JPH05269191A - Compound lens - Google Patents

Abstract

(57) [Summary] [Object] To provide a compound lens, which has excellent insertion characteristics into the eye and positional stability in the eye, and can be processed with high precision, particularly as an intraocular lens. [Structure] The tensile modulus of the optical material is 0.01 to 1.0
00 MPa and the glass transition point is 330 ° K or less, the tensile modulus of the peripheral material is 10 MPa to 500 GPa and the glass transition point is 270 ° K or more, and the optical material is relatively soft as compared with the peripheral material. A compound lens characterized by this.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a compound lens,
More specifically, the present invention relates to a compound lens in which the optical part is relatively soft as compared with the peripheral part.

[0002]

2. Description of the Related Art Conventionally, spectacles, contact lenses or intraocular lenses have been used for the correction of visual acuity after cataract surgery. In particular, intraocular lenses have recently been highly utilized due to their excellent characteristics. ing. Polymethylmethacrylate (PMMA) is well known as a material for this intraocular lens, but while PMMA has excellent optical characteristics and ability to correct visual acuity, it may damage corneal endothelial cells during intraocular insertion, The incision usually had to be larger than 6 mm, which had the drawback that there was a high possibility of complications after surgery. Moreover, biological components easily adhere in the eye,
There are also reports of cases where the optical surface becomes opaque. PMMA
Regarding the lens, the problem of opacification of the optical surface due to the attachment of biological components has been improved by various surface treatment techniques, but regarding the problems such as damage of corneal endothelial cells and complication of complications, The reality is that it has not been improved.
Therefore, a soft intraocular lens material has been devised, for example, poly (2-hydroxyethyl methacrylate), poly (N-vinyl-2-pyrrolidone), etc. as the water-containing material, and silicone as the non-water-containing material. , Acrylic acrylate polymers, etc. are known. However, soft lenses can be dehydrated and shrunk or folded and inserted through a small incision,
It is unlikely to damage intraocular tissue or to cause complications after surgery, but it is damaged during or after insertion into the eye due to insufficient optical characteristics and ability to correct vision and low mechanical strength. However, it is difficult to process the intraocular lens with high precision because the soft lens material is inferior in fine processability. On the other hand, composite lenses having a hard optical part and a soft peripheral part have also been proposed (see Japanese Patent Publication No. 55-29402 and Japanese Patent Publication No. 60-49298), but these compound lenses have a soft peripheral portion. Will it soften and swell with water,
Or it has high water absorption and absorbs moisture during processing,
Distortion occurs in the boundary region between the soft peripheral portion and the hard optical portion, and it is difficult to finish it precisely. In addition, since the peripheral portion is soft, there is a possibility that it may be damaged during or after insertion into the eye, and the positional stability in the eye is poor and there is a drawback that it tends to be displaced.

[0003]

Therefore, the problem to be solved by the present invention is that, particularly as an intraocular lens, it can be inserted through a small incision without damaging the intraocular tissue, and after insertion into the eye. An object of the present invention is to provide a compound lens which is not deviated, has excellent position stability, has good workability, and can be processed with high precision.

[0004]

That is, according to the present invention, the tensile modulus of the optical material is 0.01 to 1,000 MPa, the glass transition point is 330 ° K or less, and the tensile modulus of the peripheral material is 10 MPa. 500 GPa and glass transition point 270 °
The present invention relates to a compound lens, which is K or more and the material of the optical part is relatively softer than the material of the peripheral part. That the optical part material in the present invention is relatively soft as compared with the peripheral part material means that the tensile modulus and the glass transition point of the optical part material are lower than those of the peripheral part material.

Even if the optical part material is a compound lens relatively softer than the peripheral part material, the tensile elastic modulus of the optical part material is larger than 1,000 MPa or the glass transition point is higher than 330 ° K. When the compound lens is inserted into the eye, it cannot be folded into a small size, which makes it impossible to insert the compound lens through a small incision and may damage the intraocular tissue. On the other hand, when the tensile elastic modulus of the optical part material is smaller than 0.01 MPa, the optical characteristics of the lens are deteriorated. Although the lower limit of the glass transition point of the optical material is not particularly limited, it is usually 130 in view of optical characteristics and the like.
Materials of ° K or above are used. On the other hand, regarding the peripheral material, if the tensile elastic modulus is less than 10 MPa or the glass transition point is less than 270 ° K, the positional stability in the eye is poor and the possibility of deviation is increased, which is not preferable. If the tensile modulus is higher than 500 GPa, the intraocular tissue may be damaged during and after the insertion. Although the upper limit of the glass transition point of the peripheral material is not particularly limited, a material having a temperature of 500 ° K or less is usually used so as not to damage living tissue during and after insertion into the eye.

The compound lens of the present invention has, for example, the following (a):
It can be manufactured by a method such as (d). (A) A monomer capable of providing a predetermined soft optical material and a monomer capable of providing a predetermined hard peripheral material are polymerized in a mold having a required lens shape, or a predetermined soft optical material. And a method of molding a hard peripheral material in a mold having a required lens shape, (b) polymerizing a monomer capable of providing a predetermined soft optical material and a monomer capable of providing a predetermined hard peripheral material. A method for cutting a lumped material having a composite structure obtained as a result, or a lumped material obtained by compounding a predetermined soft optical part material and a hard peripheral part material into a desired lens shape, (c) Optical part having different reactivity After forming the lens substrate from the bulk material obtained by compounding the material and the peripheral material by polymerization or molding, the reaction is caused to occur in the highly reactive one of the optical material and the peripheral material to Softer than the How to harden than the optical portion parts. (D) After forming the lens substrate from a material composed of a single bulky polymer having reactivity (this may be a polymer blend or a polymer alloy), or softening only the optical part, or A method of hardening only the peripheral part.

Among the above methods (a) to (d), (a)
The method of (1) requires a large number of types of precision molding dies depending on the type of compound lens, etc., and thus has problems in economic efficiency, workability, etc. Since the monomer forming the part material has a long chain or has a special substituent, there is a drawback that the preparation of the monomer is complicated, and the control of the polymerization reaction is not easy. Are preferably the methods (c) and (d) above.
Regarding (c) and (d), examples of the method for softening the optical part include a method of introducing a substituent capable of softening the polymer, a method of cleaving a bond between polymer molecules, and the like. Examples of the hardening method include a method of introducing a functional group capable of hardening the polymer and a method of cleaving a bond between polymer molecules. In particular, a method of softening the optical part by introducing a substituent capable of softening the polymer is preferable. Therefore, in the following, a method of introducing a substituent capable of softening the optical part will be described in detail.

Among the methods of (c), the lump material obtained by compounding the optical part material and the peripheral part material used in the method (c) is (i) in the periphery of the preformed optical part material, A method of polymerizing a monomer that provides a peripheral material so that they are in intimate contact, (ii) a method of polymerizing a monomer that provides an optical material in the presence of a preformed peripheral material, (iii)
Both of them can be manufactured by a method in which the material of the optical part and the material of the peripheral part which have been formed in advance are compounded in a required arrangement relationship. Among these methods, (i) and (ii) are capable of suppressing polymerization distortion and optical distortion by appropriately selecting and combining the type and composition of the monomer, and at the same time, the optical part material. This is a preferable method in that the bonding between the material and the peripheral material can be made tighter. The methods (i) and (ii) can be applied to the polymerization in the above (a) and (b). Further, the method of producing the single bulk polymer (d) itself will be apparent to those skilled in the art.

The method (i) is, for example, a method of polymerizing a monomer which provides a peripheral material by using a rotary mold, and then injecting a monomer which provides an optical material, and polymerizing (Japanese Patent Publication No. 60-
No. 49298) and the method (ii) described above, for example, in the reaction of introducing a softening-capable substituent into the hollow portion of a hollow cylindrical material made of a non-reactive or low-reactive polymer. It can be carried out by, for example, a method of injecting a monomer which gives a highly reactive polymer and polymerizing.
The monomer component in these polymerizations may be in the form of a prepolymer or a solution in which a suitable polymer is dissolved in the monomer. Furthermore, the preformed optical part material or peripheral part material used in the above (i) and (ii) is also in the form of a prepolymer or a monomer in the polymer as long as it can maintain a desired shape during polymerization. May be impregnated with them, and in these cases, the polymerization of the monomer components may be completed in the above-mentioned polymerization process.

The polymerization in the above (i), (ii) and the like can be carried out by an ordinary radical polymerization reaction. For this purpose, for example, a method of using a thermal polymerization initiator such as benzoyl peroxide, azobisisobutyronitrile, azobisdimethylvaleronitrile, etc., and optionally raising the temperature stepwise, or benzoin, benzoin A method of irradiating light in the presence of a photopolymerization initiator such as methyl ether, benzophenone, Michler's ketone, or the like to perform polymerization can be employed. When the temperature is raised stepwise to perform polymerization, two or more kinds of thermal polymerization initiators having different decomposition temperatures can be used together, and when performing photopolymerization, the photopolymerization initiator and the thermal polymerization initiator are combined. In combination, the photopolymerization and the thermal polymerization may be performed simultaneously or stepwise. These thermal polymerization initiators or photopolymerization initiators are usually used in an amount of 0.01 to 10 parts by weight per 100 parts by weight of the monomer.

The lens substrate thus obtained is not only excellent in optical characteristics but also hard, and can be subjected to precise cutting and polishing, and can be easily formed into various lens shapes including intraocular lenses. It can be processed.

The reaction for introducing the substituent capable of softening the polymer constituting the optical part for producing the compound lens of the present invention includes, for example, esterification reaction, transesterification reaction, hydrosilylation reaction and the like. Preferred reactions are the esterification reaction and the transesterification reaction.
Either one of the esterification reaction and the transesterification reaction can be carried out, or both reactions can be carried out simultaneously.

Among the methods for softening the optical part by introducing a substituent into the lens substrate, in the above method (c), the reactivity of the material forming the optical part must be higher than that of the peripheral material. I won't. The method (d) can be carried out by, for example, a method of coating a portion corresponding to the peripheral portion of the reactive lens substrate so as to prevent the reaction agent from penetrating and reacting.

When an esterification reaction and / or a transesterification reaction is used in the production of the composite lens of the present invention, the material constituting the optical part has the esterification reactivity and / or the transesterification reactivity. It is necessary. Preferably, the reactive optical part material is a monomer unit (hereinafter, referred to as “alcohol-reactive monomer”) unit that is reactive to alcohol capable of softening the optical part material. A polymer containing is used. These alcohol-reactive monomers include acrylic acid esters such as alkyl acrylates and fluoroalkyl acrylates, and unsaturated carboxylic acids such as mono- or poly-carboxylic acids such as acrylic acid, methacrylic acid, itaconic acid and fumaric acid. An acid can be illustrated.

Alkyl acrylates or fluoroalkyls among alcohol-reactive monomers include the following general formula (I) CH ₂ ═CH—COOR ¹ ... (I) (wherein R ¹ is a carbon number 1 to 2 carbon atoms bonded through an alkyl group of 1 to 20 or a divalent hydrocarbon group of 1 to 4 carbon atoms
The fluoroalkyl group of 0 is shown. And a monomer represented by

Specific examples of the monomer of the general formula (I) include:
Methyl acrylate, ethyl acrylate, isopropyl acrylate, n-propyl acrylate, n-butyl acrylate, t-butyl acrylate, n-pentyl acrylate, n-hexyl acrylate, n-heptyl acrylate, n-octyl acrylate, 2-ethylhexyl acrylate, n -Nonyl acrylate,
n-decyl acrylate, n-dodecyl acrylate,
Linear, branched or cyclic C1-C20 (particularly C1-C12) alkyl acrylates such as n-undecyl acrylate, cyclohexyl acrylate and isobornyl acrylate, and 2,2,2-trifluoro Ethyl acrylate, 2,2,3,3-tetrafluoropropyl acrylate, 2,2,3,3,3-pentafluoropropyl acrylate, 2,2,2,2,2,2
-Hexafluoroisopropyl acrylate, 2,2
3,4,4,4-hexafluorobutyl acrylate,
2,2,3,3,4,4,5,5-octafluoropentyl acrylate, 2,2,3,3,4,4,5,5
6,6,7,7-dodecafluoroheptyl acrylate, 2,2,3,3,4,4,5,5,6,6,7,
7,8,8,9,9-hexadecafluorononyl acrylate, 3,3,4,4,5,5,6,6,7,7,
8,8,8-tridecafluorooctyl acrylate,
2,2,3,3-tetrafluoro-1-methylpropyl acrylate, 2,2,3,3-tetrafluoro-1,
1-dimethylpropyl acrylate, 2,2,3,3
Linear or branched carbon number 2 such as 4,4,5,5-octafluoro-1,1-dimethylpentyl acrylate
Fluoroalkyl acrylate having 20 to 20 (especially 2 to 12 carbon atoms) is included.

In the present invention, when the polymer constituting the optical part is only the alcohol-reactive monomer, the optical properties, molding processability and the like may not be sufficient, so that the following general formula (II) is used. Compound and general formula (II
It is preferable to use at least one kind of the acrylic ester represented by I) together with the alcohol-reactive monomer.

[0018]

[Chemical 1] [In the formula, A ¹ represents a polymerizable unsaturated group, for example, a vinyl group, an allyl group, a methacryloyl group or an acryloyl group, and X represents a divalent hydrocarbon group having 1 to 10 carbon atoms (preferably 1 to 4). And R ^{2 to} R ⁷ are the same or different hydrogen atoms,
Alkyl group, fluoroalkyl group, phenyl group, vinyl group or

[Chemical 2] A group (wherein R ^{8 to} R ¹⁰ are hydrogen atoms which may be the same or different, an alkyl group, a fluoroalkyl group, a phenyl group or a vinyl group), and Z is a —XA ² group (wherein
X is the same as above, and A ² is a polymerizable unsaturated group or a hydrogen atom. ) Or a fluoroalkyl group, k is an integer of 0 to 100 (preferably 0 to 20), and when k is 2 or more, a plurality of -Si (R ⁴ ) (R ⁵ ) O- units are present. It may be the same or different. ]

[0019]

[Chemical 3] (In the formula, R ¹¹ represents a fluorine atom, an alkyl group or a fluoroalkyl group, and R ¹² represents a substituted or unsubstituted alkyl group.)

In the general formulas (II) and (III), R ² to R
Examples of the alkyl group among ¹² include methyl group, ethyl group, n-propyl group, i-propyl group, n-butyl group, i-butyl group, t-butyl group, n-pentyl group, i
-Pentyl group, hexyl group, heptyl group, octyl group,
2-ethylhexyl group, nonyl group, decyl group, dodecyl group, undecyl group, cyclohexyl group, isobornyl group, and other straight-chain, branched or cyclic alkyl groups having 1 to 12 carbon atoms (preferably 1 to 8). Examples of the fluoroalkyl group among R ² to R ¹² and Z include a trifluoromethyl group, a trifluoroethyl group, a trifluoropropyl group, a pentafluorobutyl group, a heptafluoropentyl group, a nonafluorohexyl group and the like. Carbon number 1
There are 12 (preferably 1 to 8) fluoroalkyl groups. Examples of X include, for example, ethylene group and propylene group, and the polymerizable unsaturated group of A ¹ and A ² includes, for example, vinyl group, CH ₂ = C (R ¹³ ) COO- group (here And R ¹³ is a hydrogen atom, a fluorine atom, a methyl group or a fluoroalkyl group having 1 to 12 carbon atoms (preferably 1 to 8), CH ₂ = CHCONH- group, CH ₂ = C (CN)- Group, CH ₂ = C
(CN) COO- group, CH ₂ = CHC ₆ H ₄ -group and the like can be mentioned.

Specific examples of the silicone compound represented by the general formula (II) include siloxanyl monomethacrylate, siloxanyl monoacrylate, fluorosiloxanyl monomethacrylate, fluorosiloxanyl monoacrylate, siloxanyl dimethacrylate, siloxanil. Examples thereof include rudiacrylate, fluorosiloxanyl dimethacrylate, and fluorosiloxanyl diacrylate. Preferred silicone compounds are pentamethyldisiloxanylmethyl methacrylate, pentamethyldisiloxanylmethyl acrylate, pentamethyldisiloxanylpropyl methacrylate, pentamethyldisiloxanylpropyl acrylate, methylbis (trimethylsiloxy) silylpropyl methacrylate, Methylbis (trimethylsiloxy) silylpropyl acrylate,
Tris (trimethylsiloxy) silylpropyl methacrylate, tris (trimethylsiloxy) silylpropyl acrylate, methylbis (trimethylsiloxy) silylpropyl glycerol methacrylate, methylbis (trimethylsiloxy) silylpropyl glycerol acrylate, tris (trimethylsiloxy) silylpropyl glycerol methacrylate, tris ( Trimethylsiloxy) silylpropyl glycerol acrylate,
Mono [methylbis (trimethylsiloxy) siloxy] bis (trimethylsiloxy) silylpropyl glycerol methacrylate, mono [methylbis (trimethylsiloxy) siloxy] bis (trimethylsiloxy) silylpropyl glycerol acrylate, trimethylsilylethyl tetramethyldisiloxanylpropyl glycerol methacrylate, Siloxanyl monomethacrylate or siloxanyl monoacrylate such as trimethylsilylethyltetramethyldisiloxanylpropyl glycerol acrylate; (3,3,3-trifluoropropyldimethylsiloxy) bis (trimethylsiloxy) silylmethyl methacrylate, (3,3,3 3-trifluoropropyldimethylsiloxy) bis (trimethylsiloxy) silylmethyl acryl Over door, (3,3,4,4,5,5,
5-heptafluoropentyldimethylsiloxy) [methylbis (trimethylsiloxy) siloxy] trimethylsiloxysilylpropyl methacrylate, (3,3,4,
4,5,5,5-heptafluoropentyldimethylsiloxy) [methylbis (trimethylsiloxy) siloxy]
Trimethylsiloxysilylpropyl acrylate,
(3,3,4,4,5,5,5-heptafluoropentyldimethylsiloxy) (pentamethyldisiloxanyloxy) trimethylsiloxysilylmethacrylate and other fluorosiloxanyl monomethacrylates or fluorosiloxanyl monoacrylates; and Examples include siloxanyl dimethacrylate or siloxanyl diacrylate represented by the formula.

[0022]

[Chemical 4]

[0023]

[Chemical 5]

Among these silicone compounds, particularly preferred compounds are pentamethyldisiloxanylmethyl methacrylate, pentamethyldisiloxanylpropyl methacrylate, methylbis (trimethylsiloxy) silylpropyl methacrylate, tris (trimethylsiloxy) silylpropyl methacrylate and the like. Siloxanyl monomethacrylate; and (3,3,3-trifluoropropyldimethylsiloxy) bis (trimethylsiloxy) silylmethyl methacrylate, (3,3,4,4,
5,5,5-heptafluoropentyldimethylsiloxy) [methylbis (trimethylsiloxy) siloxy] trimethylsiloxysilylpropyl methacrylate,
A fluorosiloxanyl monomethacrylate such as (3,3,4,4,5,5,5-heptafluoropentyldimethylsiloxy) (pentamethyldisiloxanyloxy) trimethylsiloxysilylmethacrylate. These silicone compounds have a function of imparting oxygen permeability to the complex lens of the present invention.

Specific examples of the acrylic ester represented by the general formula (III) include methyl methacrylate, ethyl methacrylate, n-propyl methacrylate and i.
-Propyl methacrylate, n-butyl methacrylate, t-butyl methacrylate, n-pentyl methacrylate, n-hexyl methacrylate, n-heptyl methacrylate, n-octyl methacrylate, 2-ethylhexyl methacrylate, n-nonyl methacrylate, n-decyl methacrylate, n -Alkyl methacrylates such as dodecyl methacrylate, n-undecyl methacrylate, cyclohexyl methacrylate and isobornyl methacrylate; 2,2,2-trifluoroethyl methacrylate, 2,2,2-trifluoroethyl-
α-trifluoromethyl methacrylate, 2,2,3
3-tetrafluoropropyl methacrylate, 2,2
3,3,3-pentafluoropropyl methacrylate,
2,2,2,2,2,2-hexafluoroisopropyl methacrylate, 2,2,3,4,4,4-hexafluorobutyl methacrylate, 2,2,3,3,4,4
5,5-octafluoropentyl methacrylate, 2,
2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptyl methacrylate, 2,2,3,3,3
4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononyl methacrylate, 3,3,4
4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl methacrylate, 2,2,3,3-tetrafluoro-1-methylpropyl methacrylate, 2,
2,3,3-tetrafluoro-1,1-dimethylpropyl methacrylate, 2,2,3,3,4,4,5,5-
Octafluoro-1,1-dimethylpentyl methacrylate and other fluoroalkyl methacrylates; methyl-
(Α-Ethyl) acrylate, ethyl- (α-ethyl)
Acrylate, propyl- (α-ethyl) acrylate, butyl- (α-ethyl) acrylate, 2-hydroxyethyl- (α-ethyl) acrylate, 2-hydroxypropyl- (α-ethyl) acrylate, diethylaminoethyl- (α- Ethyl) acrylate, glycidyl- (α-ethyl) acrylate, methyl- (α-butyl) acrylate, ethyl- (α-butyl) acrylate, propyl- (α-butyl) acrylate, butyl-
(Α-Butyl) acrylate, 2-hydroxyethyl-
Substitution or substitution of (α-alkyl) acrylic acid such as (α-butyl) acrylate, 2-hydroxypropyl- (α-butyl) acrylate, diethylaminoethyl- (α-butyl) acrylate, glycidyl- (α-butyl) acrylate Substituted alkyl ester; methyl- (α-trifluoroethyl) acrylate, ethyl- (α-trifluoroethyl) acrylate, propyl- (α-trifluoroethyl) acrylate, butyl- (α-trifluoroethyl) acrylate, methyl- (Α-Trifluoropropyl) acrylate, ethyl- (α-trifluoropropyl) acrylate, propyl- (α-trifluoropropyl) acrylate, butyl- (α-trifluoropropyl) acrylate, methyl- (α-nonafluorohexyl) ) Ax relay , Alkyl- (α-, such as ethyl- (α-nonafluorohexyl) acrylate, propyl- (α-nonafluorohexyl) acrylate, and butyl- (α-nonafluorohexyl) acrylate.
Fluoroalkyl) acrylate; and 2,2,2-
Trifluoroethyl- (α-trifluoroethyl) acrylate, 2,2,3,3-tetrafluoropropyl-
(Α-Trifluoroethyl) acrylate, 2,2
3,3,3-Pentafluoropropyl- (α-trifluoroethyl) acrylate, 2,2,2,2,2,2-
Hexafluoroisopropyl- (α-trifluoroethyl) acrylate, 2,2,3,4,4,4-hexafluorobutyl- (α-trifluoroethyl) acrylate, 2,2,3,3,4,4,4 5,5-octafluoropentyl- (α-trifluoroethyl) acrylate,
2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptyl- (α-trifluoroethyl) acrylate, 2,2,3,3,4,4,5 , 5, 6,
6,7,7,8,8,9,9-hexadecafluorononyl- (α-trifluoroethyl) acrylate, 3,
3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl- (α-trifluoroethyl)
Acrylate, 2,2,3,3-tetrafluoro-1-
Methylpropyl- (α-trifluoroethyl) acrylate, 2,2,3,3-tetrafluoro-1,1-dimethylpropyl- (α-tolufluoroethyl) acrylate, 2,2,3,3,4,4 , 5,5-Octafluoro-1,1-dimethylpentyl- (α-trifluoroethyl) acrylate, 2,2,2-trifluoroethyl-
(Α-Nonafluorohexyl) acrylate, 2,2
3,3,3-Pentafluoropropyl- (α-nonafluorohexyl) acrylate, 2,2,2,2,2,2
-Hexafluoroisopropyl- (α-nonafluorohexyl) acrylate, 2,2,3,4,4,4-hexafluorobutyl- (α-nonafluorohexyl) acrylate, 2,2,3,3,4,4 , 5,5-Octafluoropentyl- (α-nonafluorohexyl) acrylate, 2,2,3,3,4,4,5,5,6,6
7,7-Dodecafluoroheptyl- (α-nonafluorohexyl) acrylate, 2,2,3,3,4,4
5,5,6,6,7,7,8,8,9,9-hexadecafluorononyl- (α-nonafluorohexyl) acrylate, 3,3,4,4,5,5,6,6 7, 7,
8,8,8-Tridecafluorooctyl- (α-nonafluorohexyl) acrylate, 2,2,3,3-tetrafluoro-1-methylpropyl- (α-nonafluorohexyl) acrylate, 2,2,3 , 3-Tetrafluoro-1,1-dimethylpropyl- (α-nonafluorohexyl) acrylate, 2,2,3,3,4,4
5,5-octafluoro-1,1-dimethylpentyl-
(Α-Nonafluorohexyl) acrylate, 2,2
Fluoroalkyl- (α-fluoroalkyl) such as 2-trifluoroethyl- (α-pentadecafluorononyl) acrylate and 2,2,3,3,3-pentafluoropropyl- (α-pentadecafluorononyl) acrylate An acrylate is mentioned.

Among these acrylic esters, particularly preferred compounds are alkyl methacrylates such as methyl methacrylate, ethyl methacrylate, isopropyl methacrylate, n-butyl methacrylate, t-butyl methacrylate and cyclohexyl methacrylate; and 2,2,2-trimethacrylate. Fluoromethyl methacrylate,
2,2,2-trifluoroethyl-α-trifluoromethyl methacrylate, 2,2,3,3-tetrafluoropropyl methacrylate, 2,2,3,3,3-pentafluoropropyl methacrylate, 2,2,2 , 2,
2,2-hexafluoroisopropyl methacrylate,
2,2,3,4,4,4-hexafluorobutyl methacrylate, 2,2,3,3,4,4,5,5-octafluoropentyl methacrylate, 2,2,3,3,4,4
4,5,5,6,6,7,7-dodecafluorooctyl methacrylate, 3,3,4,4,5,5,6,6
7,7,8,8,8-Tridecafluorooctyl methacrylate, 2,2,3,3-tetrafluoro-1-methylpropyl methacrylate, 2,2,3,3-tetrafluoro-1,1-dimethylpropyl Methacrylate,
2,2,3,3,4,4,5,5-octafluoro-
It is a fluoroalkyl methacrylate such as 1,1-dimethylpentyl methacrylate.

Further, in order to slightly increase the hardness of the polymer constituting the optical part of the compound lens of the present invention and further improve the processing characteristics such as machinability and abrasivity, the crosslinkable monomer is reacted with alcohol. It can be used in combination with a polymerizable monomer. Specific examples of the crosslinkable monomer include ethylene glycol dimethacrylate, ethylene glycol diacrylate, diethylene glycol dimethacrylate, diethylene glycol diacrylate, triethylene glycol dimethacrylate, triethylene glycol diacrylate, tetraethylene glycol dimethacrylate, tetraethylene. Glycol diacrylate, propylene glycol dimethacrylate, propylene glycol diacrylate, 1,4-butanediol dimethacrylate, 1,4-butanediol diacrylate, neopentyl glycol dimethacrylate, neopentyl glycol diacrylate, trimethylolpropane trimethacrylate, Polyfunctional monomers such as trimethylolpropane triacrylate It can be mentioned.

In order to develop hydrophilicity on the surface of the optical part of the compound lens of the present invention, or to make the entire polymer constituting the optical part hydrophilic, N-vinyl-2-pyrrolidone, α- Methylene-N-methylpyrrolidone, 2-
Hydrophilic such as hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, 2-hydroxybutyl methacrylate, 2-hydroxybutyl acrylate, dihydroxybutyl methacrylate, dihydroxybutyl acrylate, diethylaminoethyl methacrylate, diethylaminoethyl acrylate, dimethylaminoethyl methacrylate, dimethylaminoethyl acrylate The reactive monomer can be used in combination with the alcohol-reactive monomer.

In addition to the silicone compound, acrylic ester, crosslinkable monomer or hydrophilic monomer described above, styrene or a styrene derivative, such as trimethylsilylstyrene, fluorostyrene, trifluorostyrene, methylstyrene, trimethylstyrene, etc. , Can also be used in combination with the alcohol-reactive monomer.

The monomer composition in the polymer constituting the optical part material is appropriately selected according to the properties of the complex lens,
The alcohol-reactive monomer in the polymer constituting the optical part material is generally used within the range of 10 to 80% by weight, preferably 30 to 70% by weight, based on the total monomers. If the content of the alcohol-reactive monomer is less than 10% by weight, the optical part cannot be sufficiently softened, and if it exceeds 80% by weight, the optical part after the softening is weakened and easily broken. Become.
In addition, regarding the other monomer used in combination with the alcohol-reactive monomer, the silicone compound represented by the general formula (II) accounts for 0 to 50% by weight, particularly 10 to 40% by weight of all the monomers. The acrylic ester represented by the general formula (III) is preferably 10 to 60% by weight, particularly preferably 15 to 50% by weight, based on the total amount of monomers, and the crosslinkable monomer is preferably 0 to 0% by weight. 30% by weight, particularly preferably 0 to 20% by weight, and the hydrophilic monomer is preferably 0 to 20% by weight, particularly preferably 0 to 15% by weight, based on the total monomers. If the amount of the crosslinking monomer is too large, the material becomes brittle, and if the amount of the hydrophilic monomer is too large, the water content of the material becomes high, which is not suitable.

Next, when the esterification reaction and / or transesterification reaction is used to soften the optical part of the compound lens of the present invention, the material constituting the peripheral part of the compound lens is esterified. Those having low reactivity or non-reactivity to the reaction and transesterification reaction are used. Such a material is not particularly limited as long as it satisfies the requirements of the present invention regarding the tensile elastic modulus and the glass transition point after softening and is relatively hard as compared with the optical part.

When such a peripheral material is produced by polymerizing a monomer around the optical material,
As the monomer, a silicone compound represented by the general formula (II), an acrylic ester represented by the general formula (III), the crosslinkable monomer, the hydrophilic monomer and / or the styrene or a compound thereof Derivatives can be used. Further, in the monomer, the alcohol-reactive monomer is 0 to
It can be present in the range of 50% by weight, but in this case it is generally preferred to contain 5 to 40% by weight of the alcohol-reactive monomer. In this way, when the peripheral material contains the alcohol-reactive monomer, the composition thereof approaches that of the optical material, and it becomes possible to suppress polymerization distortion and optical distortion of the compound lens. If the content of the alcohol-reactive monomer exceeds 50% by weight, the mechanical strength of the peripheral portion becomes insufficient.

Of the materials having low reactivity or non-reactivity with respect to the esterification reaction and transesterification reaction, those which are manufactured or obtained separately from the material for the optical part are given as polymer materials. , Olefin-based polymers (polyethylene, polypropylene, ethylene-propylene block copolymers, etc.), styrene-based polymers (polystyrene, impact-resistant polystyrene, ABS resins, etc.),
Halogenated olefin polymers (polymers of vinyl chloride, vinylidene chloride, tetrafluoroethylene, etc.), hydrogenated products of styrene-butadiene block copolymers, polyacetals, polyethers (polyphenylene ether, etc.), ketone polymers (polyetherketone) , Polyetheretherketone, polyketone sulfide, etc.),
Polyurethane, polycarbonate, polyester (polybutylene terephthalate, polyarylate, polyethylene naphthalate, etc.), polyamide (nylon 4,6, nylon 11, nylon 12, nylon 6,10, nylon 6,12, polyparaphenylene terephthalamide, etc.), Polyester-amide, polyimide (polyetherimide, polyesterimide, polyamideimide, etc.), polysulfide (polyphenylene sulfide, etc.), polysulfone (polyethersulfone, polyarylsulfone, etc.), a polymer blend of two or more of these polymer materials, or There are polymer alloys and the like, and non-polymer materials include glass and ceramics (Al-O
System, Mg-O system, Al-Si-O system, Al-Mg-Si
-O system, Al-Ti-O system, Al-N system, Si-C system,
Si-N system, Al-Si-C-N system, Ti-N system, B-
N-based, Ti-B, etc.), inorganic semiconductor materials, inorganic materials such as metals, and composite materials obtained from the above-mentioned polymer material and non-polymer material can also be used.

The types and compositions of the optical material and the peripheral material used in the present invention are preferably selected so as to suppress polymerization distortion, optical distortion, etc. of the compound lens as much as possible. For example, the composition is large between both materials. It is preferably not different. Therefore, when both the optical part material and the peripheral part material are produced by polymerization, the type and composition of the monomers of both materials are appropriately adjusted, or both materials have the same monomer and composition. Preferably.
In the former case, in the optical part, the content of the alcohol-reactive monomer is increased, and in the peripheral part, the content of the alcohol-reactive monomer is relatively low, and the peripheral material It is necessary to increase the content of the monomer that gives a polymer that raises the hardness, tensile modulus, or glass transition point. In the latter case, as described in (d) above, only the optical material is reacted with alcohol.

In any of these cases, the type and composition of the monomers of the optical part material and the peripheral part material are such that, after the reaction with the alcohol, the optical part material is from 0.01 to
It has a tensile elastic modulus of 1,000 MPa and a glass transition point of 330 ° K or less, and the peripheral portion is 10 MPa to 5 MPa.
It is selected to have a tensile modulus of 00 GPa and a glass transition point above 270 ° K. It should be noted that the composition can be changed to some extent between the material of the optical part and the material of the peripheral part if a polymerization method, a molding method or the like capable of reducing the polymerization distortion and the optical distortion of the compound lens can be adopted. Further, in the present invention, the optical material and the peripheral material can be combined so as to provide a compound lens having a so-called tilted structure in which the tensile modulus or the glass transition point continuously changes from the optical portion to the peripheral portion. ..

Then, the lens substrate obtained as described above is reacted with alcohol to carry out an esterification reaction and / or
Alternatively, a transesterification reaction is performed. The alcohol used at this time varies depending on the desired tensile modulus or glass transition point of the material for the optical portion and the material for the peripheral portion, and specific examples thereof include n-butanol, n-pentanol, and n-butanol. Alcohols having 3 to 12 carbon atoms such as hexanol, n-heptanol, n-octanol, n-nonanol, n-decanol, n-undecanol, and n-dodecanol, and a part of hydrogen atoms in the alkyl group of these alcohols or Fluoroalkyl alcohols in which all are substituted with fluorine atoms can be mentioned. By such an esterification reaction and / or a transesterification reaction, the material for the optical portion made of the polymer containing the alcoholic reactive monomer unit is relatively softened as compared with the material for the peripheral portion.

When the material of the optical part is softened as compared with the material of the peripheral part by performing the esterification reaction and / or the transesterification reaction, when the reactivity of the material of the optical part and the material of the peripheral part are different, the entire lens substrate is Can be contacted with alcohol. Further, when the entire lens substrate is composed only of an alcohol-reactive polymer,
For example, a portion corresponding to the peripheral portion of the lens substrate is coated so that the alcohol does not penetrate, and then the alcohol is reacted. By such an esterification reaction and / or transesterification reaction, the material of the optical portion is softened, and the material of the peripheral portion is also softened to some extent when the alcohol-reactive monomer unit is contained. The degree of softening of the peripheral material in this case is appropriately selected in relation to the optical material.

The esterification reaction and / or transesterification reaction is usually carried out in the presence of a catalyst. This catalyst may be an alkali catalyst such as sodium hydroxide, but is preferably an acid catalyst such as concentrated sulfuric acid, methanesulfonic acid, toluenesulfonic acid. The concentration of these catalysts is
The concentration in alcohol is preferably 0.5 to 10% by weight. The treatment conditions are usually 1 to 20 at a temperature of 20 to 200 ° C.
100 hours. Details of these esterification reaction and / or transesterification reaction treatment are described in JP-B-53-31
198.

The lens substrate after the esterification reaction and / or transesterification reaction is a catalyst used in the reaction, unreacted alcohol, alcohol produced by the reaction, reaction solvent,
Since it is impregnated with water or the like, it is preferable to wash it using a Soxhlet extractor or the like to remove them. Examples of the washing solvent for that purpose include hydrocarbons such as toluene and hexane, and ketones such as acetone and methyl ethyl ketone. After cleaning, the lens substrate is 20
The washing solvent can be removed by drying at ~ 150 ° C.

In the compound lens of the present invention described in detail above, both the optical material and the peripheral material are essentially non-hydrated or low-hydrated. In addition, for this compound lens, hydrophilicity or biological property such as alkali treatment, plasma treatment with oxygen or nitrogen, plasma treatment with hydrophilic group-containing compound or vapor deposition of inorganic compound, sputtering, ion plating, etc. Further surface treatments to improve the affinity can be carried out, which improves the compatibility with tear fluid or intraocular fluid.

The shape, size, etc. of the compound lens of the present invention vary depending on the purpose of use, symptoms of eye diseases, etc., but an example of the intraocular lens is shown in FIGS.

The compound lens of the present invention, as an intraocular lens, has better flexibility as a whole lens as compared with the case where the material of the optical portion is hard and the material of the peripheral portion is soft, as a result of the intraocular tissue. It can be easily inserted from a small opening without damaging the body, and the peripheral part as a supporting member is relatively hard, so that it is excellent in positional stability in the eye and is displaced even after insertion in the eye. Never again,
It can be easily processed into a lens with excellent dimensional accuracy.

[0043]

The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. The parts are based on weight. Example 1 A mixture of 25 parts of acrylic acid, 15 parts of butyl acrylate, 5 parts of ethylene glycol dimethacrylate, 55 parts of butyl methacrylate and 0.05 part of benzoin methyl ether was poured into a polyethylene container having an inner diameter of 5 mm and a depth of 20 mm. After irradiating ultraviolet rays for 1 hour at room temperature under a nitrogen atmosphere, the polymerization was stopped to obtain a purine-like columnar product. This columnar object has an inner diameter of 15 mm and a depth of 20 mm.
Place it in the center of the polyethylene container and add 10 parts of acrylic acid and 5 parts of ethylene glycol dimethacrylate around it.
Part, butyl acrylate 30 parts, ethyl methacrylate 55 parts, benzoin methyl ether 0.05 parts and azobisisobutyronitrile 0.05 parts were injected and left at room temperature for 1 hour after standing under a nitrogen atmosphere. Irradiate with UV light for 10 hours, and then 70 ° under UV irradiation.
The temperature was raised to C and polymerization was carried out for 24 hours. After the polymerization, the obtained bulk polymer was cut and polished to prepare an intraocular lens-shaped lens substrate shown in FIG. In the cutting and polishing step, this copolymer could be processed in the same manner as an ordinary hard polymethylmethacrylate intraocular lens and had a smooth finished surface. Then, this lens substrate is attached to n-butanol 200
ml, toluene 10 ml and methanesulfonic acid 0.5
Put in a flask containing a reaction mixture consisting of ml,
Acrylic acid in the polymer was esterified by reacting at reflux temperature for 48 hours. After completion of the reaction, the polymer was washed with methanol using a Soxhlet extractor and dried to obtain a compound intraocular lens having a soft optical part and a relatively hard peripheral part. The tensile modulus / glass transition point of the optical part material is 5
MPa / 270 ° K, peripheral material is 135MPa / 310
It was ° K. The obtained compound intraocular lens could be bent by pinching both ends with tweezers, and neither constriction nor abnormal refraction was observed from the optical part to the peripheral part. In addition, for surgery to enter the eye interior of rabbits, conventional incision (6 mm
The above can be easily inserted through a smaller incision (4 to 5 mm), and even after the insertion, the positional stability is good, and the whole body does not jump out from the lens capsule unlike a soft intraocular lens. .. Further, dirt was not easily adsorbed, and even after 1 month from the operation, a clear retinal image similar to that before the operation was observed.

Example 2 In a polyethylene container having an inner diameter of 5 mm and a depth of 20 mm, 30 parts of acrylic acid, 5 parts of methacrylic acid, 10 parts of butyl acrylate, 5 parts of ethylene glycol dimethacrylate,
Butyl methacrylate 40 parts, ethyl methacrylate 1
A mixture of 0 part and 0.05 part of benzoin methyl ether was injected, and the mixture was irradiated with ultraviolet rays at room temperature for 1 hour in a nitrogen atmosphere and then the polymerization was stopped to obtain a purine-like columnar product. This columnar object was placed in the center of a polyethylene container having an inner diameter of 15 mm and a depth of 20 mm, and around it, 30 parts of butyl acrylate, 10 parts of methyl methacrylate, 5 parts of ethylene glycol dimethacrylate, 2,2,2-trifluoroethyl methacrylate. A mixture of 55 parts, 0.05 part of benzoin methyl ether and 0.05 part of azobisisobutyronitrile was injected, left for 1 hour in a nitrogen atmosphere, then irradiated with ultraviolet rays for 10 hours at room temperature, and then with ultraviolet rays. The temperature was raised to 70 ° C. under irradiation and polymerization was carried out for 24 hours. After the polymerization, the obtained bulk polymer was cut and polished to prepare an intraocular lens-shaped lens substrate shown in FIG. In the cutting and polishing step, this polymer could be processed in the same manner as an ordinary hard polymethylmethacrylate intraocular lens and had a smooth finished surface. Then, this lens substrate was put into a flask containing a reaction mixture of 200 ml of n-butanol, 10 ml of toluene and 0.5 ml of methanesulfonic acid, and reacted at reflux temperature for 48 hours to obtain acrylic acid in the polymer. Was esterified. After completion of the reaction, the polymer was washed with methanol using a Soxhlet extractor and dried to obtain a compound intraocular lens having a soft optical part and a relatively hard peripheral part. The tensile modulus / glass transition point of the optical material was 30 MPa / 310 ° K, and the peripheral material was 230 MPa / 320 ° K. The obtained compound intraocular lens could be bent by pinching both ends with tweezers, and neither constriction nor abnormal refraction was observed from the optical part to the peripheral part. In addition, in the operation to enter the eye interior of rabbits, it can be easily inserted through a smaller incision (4 to 5 mm) than the conventional incision, and even after the insertion, the positional stability is good and the silicone intraocular lens I didn't jump out of the lens capsule. Also, it is difficult to absorb dirt,
Even after 1 month from the operation, the same clear retinal image as before the operation was observed.

Example 3 In a polyethylene container having an inner diameter of 5 mm and a depth of 20 mm, 30 parts of acrylic acid, 5 parts of methacrylic acid, 10 parts of butyl methacrylate, 35 parts of 2,2,2-trifluoroethyl methacrylate and 2-ethylhexyl acrylate. 15
Part, 5 parts of ethylene glycol dimethacrylate and 0.05 part of benzoin methyl ether were injected, and the mixture was irradiated with ultraviolet rays for 1 hour at room temperature under a nitrogen atmosphere and then the polymerization was stopped to obtain a purine-like columnar product. .. This columnar object is placed in the center of a polyethylene container having an inner diameter of 15 mm and a depth of 20 mm, and methyl methacrylate 4 is placed around it.
0 parts, butyl acrylate 20 parts, 2,2,2-trifluoroethyl methacrylate 25 parts, ethylene glycol dimethacrylate 5 parts, styrene 10 parts, benzoin methyl ether 0.05 parts and azobisisobutyrovaleronitrile 0.05. After injecting a mixture of parts, the mixture was left under a nitrogen atmosphere for 5 hours, then irradiated with ultraviolet rays for 7 hours at room temperature, and further heated to 70 ° C. under irradiation with ultraviolet rays,
It was polymerized for 24 hours. After the polymerization, the obtained bulk polymer was cut and polished to prepare an intraocular lens-shaped lens substrate shown in FIG. In the cutting and polishing step, this polymer could be processed in the same manner as an ordinary hard polymethylmethacrylate intraocular lens and had a smooth finished surface. Then, this lens substrate was mixed with 200 ml of n-butanol and 10 ml of toluene.
ml and methanesulfonic acid 0.5 ml, the reaction mixture was charged into a flask and reacted at reflux temperature for 48 hours to esterify acrylic acid and methacrylic acid in the polymer, and to add 2-ethylhexyl acrylate. It was transesterified. After completion of the reaction, the polymer was washed with methanol using a Soxhlet extractor and dried to obtain a compound intraocular lens having a soft optical part and a relatively hard peripheral part. The tensile elastic modulus / glass transition point of the optical material is 12 MPa / 280 ° K, and the peripheral material is 1030 MPa / 3.
It was 40 ° K. The obtained compound intraocular lens could be bent by pinching both ends with tweezers, and neither constriction nor abnormal refraction was observed from the optical part to the peripheral part. In addition, in the operation to enter the eye interior of rabbits, it can be easily inserted through a smaller incision (4 to 5 mm) than the conventional incision, and even after the insertion, the positional stability is good and the silicone intraocular lens I didn't jump out of the lens capsule. Further, dirt was not easily adsorbed, and even after 1 month from the operation, a clear retinal image similar to that before the operation was observed.

Example 4 In a polyethylene container having an inner diameter of 5 mm and a depth of 20 mm, 5 parts of methacrylic acid, 30 parts of ethyl acrylate, 20 parts of methyl methacrylate, 5 parts of butyl methacrylate, 2,
25 parts of 2,2-trifluoroethyl methacrylate, 2
-Inject a mixture of 10 parts of ethylhexyl acrylate, 5 parts of ethylene glycol dimethacrylate, 0.05 part of benzoin methyl ether and 0.05 part of azobisisobutyrovaleronitrile, and irradiate with UV light for 7 hours at room temperature under nitrogen atmosphere. And then under UV irradiation 70
The temperature was raised to ° C and polymerization was carried out for 24 hours. After the polymerization, the obtained bulk polymer was cut and polished to prepare an intraocular lens-shaped lens substrate shown in FIG. In the cutting and polishing step, this polymer could be processed in the same manner as an ordinary hard polymethylmethacrylate intraocular lens and had a smooth finished surface. Next, as shown in FIG. 3, the lens substrate was sandwiched between clamps lined with solvent-resistant fluororubber, and a reaction mixture containing 200 ml of n-butanol, 10 ml of toluene and 0.5 ml of methanesulfonic acid was placed in the flask. The mixture was charged into the reaction mixture and reacted at reflux temperature for 48 hours to esterify methacrylic acid in the polymer and transesterify 2-ethylhexyl acrylate. After the reaction,
The polymer was washed with methanol using a Soxhlet extractor and dried to obtain a compound intraocular lens having a soft optical part and a relatively hard peripheral part. The tensile elastic modulus / glass transition point of the optical part material was 120 MPa / 300 ° K, and the peripheral part material was 630 MPa / 330 ° K. The obtained compound intraocular lens could be bent by pinching both ends with tweezers, and neither constriction nor abnormal refraction was observed from the optical part to the peripheral part. In addition, in surgery to enter the eye interior of rabbits,
It can be easily inserted from a smaller incision (4-5 mm) than the conventional incision and has good positional stability even after insertion.
It did not jump out of the lens capsule like a silicone intraocular lens. Further, dirt was not easily adsorbed, and even after 1 month from the operation, a clear retinal image similar to that before the operation was observed.

Comparative Example 1 5 parts of ethylene glycol dimethacrylate, 95 parts of methyl methacrylate and 0.0 parts of benzoin methyl ether were placed in a polyethylene container having an inner diameter of 5 mm and a depth of 20 mm.
Inject a mixture of 5 parts, irradiate with UV light for 10 hours at room temperature in a nitrogen atmosphere, and further irradiate with UV light at 70 ° C.
The temperature was raised to, and polymerization was carried out for 24 hours. After the polymerization, the obtained bulk polymer was cut and polished to prepare an intraocular lens-shaped lens substrate shown in FIG. Its tensile modulus / glass transition point was 3000 MPa / 370 ° K. The obtained intraocular lens could not be bent by pinching both ends with tweezers, and could only be inserted through a conventional incision (6 mm or more) in intraocular insertion surgery to a rabbit.

Comparative Example 2 A mixture of 30 parts of acrylic acid, 20 parts of butyl acrylate, 5 parts of ethylene glycol dimethacrylate, 45 parts of butyl methacrylate and 0.05 part of benzoin methyl ether was placed in a polyethylene container having an inner diameter of 5 mm and a depth of 20 mm. Was injected, and the mixture was irradiated with ultraviolet rays at room temperature for 10 hours in a nitrogen atmosphere, further heated to 70 ° C. under the irradiation of ultraviolet rays, and polymerized for 24 hours. After the polymerization, the obtained bulk polymer was cut and polished to prepare an intraocular lens-shaped lens substrate shown in FIG. Then, this lens substrate was put into a flask containing a reaction mixture of 200 ml of n-butanol, 10 ml of toluene and 0.5 ml of methanesulfonic acid, and reacted at reflux temperature for 48 hours to obtain acrylic acid in the polymer. Was esterified. After completion of the reaction, the polymer was washed with methanol using a Soxhlet extractor and dried to obtain an intraocular lens. Its tensile modulus / glass transition point was 3 MPa / 250 ° K. The obtained intraocular lens can be bent by pinching both ends with tweezers.
Although it was possible to insert from a smaller incision (4 to 5 mm), the peripheral part was soft, so the positional stability in the eye was poor, and protrusion from the lens capsule was recognized.

[0049]

When the compound lens of the present invention is used as an intraocular lens, the optical part material and the peripheral part material respectively have an appropriate tensile elastic modulus or glass transition point, so that the intraocular tissue can be formed. It can be easily inserted through a small opening without damaging it, and after insertion, it is excellent in positional stability in the eye and is not displaced. further,
Since the material balance of the entire lens is good, it exhibits excellent characteristics as an artificial cornea and can be suitably used as a general contact lens or the like. Moreover, since the material is excellent in workability, various lenses with good dimensional accuracy can be obtained.

[Brief description of drawings]

FIG. 1 is a sectional view and a plan view of an example of a compound intraocular lens of the present invention.

FIG. 2 is a plan view of another example of the compound intraocular lens of the present invention.

FIG. 3 is a cross-sectional view showing a state in which a softening process of the compound intraocular lens substrate of FIG. 2 is performed.

[Explanation of symbols]

 1 Hard peripheral part 2 Soft optical part 3 Clamp 4 Fluoro rubber

Continuation of front page (51) Int.Cl. ⁵ Identification number Office reference number FI Technical indication location G02B 3/00 Z 8106-2K (72) Inventor Kenji Yasuda 2-11-24 Tsukiji, Chuo-ku, Tokyo Japan joint Naru Rubber Co., Ltd.

Claims (1)

[Claims] 1. The tensile modulus of the material of the optical part is 0.01 to.
1,000MPa and glass transition point below 330 ° K,
A compound lens, wherein the peripheral elastic material has a tensile elastic modulus of 10 MPa to 500 GPa and a glass transition point of 270 ° K or higher, and the optical material is relatively soft as compared with the peripheral material.