JPH0465839B2 - - Google Patents

Info

Publication number: JPH0465839B2
Authority: JP; Japan
Prior art keywords: solvent; drying; nucleotide reagent; nucleotide; valve
Prior art date: 1983-10-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP19709883A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6089493A (ja

Inventor

Yoshiaki Oosugi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Shimadzu Corp

Original Assignee

Shimadzu Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-10-20

Filing date

1983-10-20

Publication date

1992-10-21

1983-10-20 Application filed by Shimadzu Corp filed Critical Shimadzu Corp

1983-10-20 Priority to JP19709883A priority Critical patent/JPS6089493A/ja

1985-05-20 Publication of JPS6089493A publication Critical patent/JPS6089493A/ja

1992-10-21 Publication of JPH0465839B2 publication Critical patent/JPH0465839B2/ja

Status Granted legal-status Critical Current

Links

239000003153 chemical reaction reagent Substances 0.000 claims description 49
239000002773 nucleotide Substances 0.000 claims description 35
125000003729 nucleotide group Chemical group 0.000 claims description 35
239000002904 solvent Substances 0.000 claims description 35
238000001035 drying Methods 0.000 claims description 28
230000006820 DNA synthesis Effects 0.000 claims description 14
238000005406 washing Methods 0.000 claims description 14
238000000034 method Methods 0.000 claims description 6
230000002194 synthesizing effect Effects 0.000 claims description 6
238000003786 synthesis reaction Methods 0.000 claims description 5
238000007599 discharging Methods 0.000 claims description 2
108020004414 DNA Proteins 0.000 description 12
238000002360 preparation method Methods 0.000 description 11
239000007788 liquid Substances 0.000 description 10
238000004140 cleaning Methods 0.000 description 9
230000000873 masking effect Effects 0.000 description 9
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 8
239000007810 chemical reaction solvent Substances 0.000 description 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
239000003795 chemical substances by application Substances 0.000 description 6
229910001873 dinitrogen Inorganic materials 0.000 description 6
125000006239 protecting group Chemical group 0.000 description 6
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
238000006482 condensation reaction Methods 0.000 description 4
239000007789 gas Substances 0.000 description 4
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 4
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
102000053602 DNA Human genes 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000000203 mixture Substances 0.000 description 3
239000000843 powder Substances 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
230000002411 adverse Effects 0.000 description 2
PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 2
239000000243 solution Substances 0.000 description 2
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
SFYDWLYPIXHPML-UHFFFAOYSA-N 3-nitro-1-(2,4,6-trimethylphenyl)sulfonyl-1,2,4-triazole Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)N1N=C([N+]([O-])=O)N=C1 SFYDWLYPIXHPML-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
229910052786 argon Inorganic materials 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
238000010586 diagram Methods 0.000 description 1
239000011259 mixed solution Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Saccharide Compounds (AREA)

JP19709883A 1983-10-20 1983-10-20 Ｄνａ等合成装置 Granted JPS6089493A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP19709883A JPS6089493A (ja)	1983-10-20	1983-10-20	Ｄνａ等合成装置

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP19709883A JPS6089493A (ja)	1983-10-20	1983-10-20	Ｄνａ等合成装置

Publications (2)

Publication Number	Publication Date
JPS6089493A JPS6089493A (ja)	1985-05-20
JPH0465839B2 true JPH0465839B2 (2)	1992-10-21

Family

ID=16368688

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP19709883A Granted JPS6089493A (ja)	1983-10-20	1983-10-20	Ｄνａ等合成装置

Country Status (1)

Country	Link
JP (1)	JPS6089493A (2)

1983
- 1983-10-20 JP JP19709883A patent/JPS6089493A/ja active Granted

Also Published As

Publication number	Publication date
JPS6089493A (ja)	1985-05-20

Publication	Publication Date	Title
CA1251016A (en)	1989-03-14	Polynucleotide synthesizing apparatus
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US5356596A (en)	1994-10-18	Apparatus for isolation of synthetic peptide without mechanical loss
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Jagadeeswaran et al.	1986	Use of reverse-phase chromatography in the Maxam-Gilbert method of DNA sequencing A step toward automation
JPH0634687Y2 (ja)	1994-09-07	化学分析装置
JPS6197297A (ja)	1986-05-15	ポリヌクレオチド合成装置
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JPS61221196A (ja)	1986-10-01	ポリヌクレオチド合成装置に於ける試薬、原料の給液方法
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