JPH04504117A - グリコシル化インシュリン - Google Patents

グリコシル化インシュリン

Info

Publication number
JPH04504117A
JPH04504117A JP2504720A JP50472090A JPH04504117A JP H04504117 A JPH04504117 A JP H04504117A JP 2504720 A JP2504720 A JP 2504720A JP 50472090 A JP50472090 A JP 50472090A JP H04504117 A JPH04504117 A JP H04504117A
Authority
JP
Japan
Prior art keywords
insulin
glycosylated
phe
human
human insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2504720A
Other languages
English (en)
Japanese (ja)
Inventor
ハルストレーム，ヨーン，ブロベルウ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of JPH04504117A publication Critical patent/JPH04504117A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2504720A 1989-03-08 1990-03-06 グリコシル化インシュリン Pending JPH04504117A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK111489A DK111489D0 (da) 1989-03-08 1989-03-08 Peptider
DK1114/89 1989-03-08

Publications (1)

Publication Number Publication Date
JPH04504117A true JPH04504117A (ja) 1992-07-23

Family

ID=8101165

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2504720A Pending JPH04504117A (ja) 1989-03-08 1990-03-06 グリコシル化インシュリン

Country Status (19)

Country Link
EP (1) EP0462192A1 (de)
JP (1) JPH04504117A (de)
KR (1) KR920701249A (de)
CN (1) CN1045586A (de)
AU (1) AU638701B2 (de)
CA (1) CA2049937A1 (de)
CS (1) CS114290A3 (de)
DD (1) DD296933A5 (de)
DK (1) DK111489D0 (de)
FI (1) FI914226A7 (de)
GR (1) GR1000604B (de)
HU (1) HUT59942A (de)
IL (1) IL93674A0 (de)
NO (1) NO913517L (de)
NZ (1) NZ232808A (de)
PT (1) PT93366A (de)
WO (1) WO1990010645A1 (de)
YU (1) YU45490A (de)
ZA (1) ZA901737B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2642214T3 (es) 2004-01-21 2017-11-15 Novo Nordisk Health Care Ag Conjugación de péptidos mediante transglutaminasa
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
WO2010088268A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
WO2010088300A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Crystalline insulin-conjugates
BRPI1007457A2 (pt) 2009-01-28 2015-08-25 Smartcells Inc Conjungado, formulação de liberação prolongada, e, sistema de distribuição de bomba.
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
US8623345B2 (en) 2009-03-20 2014-01-07 Smartcells Terminally-functionalized conjugates and uses thereof
EP2598522A4 (de) 2010-07-28 2014-11-12 Smartcells Inc Rekombinante lektine, bindungsstellenmodifizierte lektine und anwendungen davon
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
JP2013535467A (ja) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
EP2877200B1 (de) * 2012-07-17 2019-05-08 Case Western Reserve University O-verknüpfte kohlenhydratmodifizierte insulinanaloga
CN104902922B (zh) 2012-11-13 2017-12-12 阿道恰公司 包含经取代阴离子化合物的速效胰岛素制剂
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
WO2014160185A2 (en) 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
KR20160065930A (ko) 2013-10-04 2016-06-09 머크 샤프 앤드 돔 코포레이션 글루코스-반응성 인슐린 접합체
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
CN105597080A (zh) * 2016-01-29 2016-05-25 程潜 一种用于治疗尿毒症和尿蛋白的药物
CN105535927A (zh) * 2016-01-29 2016-05-04 山东中海制药有限公司 一种用于治疗流感、上呼吸道感染、病毒性肺炎的药物
CN105709207A (zh) * 2016-01-29 2016-06-29 徐宝贞 一种用于治疗痛风的药物
CA3025988A1 (en) 2016-06-02 2017-12-07 Sanofi Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
EP0119650A3 (de) * 1983-03-21 1987-09-30 THE PROCTER & GAMBLE COMPANY Galactosyl-Insulin-Konjugate für die Behandlung von Zuckerkranken
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.

Also Published As

Publication number Publication date
HU902787D0 (en) 1991-11-28
HUT59942A (en) 1992-07-28
NZ232808A (en) 1992-04-28
PT93366A (pt) 1990-11-07
NO913517D0 (no) 1991-09-06
DD296933A5 (de) 1991-12-19
GR900100159A (en) 1990-07-31
GR1000604B (el) 1992-08-26
WO1990010645A1 (en) 1990-09-20
NO913517L (no) 1991-11-06
EP0462192A1 (de) 1991-12-27
AU638701B2 (en) 1993-07-08
FI914226A0 (fi) 1991-09-06
CA2049937A1 (en) 1990-09-09
KR920701249A (ko) 1992-08-11
CN1045586A (zh) 1990-09-26
CS114290A3 (en) 1992-02-19
AU5280790A (en) 1990-10-09
ZA901737B (en) 1990-11-28
DK111489D0 (da) 1989-03-08
YU45490A (en) 1991-10-31
FI914226A7 (fi) 1991-09-06
IL93674A0 (en) 1990-12-23

Similar Documents

Publication Publication Date Title
JPH04504117A (ja) グリコシル化インシュリン
US20220133898A1 (en) Derivatisation of Insulin with Polysaccharides
US9452224B2 (en) Sialic acid derivatives for protein derivatisation and conjugation
EP0125299B1 (de) Glykosylierte insulinabkömmlinge
AU641991B2 (en) Novel insulin compositions
US4536572A (en) Amido-phenyl-α-D-glucopyranoside derivatives
ES2205226T3 (es) Complejo de carbohidratos extraido de mycobacterium tuberculosis y procedimiento para la preparacion del mismo.
US4489064A (en) Glycosylated insulin derivatives
JP3522798B2 (ja) 糖修飾蛋白質の製造法
US4478830A (en) Glycosylated insulin derivatives
US4489063A (en) Glycosylated insulin derivatives
SU1735307A1 (ru) Конъюгат аденилил(2 @ -5 @ ) аденилил-(2 @ -5 @ ) аденозина с бычьим сывороточным альбумином, используемый дл получени антител, специфичных к 2 @ , 5 @ - олигоаденилатам
JPH0762038B2 (ja) グリコシル化インシュリン及びそれを含む糖尿病治療剤
JPH07107080B2 (ja) グリコシル化インシュリン及びそれを含む糖尿病治療剤
JPH06508114A (ja) パリトキシン関連プロドラッグおよびその投与方法