JPH051423B2 - - Google Patents

Info

Publication number: JPH051423B2
Authority: JP; Japan
Prior art keywords: ion; sensitive; membrane; organic polymer; inorganic solid
Prior art date: 1984-02-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP59033677A

Other languages

English (en)

Japanese (ja)

Other versions

JPS60177256A (ja

Inventor

Shotaro Oka

Osamu Tawara

Takumi Maeda

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Shimadzu Corp

Original Assignee

Shimadzu Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-02-23

Filing date

1984-02-23

Publication date

1993-01-08

1984-02-23 Application filed by Shimadzu Corp filed Critical Shimadzu Corp

1984-02-23 Priority to JP59033677A priority Critical patent/JPS60177256A/ja

1985-09-11 Publication of JPS60177256A publication Critical patent/JPS60177256A/ja

1993-01-08 Publication of JPH051423B2 publication Critical patent/JPH051423B2/ja

Status Granted legal-status Critical Current

Links

239000012528 membrane Substances 0.000 claims description 52
229910003480 inorganic solid Inorganic materials 0.000 claims description 26
229920000620 organic polymer Polymers 0.000 claims description 26
230000002209 hydrophobic effect Effects 0.000 claims description 17
239000006087 Silane Coupling Agent Substances 0.000 claims description 11
239000000126 substance Substances 0.000 claims description 10
229920000642 polymer Polymers 0.000 claims description 9
229910052710 silicon Inorganic materials 0.000 claims description 5
239000010703 silicon Substances 0.000 claims description 4
-1 alkyl dialdehyde Chemical compound 0.000 claims description 3
150000002500 ions Chemical class 0.000 description 66
239000000178 monomer Substances 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
239000011521 glass Substances 0.000 description 10
229910004298 SiO 2 Inorganic materials 0.000 description 9
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
239000007787 solid Substances 0.000 description 8
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 7
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 7
239000007864 aqueous solution Substances 0.000 description 7
229910001424 calcium ion Inorganic materials 0.000 description 7
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 6
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
239000004014 plasticizer Substances 0.000 description 6
238000012643 polycondensation polymerization Methods 0.000 description 6
229920000915 polyvinyl chloride Polymers 0.000 description 6
239000004800 polyvinyl chloride Substances 0.000 description 6
239000000243 solution Substances 0.000 description 6
PWGJDPKCLMLPJW-UHFFFAOYSA-N 1,8-diaminooctane Chemical compound NCCCCCCCCN PWGJDPKCLMLPJW-UHFFFAOYSA-N 0.000 description 5
125000002887 hydroxy group Chemical group [H]O* 0.000 description 5
238000000034 method Methods 0.000 description 5
238000006116 polymerization reaction Methods 0.000 description 5
239000002904 solvent Substances 0.000 description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 4
239000011248 coating agent Substances 0.000 description 4
238000000576 coating method Methods 0.000 description 4
238000010586 diagram Methods 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000000499 gel Substances 0.000 description 4
239000007788 liquid Substances 0.000 description 4
239000000463 material Substances 0.000 description 4
229910001414 potassium ion Inorganic materials 0.000 description 4
NBQXYAJLUDQSNV-UHFFFAOYSA-N 1-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid Chemical compound C1=CC(C)=CC=C1CN1C(=O)CC(C(O)=O)C1 NBQXYAJLUDQSNV-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 description 3
108010067973 Valinomycin Proteins 0.000 description 3
FCFNRCROJUBPLU-UHFFFAOYSA-N compound M126 Natural products CC(C)C1NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC1=O FCFNRCROJUBPLU-UHFFFAOYSA-N 0.000 description 3
239000011159 matrix material Substances 0.000 description 3
239000011259 mixed solution Substances 0.000 description 3
239000001103 potassium chloride Substances 0.000 description 3
235000011164 potassium chloride Nutrition 0.000 description 3
239000000758 substrate Substances 0.000 description 3
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 3
FCFNRCROJUBPLU-DNDCDFAISA-N valinomycin Chemical compound CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC1=O FCFNRCROJUBPLU-DNDCDFAISA-N 0.000 description 3
WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 2
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
229910021607 Silver chloride Inorganic materials 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
125000003277 amino group Chemical group 0.000 description 2
239000002585 base Substances 0.000 description 2
239000001110 calcium chloride Substances 0.000 description 2
229910001628 calcium chloride Inorganic materials 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
239000002131 composite material Substances 0.000 description 2
150000003983 crown ethers Chemical class 0.000 description 2
239000008367 deionised water Substances 0.000 description 2
229910021641 deionized water Inorganic materials 0.000 description 2
229920006332 epoxy adhesive Polymers 0.000 description 2
230000005669 field effect Effects 0.000 description 2
239000012535 impurity Substances 0.000 description 2
230000007774 longterm Effects 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
230000004043 responsiveness Effects 0.000 description 2
HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 2
239000012085 test solution Substances 0.000 description 2
AHYFYQKMYMKPKD-UHFFFAOYSA-N 3-ethoxysilylpropan-1-amine Chemical compound CCO[SiH2]CCCN AHYFYQKMYMKPKD-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 1
108010093096 Immobilized Enzymes Proteins 0.000 description 1
229930191564 Monensin Natural products 0.000 description 1
GAOZTHIDHYLHMS-UHFFFAOYSA-N Monensin A Natural products O1C(CC)(C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)CCC1C(O1)(C)CCC21CC(O)C(C)C(C(C)C(OC)C(C)C(O)=O)O2 GAOZTHIDHYLHMS-UHFFFAOYSA-N 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
239000002262 Schiff base Substances 0.000 description 1
150000004753 Schiff bases Chemical class 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
238000004873 anchoring Methods 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
229910052681 coesite Inorganic materials 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
239000007822 coupling agent Substances 0.000 description 1
229910052906 cristobalite Inorganic materials 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
CJAONIOAQZUHPN-KKLWWLSJSA-N ethyl 12-[[2-[(2r,3r)-3-[2-[(12-ethoxy-12-oxododecyl)-methylamino]-2-oxoethoxy]butan-2-yl]oxyacetyl]-methylamino]dodecanoate Chemical compound CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC CJAONIOAQZUHPN-KKLWWLSJSA-N 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
238000007654 immersion Methods 0.000 description 1
239000002555 ionophore Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
229960005358 monensin Drugs 0.000 description 1
GAOZTHIDHYLHMS-KEOBGNEYSA-N monensin A Chemical compound C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C(O)=O)O2 GAOZTHIDHYLHMS-KEOBGNEYSA-N 0.000 description 1
238000000465 moulding Methods 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
150000002903 organophosphorus compounds Chemical class 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000004065 semiconductor Substances 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
229910052682 stishovite Inorganic materials 0.000 description 1
229910052905 tridymite Inorganic materials 0.000 description 1
239000004034 viscosity adjusting agent Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Microelectronics & Electronic Packaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Electrochemistry (AREA)
Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Pathology (AREA)
Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

JP59033677A 1984-02-23 1984-02-23 イオンセンサ− Granted JPS60177256A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP59033677A JPS60177256A (ja)	1984-02-23	1984-02-23	イオンセンサ−

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP59033677A JPS60177256A (ja)	1984-02-23	1984-02-23	イオンセンサ−

Publications (2)

Publication Number	Publication Date
JPS60177256A JPS60177256A (ja)	1985-09-11
JPH051423B2 true JPH051423B2 (de)	1993-01-08

Family

ID=12393076

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP59033677A Granted JPS60177256A (ja)	1984-02-23	1984-02-23	イオンセンサ−

Country Status (1)

Country	Link
JP (1)	JPS60177256A (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8400916A (nl) *	1984-03-22	1985-10-16	Stichting Ct Voor Micro Elektr	Werkwijze voor het vervaardigen van een isfet en een aldus vervaardigde isfet.
JPH063428B2 (ja) *	1985-01-24	1994-01-12	工業技術院長	化学修飾ガラス膜イオン選択性電極

1984
- 1984-02-23 JP JP59033677A patent/JPS60177256A/ja active Granted

Also Published As

Publication number	Publication date
JPS60177256A (ja)	1985-09-11

Publication	Publication Date	Title
Nakamoto et al.	1988	A lift-off method for patterning enzyme-immobilized membranes in multi-biosensors
EP0258951B1 (de)	1993-12-08	Verfahren zur Herstellung eines REFETs oder eines CHEMFETs, sowie deren Herstellung
US4881109A (en)	1989-11-14	Sensor using a field effect transistor and method of fabricating the same
Liu et al.	1993	Potentiometric ion-and bioselective electrodes based on asymmetric polyurethane membranes
Munoz et al.	1997	Photosensitive polyurethanes applied to the development of CHEMFET and ENFET devices for biomedical sensing
EP0177544B1 (de)	1992-08-12	Verfahren zur herstellung eines isfet und nach diesem verfahren hergestellte isfet
JPH0431544B2 (de)	1992-05-26
JPS61165656A (ja)	1986-07-26	固定化酵素薄膜の形成法
EP0300575B1 (de)	1992-12-09	Iondetektor mit einer selektiven organischen Membran
US5417835A (en)	1995-05-23	Solid state ion sensor with polyimide membrane
Skowronska-Ptasinska et al.	1990	Reference field effect transistors based on chemically modified ISFETs
US11193906B1 (en)	2021-12-07	Solid-contact ion-selective and reference electrodes covalently attached to functionalized polymers
JPH051423B2 (de)	1993-01-08
Yun et al.	2018	A wet-chemistry-based hydrogel sensing platform for 2D imaging of pressure, chemicals and temperature
Battilotti et al.	1989	Ion-selective membrane chemically bound to a field-effect transistor
JPS6366454A (ja)	1988-03-25	酵素センサ−およびその製造方法
Tietje-Girault et al.	1990	Photopolymerisation of ion-selective membranes onto silicon nitride surfaces for ISFET fabrication
Wakida et al.	1990	Urushi matrix sodium, potassium, calcium and chloride-selective field-effect transistors
JPH0564732B2 (de)	1993-09-16
JPS61274682A (ja)	1986-12-04	酵素固定化膜の製造法
JPS63217265A (ja)	1988-09-09	半導体イオンセンサの製造方法
JPH0533743B2 (de)	1993-05-20
JPS6254155A (ja)	1987-03-09	半導体バイオセンサ酵素固定化膜の形成方法
JPS61283862A (ja)	1986-12-13	酵素固定化膜の製造方法
JPH02240555A (ja)	1990-09-25	グルコースセンサ