JPH0497746A - Spraying of medicinal solution - Google Patents

Abstract

PURPOSE:To spray several kinds of medicinal solution simultaneously by one operation by storing one or more kinds of medicinal solution differing from on in an aerosol container into a liquid reservoir section of a catheter to inject the aerosol contents. CONSTITUTION:When two kinds of medicinal solutions are sprayed to treat pneumonia of a cattle, first, a pressure resistant container for aerosol is filled with a first medicinal solution and an injection agent, and an aerosol container 2 equipped with a valve for aerosol is prepared. After the feeding of a second medicinal solution from a connector 9, a mounting part 4 of a catheter 1 is mounted on a stem 3 of the aerosol container 2. Then, an injection part 6 is inserted into a nostril of the cattle from the side of a tip thereof and further into an internal branch of a trachea passing through the trachea. Thereafter, the mounting part 4 is pressed to push down the stem 3 so that the aerosol content namely, the injection agent and the first medicinal solution are jetted. As a flow of injection containing the injection agent and the first medicinal solution reaches a liquid reservoir section 7, it is sprayed at jetting section 6 with the first and second medicinal solutions being mixed together as accompanying the second medicinal solutions stored within the liquid reservoir section 7.

Description

DETAILED DESCRIPTION OF THE INVENTION "Industrial Application Field" The present invention relates to a method of spraying a medicinal solution, and particularly to a method of efficiently spraying a plurality of types of medicinal solutions into the stomach, lungs, etc. of livestock by one spraying.

``Prior Art'' Traditionally, as a treatment for cases of pneumonia in livestock such as cows, there have been two methods: administering a drug by injection, or inserting a needle into the trachea and pumping the drug with a syringe. A method of injecting a drug into the trachea (intratracheal injection) is known.

However, in the case of the above-mentioned injection administration, the therapeutic effect is not sufficient because the drug is indirectly transferred to the lungs via the blood, and in the case of intratracheal injection, the drug may be concentrated locally in the trachea. However, the distribution to the lungs is limited, and sufficient therapeutic effects have not yet been achieved.

To address this problem, the applicant of the present application has proposed a catheter for livestock that sprays a medicinal solution directly into the stomach, lungs, etc. of livestock.

This livestock catheter consists of an aerosol button body that is removably attached to an aerosol container containing a medicinal solution and a propellant or a discharge port of a device, a tube that connects the aerosol button body and the injection part, and a tip of the tube. It generally consists of an injection section connected to a section.

For example, the following procedure is used to treat pneumonia in cattle using such a catheter for livestock.

First, a medical solution for treatment is sealed in a pressure-resistant aerosol container together with a propellant such as carbon dioxide gas, and an aerosol container is prepared which is equipped with an aerosol valve. Next, after attaching the aerosol button body of the livestock catheter to the stem of this aerosol container, the injection part is inserted from the distal end into the cow's nostril and into the trachea. Then, by pressing the aerosol button body and pushing down the stem, the medicinal solution and propellant in the aerosol container are sprayed into the cow's trachea.

``Problems to be Solved by the Invention'' By the way, although the above-mentioned livestock catheter has the excellent effect of being able to spray the medicinal solution over a wide range of affected areas,
There was a problem in that only one type of chemical solution sealed in the aerosol container could be sprayed. In other words, due to the nature of chemical solutions, there are almost no chemical solutions that have good stability even when two or more types of drug solutions are mixed, and it is often difficult to seal two or more types of drug solutions in an aerosol container. The majority of the medicinal solutions available are encapsulated in ampoules and the like, and are commercially available as medicinal solutions effective against a single medical condition. Therefore, if it is necessary to spray multiple types of medicinal liquids depending on the medical condition of the livestock, it is necessary to perform the above operation several times in succession, which is inconvenient and complicated.

This invention was made to solve the above problems, and it is possible to simultaneously spray multiple types of chemical solutions in one operation.
The object of the present invention is to provide a method of spraying a medicinal solution that can provide even more effective treatment.

"Means for Solving the Problems" The chemical liquid spraying method of the present invention includes: a tube for guiding the aerosol contents from an aerosol container containing a chemical liquid and a propellant; and an injection part connected to the tip of the tube. Using a drug solution spraying catheter comprising a liquid reservoir provided in the middle of the tube, one or more types of drug solution different from the drug solution in the aerosol container is stored in the solution reservoir of the drug solution spraying catheter, and the aerosol content is The solution is to spray a chemical liquid in an aerosol container and a chemical liquid stored in a liquid reservoir from a spraying part by spraying a substance.

"Function" When injecting the aerosol contents from an aerosol container containing a medicinal solution and a propellant, the medicinal solution stored in the liquid reservoir is entrained in the jet flow, so the desired multiple types of medicinal solutions are preliminarily injected into the liquid reservoir. By injecting it into the tank, multiple types of chemical solutions can be sprayed simultaneously in a single operation.

Embodiment FIG. 1 shows an example of a medical liquid spraying catheter suitably used in the medical liquid spraying method of the present invention. 1st
In the figure, reference numeral 1 denotes a catheter for spraying a medical solution (hereinafter abbreviated as catheter). This catheter 1 includes, for example, a stem 3 of an aerosol container 2 indicated by a chain double-dashed line in FIG.
is removably attached to, and when attached,
A mounting part 4 having a passage through which the injection port 3a of the stem 3 and the tube 5 communicate, a tube 5 connected to the connector 9 of the mounting part 4, and an injection part 6 connected to the tip of the tube 5. , and a liquid reservoir section 7 and ' provided in the middle of the tube 5.

As shown in FIG. 2, the attachment part 4 consists of an attachment part body 8 which also serves as an aerosol button, and a connector 9 attached to this attachment part body 8.

The attachment main body 8 is detachably attached to the aerosol container 2 by fitting its internal hole 10 into the stem 3 of the aerosol container 2. Further, a connector mounting hole It is formed at the upper end of the internal hole lO of the mounting part main body 8, communicating with this and opening on the side wall side of the mounting part main body 8. A connector 9 is attached. The connector 9 consists of a protrusion 12 that fits into the connector mounting hole 11 and a large diameter portion 13 to which the tube 5 is attached. A groove 13a is formed in the large diameter portion 13 along the circumferential direction on the surface opposite to the protrusion 12, and one end of the tube 5 is fitted and attached to this groove 13a.

The tube 5 is a flexible material made of polyethylene, silicone, etc., and has an outer diameter of about 2 to 10 mm and a length of about 70 to 200 cm, so that it can be inserted into and removed from the trachea through the nostril of a cow, for example. It was formed. In the middle of this tube 5, there is provided a liquid reservoir 7 for storing a medical solution. The shape of the liquid reservoir 7 is not particularly limited as long as it can store the medicinal solution. For example, as shown in FIG. It may also be fixed.

Further, an injection section 6 is integrally attached to the other end of the tube 5. The injection section 6 includes a substantially cylindrical injection section main body 1 that is engaged with the tip opening of the tube 5, as shown in FIG.
4, a cylindrical body 16 inserted into the internal hole 15 of the injection part main body 14, and an exterior work 7 inserted into the injection part main body 14 and the tip of the tube 5. be. The injection part main body 14 is inserted into the small diameter part 18 on the rear end side or into the tube 5, and the locking step part 18a formed on the outer periphery of the small diameter part 18 engages and comes into close contact with the inner surface of the tube 5, thereby locking thereto. It is something to do.

The injection part main body 14 has the above-mentioned cylindrical body 16 in its internal hole 15.
A protrusion 19 is formed on the distal end side of the internal hole 15 for fixing the internal hole 15, and an injection hole 20 that communicates with the internal hole 15 and opens at the distal end surface, and a plurality of injection holes that communicate with the injection hole 20. Groove 2I... is formed in a nozzle having a mechanical break-up mechanism. The injection hole 20 has a small diameter opening on the tip side, and an injection groove 2 on the inner hole 15 side.
It communicates with 1. The injection grooves 20- are each opened into the internal hole 15, and one end thereof is connected to the injection hole 2.
0 and extends in the outer circumferential direction of the attachment portion main body 8.

The cylindrical body 16 is inserted into the internal hole 15 of the injection part main body 14 and fixed to the protrusion 19, and has a small diameter part 22 formed at its tip.

As a result, the gap between the inner surface of the internal hole 15 and the outer surface of the cylindrical body 16 becomes a flow path 2 for the contents from the aerosol container 2.
3, and the flow passage 23 communicates with the injection grooves 21 through the side of the small diameter portion 22.

The exterior work 7 is a substantially cylindrical piece made of metal such as brass, synthetic resin such as polyethylene, or rubber, and has a rounded tip and a tapered surface on the rear end to remove the pointed end. . In addition, this exterior work 7 has its outer surface smoothed so that there are no irregularities due to paris, etc., and is designed to avoid damaging the inner wall when inserted into the trachea of livestock. . Furthermore, the exterior work 7 is selected in advance to have an appropriate size and outer diameter so that it can be easily inserted into and removed from the nostrils, trachea, etc. of livestock such as cattle.

For example, to treat pneumonia in cattle by spraying two types of medicinal solutions using a catheter l with such a configuration, first fill an aerosol pressure-resistant container with the first medicinal solution and a propellant, and then attach an aerosol valve. Prepare an aerosol container 2. Examples of propellants used here include carbon dioxide gas, nitrogen, compressed air, Freon gas, liquefied petroleum gas, and dimethyl ether.

In addition, the drug solution in the present invention includes, for example, venisoline antibiotics such as pennlupenine, cloxacillin, nocloxanoline, and ampicillin, cephalosporin antibiotics such as cefazolin, cephalothin, and cefanxin, tetracycline, chlortetracycline, and oxnotetracycline. , tetracycline antibiotics such as doquinzycline, dihydrostreptomycin,
kanamynon, gentamicin, spectinomynon,
Aminocricont antibiotics from Furanoomainonano,
Macrolide antibiotics such as tyloinone, erythrominone, kitasamainone, mirosaminone, and nyosaminone, chloramphenicol, cyanophenicol,
Other antibiotics such as lincomycin, tiamulin,
Synthetic antibacterial agents such as norfloxanone and ofloxanone,
Contains as active ingredients drugs such as respiratory stimulants such as rohenine hydrochloride, dimorpholamine, and bentetrazole, antitussive expectorants such as isoproterenol, L-methylephedrine hydrochloride, epinephrine hydrochloride, and ephedrine hydrochloride, and enzyme agents such as chymotrivun and hyaluronidase. If these drugs are oil-soluble, they are used in a liquid state dissolved in a solvent such as an appropriate organic solvent, and if they are water-soluble, they are used in a liquid state dissolved in a solvent such as water. Furthermore, these may be used as an emulsion formulation as appropriate.

Next, a long tube 5 is prepared, and the central portion thereof is wound several times and fixed to form a liquid reservoir 7. And this liquid reservoir 7
After injecting one or more types of medicinal solution different from the medicinal solution in the aerosol container (hereinafter referred to as the second medicinal solution) through the detached connector 9 using a syringe or the like, attaching the catheter l to the stem 3 of the aerosol container 2. Attach part 4.

Next, insert the injection part 6 into the cow's nostril from its tip side,
This is further advanced and inserted through the trachea to the endotracheal bifurcation. Thereafter, the attachment portion 4 is pressed and the stem 3 is pushed down to eject the aerosol contents, that is, the propellant and the first chemical solution. When the jet flow containing the propellant and the first chemical liquid reaches the liquid reservoir 7, the liquid reservoir ff1
Since the second chemical liquid stored in the second chemical liquid is entrained, the first chemical liquid and the second chemical liquid are sprayed from the spouting part 6 in a mixed state. In this way, two types of chemical solutions can be sprayed in one operation.

With such a catheter 1, by injecting the desired drug solution into the liquid reservoir 7, multiple types of drug solutions can be sprayed in a single operation, so that sufficient therapeutic effects can be obtained. .

In addition, in the spraying method of the present invention, a long flexible tube 5 is wound multiple times to form a liquid reservoir 7, and one or more types of chemical solutions are mixed and stored in the liquid reservoir 7. Since no special members are required, the operation is very simple.

Furthermore, simply by attaching the attachment part 4 to the aerosol container 2 and pressing the attachment part 4, a plurality of types of medicinal solutions can be directly injected to the affected area, making it extremely easy to use.

Furthermore, since two or more types of chemical liquids are mixed immediately before use, it can be applied without any disadvantages even in a mixed system of chemical liquids that lack storage stability when mixed.

Further, it is preferable that the tube 5 is a transparent tube, since the remaining amount of the chemical solution stored in the liquid reservoir section 7 can be visually confirmed.

4 and 5 show the second and third embodiments of the catheter used in the present invention, respectively.
The liquid reservoir portion 7 has a different shape from that shown in the figure.

In the example shown in FIG. 4, a hollow part is formed by expanding the diameter of the middle part of the tube 5, and this hollow part is used as the liquid reservoir part 7.

In the example shown in FIG. 5, a medicine bottle 24 containing a medicine liquid is used as the liquid reservoir 7.

That is, one end 5a of the tube 5 connected to the attachment part 4 is inserted into the gas phase of the medicine liquid filled in the medicine bottle 24, and one end is communicated with the injection part 6, and the other end is connected to the medicine bottle 24. A second tube 5b that opens into the liquid phase is connected to the medicine bottle 24 in an airtight manner to form a liquid reservoir 7. If you stain like this,
The medicine bottle 24 containing the medicine liquid can be used as it is as the liquid reservoir 7, which has the effect of further simplifying the operation during spraying.

Note that a plurality of liquid reservoirs 7 may be connected in parallel or in series and interposed between the tubes 5 (one may be used).

``Effects of the Invention As explained above, the method for spraying a medical liquid of the present invention involves storing one or more types of medical liquid different from the medical liquid in the aerosol container in the liquid reservoir part of the catheter, and spraying the aerosol contents into the aerosol container. Since the chemical liquid and the chemical liquid stored in the liquid reservoir are sprayed from the spraying part, if multiple types of chemical liquids are mixed in the liquid reservoir in advance, multiple types of chemical liquids can be sprayed at the same time in one operation. It can be highly effective in treating livestock, etc.

Furthermore, since the spraying method of the present invention involves mixing multiple types of chemical solutions immediately before use, it can be applied to mixed systems of chemical solutions that lack stability when mixed and left as is. I can do it.

[Brief explanation of drawings]

1 to 3 are diagrams showing an embodiment of a medical liquid spraying catheter suitably used in the chemical liquid spraying method of the present invention. FIG. 3 is a schematic configuration diagram of the injection unit, and FIGS. . Catheter for spraying drug solution, 2-air bouquet container, 4-attachment part, 5-tube, 6-injection part, 7-liquid reservoir part.

Claims (1)

[Scope of Claims] A tube that guides the aerosol contents from an aerosol container containing a medicinal solution and a propellant, an injection section connected to the tip of this tube, and a liquid reservoir section provided in the middle of the tube. One or more types of medicinal liquid different from the medicinal liquid in the aerosol container is stored in the liquid reservoir part of the medicinal liquid atomizing catheter, and the aerosol contents are sprayed to spray the medicinal liquid and the medicinal liquid in the aerosol container. A chemical liquid spraying method characterized in that a chemical liquid stored in a liquid reservoir is sprayed from a spraying part.