. It has a container bottom 28 having an inner surface 30. The container bottom 28 is the container bottom 2 It has two holes 36, 37 extending axially through it. The container bottom 28 is It is provided with a stepped container wall 31 which is ring-shaped and cylindrical.

Preferably two longitudinally extending and diametrically arranged grooves 34,35 is formed on the outer surface 33 of the first stepped portion 32 of the container wall 31. With this first stage Portion 32 is in close proximity to container bottom 28. The male thread 40 connects to the next second stepped portion 39 is formed on the outer surface 38 of. The outer surface 41 of the next third stepped portion 42 is the outer surface 41 of the syringe l. Preferably formed as a knurled surface for better handling . An external thread 45 is formed on the outer surface 43 of the next fourth stepped portion 44 . lastly, Preferably two longitudinally extending and preferably diametrically arranged Grooves 48 , 49 are formed in the outer surface 46 of the next fifth stepped section 47 of the container wall 31 . Ru.

Therein, a container housing 6 extends from the container bottom 28 and is fitted with a septum 50. or preferably two therapeutic agent container chambers (cartridge chambers) separated from each other. )7.8.

Therein, container housings 6 extend from container bottom 28 and are interconnected by septum 50. Preferably two or more therapeutic agent container chambers (cartridge chambers) selectively separated from each other. )7.8.

The housing element 11 also has a cup-shaped configuration and extends in the axial direction of the bottom of the housing. It has a housing bottom 51 with an outer surface 52 and an axial inner surface 53 of the housing bottom. ing. In the front region 54 of the side wall 55 of the housing element II, its inner surface 56 is preferably Or maybe two fi5s? , 58, the grooves 57,58 extending longitudinally. are preferably diametrically arranged with adjustment springs 59, 60 each. It is located. The adjustment spring 59,60 is also integral with the housing element 11. good.

The housing bottom 5I has two holes 61, 6 passing through the housing bottom in the axial direction. It has 2.

Preferably, the counting and metering means 12.13 are arranged inside the housing element 11. Preferably, the housing is removably mounted inside the housing.

Counting and metering means 12.13 are located on the inner surface 53 of the housing bottom of the housing element 11. Preferably, it is fixed.

The release device 14.15 is preferably a piston rod 65.66, which The tongue rods 65 and 66 extend in the axial direction and have one end or outer side. An actuation knob 63,64 is provided. The piston rods 65 and 66 are counting and measuring hands. It is in operative communication with stage 12.13 and has a pressure pad 67.6 at the other end or inside. It has 8.

Other members of the syringe 1 of the present invention include a front fixing cap 91, a rear fixing cap 71, and - one or more therapeutic agent containers 80;

The front fixation cap 91 includes a bottom wall 95 having a bottom inner surface 94 and a tubular transverse member 96. It has a cup-shaped body. The tubular transverse member 96 is provided with an internal thread 92 in the front region of its inner surface. It is growing. The bottom wall 95 of the fixed cap 91 is provided with a center hole 97.

The rear fixation cap 71 includes a bottom wall 75 having a bottom inner surface 74 and a tubular transverse member 76. It has a cup-shaped body. The tubular transverse member 76 is provided with an internal thread 72 in the front region of its inner surface. It is growing. The bottom wall 75 of the fixed cap 7I is provided with a center hole 77. Fixed cap The transverse member 76 and/or the bottom wall 75 of the top 71 have at least one viewing and operating opening. A mouth portion 78 is provided.

The commercially available therapeutic agent container 80 consists of a tubular member having an opening 81,82.

The filled therapeutic agent container 80 has an opening 81 facing the supply channel 19.20 that is pierceable. The opening 82 is closed with a flexible membrane 87 and faces the pressure pad 67 of the release device I4. It is closed by a seal, in particular a piston 83, movable within the tubular member.

As shown in FIGS. 4, 5, 7, 8, 1O and 11, the present invention The therapeutic agent container used with the syringe 1 does not necessarily have to have a circular cross section. , according to the invention other cross-sectional shapes, such as semicircular, triangular or quadrant cross-sectional shapes. It may be in the form of In a container of such shape, a container chamber 9, provided in the syringe 1 for lO The space required can be reduced relative to the therapeutic agent container to be accommodated. the result , the overall dimensions (length and diameter) of the syringe of the invention can be reduced, and This improves the storage and handling properties of the syringe.

The invention also provides a method for counting and dispensing different therapeutic agents in different therapeutic agent containers 9.10. The intention is to design the syringe so that the injection can be performed using a single counting and metering device. are doing.

In addition, electric power can be used instead of springs or spring motors to control and drive counting and weighing devices. It is also an object of the present invention to use a mechanical servo motor. These servo motors are , by a microprocessor with a fixed program or a rewritable program. controlled by

Patients who have difficulty handling at least some technical equipment (especially young and elderly patients) A microelectronic syringe used by It is recommended to adopt technology.

In this type of syringe, "counting" is done by a microcomputer, and "weighing" is done by a microcomputer. It is done with an electric servo motor. with solar cells or with any type of terminal An internal storage battery, charged via the power supply, ensures the necessary power supply.

Next, the assembly of the syringe 1 of the present invention will be explained.

(1) First, the container housing 6 is "loaded" with two therapeutic agent containers 9.10. Ru. In other words, the two containers 9, 10 are arranged such that the front edges of the containers 9, 10 are inside the container bottom 28. Slide it in the insertion direction E into the container chamber 7.8 of the container housing 6 until it abuts the surface 30. be moved.

(2) The housing element 11 is attached to the stepped portion 47 of the container wall 31 of the container housing 6. Virtually mounted. Adjustment springs 59,60 are attached to the side walls 55 of the housing element 11. 54 and formed in the stepped portion 47 of the container wall 31 of the container housing 6. into the grooves 48 and 49. The housing element 11 thus forms a container housing. It is fixed so as not to rotate relative to the rod 6. At the same time, the piston rod 65 ．． The two pressure pads 67.68 of 66 are associated with the two therapeutic agent containers 9.10. located precisely in front of the opening 81.82 and the displaceable lid 83.84, where Arranged.

(3) Here, the rear fixing cap 71 is attached to the fourth stepped portion 44 of the container housing 6. the housing element until the male thread 45 engages the female thread 72 of the rear fixation cap 71. 11. When the rear fixed cap 71 is rotated, its bottom inner surface 74 Press down on the bottom outer surface 52 of the housing element 11 so that the front edge of the housing element 11 is aligned with the container housing. the bottom outer surface 52 in the direction of arrow E until it abuts the rear edge of the fourth stepped portion 44 of the ring 6. push. Thereby, the housing element 11 is axially aligned with respect to the container housing 6. fixed in direction.

(4) In order to arrange and fix the needle body 4 to the container housing 6, The annular extension 21 of 4 is slid axially into the first stepped section 32 of the container housing 6. As a result, the adjustment spring 2 disposed on or formed on the extension 21 4.25 engages into a groove 34.35 formed in the first stepped portion 32.

The adjustment springs 24, 25 of the needle body 4 and the grooves 34, 35 of the container housing 6 The supply channels 19 , 20 of the device 5 are connected to holes formed in the container bottom 28 of the container housing 6 . 36.37 and an opening 85 located directly behind the hole 36.37. ．． 86 and a pierceable membrane 87 disposed therein and associated with the therapeutic agent container 9, IO. ．． aligned, arranged, or positioned so that it rests precisely in front of 88 be done.

(5) The front fixing cap 91 slides on the needle body 4, and its internal thread 92 is attached to the container housing. The external thread 40 of the ring 6 is engaged with the external thread 40 of the ring 6. When the fixing cap 91 is turned, its bottom inner surface 94 presses the front shoulder surface 26 of the needle body 4, pushes the needle body 4 in the direction, and the rear end of the needle body 4 abuts the front end of the second stepped portion 39 of the container housing 6. This allows the needle The body 4 is axially fixed to the container housing 6.

(6) Finally, the protective cap 99 protrudes from the front fixing cap 91.

the injection needle 18. This ensures that the user does not suffer any injury and The firing point is protected.

(7) The syringe is normally disassembled for cleaning, maintenance or refilling in reverse order. Ru. Of course, you can remove only the front fixing cap 91 and replace only the needle body 4. It may be removed for this purpose. On the other hand, if the needle body 4 is left in the syringe 1, the syringe 1 Open only the rear part of the container and replace, for example, one or both of the therapeutic agent containers 9 and 10. , or the counting and metering means 12.13 may be adjusted or repaired.

Figures 4.5.7.8.10 and 11 are front views of therapeutic drug containers 9.10, etc. . As is clear from the figure, these containers do not necessarily have to have a round cross section. , other cross-sections may also be provided, in particular semicircular, triangular or quadrant cross-sections.

Container 9, IO, etc. may be separate containers, or they may be integrated into an integrally manufactured tank. It may be converted into This tank has a cross section in the shape of a semicircle, third circle, or quadrant. It consists of several special containers.

These containers may contain the same or different therapeutic agents, especially different insulins. do.

Place the correct therapeutic drug container in front of the counting/measuring means 12, 13 etc. to ensure the desired drug. There is a problem in that they must be placed in each. This means that the container housing by giving the container a special cross-section that ensures constant placement within the container, or is a mark 100 corresponding to the individual marks provided on the container housing (see Figure 5). This is achieved by applying this to the container. This results in the container being placed in a particular position, i.e. This makes it possible to position it at a desired position.

In a preferred embodiment of the invention, the liquid/therapeutic agent container is refillable.

In Figure 15.16, a refilling valve device 89 is provided on the therapeutic drug container. . A chamber 90 filled with disinfectant extends in front of the piston 83 for sterilization and reuse. /or provided on the back and closed with a piston. During the filling process, the bactericidal agent is a therapeutic agent moisten the walls of the container. The piston 83 itself contains a disinfectant and/or a disinfectant. It is configured to include a chamber 90 for bacterial medicine.

The blood glucose measuring device may be structurally combined into an insulin syringe.

Here, the necessary display elements, the measurement of the dose and/or the administered drug and/or microprocessor with control unit for piston travel - is best used in blood sugar measuring devices.

Both the measured blood sugar level and the amount of insulin administered are measured at their corresponding times. Both are required and/or can be transmitted. That is, the measured blood sugar Both the value and the amount of insulin administered are displayed in the observation/display window of the injection/glucose meter. , also PC/AT.

That is, it can be transmitted to/from the terminal (two-way data transmission measuring device). PC/AT and PC/AT-measuring devices are possible).

Insulin injections/glucose monitoring devices are designed with patient needs in mind and/or having a drug calculation program that instructs the person on the corrected dosage; can be inserted into the insulin injection/blood sugar measuring device at any time using a PC/AT terminal. can/can move.

In order to avoid dissipation and evaporation of the liquid between the containers 9 and 10, the needle body 4 has an adjustable closure device (body), i.e. a displaceable closure device (body) or a supply flow Provided with a needle that attaches itself, which can interrupt the communication between the passage 19, 20 and the injection needle 18. There must be.

Figures 17 and 18 illustrate a preferred embodiment of the invention.

The needle body 112 (which can be actuated by a spring 113) The housing 129 is disposed so as to be freely displaceable in the direction of the arrow X-Y along the direction axis. and is supported. The liquid is supplied from the supply channels 119 and 120 to the injection needle 118. , a body formed in the needle body 112, preferably interrupted by the needle 111 itself. can do.

Another preferred embodiment of the invention is shown in FIG. In this example, the longitudinal direction of the syringe rotatably arranged around an adaxial axis (can be actuated by a spring) ) Regarding the needle body 114. Supply of liquid from supply channels 119 and 120 to injection needle 118 The supply is formed in a needle body 114 and a housing 116 that houses the needle body 114. The flow path device 115 can be interrupted by a flow path device 115. A closure that protects the syringe needle tip. The needle body 114 may be rotated by a chain cap (not shown).

In another preferred embodiment of the invention, shown in FIG. needle body 117 along the longitudinal axis of the syringe in the direction of arrow X-Y. The syringe is arranged so as to be rotatable about the longitudinal axis of the syringe with displacement in the direction of .

The supply of liquid from the supply channels 119, 120 to the injection needle 118 is here performed through the needle body 1. A main body 121 formed in 17, a needle main body 117, and a needle main body 117 are accommodated. the flow path device 122 formed in the housing 123; closure device That is, the main body 121 is operated from the rear side of the syringe with respect to the needle tip 118.

17 and 18, the closure device or body 111 is shown on the front side of the syringe, i.e. on the needle. It can be operated from 118. Preferably, the needle body 112 is attached to the housing member 126. It is fixed to a spring plate 124 which is supported by a shoulder 125. Housing member 12 6 is firmly fixed to the housing element 127. (Pressure) spring 113 is , is sandwiched between housing member 126 and housing element 127. spring 113 presses the spring plate 124 against the shoulder 125 in the direction of arrow X. Figure 18 As shown in FIG. It is movable against the force of the spring 113. The cap is a syringe housing 12 9, the cap is pressed against the needle body ]12 in the direction of arrow Y. It will be done. supported by the injection device 130 and located near the supply channel 119, 120; The ends of the body 111 that close the two supply channels 119,120. Injection device 1 30 injection needles 118 are preferably 131 as shown in FIGS. 18 and 19. It is removably attached to the needle body 112 while being screwed into the needle body 112 with rollers. It is being

It also includes a closure device or closure that closes off the supply channel 119, 120 in the inactive position of the syringe. The chain body may be attached directly to the closure cap 128. The closure device or closure body is It is extremely thin and can bend or break if the syringe is not properly closed. There is a risk of

Additionally, the closure device 111112 can be actuated from the longitudinal side of the syringe. It may be designed to do so.

The closure device 111112 is advantageously configured as shown in FIGS. 17, 18 and 20. can be inserted into the injection channel 132 at the mouth of the supply channel 119, 120. can.

The injection closing position, where the liquid is mixed and an airtight seal is ensured, is adjustable or movable. Can be obtained with a possible closure device.

For example, if the device is used for a long time in a vest, jacket, or shirt pocket and is worn on the body. The syringe may heat up, causing water or other solvents to evaporate from the liquid therapeutic agent. . This increases the concentration of therapeutic agent. The drug then becomes useful for the patient's health. Administered to patients at concentrations too high to be harmful. The measurements described above are intended to address such adverse effects as well as drug Prevents the possibility of inadvertent mixing of different therapeutic agents prior to administration.

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Claims (1)

[Claims] 1. a container housing and a therapeutic agent container disposed within the container housing; A removably connected syringe needle and a device for counting and metering the amount of therapeutic agent to be administered. In a syringe for dispensing a liquid therapeutic agent, in particular insulin, the syringe has a counting and metering device for dispensing the drug and a release device for expelling the therapeutic agent from the discontinuing needle, comprising: (a) in said container housing (6); A plurality of therapeutic drug containers (9, 10) filled with different types of liquid therapeutic drugs, in particular different types of insulin, are arranged, one end (81) of each therapeutic drug container being provided with a pierceable membrane (87). (b) said injection needle (17) is connected to an injection needle device (5) disposed in the needle body (4); ), the needle device comprises an injection member 18 and a plurality of supply channels (19, 20) terminating in the injection member 18 and optionally extending to the needle tip (18a); (c) Before The ends of the supply channels (19, 20) are formed as sharp blades for piercing the membrane (87) of the therapeutic agent container (9, 10), or alternatively , in particular via a tube or the like; (d) the needle body (4) is connected to the container chamber (7, 8) by means of a first anti-rotation device (24, 25/34, 35); (e) at least one counting and metering device (12, 13) or said therapeutic agent container (9); , 10) are provided, said counting and metering devices being arranged in a housing element (11), said housing element having a second rotational arrester. It is fixed against rotation to the container chamber (7, 8) using devices (48, 49/59, 60), and is secured against rotation using a second fixing device (71). (f) each of said counting and metering devices (12, 13) has at least one release device (14, 15) for release of said therapeutic agent; The devices each A movable closure, in particular a syringe, in operative communication with a piston (65, 66) of a therapeutic agent container (9, 10). 2. The needle body (4) consists of a member (2) which is substantially polygonal, in particular cylindrical in cross section, and the injection needle device (5) has at least two supply channels (19, 20) at the front. The injection member (18) having a needle tip (18a) has one end at the front shoulder surface (26) and the other end at the rear shoulder surface (27), and is buried so as to protrude from the needle body (4). The syringe according to claim 1. 3. The member (2) has an axial direction on the protruding side of the supply channel (19, 20). An annular extension (21) is provided extending in the axial direction, the lateral inner surface of said extension being formed with one or several, in particular two, grooves (22, 23), which grooves extend in the axial direction, i.e. 3. A syringe according to claim 2, wherein the grooves extend longitudinally and are preferably diametrically arranged, into which adjustment springs are respectively inserted. 4. The axial extension may be polygonal or elliptical, or may have other geometric shapes. 2 . 2 . 2 . The syringe described in. 5. The adjustment springs (24, 25) also have a protrusion corresponding to the extension (21). 4. The syringe of claim 3, wherein the syringe is integrally molded as a material. 6. Said container housing (8) has an axially forwardly located outer surface (29) and an axially located outer surface (29). 6. The container according to claim 1, wherein the container bottom has two holes (36, 37) extending axially through the bottom. Syringe as described. 7. A stepped container wall (31) of generally annular cylindrical form is molded into said container bottom (28). 7. The syringe according to claim 6, wherein: 8. Preferably two longitudinally extending and diametrically arranged grooves (34, 35) are provided in the vicinity of said container bottom (28) and in a first stepped section associated with the container wall (31). A syringe according to claim 6 or 7, characterized in that it is formed on the lateral outer surface (33) of the portion (32). 9. a first stepped portion adjacent to the container bottom (28) and related to the container wall (31); On the lateral outer surface (33) of the portion (32) or on the vessel bottom (28) itself, extending in the axial direction and having a polygonal or elliptical or other geometrical shape, the feed channel (19, 20 6.) The connecting sleeve, through which one or more holes pass through, is configured to allow a secure connection with the extension of the member (2). or the syringe described in 7. 10. A syringe according to any of claims 5 to 9, characterized in that the lateral outer surface (38) of the second stepped portion (39) is formed with an external thread (40). 11. The lateral outer surface (41) of the next third stepped portion (42) is suitable for handling the syringe (1). 11. A syringe according to any one of claims 5 to 10, characterized in that the syringe is configured as a knurled surface to improve injection. 12. A male thread (45) is formed on the lateral outer surface (43) of the next fourth stepped portion (44). The syringe according to any one of claims 5 to 11, characterized in that: 13. Preferably two longitudinally extending and preferably diametrically arranged grooves (48, 49) are provided on the lateral outer surface (46) of the fifth stepped section (47) next to said container wall (31). The syringe according to any one of claims 5 to 12, characterized in that the syringe is formed as follows. 14. The interior of the container housing (6) extends from and is spaced apart from the container bottom (28). Preferably one or more therapeutic agent containers optionally separated from each other by a wall (50). The syringe according to any one of claims 5 to 13, characterized in that it has a cartridge chamber. 15. Said housing element (11) also has a generally cup-shaped configuration, and the housing element (11) Claims 1 to 14, characterized in that the housing bottom (51) has an axially outer surface (52) of the housing bottom and an axially inner surface (53) of the housing bottom. A syringe as described in any of the above. 16. Preferably two grooves (57, 58), extending longitudinally and preferably arranged diametrically, into which adjustment springs (59, 60) are respectively inserted, are provided in the front. Syringe according to claim 15, characterized in that it is formed on the lateral inner surface (56) of the front region (54) of the side wall (55) of the housing element (11). 17. Syringe according to claim 15 or 16, characterized in that the adjustment spring (59, 60) is molded in one piece with the housing element (11). 18. Syringe according to claims 15 to 17, characterized in that the housing bottom (51) has two holes (61, 62) passing axially through the bottom. 19. Claims characterized in that the counting and metering means (12, 13) are preferably arranged inside the housing element (11) and are preferably removably fixed inside the housing. The syringe according to items 1 to 18. 20. Said counting and metering means (12, 13) are arranged in the halves of said housing element (11). 20. Syringe according to claim 19, characterized in that it is fixed to the inner surface (53) of the housing bottom. 21. Preferably, said release device (14, 15) is a piston rod (65, 66), which extends axially and has an actuating nozzle at one end or outside. (63, 64) and is in operative communication with the counting and metering means (12, 13) and is provided at the other end or inside with a pressure pad (67, 68). 21. The syringe according to any one of claims 1 to 20. 22. Injection according to any of claims 1 to 21, characterized by a front fixation cap (91), a rear fixation cap (71) and a plurality of therapeutic agent containers (80). vessel. 23. The front fixing cap (91) has a bottom wall (95) having a bottom inner surface (94) and a tube. a cup-shaped body with a tubular transverse member (96), which is provided with an internal thread (92) in the front region of its transverse inner surface, and the bottom wall (95) of said fixing cap (91) has a central 23. Syringe according to claim 22, characterized in that it has a central hole (97). 24. Said rear cap (71) is a cup-shaped body having a bottom wall (75) with a bottom inner surface (74) and a tubular transverse member (75), which has an internal thread (72) in the front region of its transverse inner surface. ) The syringe according to claim 22, characterized in that the syringe comprises: 25. The bottom wall (75) of the fixation cap (71) comprises a central hole (77) and a lateral member (76), and/or the bottom wall (75) of the fixation cap (71) includes at least one A claim characterized in that it is provided with a viewing and operating opening (78). The syringe according to item 22. 26. A union nut secures the needle body (4) to the container housing (6). The needle body (4) is used for The syringe according to any one of claims 1 to 25, characterized in that: 27. A spring serves to secure the needle body (4) to the container housing (6). The syringe according to any one of claims 1 to 26, characterized in that it is used as a lid for a bottle. 28. 27. According to any one of claims 1 to 26, characterized in that laterally arranged leaf springs are used for fixing the needle body (4) to the container housing (6). syringe. 29. In order to secure the needle body (4) to the container housing (8), the actuating position 27. A syringe according to any one of claims 1 to 26, characterized in that both parts are each provided with a locking element which is interengagable in position. 30. The therapeutic agent containers (9, 10) used in the syringe (1) are not necessarily round. other cross-sectional shapes, especially in the form of semicircles, thirds, or quadrants; The method according to any one of claims 1 to 29 may have a planar shape. A syringe as described in any of the above. 31. The therapeutic agent containers (9, 10) used in the syringe (1) are not necessarily round. Individual containers may also have a particularly effective insulator, but may have other cross-sectional shapes, in particular regular polygons, non-regular polygons, or other geometric cross-sections. Claims 1 to 3, characterized in that they may have different volumes, in particular in a fixed ratio, such as 1/3:2/3 or 1/2:1/2, as required for phosphorus therapy. The syringe according to any of Item 29. 32. Claim 32 provides a single-piece therapeutic agent container of any cross-section in which a plurality of chambers, each containing the same or different therapeutic agents, may have different dimensions. Syringe as described. 33. The single-piece therapeutic agent container must be placed in a precisely defined position to avoid incorrect placement. 33. A syringe according to claim 32, characterized in that it has a geometric cross-section of any shape that allows it to be inserted into a therapeutic agent container chamber with the same cross-section at any position. 34. The single-piece therapeutic agent container must be placed in a precisely defined position to avoid incorrect placement. It can be inserted into a corresponding therapeutic drug container with corresponding markings located in the 33. A syringe according to claim 32, characterized in that it has any type of geometric or mechanical markings. 35. Claims 1 to 34, characterized in that only one counting and metering means is used for counting and metering the different medicines contained in the different therapeutic agent containers (9, 10). A syringe as described in any of the above. 36. for controlling and driving said piston, counting and metering means (12, 13); Therefore, one or more electric servo motors or steps can be used instead of mechanical manual functions. A fixedly programmed microprocessor is used. The "counting" operation is performed by the minicomputer and the "weighing" operation is controlled by the servo motor or a freely programmable microprocessor. 36. A syringe according to any one of claims 1 to 35, characterized in that the steps are carried out by a stepping motor. 37. Said piston or actuation knob (83, 63, 64) is particularly 37. A syringe according to any one of claims 1 to 36, characterized in that it can be operated by pressure generated by the syringe. 38. The dosage of said therapeutic agent is determined by the respective supply channels (19, 20) and/or is measured for the injection needle (17) and/or the injection member (18) itself. the therapeutic agent is dispensed and/or pumped in metered amounts and controlled A syringe according to any one of claims 1 to 18, characterized in that the operations are performed by a microprocessor. 39. The dosage of said therapeutic agent is determined by the displacement of the piston (83) of the respective therapeutic agent container and/or by the movement of liquid in the respective supply channel (19, 20) and/or by the displacement of the liquid in said injection needle (17). and/or the movement of liquid in said injection member (18) by optical or magnetic or electrical methods, for example by measuring resistance, in particular using the Doppler effect. The syringe according to any one of claims 1 to 31, characterized by: 40. In particular, the dosage of the liquid and/or the dosage of the remaining liquid is provided in at least one table. A syringe according to claim 39, characterized in that it is made visible by an indicating element. 41. The microprocessor and the servo motor can be connected by installing a storage battery that can be recharged by a solar cell or any external power unit. The feature is that the necessary power supply to the motor or step motor is ensured. The syringe according to any one of claims 36 to 40. 42. (a) within the container housing (6) two or more therapeutic agent containers (9, 10) are insertable in the insertion direction (E) into the container chamber (7, 8) of the container housing (6); The front end of the container chamber (9, 10) is thereby brought into contact with the inner surface (30) of the container bottom (28). (b) the housing element (11) is attached to the step (47) of the container wall (31) of the container housing (6), and in the attached state the housing element (11) is attached to the side wall ( The adjustment springs (59, 60) provided in the portion (54) of the container housing the housing element (11) is rotated relative to the container housing. The two pressure pads on the piston rod (65, 66) The doors (67, 68) are disposed directly in front of the openings (81, 82) and movable closures (83, 84) disposed in the openings and attached to the two therapeutic drug containers (9, 10). , (c) The rear fixing cap (71) has its female thread (72) engaged with the male thread (45) of the fourth step (44) of the container housing (6), and the fixing cap (71) is rotated. The housing element (11) is adapted to slide over the housing element (11) until the bottom inner surface (74) rests on the outer housing bottom surface (52), the housing element (11) having its front end in the fourth position of the container housing (6). an annular extension of the needle body (4), movable in direction (E) until it abuts the rear end of the step (44), and (d) for fixing the needle body (4) in the container housing (6); The body (21) is axially slidable on the first step (32) of the container housing (6), and upon sliding, the adjustment spring (24, 25) is engaged with the grooves (34, 35) formed in the first step (32), and the adjustment grooves (24, 25) of the needle body (4) and the grooves (34, 3) of the container housing (6) 5) means that the supply channels (19, 20) of the injection needle device (5) are directly in front of the holes (36, 37) formed in the container bottom (28) of the container housing (6), and , 3 7) and in front of the penetrable member (87, 88) disposed in the opening and attached to the therapeutic agent container (9, 10). (e) The front fixing cap (91) has its female thread (92) engaged with the male thread (40) of the container housing (6), and the fixing cap (91) is rotated to close the fixing cap (91). The needle body (4) is adapted to slide over the needle body (4) until its bottom inner surface (94) contacts the front shoulder surface (26) of the needle body (4); container c The needle body (4) is movable in the (K) direction until it abuts the second step (39) of the housing (6), and the needle body (4) is fixed in the axial direction with respect to the container housing (6), and (f) the protection The cap (99) protects the user from injury and the needle (18) from damage. It is slidable on the injection outside (18) protruding from the front fixed cap (91) for (g) The syringe (1) is dispensed in reverse order for cleaning, maintenance or refilling. It is possible to remove only the needle body (4) for replacement by removing only the front fixation cap (91), and on the other hand, if the needle body (4) is left in the syringe (1). may, for example, take one or several therapeutic agent containers (9, 10). or cleaning, adjusting or repairing the counting/measuring means (12, 13). 42. Syringe according to any of claims 1 to 41, characterized in that only the rear part of the syringe (1) can be removed in order to remove the syringe (1). 43. Different therapeutic agents, especially insulins with individual components, may be used, regardless of whether the therapeutic agents are introduced into an additional container before injection or mixed and subsequently injected. 43. The syringe according to any one of claims 1 to 42, wherein the phosphorus can be freely mixed and used simultaneously or sequentially in a single injection. 44. The liquid/therapeutic container is refillable, and (a) a refill valve arrangement is provided on the therapeutic container, and (b) a chamber filled with sterilizing agent is provided for sterilization and reuse. is provided in front of and/or behind the piston (83) and is sealed by the piston, said sterilizing agent moistening the therapeutic agent container during the filling process. The syringe described in. 45. 45. Syringe according to claim 44, characterized in that, in particular, the piston (83) itself is configured to accommodate a sterilizing agent and/or to include a sterilizing agent chamber. 46. The blood glucose measuring device is structurally integrated with the insulin syringe and is A microprocessor is used to measure blood sugar, and the microprocessor The service shall include the necessary display elements and the measurement of the dose and/or the amount administered and/or the 46. A syringe according to any one of claims 1 to 45, characterized in that it includes a control unit for the ton displacement. 47. Both the measured blood glucose level and the insulin dose are measured at their corresponding times. Both the measured blood glucose level and the insulin dose may be required and/or transmitted at the observation/display window of the injection/glucose measuring device and also at the P C/AT, i.e. Bidirectional data transmission from measurement/injection device to computer, etc. possible 47. A syringe according to claim 46, characterized in that it can be transmitted to/from a capable terminal. 48. Insulin injections/glucose monitoring devices should be used in consideration of patient needs and/or The system has a dosage calculation program that instructs the patient to modify the dosage, and the modified program is transmitted to the insulin injection/blood glucose measuring device using a PC/AT terminal (including remote transmission via modem, etc.). The request is characterized in that it can be transported at any time to The syringe according to item 46. 49. In order to prevent diffusion between the containers (9, 10) as well as evaporation of the liquid, the needle bodies (112, 114, 117) are provided with adjustable or movable closure devices (111, 112). 49. Any one of claims 1 to 48, characterized in that the closure device is provided, and the communication between the supply channel (119, 120) and the injection needle (118) can be interrupted. The syringe described in. 50. The needle body (4) (which can be actuated by a spring) is movable in the longitudinal axis of the syringe, and the supply of liquid from the supply channels (19, 20) to the injection needle (18) is controlled by the needle. be interrupted by a plunger formed in the body (4); The syringe according to claim 49, characterized in that: 51. The needle body (114) (which can be actuated by a spring) is rotatable about the longitudinal axis (L) of the syringe and directs liquid from the supply channels (119, 120) to the injection needle (118). The supply includes a rotatable outer body (114) and a rotatable outer body (114) containing the same. 50. A syringe according to claim 49, characterized in that it is interrupted by a channel arrangement (115) formed in the housing (116) containing the syringe. 52. The needle body (117) (which can be actuated by a spring) is movable along the longitudinal axis (L) of the syringe and rotatable about this axis. The supply of liquid from the supply channels (119, 120) to the outside of the injection (118) is carried out by the needle book. interrupted by a body (121) formed in the body (117) and by a channel arrangement (122) formed in the rotatable needle body (117) and the housing (123) containing it; A syringe according to claim 49, characterized in that: 53. The connecting channel (115, 122) is composed of a tube device that can be compressed from the outside from the main body (111, 121) and a connecting part of the supply channel (119, 120). 53. A syringe according to any one of claims 49 to 52, characterized in that the syringe is interrupted without piercing the syringe. 54. The main body (121) is actuated from the rear side of the syringe toward the needle tip (118). The syringe according to claim 50, characterized in that: 55. 51. Syringe according to claim 50, characterized in that the body (11) is actuated from the front side of the syringe, i.e. from the needle tip (118). 56. 51. Syringe according to claim 50, characterized in that the body (111, 121) is actuated from the longitudinal side of the syringe. 57. Any one of claims 50 to 56, characterized in that the main body (111, 112) is inserted into an injection channel (132) in which the supply channel (119, 120) is open. The syringe described in. 58. It is characterized in that the filling and closing position, which ensures mixing of the liquid as well as a gas-tight seal, is achieved by an adjustable, i.e. movable, closing device (111, 121). The syringe according to any one of claims 49 to 57. 59. The needle (111), together with its fitting, The needle (111) is movable by force along the longitudinal axis (L) of the syringe, and the needle (111) is thus moved from the open position shown in FIG. 17 to the closed position shown in FIG. Claims 49 to 58, characterized in that the invention is movable. syringe. 60. A claim characterized in that the movement is effected by the cap (128) of the syringe. The syringe according to item 59. 61. Claim characterized in that when the cap (128) of the syringe is removed, the needle (11) is pushed by the spring (113) into the injection position shown in FIG. The syringe according to item 59 or item 60.