JPH0533203B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention provides an oil (hereinafter referred to as evening primrose oil) obtained from the seeds of evening primrose (Oenothera tetraptera Cav.), which is a plant that grows naturally or is cultivated mainly in North America.
Seeds of sunflower (Helianthus annuus L.), roots of Bupleurum falcatum L.,
and at least one extract obtained from the rhizome of Sanguisorba officinalis L., which has excellent usability and storage stability and is free from skin irritation. Conventionally, vegetable oils such as olive oil, almond oil, safflower oil, and castor oil have been widely used as raw materials for cosmetics. Furthermore, in recent years, there has been an increasing demand for raw materials for cosmetics obtained from natural plants in order to meet consumer demands. However, the number of vegetable oils commonly used in cosmetics is limited, and even skin cosmetics containing these vegetable oils have poor usability, storage stability, and safety for the skin. There was nothing that was completely satisfying. As a result of intensive research into skin cosmetics formulated with various liquid oils obtained from natural plants, the present inventors found that skin cosmetics formulated with evening primrose oil do not contain conventionally used vegetable oils. Compared to skin cosmetics formulated with this product, (1) it has good affinity with the skin, is not sticky, gives the skin a suitable oily and moisturizing feel, and has an excellent feeling of use; Furthermore, we discovered that (2) it is safe for the skin. Evening primrose oil is a liquid oil produced by a well-known method in which evening primrose seeds are pressed or extracted with a solvent, and the resulting oil is refined through processes such as deacidification and deodorization.The main component is linoleic acid. is a triglyceride. Its properties are shown in Table 1.

[Table] As shown in Table 1, compared to vegetable oils such as olive oil, almond oil, and safflower oil that have been traditionally used in skin cosmetics, evening primrose oil has linoleic acid and γ-linolenic acid in its fatty acids. It is a vegetable oil with a high degree of unsaturation (iodine value). As shown in the Examples below, skin cosmetics containing evening primrose oil have better affinity with the skin than skin cosmetics containing olive oil, almond oil, safflower oil, etc. It is non-sticky, gives a moisturizing feel, and has a clearly excellent feeling of use. However, as mentioned above, evening primrose oil is a highly unsaturated vegetable oil, so
It was confirmed that it is desirable to include a storage stabilizer (antioxidant) in skin cosmetics together with evening primrose oil. Therefore, the present inventors investigated evening primrose oil and the conventionally used dibutylhydroxytoluene (hereinafter referred to as
The results of preparing various skin cosmetics containing antioxidants such as BHT (abbreviated as BHT), butylhydroxyanisole (abbreviated as BHA hereinafter), and tocopherol, and conducting storage stability tests as explained in the Examples below. (1) In the case of skin cosmetics such as skin milks, skin creams, oil-water double-layer lotions, and face packs, evening primrose oil is usually used in the presence of the above-mentioned conventional anti-strengthening agents. It is possible to incorporate up to 5% by weight (hereinafter referred to as wt%) based on the total amount of cosmetics, but 5wt%
It has been found that if the amount exceeds 100, a rancid odor and discoloration derived from evening primrose oil will occur, making it difficult to obtain long-term storage stability (2 to 3 hours). (2) Nourishing oils, which are anhydrous skin cosmetics;
In cleansing oils, sun oils, baby oils, etc., evening primrose oil can be blended up to 60wt% of the total amount of the skin cosmetics, and it is possible to incorporate evening primrose oil into cleansing oils, sun oils, baby oils, etc. It was possible to obtain sufficient long-term storage stability by appropriately blending the ingredients, but when the amount of evening primrose oil exceeded 60wt% and 70wt%.
There was also a tendency for storage stability to decrease as the temperature increased. (3) Adjust the amount of evening primrose oil to 5wt% or 60wt as above.
%, it is possible to improve storage stability to some extent by increasing the amount of antioxidant, but in this case, increasing the amount of antioxidant may cause problems such as skin irritation, etc. It was found that this problem occurred. As mentioned above, in skin cosmetics containing evening primrose oil, as long as conventionally used antioxidants are included, the amount of evening primrose oil blended is limited depending on the type of skin cosmetic. This was something that would occur. Therefore, as a result of intensive research into storage stabilizers or antioxidants that can stably preserve skin cosmetics containing evening primrose oil over a long period of time, the present inventors found that BHT, BHA, tocopherols, etc. The present invention has been completed by discovering extracts obtained from sunflower seeds, cypress roots, and rhizomes that provide storage stability equivalent to or superior to antioxidants and do not irritate the skin. That is, the present invention provides evening primrose oil, sunflower seeds,
This skin cosmetic is characterized by containing at least one type of extract obtained from the root of Mishimasaiko and the rhizome of Chiyu. In order to obtain extracts to be incorporated into the skin cosmetics of the present invention from sunflower seeds, roots and rhizomes of Chiyu, a well-known extraction method can be used. After washing, crush and add 5 to 10 times its weight of water or hydrous alcohol (usually ethyl alcohol concentration 10% or less)
The desired extract can be obtained by boiling or cold-immersing the mixture, then concentrating the separately obtained extract, removing water or alcohol under reduced pressure, and drying. In addition, the above extract with water or hydrous alcohol may be further treated with a porous polystyrene resin adsorbent (for example, Diaion HP, manufactured by Mitsubishi Chemical Corporation).
The extract obtained by eluting the adsorbed matter with alcohol or aqueous alcohol (ethyl alcohol concentration of about 50% or more) has good properties in terms of color, odor, storage stability effect, and skin irritation test. It had the following characteristics. The present invention will be explained below based on Test Examples and Examples. Note that the skin cosmetics of the present invention are not limited to those described in the Examples. Judgment or evaluation methods such as storage stability tests, usability evaluations, skin irritation tests, etc. described in Test Examples and Examples are shown below. (1) Storage stability test After storing the same sample in a constant temperature room at 5°C and 45°C for 3 months, the changes in appearance (color) and odor of both samples over time were compared. Judgment results are at 45℃ compared to products stored at 5℃.
Differences in color and odor of preserved products were indicated by ◎, ○, △, and × according to the following criteria. “Odor” Exactly the same …◎ Very slightly rancid odor …○ Slightly 〃 …△ Strongly 〃 …× “Color” Exactly the same …◎ Very slightly colored …○ Slightly 〃 …△ Strongly 〃 ...× (2) Evaluation of usability Approximately 0.5 g of control and example or comparative sample samples were placed on each side of the left and right sides of the faces of 20 female test subjects.
Immediately after application, the test subjects themselves evaluated items such as ``stickiness,''``moistness,'' ``compatibility with the skin,''``oiliness,'' and ``irritation,'' using a paired comparison method. evaluated. The evaluation results showed that the examples and comparisons were more sticky than the control, "moisturizing", "fits well with the skin", "preferable oily feeling", and "irritating" for each of the above evaluation items. It is shown by the number of people who answered "I feel that way." (3) Human skin patch test 0.05 g of the sample was applied to the skin of the flexor side of the forearm of 25 subjects using a patch test adhesive plaster with a circular lint cloth with a diameter of 1.0 cm for 24 hours. The judgment results were determined by selecting the one with the strongest reaction 1 hour and 24 hours after removal of the bandage, and evaluating each sample on 25 subjects according to the criteria below. ±) or more people.

[Table] Test Example Olive oil, almond oil, safflower oil, which are raw materials for cosmetics that showed the characteristic values shown in Table 1, and evening primrose oil used in this invention were each obtained by the method shown in the production example below. Samples were prepared by uniformly blending sunflower seed extract, root extract of Mishima saiko, and rhizome extract of Chiyu in a range of 0 to 0.3 wt% based on the total amount of the above vegetable oil, and the storage stability of each sample was determined. I conducted a test. As a result, (1) For samples without the above extract (i.e., vegetable oil alone), evening primrose oil showed the same storage stability as safflower oil, but was slightly more stable than olive oil and almond oil. It showed poor storage stability. However, (2) for samples containing 0.1 to 0.3 wt% of the above extract, evening primrose oil had storage stability similar to other olive oils, almond oils, and safflower oils. In particular, evening primrose oil containing 0.2 wt% or more of the above extract showed no change in color or odor and had excellent storage stability. Production example: Preparation of sunflower seeds, Mishimasaiko root, Chuyu rhizome extract Dried sunflower seeds, Mishimasaiko root,
Wash 100g of each of the rhizomes of Chiyu with water, crush them,
ml of water was added, boiled for about 2 hours, and separated to obtain separate extracts. Next, these extracts were treated with Diaion HP, a porous polystyrene-based resin adsorbent, and the adsorbed substances were eluted with hydrous alcohol (ethanol 90wt%), and the solvent, hydrous alcohol, was removed under reduced pressure to separate each sample. The extract, which is a dried powder, is extracted from sunflower seeds.
7.2 g, 5.5 g from the root of Mishimasaiko, and only 3.5 g from the rhizome of Chiyu. Hereinafter, the sunflower seed extract prepared by the above method will be abbreviated as Sunflower A, the Mishima Saiko root extract as Saiko A, and the Chuyu rhizome extract as Chuyu A.

[Table] (2) Preparation method After heating and dissolving components (A) and (B) at a temperature of 80°C, mix them, cool while stirring, and when the temperature reaches 50°C, add component (C). Then, stirring was continued until the temperature reached 30°C to prepare each cream. (3) Properties of creams Table 2 shows the results of human skin patch tests, storage stability tests, and usability evaluations for each cream. In addition, in the usability evaluation, control (1) and example (1)
and Comparative Example (1), Control (2) and Examples (2) and (3).
and Comparative Example (2) were compared.

[Table] As shown in Table 2, the skin cream of the present invention has good affinity with the skin, is not sticky, gives the skin a suitable oily and moisturizing feeling, and does not irritate the skin. It was recognized that the product had a feeling of use. Furthermore, regarding storage stability, evening primrose oil
When compounded at 10wt%, the conventional storage stabilizer
In the skin cream of Comparative Example (2) using BHT, a slight rancid odor and coloring were observed, but
The skin creams of Examples (1) to (3) containing Himawari A, Saiko A, and Chuyu A instead of BHT exhibited excellent storage stability with no change in odor or color. .

[Table] (2) Preparation method All ingredients were mixed and heated to a temperature of 60°C to uniformly dissolve and mix, and then cooled to 30°C with stirring to prepare each nourishing oil. (3) Characteristics of Nourishing Oils Human skin patch test of each Nourishing Oil,
The results of the storage stability test and usability evaluation are shown in Table 3.

[Table] As shown in Table 3, the nourishing oil of the present invention has good affinity with the skin, is not sticky, gives the skin a suitable oily feel and moisturizing feeling,
It clearly had an excellent usability. In addition, the amount of evening primrose oil is as a storage stabilizer.
When BHA was used, the amount was up to about 60 wt%, but when Sunflower A, Saiko A, Chuyu A, etc. were used, there was no restriction on the amount of evening primrose oil blended. That is, in the nourishing oils of Comparative Examples (4) and (5) and Examples (4) and (5) in which the amount of evening primrose oil was 70 wt%, Comparative Example (4) in which BHA was blended at 0.2 wt%. ) has insufficient storage stability, and comparative example (5) containing 0.3wt% BHA causes skin irritation ((±)...
2 people, (+)...3 people), and in the usability evaluation, 4 test subjects complained of irritation, which was not favorable. However, instead of BHA, sunflower A,
Examples (4) and (5) containing Saiko A, Chuyu A, etc. had excellent storage stability and did not cause skin irritation.

[Table] (2) Preparation method Components (A) and (B) were heated separately as needed to mix and dissolve them uniformly, and then the components (A) and (B) were mixed to prepare. (3) Characteristics of skin lotions Human skin patch test of each skin lotion,
Table 4 shows the results of the storage stability test and usability evaluation.

[Table] As shown in Table 4, the skin lotion of the present invention clearly had an excellent feeling of use.
In addition, a comparative example in which the amount of evening primrose oil was 10.0wt%
(7) and Example (6) are comparative examples in which only 0.15wt% of tocopherol, a well-known antioxidant, is blended.
In the case of (7), the storage stability was somewhat poor, but Sunflower A, Saiko A, and Chuyu A were each used separately.
The storage stability of Example (6) containing 0.05 wt% was sufficiently excellent.

Claims (1)

[Claims] Oil obtained from the seeds of evening primrose (Oenothera tetraptera Car.) and sunflower (Helianthus
annuus L) seeds, Bupleurum
falcatum L) roots, and the roots of Sanguisorba falcatum L.
1. A skin cosmetic comprising at least one extract obtained from the rhizome of L. officinalis L.