JPH0481567B2 - - Google Patents
Info
- Publication number
- JPH0481567B2 JPH0481567B2 JP4246884A JP4246884A JPH0481567B2 JP H0481567 B2 JPH0481567 B2 JP H0481567B2 JP 4246884 A JP4246884 A JP 4246884A JP 4246884 A JP4246884 A JP 4246884A JP H0481567 B2 JPH0481567 B2 JP H0481567B2
- Authority
- JP
- Japan
- Prior art keywords
- urea
- taurine
- present
- skin
- cosmetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 40
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 30
- 239000004202 carbamide Substances 0.000 claims description 30
- 229960003080 taurine Drugs 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 11
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 229910021529 ammonia Inorganic materials 0.000 description 6
- 239000003921 oil Substances 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- -1 Stearic acid monoglycerin ester Chemical class 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 206010048218 Xeroderma Diseases 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 206010021198 ichthyosis Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 229950011392 sorbitan stearate Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
本発明は尿素と共にタウリンを配合することに
より尿素の経日安定性を向上させた皮膚外用剤に
関するものである。
尿素は皮膚外用剤中に配合した場合、湿潤効
果、細胞賦活効果、創傷治癒効果等が期待され
る。しかしながら水の共存下で徐々に分解し、系
のPHが上昇すると共にアンモニア及び炭酸ガスが
発生して悪臭を生じるために種々の効果が期待さ
れつつも皮膚外用剤中に配合される機会が少なか
つた。
また尿素を安定に皮膚外用剤に配合する努力は
いくつか報告があるが、そのいずれもが満足のい
く結果を得ていない。
例えば、尿素とともに乳酸を配合する報告では
初期PHは低下できるものの経日安定性向上には効
果がない。
本発明者らはかかる事情にかんがみ鋭意研究の
結果、尿素と共にタウリンを配合することにより
尿素の経日安定性を向上させられることを見い出
し、本発明をなすに至つた。
すなわち本発明は尿素とタウリンとを含有する
ことを特徴とする皮膚外用剤を提供するものであ
る。
以下本発明の構成について詳述する。
本発明で用いられる尿素は通常市販されている
もので構わない。
尿素の配合量は0.1〜20重量％の範囲で、それ
以下の水準では前述の尿素の皮膚に対する効果が
少なく、またそれ以上の水準は薬事法上、皮膚外
用剤の範囲を逸脱するものであり規則を受ける。
安定性を向上させる目的で配合されるタウリン
の量は、尿素に対して1/10重量以上３倍量以下が
望ましい。ただし過剰のタウリンの添加は、タウ
リン自身が変質し、変色、変臭等を生じるために
注意が必要である。
尿素及びタウリンを配合できる皮膚外用剤基剤
は通常考えられる皮膚外用剤基剤、例えば、水溶
液系、可溶化系、乳化系、粉末分散系、水−油系
２層状化粧料、水−油−粉末系３層状化粧料等ど
のような基剤でもよく、用途も化粧水、乳液、ク
リーム、パツク等の基礎化粧料、乳化口紅、フア
ウンデイシヨン等のメイクアツプ化粧料、シヤン
プー、リンス、ヘアトニツク等の頭髪化粧料等の
化粧料のほかに乾皮症治療薬などの医療品等多岐
に渡るが、本発明の効果は、尿素水溶液の形で含
まれているものにおいて発揮される。尿素水溶液
の濃度は任意である。また、上述のように尿素水
溶液が油相と乳化された形等になつていても全く
さしつかえなく本発明の効果は発揮される。しか
しながら、基剤自身が塩基性を示すものでついて
はタウリンによる安定性維持効果以上に塩基性物
質による分解促進の方が大きい場合があり、好ま
しくない。
本発明の皮膚外用剤には必要に応じて、本発明
の効果を損なわない範囲で保湿剤、増粘剤、防腐
剤、乳化剤、酸化防止剤、金属イオン封鎖剤、紫
外線吸収剤、粉末、薬効成分、色剤、香料等を配
合できる。
本発明に従つて皮膚外用剤中に尿素とタウリン
を同時に配合した場合の尿素の経日安定性は、タ
ウリンを併用しない場合に比較して著しく向上す
る。すなわち、(1)尿素の分解によるアンモニアの
発生がおこらず、アンモニア臭による化粧料の劣
化がない。(2)タウリンを併用しない系ではPH値が
急激に上昇するが、併用した場合にはPH上昇がほ
とんどおこらない。
つぎに本発明を実施例および比較例によりさら
に詳細に説明するが、本発明はこれにより限定さ
れるものではない。
実施例１〜２、比較例１〜３
The present invention relates to an external skin preparation that improves the stability of urea over time by incorporating taurine together with urea. When urea is incorporated into external skin preparations, it is expected to have moisturizing effects, cell activation effects, wound healing effects, etc. However, it gradually decomposes in the coexistence of water, raising the pH of the system and emitting ammonia and carbon dioxide gas, producing a bad odor, so although it is expected to have various effects, it is rarely incorporated into external skin preparations. Nakatsuta. In addition, there have been several reports of efforts to stably incorporate urea into external preparations for the skin, but none of them have yielded satisfactory results. For example, reports of combining lactic acid with urea show that although the initial pH can be lowered, it is not effective in improving stability over time. In view of the above circumstances, the present inventors conducted intensive research and found that the stability of urea over time can be improved by blending taurine with urea, leading to the present invention. That is, the present invention provides an external skin preparation characterized by containing urea and taurine. The configuration of the present invention will be explained in detail below. The urea used in the present invention may be any commercially available urea. The amount of urea to be added is in the range of 0.1 to 20% by weight; if the level is lower than that, the above-mentioned effect of urea on the skin will be small, and if the level is higher than that, it is outside the scope of topical skin preparations under the Pharmaceutical Affairs Law. Subject to rules. The amount of taurine added for the purpose of improving stability is desirably 1/10 or more and 3 times or less the weight of urea. However, care must be taken when adding excessive taurine, as the taurine itself deteriorates, causing discoloration, odor, etc. The skin external preparation bases that can contain urea and taurine include the usual skin external preparation bases, such as aqueous solutions, solubilized systems, emulsified systems, powder dispersion systems, water-oil two-layer cosmetics, and water-oil cosmetics. Any base such as powder type three-layer cosmetics may be used, and the applications include basic cosmetics such as lotions, milky lotions, creams, and packs, makeup cosmetics such as emulsified lipsticks and foundations, shampoos, conditioners, hair tonics, etc. In addition to cosmetics such as hair cosmetics, medical products such as drugs for treating xeroderma, the effects of the present invention are exhibited in products containing the urea solution in the form of an aqueous urea solution. The concentration of the urea aqueous solution is arbitrary. Further, as described above, even if the urea aqueous solution is in an emulsified form with the oil phase, the effects of the present invention can be exhibited without any problem. However, if the base itself is basic, the decomposition promotion by the basic substance may be greater than the stability maintaining effect by taurine, which is not preferable. The skin external preparation of the present invention may contain moisturizers, thickeners, preservatives, emulsifiers, antioxidants, sequestrants, ultraviolet absorbers, powders, medicinal agents, etc., as necessary, to the extent that the effects of the present invention are not impaired. Ingredients, colorants, fragrances, etc. can be added. According to the present invention, when urea and taurine are simultaneously incorporated into a skin preparation for external use, the stability over time of urea is significantly improved compared to when taurine is not used in combination. That is, (1) ammonia is not generated due to decomposition of urea, and cosmetics do not deteriorate due to ammonia odor. (2) In a system without taurine, the PH value rises rapidly, but when used in combination, there is almost no PH increase. Next, the present invention will be explained in more detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto. Examples 1-2, Comparative Examples 1-3
【表】
基剤＝化粧水
エタノール 13.0wt％
１，３−ブチレングリコール− 10.0
P.O.E（50）オレイルエーテル 0.8
防腐剤 適量
香 料 適量
上記各成分と尿素および添加剤を加え、さらに
全量を100とする量の精製水を加える。
匂い変化……50℃１ケ月保存品の匂い。○印はア
ンモニア臭なし。×印はアンモニア臭あり。
尿素の定量値……50℃１ケ月保存品の尿素の定量
値。高速液体クロマトグラフイー法による。
比較例１、２、３はそれぞれ添加剤無添加また
はタウリン以外の添加剤を配合した試料である
が、タウリンを添加した例、すなわち実施例１、
２と比較すると、PH変化、アンモニア臭、匂い変
化が激しく、尿素定量値は低い。実施例において
はこれらのいずれも満足している。
実施例 ３
ナイトクリーム
Ａ セタノール 4.0wt％
ワセリン 7.0
スクワラン 21.0
ステアリン酸モノグリセリンエステル
2.2
P.O.E（20）ソルビタンステアレート 2.8
イソプロピルミリステート 6.0
エチルパラベン 0.3
香 料 0.2
Ｂグリセリン 10.0
プロピレングリコール 5.0
尿 素 0.5
タウリン 1.5wt％
精製水 39.0
Ａに属する油相部の原料およびＢに属する水相
部の原料をそれぞれ70℃に加熱し、溶解したの
ち、油相部を水相部中に混合し、乳化機にて乳化
する。乳化物を熱交換機にて終温30℃まで冷却し
たのち充填をおこなう。
実施例３に記載された処方からタウリンのみを
除去（精製水で置換）した処方を実施例３と同時
に調製し、40℃にて２ケ月保存したのち尿素の定
量をおこなつたところ、実施例３では98〜99％残
存していたのに対し、タウリンを除去したものは
87〜89％減少していた。
実施例 ４
フアウンデーシヨン
Ａ セタノール 3.5wt％
脱臭ラノリン 4.0
ホホバ油 5.0
ワセリン 2.0
スクワラン 6.0
ステアリン酸モノグリセリンエステル
2.5
P.O.E.（60）硬化ヒマシ油 1.5wt％
P.O.E.（25）セチルエーテル 1.0
プロピルパラベン 0.8
香 料 0.2
Ｂ グリセリン 3.0
プロピレングリコール 8.0
調合粉末 12.0
尿 素 3.0
タウリン 2.0
精製水 46.0
製造方法は実施例３に準ずる。
実施例４に記載された処方によりタウリンのみ
を除去（精製水で置換）した処方を実施例４と同
様に調製し、40℃にて２ケ月保存したのち尿素の
定量を行つたところ、実施例４では97〜98％残存
していたのに対し、タウリンを除去したものは85
〜90％に減少していた。[Table] Base = lotion ethanol 13.0wt% 1,3-butylene glycol - 10.0 POE (50) oleyl ether 0.8 Preservative appropriate amount Fragrance appropriate amount Add each of the above ingredients, urea and additives, and make the total amount 100 Add a certain amount of purified water. Change in odor...Odor of product stored at 50℃ for 1 month. ○ indicates no ammonia odor. × indicates ammonia odor. Quantitative value of urea: Quantitative value of urea for products stored at 50℃ for one month. By high performance liquid chromatography method. Comparative Examples 1, 2, and 3 are samples with no additives added or with additives other than taurine, but examples with taurine added, that is, Example 1,
Compared to 2, the pH change, ammonia odor, and odor change are severe, and the urea quantitative value is low. In the example, all of these are satisfied. Example 3 Night cream A Setanol 4.0wt% Vaseline 7.0 Squalane 21.0 Stearic acid monoglycerin ester
2.2 POE (20) Sorbitan Stearate 2.8 Isopropyl myristate 6.0 Ethylparaben 0.3 Fragrance 0.2 B Glycerin 10.0 Propylene Glycol 5.0 Urea 0.5 Taurine 1.5wt% Purified Water 39.0 Raw materials for the oil phase belonging to A and the water phase belonging to B After each of the raw materials is heated to 70°C and dissolved, the oil phase is mixed into the water phase and emulsified using an emulsifier. Filling is performed after the emulsion is cooled to a final temperature of 30°C using a heat exchanger. A formulation in which only taurine was removed (replaced with purified water) from the formulation described in Example 3 was prepared at the same time as Example 3, and after being stored at 40°C for 2 months, urea was quantified. 3 had 98-99% remaining, while the one with taurine removed
It was down 87-89%. Example 4 Foundation A Setanol 3.5wt% Deodorized lanolin 4.0 Jojoba oil 5.0 Vaseline 2.0 Squalane 6.0 Stearic acid monoglycerin ester
2.5 POE (60) Hydrogenated castor oil 1.5wt% POE (25) Cetyl ether 1.0 Propyl paraben 0.8 Fragrance 0.2 B Glycerin 3.0 Propylene glycol 8.0 Mixed powder 12.0 Urea 3.0 Taurine 2.0 Purified water 46.0 The manufacturing method is in accordance with Example 3. A formulation in which only taurine was removed (replaced with purified water) using the formulation described in Example 4 was prepared in the same manner as in Example 4, and after being stored at 40°C for 2 months, urea was quantified. 4 had 97-98% remaining, while the one with taurine removed had 85% remaining.
It had decreased to ~90%.
Claims (1)
る皮膚外用剤。1. A skin external preparation characterized by containing urea and taurine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4246884A JPS60185708A (en) | 1984-03-06 | 1984-03-06 | External preparation for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4246884A JPS60185708A (en) | 1984-03-06 | 1984-03-06 | External preparation for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60185708A JPS60185708A (en) | 1985-09-21 |
| JPH0481567B2 true JPH0481567B2 (en) | 1992-12-24 |
Family
ID=12636900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4246884A Granted JPS60185708A (en) | 1984-03-06 | 1984-03-06 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60185708A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61145109A (en) * | 1984-12-19 | 1986-07-02 | Nakanishi Eiko | Cosmetic |
| JP3542665B2 (en) * | 1995-07-07 | 2004-07-14 | 株式会社資生堂 | Anti-aging skin external preparation, collagen cross-linking inhibition skin external preparation and anti-ultraviolet skin external preparation |
| FR2782922B1 (en) * | 1998-09-09 | 2002-07-19 | Oreal | COMPOSITION CONTAINING UREA AND ITS USES IN THE COSMETIC AND / OR DERMATOLOGICAL FIELD |
| WO2013054809A1 (en) * | 2011-10-14 | 2013-04-18 | 大正製薬株式会社 | External preparation for skin |
-
1984
- 1984-03-06 JP JP4246884A patent/JPS60185708A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60185708A (en) | 1985-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5587149A (en) | Topical application emulsions | |
| US4992478A (en) | Antiinflammatory skin moisturizing composition and method of preparing same | |
| JP4252899B2 (en) | Topically applied composition containing multivesicular emulsion and method for producing the same | |
| JP3609834B2 (en) | Skin preparation | |
| US6139824A (en) | Deodorant composition | |
| JPH1053510A (en) | Composition for external use | |
| JPWO1997002803A1 (en) | topical skin preparations | |
| EP0336899A2 (en) | Skin moisturizing composition and method of preparing same | |
| JP2764510B2 (en) | Whitening cosmetics | |
| JPH027287B2 (en) | ||
| DE69800168T2 (en) | Emulsion containing ascorbic acid and its uses in cosmetics and dermatology | |
| JP2691662B2 (en) | Cosmetics | |
| JP2572730B2 (en) | Skin cosmetics | |
| JPS6130509A (en) | Dermal external drug | |
| JPH0481567B2 (en) | ||
| JP3093353B2 (en) | External preparation for skin | |
| JP3133532B2 (en) | Hair restoration cosmetics | |
| JP2004067626A (en) | External preparation composition | |
| JPH11255661A (en) | External preparation for atopic dermatitis | |
| JP2522803B2 (en) | Cosmetics | |
| JP3712673B2 (en) | Gel composition and oil-in-water (O / W) type composition | |
| JPS63215611A (en) | Cosmetic | |
| JP2000169328A (en) | Epidermal permeation barrier enhancer and skin cosmetic | |
| JP2566792B2 (en) | Hair growth and hair growth promoter | |
| JPS6147407A (en) | External remedy for skin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |