JPH0495014A - Sebum secretion promoter - Google Patents

Abstract

PURPOSE:To obtain a sebum secretion promoter, containing cycleanine as an active ingredient, having promoting action on sebum secretion and capable of sustainedly promoting supply of an oil to the skin. CONSTITUTION:A sebum secretion promoter, containing cycleanine as an active ingredient at preferably 0.0005-5wt.% concentration, capable of accelerating sebum secretory function essentially held by the human skin, sustainedly supply ing an oil in a natural form to the skin and imparting smoothness and moistness to the skin and hair without exhibiting toxicity to human bodies and effective in treatment and prognosis such as improvement of dry type eczema such as senile xeroderma or atopic dermatitis.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a sebum secretion promoter that has a sustained sebum secretion effect on the skin.

[Prior Art] The health and beauty of skin and hair are maintained by sebum secreted from sebaceous glands. However, from adolescence to old age, the sebum secretion function declines significantly, especially in women, and the skin loses its smoothness and moisture. For the purpose of replenishing oil to the skin where sebum secretion has declined, oil replenishing pharmaceuticals, external products, and cosmetics in various formulations such as creams, lotions, and emulsions have been used.

[Problem to be solved by the invention] However, in conventional oil replenishment products, although the oily components in the base temporarily remain on the skin surface, they gradually disappear due to external factors such as friction. The effect is not long-lasting.

An object of the present invention is to provide a sebum secretion promoter that has a sebum secretion promoting effect and promotes the continuous supply of oil to the skin.

[Means for Solving the Problems] In order to solve the above problems, the present inventors investigated various physiologically active substances, and as a result, they obtained the knowledge that cycreanin improves sebaceous gland function and completed the present invention. Ta.

That is, the present invention provides a sebum secretion promoter characterized by containing cycreanin as an active ingredient.

By incorporating cycleanine into oil-replenishing products, in addition to the conventional oil-replenishing function and the function of basic cosmetics, it advances the sebum secretion function of human skin, allowing it to be produced more naturally and sustainably. It becomes possible to supply oil to the skin. First, the sebum secretion promoter of the present invention is
It is effective in improving the treatment and prognosis of dry eczema such as senile xeroderma and atopic dermatitis.

In addition, there is a skin cosmetic (Japanese Patent Application Laid-Open No. 60-209508) that contains cephalanthine, an alkaloid contained in plants of the family Cycleanin, similar to cycreanin, but cephalanthine stimulates and nourishes the skin and peripheral blood vessels. Yes, but there is no mention of the effect of enhancing sebaceous gland function.

Also, focusing on the hair growth promoting effect of cycreanin, it was formulated as an active ingredient in a hair tonic (Japanese Patent Application Laid-open No. 6461413).
However, its action on sebaceous glands is not known and there have been no examples of its use as a sebum secretion stimulant.

In order to obtain cycleanine used in the present invention, extraction and purification may be performed according to known extraction methods for plant alkaloids, or it may be produced by synthesis (Japanese Patent Publication No.
No. 31667, Japanese Unexamined Patent Publication No. 5513268).

In the case of the extraction method, the whole plant, root, or stem of a plant belonging to the family Tussolafaceae, such as Tamasa Kidzurahuji or Myaconomatsuzurafuno, is used as the raw material. ■Inorganic or organic dilute acids are mixed with alcohol such as methanol or ethanol as appropriate. A method for obtaining an extracted extract using solvents mixed in the ratio of 1. Dissolve this extracted extract in a strong acid, remove insoluble matter, and then add an organic solvent such as ether, chloroform, benzene, etc. to acidic and neutral 2. Remove the substances by dissolving them in these solvents, make the aqueous layer alkaline, and use both precipitated fractions, or 2. Use silica gel column chromatography to elute this fraction with a chloroform-methanol solvent. Examples include a method of separating and obtaining highly pure cycleanine.

In the present invention, any of the above-mentioned extracts (1), (2) and purified cycleanine (4) may be used.

Next, the results of a test on the sebum secretion-promoting effect of cycleanine, extracts (1) and extracts (2) of plants of the family Cypressaceae containing this as an active ingredient, which are incorporated into the cosmetics of the present invention, are shown.

An ethanol solution of each of the following samples was administered in an amount of 0.005 mg to the medial side of the right auricle of an IO week old hamster for 14 days.

In addition, as a control, only ethanol solution was similarly administered to the inner side of the left auricle of each hamster. After administration for 14 days, the size (area) of the sebaceous glands in the inner part of the collected auricle was measured using an image analysis device.

(Sample) Extract ■: An extract obtained by extracting the dried product of Tamasakidurahuji using a mixed solution (1:1) of 0, IN diluted hydrochloric acid and methanol.

Extract ■: Extract ■ was dissolved in hydrochloric acid, then chloroform was added to the solution from which insoluble matter was removed, acidic and neutral substances were transferred and removed in these solvents, and ammonia was added to make the solution alkaline. precipitation.

Cycleanine: Extract (1) was subjected to silica gel column chromatography and eluted with chloroform containing 5% methanol to obtain a cycreanin fraction.

Table 1 Extract■ 5% 4 133.47±23.
26 Extract■ 1% 4 120.53+1
2.50 Cycleanine 1% 4 127.6
5±1490 As is clear from Table 1, extracts ■, ■ and cycreanin increase the size of sebaceous glands in the auricle.

In the sebum secretion promoter of the present invention, the components other than cycreanin or the plant extract containing the same may be conventionally known components. The dosage form of the present invention can be in various forms, such as lotion, oil, ointment, cream, milky lotion, and the like. Cycleanine is not toxic to the human body, and the concentration of cycloanine in these dosage forms may be within a range that does not affect its performance depending on the dosage form, but 0.
It is desirable that the content be in the range of 0.005 to 5% by weight.

The method of use is to apply it to dry areas of the skin at least once a day, preferably 2 to 4 times a day.

[Example] Next, the present invention will be explained in more detail with reference to Examples.

In the examples, all compounding amounts are expressed in weight%. In addition, as cycleanine, extract ①, and extract ②, the above-mentioned ones were used.

Example 1 (Lotion) Ingredients Amount Cycleanine-containing extract ■ 0.5 Glycerin 6.0 Ethanol
8.0 Polyoxyethylene hydrogenated castor oil (60E, O,) 0.8 Methyl paraoxybenzoate 0.05 Quaic acid 0.05 Sodium citrate 0.07 Fragrance
0.1 Purified water meter Example 2 (oil form) Ingredients Cycleanine-containing extract ■ Cholesteryl stearate Olive oil Squalane Meter Remaining amount 0.005 Remaining amount Example 3 (Cream) Ingredients Cycleanine Saraci Beeswax Setanol Lanolin Liquid paraffin self Emulsified Glyceryl Monostearate Monostearic Acid Blending Amount 0.01 4.0 2.0 Polyoxyethylene Sorbitan (20E Propyl Paraoxybenzoate Methylpropylene Glycol Paraoxybenzoate Fragrance Purified Water Meter Example 4 (Emulsion) Ingredients Cycleanine Fluidity Paraffin vaseline Beeswax sesquioleate sorbitan polyoxyethylene oleyl ether (20E, O,) Ethyl propylene glycol paraoxybenzoate carboxyvinyl polymer 0,) 1.5 l O12 0,2 Remaining amount 0.001 5.0 2.0 1.0 2.0 2.5 0.2 5.0 0.5 Potassium hydroxide 0.3 Flavor
02 Purified water
Remaining needle 10
0 Test Example 32 women aged 39 to 53 were tested in 8 groups, 1 to 4.
They were divided into groups, and the first group had the cream of Example 3, the second group had the cream of Example 3 in which the cycleanine was replaced with the extract ■, and the third group had the same extract ■. The cream and the control cream (example 3 except cycreanin) were applied to the forehead once a day for the remaining group 4.

After 4 weeks, the same area was washed with a facial cleanser and left for 2 hours, then cigarette paper (2 x 3 cx) was applied for 3 hours to collect skin lipids, and the lipids were extracted from the cigarette paper and its weight was calculated. It was measured.

As a result, as shown in the table below, a significant increase in skin surface lipids was observed in the group administered with the cream containing cycreanin and extract.

Note 1) Unit: mg/cm"/3hr [Effects of the Invention] The skin cosmetics of the present invention advance the sebum secretion function inherent in human skin, continuously supply oil to the skin in a natural manner, and improve skin health. The sebum secretion promoter of the present invention is effective in improving the treatment and prognosis of dry eczema such as atopic dermatitis.

Patent applicant: Sunstar Co., Ltd.

Claims (1)

[Claims] A sebum secretion stimulant characterized by containing cycreanin as an active ingredient.