JPH0461842B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention is based on the general formula The present invention relates to a liquid preparation and an aerosol preparation for controlling indoor mites, which are characterized in that the compound represented by the above or one or two of a pyrethroid synergist and an insect repellent are added thereto. An extremely wide variety of mites inhabit the earth, and for example, citrus spider mites, two-spotted spider mites, etc. that parasitize plants cause great damage to agricultural crops. These acaricides for agricultural use have been under development for a long time, and new and promising compounds have recently been discovered one after another. On the other hand, due to changes in the living environment in recent years, dust mites, dust mites, etc. have been occurring in homes, causing not only discomfort but also problems such as allergic asthma and skin rashes. It has been known that organic phosphorus agents such as Sumithion and Diazinon are effective against these indoor mites, but there are obstacles to practical application due to safety and resistance issues for humans and livestock, and accurate extermination is difficult. Establishment of a method became urgently needed. In view of the above-mentioned current situation, the present inventors continued intensive research with the aim of developing acaricides that can be safely used indoors, and as a result, we found that phenothrin, a pyrethroid compound represented by the general formula () alone, or combined with isobornyl thiocyanate (hereinafter referred to as IBTA), octachlorodipropyl ether (hereinafter referred to as S-421), piperonyl butoxide, N-(2-ethylhexyl)-bicyclo[2,2,1]hepta-
5-ene-2,3-dicarboximide (hereinafter referred to as cinepirin 222), N-(2-ethylhexyl)-1-isopropyl-4-methylbicyclo[2,2,2]oct-5-ene-2, 3-dicarboximide (hereinafter referred to as cinepirin 500),
Synergists for pyrethroid such as 2-butoxy-2'-thiocyanodiethyl ether (hereinafter referred to as Riesen 384) and insect pests such as N,N-diethyl-m-toluamide (hereinafter referred to as DEET) and benzyl benzoate. The present invention has been completed by discovering that a composition containing one or two types of repellents exhibits an extremely high acaricidal effect on white mites, dust mites, dust mites, and the like. By the way, pyrethroids of the general formula () have high insecticidal power and a wide insecticidal spectrum, and are widely used as highly safe insecticides for household and agricultural purposes. is extremely weak and has traditionally been considered difficult to apply to all mites. However, the present inventors believe that there are some ecological differences between mites that live on plants, such as citrus spider mites and red-spotted spider mites, and mites that occur indoors, such as white mites and house dust mites, and have investigated the effects of various compounds on the latter mites. As a result of our investigation, we surprisingly found that the pyrethroids of the general formula () have high acaricidal efficacy specifically against mites living indoors, and that several pyrethroids, which have recently been announced to have excellent acaricidal activity, We discovered that the new pyrethroids are not necessarily effective against mites that live indoors. Furthermore, the compound in which a cyano group is introduced into the benzyl position of the alcohol moiety in the general formula () has superior insecticidal and spider mite-killing activity compared to the original compound, but it is effective against mites living indoors. On the contrary, it was revealed that the activity decreased. These findings were completely unexpected based on conventional knowledge, and considering that the pyrethroids of the general formula () are widely used as insecticides safe for humans and livestock, they are not suitable for indoor use. It is extremely useful for developing acaricides. There are two asymmetric carbon atoms in the acid moiety of the compound of general formula (), and four optical isomers are possible, and each of them or any mixture thereof is of course included in the present invention. In addition, pyrethroid synergists such as IBTA, S-421, piperonyl butoxide, sinepirin 222, sinepirin 500, and Riesen 384, and insect repellents such as DEET and benzyl benzoate have some acaricidal effect. It was further confirmed that a composition prepared by adding one or two of the above synergist and insect repellent to the pyrethroid of the general formula () exhibits an extremely high acaricidal effect that is more than additive. . There are still many unknowns as to why the pyrethroids of the general formula () have a high extermination effect specifically against white mites and house dust mites that occur indoors, but this type of mite belongs to the asteroid class, while spider mites that grow on plants This is thought to be partially related to the morphological difference that the species is a prospirochlear species. Synergists for pyrethroid do not have insecticidal power by themselves, but when used together with pyrethroids, they are known to suppress the metabolic decomposition of pyrethroids in insect bodies and improve their insecticidal power. It itself shows some acaricidal activity against insects, suggesting a difference in the mechanism of action between insects and mites. Furthermore, the fact that a mixed composition of the pyrethroid of the general formula () and a pyrethroid synergist exhibits a high synergistic effect has high practical value because the latter is very inexpensive. DEET, benzyl benzoate is a compound that is widely used as a repellent for mosquitoes, flies, etc., and it is interesting that it showed acaricidal effect. It can be used as a multipurpose composition including extermination of mites. Although it is possible to apply the above-mentioned active ingredients as they are to the acaricide of the present invention, it is usually preferable to use carriers and other compounding agents to form various liquid formulations (herein, liquid formulation refers to water-soluble formulations) depending on the purpose of use. emulsified, emulsified,
Alternatively, it refers to liquid preparations that exhibit a suspension, and is used as emulsions, wettable powders, oil preparations, flowable preparations, aqueous solutions, etc.) and aerosol preparations. Examples of liquid carriers include water, alcohols (methyl alcohol, ethyl alcohol, ethylene glycol, etc.), ketones (acetone, methyl ethyl ketone, cyclohexanone, etc.), ethers (ethyl ether, dioxane, cellosolves, etc.), aliphatic Hydrocarbons (gasoline, kerosene, kerosene, etc.),
Aromatic hydrocarbons (benzene, toluene, xylene, methylnaphthalene, etc.), halogenated hydrocarbons (dichloromethane, trichlorobenzene, etc.),
Solvents such as esters, acid amides, nitriles, etc. are suitable, and one or a mixture of two or more of these may be used. Examples of solid carriers include clays (kaolin, bentonite, etc.), talcs, silicas,
Alumina powder, activated carbon, vegetable powder, etc. are suitable, and one or a mixture of two or more of these may be used. In addition, as compounding agents, emulsifiers,
Dispersants, spreading agents, penetrants, surfactants, stabilizers, etc. are suitable, and one or a mixture of two or more of these may be used. Alternatively, other acaricides, antioxidants, insecticides, fungicides, microbicides, flavorings, and colorants that are not likely to inhibit the activity of the active ingredient of the present invention may be added. The amount of the active ingredient in the acaricide of the present invention and its usage amount are appropriately determined depending on the dosage form, application target, application method, application location, etc. For example, to exterminate mites living on tatami mats such as mites, 0.1 mg or more, preferably 1 ml to 2 g of the pyrethroid compound of the general formula () is used per tatami mat. Note that tatami mats are inhabited by insect pests such as wasps and wasps, and the composition of the present invention can also exterminate these pests at the same time. EXAMPLES Hereinafter, the present invention will be explained in detail with reference to examples, but the present invention is not limited to the following examples unless the gist thereof is exceeded. Test Example 1 10g of powdered feed treated with the test compound and 10g of powdered feed containing approximately 2,500 woolly mites were mixed,
A test powder feed of a predetermined concentration was obtained. Put 5g of this powdered feed into a 6cm diameter tray, and keep it at a temperature of 25°C.
It was placed at a temperature of 75%. One week and two weeks later, the number of surviving mites in 0.2 g of feed was determined by the saturated saline suspension method, and the reproduction suppression rate was calculated according to the formula below. The test was repeated three times for each concentration. Reproduction suppression rate = Number of mites in untreated area - Number of mites in treated area / Number of mites in untreated area x 100 Note that the symbol (a) in the general formula () of the test compound,
(b), (c), and (d) each represent the following meanings. (a); Acid part dl-cis/trans form (b); Acid part d-cis/trans form (c); Acid part dl-cis form (d); Acid part d-trans form

【table】

[Table] Target compounds (A) Target compound (B) Target compound (C) From the above results, the composition of the present invention, that is, the compound of the general formula () or the composition in which one or two of a pyrethroid synergist and an insect repellent were added (test compound examples 1 to 5) was excellent. It showed acaricidal effect. On the other hand, the activity of other pyrethroid compounds (control compounds (A), (B), and (C)), pyrethroid synergists, or insect repellents alone was very low, and the usefulness of the composition of the present invention was confirmed. Ta. Example 1 2.0 g of d-phenothrin and 5.0 g of IBTA were dissolved in refined kerosene, filled into an aerosol container, and a valve section was attached. A propellant was then pressurized and filled through the valve section to obtain an aerosol. In a 6-tatami room where woolly mites were breeding, approximately 1/4 of the above-mentioned adjusted aerosol was injected into the tatami area, and when the density of mites was examined one week later, it was found to have decreased to less than 5%. Example 2 To 5 parts of d-phenothrin and 5 parts of benzozyl benzoate, 15 parts of Solpol SM-100 (registered trademark of Toho Chemical) and 75 parts of purified water were added to obtain an aqueous emulsion. This emulsion was diluted ⁵⁰⁰ times with water and
After treating 100 g, about 300 Dermatophagoides nigra were released onto the resulting carpet, and two days later, the number of surviving Dermatophagoides nigra was less than 5. Example 3 10 parts of dl-cis-phenothrin, 20 parts of IBTA, 35 parts of diatomaceous earth, 30 parts of clay, 3 parts of lauryl sulfonate
1 part and 2 parts of carboxymethyl cellulose were ground and mixed to obtain a wettable powder. This wettable powder was diluted 1,000 times with water and applied to the carpet surface at a rate of 100 g/m ² . After drying, this carpet was used, but no mites were observed to live there, and there were no problems such as strange odors.

Claims (1)

[Claims] 1 formula or octachlorodipropyl ether, N-(2-ethylhexyl)-1
-isopropyl-4-methylbicyclo[2,2,
2] Oct-5-ene-2,3-dicarboximide, N-(2-ethylhexyl)-bicyclo[2,2,1]hept-5-ene-2,3-dicarboximide, piperonyl butoxy One or two of the following pyrethroid synergists, isobornyl thiocyanoacetate and 2-butoxy-2'-thiocyanodiethyl ether, and pest repellents N,N-diethyl-m-toluamide and benzylbenzoate were added. A liquid agent and an aerosol agent for indoor tick control, which are characterized by: