JPH05500020A - unit dose container - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] unit dose container The present invention relates to thermoplastic containers suitable for use in holding and transferring injection solutions to syringes.

There are many different forms of syringes currently available for use by healthcare professionals. . The most appropriate syringe design for any one situation will depend on the specific use, depending on the nature of the solution used and the intended location of the injection.

One particular design difference in the various syringes is that the open end is adapted to fit a hypodermic needle. This is a method of shaping it so that it can be

The two most common forms of needle attachment are friction fit attachment (e.g. luer slip attachment). Attached part (luer 5 lip fitting)] and combination of thread and frictional engagement For example, Luer 1ock fitting )]. The threaded mounting of interest in the context of the present invention is the Luer lock mounting. A female fitting with an internal thread, such as the case of a part, is a part, and henceforth is referred to as a threaded connection of a syringe. All part names are female type mounting. The threaded attachment prevents the needle from coming out of the syringe barrel. Preferred installation under usage conditions (epidural injections) where there is some expectation of dislodgement. is the department. The present invention is particularly designed for transferring injection solutions into a syringe with a screw thread attachment. Concerning suitable containers for

[Conventional technology]

In the past, common operations using hypodermic syringes by surgeons or other health care professionals The process uses a wide-channel needle attached to the syringe barrel to transfer the injection solution from the glass bottle to the syringe. Was that. After transfer, remove this wide channel button from the syringe and release it to the patient. Replace the needle with a narrower channel suitable for injecting the solution. This past work will go It will be appreciated that this required the use of some additional parts. 2. Note to people Transferring the solution for injection requires careful sterilization of the parts, and this traditional procedure It is necessary to take separate sterilization measures at each stage.

Ampules or vials containing single doses to avoid such transfer problems. It was proposed to make a bottle.

This single-dose vial has a cartridge attached to a syringe that can be attached to a hypodermic needle. It was made to be installed like a. Such single-use I vials are commonly Vials are usually made of glass, sealed with a rubber membrane, and have needles on both sides of the syringe. make a hole in

Another arrangement is disclosed in Australian Patent No. 556.483, where The single-dose container is described as being made of thermoplastic material, and this container holds the injectable solution. The needle attachment of the syringe to be transferred opens into the part and cooperates so that they engage directly. It has become. This patent covers standard friction fit needle installations, e.g. Lua slip installations. It describes a satisfactory arrangement for use with screw threading mechanisms such as Luarotsuta machines. does not address issues related to syringes that utilize

The object of the present invention is to provide an injection solution to a syringe with a threaded fitting, which has not been possible hitherto. The screw-on mounting is more secure, easier and more convenient than other methods. An object of the present invention is to provide a container suitable for use with a syringe.

[Description of the invention]

According to the invention, the liquid-containing body comprises a body, a neck and an outlet opening at the distal end of the neck. A thermoplastic unit I container is provided, the exit opening being sealed with a non-reclosable lid, and the neck The outer wall of the portion includes a threaded portion located at or near the outermost edge of the neck; After removing the cap, the threaded part threads into the threaded path facing inward at the end of the syringe. to allow a sealed connection of the container with said syringe, thereby allowing the container to The liquid in the container can be transferred directly from the container to the syringe.

The lid is preferably attached to the outlet opening along the break line and should not be shaken or It can be easily separated by the twisting action. Preferably the outer wall of the container neck is threaded. It has a mating part and a non-screwing part. In such an embodiment, the threaded portion is used for mounting the syringe. has a cross-sectional diameter greater than the distance between the opposite peaks of the syringe and It is designed to screw into the thread path for convenient connection.

The diameter of the non-threaded part is equal to the distance between the crests of the threads on opposite sides of the syringe mounting part. or preferably smaller, so that the neck can be When drawn into the threads of a gun, it can effectively pass through the thread.

The threaded part may be of any shape that can be threaded into the thread path of the syringe mounting part. good. Most preferably, the threaded portion of the neck is located at the edge of the outlet opening and The gun mount consists of a shoulder shaped to thread into the threaded path of the section. Special aspects of the invention One example is a cylindrical neck with a peripheral layer forming a threaded fit at the edge of the exit opening ( It is a container with a non-threaded part). In other words, shape a container with parallel sides. It is also possible to do so. The screw thread installation is as shown in the section, while the Lua lock installation is as shown in the section. If a central cone is included, these sides should be sized to seal against the Lua cone. is preferred. Alternatively, the container may have an inverted truncated conical neck; The front edge of the syringe mount is formed to engage with the thread (threaded part) of the syringe mounting part, and The trailing section of the truncated cone that forms the non-threaded part of the neck. 5ection).

The container of the present invention can be used in a syringe having a screw thread attachment section, for example, a "Luer lock attachment section". It is particularly useful for use in The Luer lock installation has a conical shape in the center and a conical shape on the outer periphery. It consists of a wall and a bottom wall. The outer wall of the cone, the bottom wall and the inner side of the peripheral wall together form an annular passage. The inner side of the peripheral wall is provided with a thread.

An attachment like that of a Luer lock can be used with a syringe that has a The mouth opening must be large enough to accommodate the central male cone of the syringe. .

In one embodiment of the invention, the neck diameter is at least one portion of the neck of the container. In minutes, the syringe fitting is equal to or slightly smaller than the corresponding outer diameter of the cone of the part.

Since the container of the present invention is made of thermoplastic material, it can be slightly deformed, and The diameter of the neck is slightly smaller than the outer diameter of the syringe in at least one area. most preferably in seal-forming contact with the cone at that point or points. Yes.

When the sealing engagement is facilitated in this way, the threaded part of the container neck is sealed between the mounting part and the threaded part of the container neck. Although it is desirable to create a sealed condition, it is not necessary. But long Alternatively, the sealing engagement may be between the threaded portion of the neck and the peripheral wall of the mounting portion, or alternatively, the It is extremely important that this occurs at the opening of the medial part of the neck and the central female cone. If sealed If there is no connection, the ingress of non-sterile air into the container is possible, and this This may lead to contamination of the contents.

The seal between the container and the syringe fitting is such that the threaded neck part is circular in its cross-sectional diameter. It is also enhanced if the diameter is slightly larger than the inner diameter of the shaped passage. This means that the container screws onto the syringe. In this case, the threaded part deforms slightly and comes into sealing contact with the inside of the peripheral wall. means.

The container body may have any shape. However, the top of the body is shaped into a hexagon. It is preferable to The hexagonal shape is tolerant as it withstands radial and axial forces. It strengthens the container, making it easier to connect the syringe to the container. Then the hexagonal top of the main body Further strengthen each side with one yoke. In addition, the yoke is made with holes when manufacturing containers. Reduce the risk of being opened.

In use, transfer of the injection solution into containers made according to the invention is carried out as follows. Ru.

first by rocking or twisting the non-resealable lid and then into the outlet opening. Separate and remove along adjacent break lines. Keep the container in an upright position and drain the solution. Place the syringe you are about to transfer into it so that the threaded fitting is aligned with the outlet opening. (The syringe piston must be fully inserted. Then the container Inject the container by rotating the syringe and container relative to each other until they are fully engaged with the threads on the syringe. The device is installed by sealingly screwing it together with the part. Once so connected, pour the contents of the container into the syringe. The action of pulling the piston back allows it to be drawn into the syringe If necessary, the outer wall of the container can be partially deformed to facilitate the transfer of the solution. I can help.

The invention will be further described below with reference to preferred embodiments of the invention as shown in the accompanying drawings. Ru. That is, FIG. 1 shows a unit dose container made in accordance with the present invention sealed with a non-reclosable lid. Figure 2 is a front view of the container; Figure 2 shows the unit dose container of Figure 1 with the lid removed from the outlet opening; Figure 3 shows the top of another embodiment of the invention. Figure 4 shows the exit opening. 5 shows the unit dose container of FIG. 2 with the syringe connected, and FIG. 5 shows the opening shown in FIG. The section and the syringe attachment are exploded views of the connection between the section and the syringe attachment section.

FIG. 1 shows a container 18 of thermoplastic material, which can be easily deformed. Ru. Materials suitable for the manufacture of such containers are known in the art, but Contains polyethylene and polypropylene. The container 1 consists of a body 2 and a neck 3. neck There is a non-resealable lid 4 at the distal end of the neck 3, which connects to the distal end of the neck 3 along a break line 5. . 9 part 3 has the shape of a cone with the tip expanding outward, and this shape is shown in Figure 2. easily confirmed.

FIG. 3 shows another embodiment of the invention in which the top of the body is hexagonally shaped; The main body is reinforced with one yoke on each side.

The non-resealable lid 4 can be removed from the neck 3 by rocking or twisting and will not break. It is separated from the neck 3 along the line break 5. After removing the non-resealable lid, the distal end of the cervix 3 The open LJ part 7 appears and the liquid in the container can pass through it.

The neck 3 includes a screw thread, which is a shoulder 8 on the edge around the lower protrusion. Also, the neck The part has a non-threaded part 9 of reduced cross-sectional diameter. Figures 4 and 5 show the amount of liquid in the container. such container connected to a syringe to facilitate transfer to the syringe shows. These figures show a needle with a Luerlock needle attachment section 10 attached. child The mounting section has a central conical cone 11, an outer circumferential wall 12 and a bottom wall 13. The wall delimits the annular passage I4. A screw thread 15 is formed on the inner wall of the peripheral wall 12. Ru. The central Luer cone 11 is provided with a transfer passage 16, which is open at its outermost end 17. Ru.

In Figure 3, the threaded part has a sharper profile (less edges). The threaded mounting is designed to be screwed into the part, but in order to ensure the threaded fit, it is necessary to It may be necessary to continue applying additional opening force. This neck is as shown below for container 1. The Luer lock attachment is made to be screwed together with part 10. Contain the non-resealable lid 4. After removal from container 1, keep the container in an upright position and syringe attachment point IO to container 1. , thereby inserting the central Luer cone 11 into the outlet opening 7 . do. By rotating the container relative to the syringe attachment section, the neck section 3 is screwed into place. The part 8 is screwed into the screw 15. The syringe attachment section has an exit opening to aid in the initial screwing. It may also be pushed down slightly into the mouth 7. −〇, When the screws “engage”, shoulder 8 will spring up. 15 and contacts the lower surface I7 of the screw and the inner surface of the peripheral wall 12.

The non-threaded part 9 of the neck part 3 has a narrower cross-section, and the container can be screwed into the part when attaching the syringe. The screw I5 can move freely into the passageway 14 without being obstructed when the screw I5 is opened.

The inner diameter of the neck 3 is slightly smaller than the outer cross-sectional diameter of the cone 11 at point 19. No. As can be seen in Figure 5, this generally involves a sealing connection with the component at the point indicated at 20. ensure that the The degree of sealing at 20 is such that the side wall of the cone is slightly inclined A luer such as in a standard luer cone where the bottom of the luer is slightly increased in diameter than the top of the cone. Alloc attachment is improved when screwing the container onto the part.

Therefore, as the container 1 is screwed into the part 10, the threaded mounting is indicated by 1ffi19. The neck portion is compressed outwardly to increase the inner diameter of the neck at this location. this As the container is screwed into the needle fitting part 1 against the outer wall of the cone 11 As a result of 9 being pressed more tightly, strain is produced in the neck.

In FIG. 5, the position of the container when it is fully screwed onto the needle is also indicated by hatched lines. child In this position, the top of the outlet opening 7 is in contact with the bottom 13 of the needle attachment part and the container The needle attachment of the device further ensures a sealing engagement with the part.

Once the container is fully secured to the needle mount, the injection solution in the container cannot be transferred. It is easily performed by pulling back the piston of the syringe barrel. Make sure the side walls of the container are Most preferably, the container is soft enough to partially collapse the container when withdrawing the injection solution. Yes. Transfer of the solution can be aided by squeezing the outer wall 21 of the container. .

The containers of the present invention can be filled with a solution of any drug suitable for injection, but Autoclave for use under conditions with particularly high requirements for easy handling and sterility. sterilizable local anesthetics such as lidocaine, brylcoin, mepivocaine, bupi Particular preference is given to using aqueous solutions of bocaine, etidocaine or other drugs.

Finally, without departing from the spirit or scope of the invention as defined in the following claims: , various changes, modifications and/or additions may be made to the above-mentioned configuration and parts. Needless to say.

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Claims (11)

[Claims] 1. A thermoplastic body containing liquid consisting of a neck and an outlet opening at the end of the neck a unit dose container in which the outlet opening is sealed with a non-reclosable lid; , the outer wall of the head includes a screw threaded portion located at or near the outermost edge of the neck; As a result, the rear threaded part, excluding the lid, is connected to the thread path facing inward at the distal end of the syringe. A threaded fit allows for a sealed connection of the container with said syringe, thereby A thermoplastic material that holds liquid that can be transferred directly from the container to the syringe. Unit dose container. 2. The outer wall of the container neck includes a threaded part and a non-threaded part, and the threaded part is connected to the threaded part. The distal end of the syringe is adapted to engage the threaded passageway, and the unthreaded portion is adapted to engage the threaded passageway at the end of the syringe. The container of claim 1 is shaped so as not to interfere with the threads when connected to a syringe. vessel. 3. A threaded engagement is located on the rim of the outlet opening, and a threaded portion is located at the end of the syringe. 3. A container according to claim 2, comprising a shoulder shaped to fit within the channel. 4. The neck is in the shape of an inverted truncated cone, and the rim of the exit opening 4. The method according to claim 1, wherein the syringe is configured to threadably engage a threaded passageway at the distal end of the syringe. A container as described in one or more of the following items. 5. 4. A container according to any one of claims 1 to 3, wherein the neck has parallel sides. 6. The top of the body is hexagonal and reinforced with one yoke on each side A container according to any one of claims 1 to 5. 7. Ensure the outlet opening is shaped for threaded engagement with the Luer lock fitting. 7. A container according to any one of claims 1 to 6. 8. Installation in which the container includes a central cone surrounded by a peripheral wall with inwardly facing threads 8. The syringe according to claim 1, wherein the syringe is adapted to be connected to a syringe having a a container, the container having an inner diameter in at least one portion of the container neck; container, characterized in that the outer diameter of the central cone is smaller than or equal to the outer diameter of the corresponding central cone. 9. of the peripheral wall of the syringe where the threaded part of the neck attempts to connect the container in cross-sectional diameter. 9. A container according to claim 8, wherein the distance between opposite sides is greater than the distance between opposite sides. 10. 10. A non-resealable lid adheres to the outlet opening along the break line. A container as described in any one of the items. 11. Substantially as described above with reference to what is shown in any one of the accompanying drawings: container.