JPH0496018A - Contact lens - Google Patents

Abstract

PURPOSE:To improve the resistance of a lens to sticking of stains and the property to desorb the stains by forming the contact lens of a specific compd. essentially consisting of fumarate or maleate. CONSTITUTION:The contact lens is formed of the polymer formed by polymerizing the fumarate or maleate expressed by formula I as its essential component. In the formula, at least either of R1, R2 is a fluorocarbon group contg. a -OH group. The ester substituent of the fumarate or maleate expressed by the formula I is more preferably the fluorocarbon group contg. the -OH and is 2 to 18C straight chain or branched fluoroalkyl group or 2 to 18C fluorocarbon group having an ether bond.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to contact lenses.

More specifically, the present invention relates to a contact lens that has excellent dirt adhesion resistance and dirt removability when worn.

[Conventional technology]

Contact lenses are made of polymethyl methacrylate, polyhydroxyethyl methacrylate, siloxanyl copolymers, etc., each with their own properties such as strength, water wettability, and flexibility.
It has been used because of its oxygen permeability. However, when using contact lenses, there has not been a contact lens that does not attract stains due to tear fluid and has a self-cleaning ability that allows proteins, lipids, etc. to be easily removed even if they are attached. For this reason, contact lens wearers are required to clean the lenses with a lens cleaning agent every day or at regular intervals, which is inconvenient for use.

In order to solve this problem, copolymerization of fluorine-containing monomers has been studied in recent years (for example, JP-A-51-55
(No. 3911, JP-A-54-29660, JP-A-61-73706) The stain resistance and stain releasability are insufficient.

Also, are copolymers using fumarate monomers being considered for the purpose of improving the drawbacks of conventional (meth)acrylate monomers?
JP-A-62-50728, JP-A-62-50728, JP-A-62-50728.
106432, JP 62-160419, JP 62-212618, JP 62-39
589, JP 62-235919, JP 63-11908, JP 63-32518, JP 63-132216, JP 63-
(No. 266422, Japanese Patent Application Laid-Open No. 63-271411) The stain resistance and stain releasability are not satisfactory, and the use of fluorine-containing monomers makes it difficult for stains to adhere (
However, dirt accumulates little by little, and once it gets too much, it cannot be easily cleaned, so there is a problem in that dirt accumulates while being worn.

[Problems to be solved by the present invention]

The present invention focuses on strength, which is the basic characteristic of contact lenses.
The purpose of the present invention is to provide a contact lens that has excellent dirt adhesion resistance and dirt removability in addition to water wettability and oxygen permeability.

[Means for Solving the Problem] As a result of intensive research to develop a new contact lens that solves the above-mentioned problems, the present inventors found that a fluorine-containing monomer with a specific structure, The present inventors have found that the present invention is suitable for that purpose, and have completed the present invention.

That is, the present invention provides a contact lens comprising a polymer obtained by polymerizing a fumarate ester or a maleate ester represented by the general formula (I) as an essential component (wherein at least one of R1 and R2 contains a 10H group). It is a fluorocarbon group.)

In the present invention, it is preferable that the fumaric ester or maleic ester represented by the general formula (I) has an ester substituent having a fluorocarbon group containing 10H group and having 2 to 18 carbon atoms. A linear or branched fluoroalkyl group, or a fluorocarbon group containing an ether bond having 2 to 18 carbon atoms.

Examples of the fluorocarbon group containing these -〇H groups include the general formula: -CH2CH2H2-0-(CF2),
X.

H CH2CH2H2C,, F2. , , , and H + CH2CH20−+rCH2CHCH2+ CF2
+r-0-C-F2 has something represented by +H.

Among these, n is an integer of 1 to 4, m is an integer of 2 to 8,
i is 0 or 1, J is an integer of 1 to 7, k is an integer of 1 to 5,
Preferably, X is hydrogen or fluorine.

Further, in the present invention, in general formula (I), R1
, R2 may be the same or different, and R
,, one of R2 is a fluorocarbon group containing a -〇H group, and the other or other substituent, such as hydrogen, an alkyl group, a hydroxyalkyl group, a fluoroalkyl group, a fluoroalkyl ether group, (-CH2+-5i −
R, group (where r is 2 or 3, R3, R,, R5 is a substituent selected from methyl group, trimethylsiloxy group, pentamethyldisiloxanyloxy group, methylbis(trimethylsiloxy)siloxy group) It may be a fumarate ester or a maleate ester, which is a substituent selected from .).

The reason why contact lenses made of a copolymer using the monomer represented by the general formula (I) of the present invention is difficult for dirt to adhere to and also for easy removal of adhered dirt is not necessarily clear. Compared to the case where fluorine-containing monomers are simply mixed and copolymerized, fluorine atoms and hydroxyl groups, which are hydrophilic groups, are located close to each other on the surface of the copolymer, so protein It is thought that dirt components such as lipids have difficulty approaching the surface of the copolymer, and even if they do adhere, their bonding state is extremely weak and they are easily separated.

These monomers used in the present invention are new, or the corresponding fluorine-containing epoxy compound and fumaric acid or maleic acid are prepared by known methods (for example,
42 (55) P, 345-350 (1985), JP-A-61-73706).

For example, di(2,2-perfluoroethylglyceryl)
Fumarate and the corresponding maleate were prepared by adding 0.14 mol of potassium hydroxide to 1 mol of 2-hydroxyperfluoroethyl glycidyl ether, and adding 0.5 mol of fumaric acid little by little under a nitrogen gas stream to 70 to 90
The reaction was carried out at a temperature of °C, and after the reaction was allowed to cool, diluted with chloroform and filtered, the filtrate was washed with dilute alkaline water and then with saturated saline, the chloroform layer was separated and a desiccant was added. After dehydration, the solvent is removed under reduced pressure.

The contact lens of the present invention is a copolymer of a monomer represented by general formula (I) and a monomer copolymerizable with the monomer, in which the monomer represented by general formula (I) contains 0 .1~99
．． It is used in a range of 9 parts by weight.

If it is less than 0.1 part by weight, a large amount of dirt will adhere to it and the ability to remove the dirt will be poor, which is not preferable. The larger the content of these monomers is, the less dirt will adhere to it and the better the removability will be, or from the viewpoint of balance with other physical properties, it is used in an amount of 99.9 parts by weight or less.

Monomers copolymerizable with the monomer represented by general formula (I) used in the present invention include, for example, trifluoroethyl acrylate, tetrafluoroethyl acrylate, tetrafluoropropyl acrylate, pentafluoropropyl acrylate, and hexafluoropropyl acrylate. Fluorine acrylic acid fluoroalkyl esters such as fluorobutyl acrylate, hexafluoroisopropyl acrylate, heptafluorobutyl acrylate, and octafluoropentyl acrylate, and corresponding methacrylic acid fluoroalkyl esters, fumaric acid fluoroalkyl esters, maleic acid fluoroalkyl esters, etc. Containing monomers such as methyl methacrylate, ethyl methacrylate, t
-butyl methacrylate, n-butyl methacrylate,
Monomers such as methacrylates such as cyclohexyl methacrylate and benzyl methacrylate, their corresponding acrylates, fumarates, maleates, and aromatic vinyl compounds such as styrene, t-butylstyrene, and α-methylstyrene. It is used to add hardness to contact lenses and increase their mechanical strength. Among these monomers, trifluoroethyl methacrylate, hexafluoroisopropyl methacrylate, methyl methacrylate, cyclohexyl methacrylate, di-t-butyl fumarate, ditrifluoroethyl fumarate, dihexafluoroisopropyl fumarate, and the like are preferred.

These copolymerizable monomers are generally used in an amount of 3 to 95% by weight.

Furthermore, siloxane monomers or oligomers that impart oxygen permeability to contact lenses are used. For example, general formula (III) (wherein R' and R2 are each hydrogen or methyl group, l
is an integer of 1 to 5, and m is an integer of 1 to 3). Examples of such monomers include tris(trimethylsiloxy)silylpropyl methacrylate, Bis(trimethylsiloxy)methylsilylpropyl methacrylate, tris(trimethylsiloxy)silylethyl methacrylate, tris(trimethylsiloxy)silylbutyl methacrylate, tris(trimethylsiloxy)silylheptyl methacrylate, bis(trimethylsiloxy)silylpropyl methacrylate and their corresponding counterparts. There are acrylates, etc.

General formula (IV) (R6 and R6 in the formula are each hydrogen or methyl group,
l, X2, X3, X4, XS and X6 are the same or different alkyl groups, halogenated alkyl groups or trimethylsiloxanyl groups, p and q are the same or different integers of 1 to 5, n is 0 or 1 It is an integer between ~100.

), and examples of such monomers include 1,3-bis(3-methacryloxypropyl)-1,1,3,3-tetramethyldisiloxane. , 1.3-bis(3-methacryloxypropyl)tetrakis(trimethylsiloxy)disiloxane, 1.5-bis(3-methacryloxypropyl)-1
, 1,3,3,5,5-hexamethyltrisiloxane,
1.3-bis(2-methacryloxyethyl)-1,1,
3,3-tetramethyldisiloxane, 1,7-bis(3
-methacryloxypropyl)-1,7-tetrakis(trimethylsiloxy)-3,5-tetramethyltetrasiloxane and their corresponding acrylates α,ω-bis(3methacryloxypropyldimethylsiloxy)3,3
゜3 Trifluoropropyl-methylpolysiloxane, α
, ω-bis(3-methacryloxypropyl)tetrakis(trimethylsiloxy)silyl 3,3.3)lifluoropropylmethylpolysiloxane, α,ωbis(2-methacryloxypropyldimethylsiloxy)3.3.3)
Lifluoropropylmethylpolysiloxane, α,ω-bis(3-methacryloxypropyl)dimethylpolysiloxane, α,ω-bis(3-methacryloxypropyl)tetrakis(trimethylsiloxy)silyldimethylpolysiloxane, α,ω-bis (2-methacryloxyethyl)
Dimethylpolysiloxane, etc.

General formula (V) (wherein R1 and R2 are hydrogen or methyl groups, R1 and R
i is a linear or branched divalent hydrocarbon group having 2 to 7 carbon atoms or a 1,000C82CH2-0÷) group in which p is 1 to 20, and R4, R,, R2 and Ri are each carbon Number 1~
12 hydrocarbon group or trimethylsiloxy group, R
, , R, , RQ and R7 are each a hydrocarbon group having 1 to 12 carbon atoms or a halogen-substituted hydrocarbon group, and R
8 is a divalent hydrocarbon group having 4 to 13 carbon atoms, X is a COO- group or -NHCOO- group bonded to R, l and β' are integers of 0 to 20, m and n is 0-100
is an integer. ) There is a difunctional organosiloxane oligomer represented by

These monomers or oligomers are used in an amount of 3 to 95% by weight.

Further, fumaric acid esters and maleic acid esters having a siloxane group corresponding to the siloxane monomer represented by the general formula (I[) can also be copolymerized and are used in the range of 3 to 95% by weight.

Among these siloxane monomers or oligomers, tris(trimethylsiloxy)silylpropyl methacrylate (general formula ■), α,ω-bis(3-methacryloxypropyl) dimethylpolysiloxane (n#45 in general formula ■), α, ω to hexamethylene diisocyanate
- Siloxane oligomer to which his(3-hydroxypropyl)dimethylpolysiloxane is added and further glycidyl methacrylate (m=n in general 2)
″−.

45, l=I! '=1) Bis[tris(trimethylsiloxy)silylpropyl]fumarate and the corresponding malates are preferred.

In addition, in order to further impart hydrophilicity to contact lenses to improve water wettability or to make them soft contact lenses by absorbing water, for example, methacrylic acid, acrylic acid, itaconic acid, 2-hydroxyethyl methacrylate, 2- Hydroxyethyl acrylate, 2-hydroxypropyl methacrylate, 2-hydroxypropyl acrylate,
Hydrophilic monomers such as glycerol methacrylate, polyethylene glycol methacrylate, N,N'-dimethylacrylamide, N-methylacrylamide, and N-vinylpyrrolidone are used.

These hydrophilic monomers are generally used in an amount of 5 to 90% by weight.

Among these hydrophilic monomers, methacrylic acid, itaconic acid, 2-hydroxyethyl methacrylate, 2-hydroxypropyl methacrylate, glycerol methacrylate, and N-vinylpyrrolidone are preferably used.

In order to improve the dimensional stability of contact lenses, for example, ethylene glycol dimethacrylate, diethylene glycol dimethacrylate, triethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, polyethylene glycol dimethacrylate, trimethylolpropane trimethacrylate, pentaerythritol tetra A crosslinking monomer selected from methacrylate, bisphenol A dimethacrylate, vinyl methacrylate, acrylic methacrylate, acrylates corresponding to these methacrylates, divinylbenzene, triacrylisocyanurate, etc. is used.

Among these, ethylene glycol dimethacrylate,
Diethylene glycol dimethacrylate, triethylene glycol dimethacrylate, and tetraethylene glycol dimethacrylate are preferably used, and these crosslinking monomers are used within the range of 0.1 to 15% by weight.

We combined these copolymerizable monomers to improve the balance of contact lenses' optical properties, oxygen permeability, mechanical strength, deformation recovery, dimensional stability in lachrymal fluid, and its change over time. Mixtures can be used.

For example, in the case of hard contact lenses, 40 to 85 parts by weight of siloxane monomer, 5 to 20 parts by weight of alkyl methacrylate, 5 to 15 parts by weight of hydrophilic monomer, and 0.1 to 10 parts by weight of crosslinking monomer. Parts by weight and a mixture within the range of 2 to 50 parts by weight of the monomer represented by formula (I) of the present invention are preferable, and in the case of a water-containing soft contact lens, 70 to 98 parts by weight of the hydrophilic monomer, alkyl Methacrylate 0~
A mixture of 20 parts by weight, 0.1 to 10 parts by weight of the crosslinkable monomer, and 2 to 30 parts by weight of the monomer represented by formula (I) of the present invention is preferable.

The contact lens of the present invention is made by mixing monomers and a commonly used radical polymerization initiator, and polymerizing the mixture by heating, ultraviolet irradiation, etc., and then cutting and polishing the polymer, and then casting the mixture by polymerizing in a mold. It can be manufactured by the method. Examples of the radical polymerization initiator include peroxides such as benzoyl peroxide and lauroyl peroxide, azobisisobutyronitrile,
Azo compounds such as azobisdimethylvaleronitrile can be used. The amount used is usually 100% of the total monomer mixture.
It is within the range of 0.01 to 1 part by weight per part by weight.

In addition, in photopolymerization, for example, benzoin ethyl ether, benzoin n-butyl ether, benzyl dimethyl ketal, acetophenone, α.

A photosensitizer such as α-jethoxyacetophenone or anthraquinone was added at 0.0% per 100 parts by weight of the total monomer mixture.
It is used within the range of 0.05 to 3 parts by weight.

Further, the contact lens of the present invention can contain additives such as colorants and ultraviolet absorbers, if desired.

〔Example〕

EXAMPLES Hereinafter, the present invention will be explained in detail with reference to examples, but the present invention is not limited to these examples in any way. The physical properties were determined as follows.

(Stain adhesion, removability) Journal of the Japanese Contact Lens Society, 23 P, 10-14
(1981).

<Stain adhesion> A model lens (
Diameter 13mm, thickness 0.2mm, base curve 7.8m
m.

power 0.0) at 25°C for 20 hours, remove the lens, wash the lens surface with a certain amount of purified water, combine the washing solution with the immersion solution, and quantify the amount of remaining protein in it.
The difference from the initial protein content was calculated, and the amount of protein attached per lens was defined as the stain adhesion.

<Stain Removal Property> A model lens was immersed in an aqueous protein solution adjusted to a concentration of 17 ppm at 25°C for 20 hours, taken out, and washed with purified water to create a model lens with dirt attached to it. This lens was immersed in a 0.75% sodium dodecyl sulfate (abbreviated as SDS) aqueous solution at 40°C for 24 hours.
Proteins were extracted from the lenses. The lens was taken out, its surface was washed with a certain amount of SDS aqueous solution, and the amount of protein in this was determined by combining it with the extract and the value was taken as the stain releasability.

Example 1 90 parts by weight of 2-hydroxyethyl methacrylate (hereinafter abbreviated as HEMA), bis(1,1,2,2-tetrafluoroethoxy-2-hydroxypropyl) fumarate (
10 parts by weight of ethylene glycol dimethacrylate (hereinafter abbreviated as ED) were uniformly mixed, and 0.1 part by weight of azobisisobutyronitrile (hereinafter abbreviated as AIBN) was mixed uniformly. After melting and degassing under vacuum, it was poured between two glass plates with a 5 mm thick spacer and heated at 60 °C for 12 h and at 90 °C.
The mixture was heated for 36 hours to polymerize. Contact lenses were manufactured from the obtained polymer by cutting and polishing.

This lens was immersed in physiological saline for 48 hours to obtain a hydrous soft contact lens.

As a result of evaluating the stain adhesion and removability of this lens, the amount of protein stain attached was 0.3 μg/lens, and the amount of stain removed was 1.4 μg/lens.

Comparative Example 1 In Example 1, EDl was added to 100 parts by weight of HEMA.
, 0 parts by weight of AIBN, and 0.1 parts by weight of AIBN were uniformly mixed and polymerized to produce contact lenses. After being treated in the same manner as in Example 1, stain adhesion and releasability were evaluated. As a result, the amount of protein attached was 1.5 μg/lens, and the amount of dirt removed was 0.3 μg/lens.

Comparing Example 1 and Comparative Example 1, it is clear that the copolymer of the present invention is less likely to attach proteins and is more likely to release attached proteins.

Comparative Example 2 In Example 1, a hydrous soft contact lens was produced from a polymer polymerized using trifluoroethyl methacrylate (hereinafter abbreviated as 3FM) containing only fluorine atoms instead of TF) (MAO). As a result of evaluating the dirt adhesion and removability of this product, as shown in Table 1,
It is clear that the addition of 3FM does not improve protein adhesion nor does it improve detachability.

As is clear from comparing Example 1 and Comparative Examples 1 and 2,
It can be seen that the copolymer of the present invention has very specific properties in terms of stain adhesion and release properties.

Example 2 90 parts by weight of methyl methacrylate (hereinafter abbreviated as MMA) and 10 parts by weight of TFHMA were uniformly mixed, and AIBN
After dissolving 0.1 part by weight and degassing under vacuum, it was poured into the same glass cell for cast polymerization as in Example 1, and 60%
Polymerization was carried out by heating at ℃ for 96 hours. The obtained polymer was processed into a hard contact lens. As a result of evaluating the dirt adhesion and removability of this lens, as shown in Table 1, it was found that dirt was difficult to adhere to and easy to remove.

Examples 3 and 4 In Example 2, Tris(
Trimethylsiloxy)silylpropyl methacrylate
(hereinafter abbreviated as TSSMA) and 3FM were used to polymerize each of the compositions shown in Table 1 to obtain polymers.

Fabricate hard contact lenses from the obtained polymer,
The stain adhesion and removability were evaluated. As shown in Table 1,
It was difficult for dirt to adhere to it, and it was easy to remove it.

Examples 5 to 8 In Examples 1 to 4, instead of TFHMA, bis(4
,4,5,5,6,6,7,7,7-nonafluoro-2
-Hydroxyheptane) fumarate (hereinafter FBHMA)
) was used to obtain a polymer. Contact lenses were manufactured from each of the obtained polymers and the stain adhesion properties were evaluated. As shown in Table 1, the lenses showed excellent performance in that they were difficult to adhere to and that the adhered stains were easy to remove. .

Example 9 99.9 parts by weight of TFHMA and 1 part by weight of EDo were polymerized to obtain a polymer. A contact lens was produced from the obtained polymer and immersed in physiological saline for 48 hours to obtain a water-containing contact lens.

As a result of evaluating the dirt adhesion and removability of this lens, the first
As shown in the table, the amount of dirt deposited was extremely small. The reason why the amount of dirt removed is small is considered to be because the amount of adhesion is extremely small.

Example 10 In the same manner as in Example 9, FBHMA was polymerized with ED to produce a contact lens. As a result of evaluating the dirt adhesion and detachability of this lens, it was found to be as difficult to adhere and to be detached as TFHMA.

Example 11 80 parts by weight of HEMA, 15 parts by weight of hydroxypropyl methacrylate (hereinafter abbreviated as HPMA), 5 parts by weight of TFHMA, 5 parts by weight of EDl, and 1 part by weight of AIBNo were uniformly mixed, degassed under vacuum, and then heated for a long time. Pour approximately 30 g each into a test tube with a length of 180 mm and an inner diameter of 16 mm, and heat at 4°C for 8 hours.
Polymerization was carried out by heating at 60°C for 12 hours and at 90°C for 48 hours. The obtained polymer was transparent and uniform with no optical distortion. A disc strip button with a thickness of 5 mm and a diameter of 12.7 mm was cut from this polymer, dried in a desiccator for 24 hours, and then a contact lens was manufactured by cutting and polishing. It was immersed in saline for 48 hours to obtain a hydrous contact lens. As a result of evaluating the stain adhesion and removability of this contact lens, it was found that protein stains were difficult to adhere to and the adhered stains were easily removable. The results are shown in Table 2. Note that the swelling ratio of this polymer was 1.21.

Examples 12 to 13 Polymers were obtained in the same manner as in Example 11, except that the monomers of Example 11 were used and the mixed composition was changed to the composition shown in Table 2. A prototype lens was made from the obtained polymer, and its dirt adhesion and releasability were evaluated. The results are shown in Table 2.

Example 14 TSSMA 63 parts by weight, TFHFA 25 parts by weight, MM
A 12 parts by weight, 6 parts by weight of tetraethylene glycol dimethacrylate (hereinafter abbreviated as 4ED), AIBN 0
．． After uniformly mixing 086 parts by weight and degassing under vacuum,
Approximately 28 g each was injected into a test tube with a length of 180 mm and an inner diameter of 16 mm.
Polymerization was carried out by heating at 10°C for 10 hours.

The obtained polymer was transparent, had a Vickers hardness of 7.6, and an oxygen permeability coefficient of 83 x 10-ml ・an/ad, se
c, mmHg, and was uniform with no optical distortion. Disc-shaped buttons with a thickness of 5 mm and a diameter of 12.7 mm were cut from this polymer, dried in a vacuum desiccator for 24 hours, and then contact lenses were manufactured by cutting and polishing. The obtained hard contact lenses were stored for one week in a storage solution consisting of physiological saline and a nonionic surfactant, and then their stain adhesion and removability were evaluated. The results are shown in Table 2.

Example 15 A polymer was obtained in the same manner as in Example 14, except that the monomers of Example 14 were used and the mixed composition was changed to the composition shown in Table 2. A prototype lens was made from the obtained polymer, and its dirt adhesion and release properties were evaluated. The results are shown in Table 2.

Examples 16 and 17 In Examples 11 and 12, instead of TFHFA, F
A polymer was obtained by polymerizing in the same manner as in Example 11, except that BHMA was used. A contact lens was prepared from the obtained copolymer, and its stain adhesion and releasability were evaluated. The results are shown in Table 2.

Comparative Example 4 In Example 11, a polymer was obtained which was polymerized with the monomer composition shown in Table 2 without using TFHFA. Lenses were made from the obtained polymer and their dirt adhesion and removal properties were evaluated. The results are shown in Table 1. From Table 2, it is clear that the contact lenses of the present invention do not allow proteins to adhere easily, and the adhered stains are easily removed.

Comparative Example 5 A polymer was produced in the same manner as in Example 12, except that MMA was used instead of TFHFA.

The resulting copolymer was processed into lenses, and its dirt adhesion and release properties were evaluated.

Example 18 α,ω-bis(3-methacryloxypropyl)dimethylpolysiloxane (n of general formula ■ is about 45)
55 parts by weight, 20 parts by weight of n-butyl acrylate, 15 parts by weight of trifluoroethyl acrylate, TFHFA
11 parts by weight of ED and 4 parts by weight of ED were mixed uniformly, 0.5 parts by weight of benzyl dimethyl ketal was dissolved therein, degassed in vacuum, and molded from polypropylene to make a lens manufacturing mold (concave mold). A mold (convex mold) also made of polypropylene was placed on top of this, and the mixture was irradiated with an ultraviolet lamp having a main wavelength of 350 nm to polymerize. The obtained lenses were immersed and stored in physiological saline for 2 days, and then dirt adhesion and removability were evaluated. When lysozyme was used as a model stain, the adhesion was 0.2 μg/sheet and the releasability was 1.4 μg/sheet.

Comparative Example 6 In Example 18, instead of 11 parts by weight of TFHPA, 5 parts by weight of n-butyl acrylate (25 parts by weight in total),
A lens was manufactured by cast polymerization in the same manner as in Example 18, except that 6 parts by weight of methacrylic acid was used. The obtained lens was a soft lens with a hardness (IRHD) of 83. As a result of evaluating the stain adhesion and removability of this, the stain adhesion was 2 μg/sheet, and the releasability was 0.9 μg/sheet.

Margins below [Effects of the Invention] The contact lens of the present invention has the characteristics that stains such as proteins and lipids are difficult to adhere to, and that the adhered stains are also easily removed, and can be used as hard contact lenses and soft contact lenses. Easy to wear,
Even when worn for a long period of time, there is no fogging of the lenses or deterioration of vision, there is little damage to the cornea, and daily cleaning is easy.
It's very useful.

Patent applicant: Asahi Kasei Industries, Ltd.

Claims (1)

[Scope of Claims] 1. A contact lens made of a polymer obtained by polymerizing fumaric acid ester or maleic acid ester represented by the general formula (I) as an essential component. ▲There are mathematical formulas, chemical formulas, tables, etc.▼(I) (In the formula, at least one of R_1 and R_2 is a fluorocarbon group containing an -OH group.)