JPH0518828B2 - - Google Patents

Info

Publication number
JPH0518828B2
JPH0518828B2 JP63071712A JP7171288A JPH0518828B2 JP H0518828 B2 JPH0518828 B2 JP H0518828B2 JP 63071712 A JP63071712 A JP 63071712A JP 7171288 A JP7171288 A JP 7171288A JP H0518828 B2 JPH0518828 B2 JP H0518828B2
Authority
JP
Japan
Prior art keywords
formula
evaporated
give
title compound
methylene chloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63071712A
Other languages
English (en)
Japanese (ja)
Other versions
JPS63255266A (ja
Inventor
Edowaado Kurosu Piitaa
Edomando Arosumisu Jon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS63255266A publication Critical patent/JPS63255266A/ja
Publication of JPH0518828B2 publication Critical patent/JPH0518828B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Saccharide Compounds (AREA)
JP63071712A 1987-03-25 1988-03-25 抗不整脈剤 Granted JPS63255266A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878707122A GB8707122D0 (en) 1987-03-25 1987-03-25 Antiarrhythmic agents
GB8707122 1987-03-25

Publications (2)

Publication Number Publication Date
JPS63255266A JPS63255266A (ja) 1988-10-21
JPH0518828B2 true JPH0518828B2 (2) 1993-03-15

Family

ID=10614608

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63071712A Granted JPS63255266A (ja) 1987-03-25 1988-03-25 抗不整脈剤

Country Status (11)

Country Link
US (2) US4829071A (2)
EP (1) EP0286277B1 (2)
JP (1) JPS63255266A (2)
AT (1) ATE53996T1 (2)
DE (1) DE3860245D1 (2)
DK (1) DK170201B1 (2)
ES (1) ES2016408B3 (2)
GB (1) GB8707122D0 (2)
GR (1) GR3000581T3 (2)
IE (1) IE60004B1 (2)
PT (1) PT87050B (2)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8707122D0 (en) * 1987-03-25 1987-04-29 Pfizer Ltd Antiarrhythmic agents
US5006523A (en) * 1989-10-26 1991-04-09 E. R. Squibb & Sons, Inc. Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
DK148292D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Forbindelser
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
PT807101E (pt) * 1995-02-01 2001-12-28 Upjohn Co 2-aminoindanos comoligandos selectivos de dopamina d3
DE19547263C2 (de) * 1995-12-07 1999-04-29 Cardiotec Inc Amidinohydrazone vom Benzo[b]furan abgeleiteter Ketone, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US6083991A (en) 1997-06-04 2000-07-04 University Of Florida Research Foundation, Inc. Anti-arrhythmic composition and methods of treatment

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2456911A (en) * 1945-05-04 1948-12-21 Wyeth Corp Disubstituted acetamidyl derivatives of amino quinolines
GB1024650A (en) * 1961-11-03 1966-03-30 Byk Gulden Lomberg Chem Fab Benzofuran derivatives and process for their production
US3513239A (en) * 1967-03-15 1970-05-19 Smithkline Corp Pharmaceutical compositions containing 2-aminoalkyl coumaran derivatives and methods of treating depression therewith
US3923813A (en) * 1969-12-19 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindanes
US4192888A (en) * 1978-04-10 1980-03-11 Smithkline Corporation Pharmaceutical compositions and method of inhibiting phenylethanolamine N-methyltransferase
CA1175851A (en) * 1980-09-26 1984-10-09 Beecham Group Limited Secondary amines
US4435422A (en) * 1982-09-15 1984-03-06 Abbott Laboratories 5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and their use in diuretic compositions
US4656190A (en) * 1983-11-14 1987-04-07 Merck & Co., Inc. Indene derivatives and their use as PAF-antagonists
EP0164865B1 (en) * 1984-05-04 1988-12-21 The Upjohn Company N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use
GB8412045D0 (en) * 1984-05-11 1984-06-20 Unilever Plc Detergent compositions
GB8707122D0 (en) * 1987-03-25 1987-04-29 Pfizer Ltd Antiarrhythmic agents

Also Published As

Publication number Publication date
DK160688D0 (da) 1988-03-24
DK170201B1 (da) 1995-06-12
ES2016408B3 (es) 1990-11-01
EP0286277A1 (en) 1988-10-12
DK160688A (da) 1989-01-10
GR3000581T3 (en) 1991-07-31
IE880886L (en) 1988-09-25
GB8707122D0 (en) 1987-04-29
PT87050B (pt) 1992-07-31
US5130334A (en) 1992-07-14
DE3860245D1 (de) 1990-07-26
IE60004B1 (en) 1994-05-18
ATE53996T1 (de) 1990-07-15
JPS63255266A (ja) 1988-10-21
EP0286277B1 (en) 1990-06-20
PT87050A (pt) 1988-04-01
US4829071A (en) 1989-05-09

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