JPH04504117A - グリコシル化インシュリン - Google Patents

グリコシル化インシュリン

Info

Publication number
JPH04504117A
JPH04504117A JP2504720A JP50472090A JPH04504117A JP H04504117 A JPH04504117 A JP H04504117A JP 2504720 A JP2504720 A JP 2504720A JP 50472090 A JP50472090 A JP 50472090A JP H04504117 A JPH04504117 A JP H04504117A
Authority
JP
Japan
Prior art keywords
insulin
glycosylated
phe
human
human insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2504720A
Other languages
English (en)
Japanese (ja)
Inventor
ハルストレーム，ヨーン，ブロベルウ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of JPH04504117A publication Critical patent/JPH04504117A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2504720A 1989-03-08 1990-03-06 グリコシル化インシュリン Pending JPH04504117A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK111489A DK111489D0 (da) 1989-03-08 1989-03-08 Peptider
DK1114/89 1989-03-08

Publications (1)

Publication Number Publication Date
JPH04504117A true JPH04504117A (ja) 1992-07-23

Family

ID=8101165

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2504720A Pending JPH04504117A (ja) 1989-03-08 1990-03-06 グリコシル化インシュリン

Country Status (19)

Country Link
EP (1) EP0462192A1 (da)
JP (1) JPH04504117A (da)
KR (1) KR920701249A (da)
CN (1) CN1045586A (da)
AU (1) AU638701B2 (da)
CA (1) CA2049937A1 (da)
CS (1) CS114290A3 (da)
DD (1) DD296933A5 (da)
DK (1) DK111489D0 (da)
FI (1) FI914226A0 (da)
GR (1) GR1000604B (da)
HU (1) HUT59942A (da)
IL (1) IL93674A0 (da)
NO (1) NO913517L (da)
NZ (1) NZ232808A (da)
PT (1) PT93366A (da)
WO (1) WO1990010645A1 (da)
YU (1) YU45490A (da)
ZA (1) ZA901737B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2033662B1 (en) 2004-01-21 2012-10-17 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
RU2011135730A (ru) 2009-01-28 2013-03-10 Смартселлз, Инк. Кристаллические инсулин-коньюгаты
JP2012516339A (ja) 2009-01-28 2012-07-19 スマートセルズ・インコーポレイテツド 外因的刺激型制御放出物質体およびその使用
WO2010088294A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Conjugate based systems for controlled drug delivery
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
JP2012520879A (ja) 2009-03-20 2012-09-10 スマートセルズ・インコーポレイテツド 末端官能基化コンジュゲートおよびその用途
JP2013535467A (ja) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
WO2012015681A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
WO2012015691A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinant lectins, binding-site modified lectins and uses thereof
DK2877200T3 (da) * 2012-07-17 2019-08-12 Univ Case Western Reserve O-bundne carbonhydratmodificerede insulinanaloger
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
EP2919804B1 (fr) * 2012-11-13 2018-01-31 Adocia Formulation à action rapide d'insuline comprenant un composé anionique substitué
EP2925345B1 (en) 2012-12-03 2018-09-05 Merck Sharp & Dohme Corp. Method for making o-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
US9884125B2 (en) 2013-10-04 2018-02-06 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
CN105535927A (zh) * 2016-01-29 2016-05-04 山东中海制药有限公司 一种用于治疗流感、上呼吸道感染、病毒性肺炎的药物
CN105709207A (zh) * 2016-01-29 2016-06-29 徐宝贞 一种用于治疗痛风的药物
CN105597080A (zh) 2016-01-29 2016-05-25 程潜 一种用于治疗尿毒症和尿蛋白的药物
MX2018014929A (es) 2016-06-02 2019-08-26 Sanofi Sa Conjugados de un agente farmaceutico y una porcion capaz de unirse a una proteina sensora de glucosa.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
EP0119650A3 (en) * 1983-03-21 1987-09-30 THE PROCTER & GAMBLE COMPANY Galactosyl-insulin conjugates useful in treating diabetics
HU206890B (en) * 1986-10-13 1993-01-28 Sandoz Ag Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components

Also Published As

Publication number Publication date
PT93366A (pt) 1990-11-07
NO913517D0 (no) 1991-09-06
DK111489D0 (da) 1989-03-08
FI914226A7 (fi) 1991-09-06
CA2049937A1 (en) 1990-09-09
WO1990010645A1 (en) 1990-09-20
NO913517L (no) 1991-11-06
FI914226A0 (fi) 1991-09-06
KR920701249A (ko) 1992-08-11
EP0462192A1 (en) 1991-12-27
AU638701B2 (en) 1993-07-08
HUT59942A (en) 1992-07-28
DD296933A5 (de) 1991-12-19
NZ232808A (en) 1992-04-28
GR1000604B (el) 1992-08-26
YU45490A (en) 1991-10-31
AU5280790A (en) 1990-10-09
GR900100159A (en) 1990-07-31
HU902787D0 (en) 1991-11-28
ZA901737B (en) 1990-11-28
CN1045586A (zh) 1990-09-26
CS114290A3 (en) 1992-02-19
IL93674A0 (en) 1990-12-23

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