JPH0558836A - Curable sizing agent for filling root canal - Google Patents
Curable sizing agent for filling root canalInfo
- Publication number
- JPH0558836A JPH0558836A JP3062611A JP6261191A JPH0558836A JP H0558836 A JPH0558836 A JP H0558836A JP 3062611 A JP3062611 A JP 3062611A JP 6261191 A JP6261191 A JP 6261191A JP H0558836 A JPH0558836 A JP H0558836A
- Authority
- JP
- Japan
- Prior art keywords
- agent
- root canal
- filling
- sizing agent
- root
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004262 dental pulp cavity Anatomy 0.000 title claims abstract description 22
- 238000004513 sizing Methods 0.000 title abstract description 7
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 16
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 16
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims abstract description 13
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims abstract description 13
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000011344 liquid material Substances 0.000 claims abstract description 7
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims description 19
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 12
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 8
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 8
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 8
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 abstract description 8
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract description 8
- 235000011010 calcium phosphates Nutrition 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 4
- 239000011787 zinc oxide Substances 0.000 abstract description 4
- 230000007794 irritation Effects 0.000 abstract description 3
- 235000011837 pasties Nutrition 0.000 abstract description 3
- 239000000945 filler Substances 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 229910044991 metal oxide Inorganic materials 0.000 abstract description 2
- 150000004706 metal oxides Chemical class 0.000 abstract description 2
- 238000007789 sealing Methods 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 5
- 229910014770 Ca4P2O9 Inorganic materials 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- 229910000014 Bismuth subcarbonate Inorganic materials 0.000 description 7
- MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 description 7
- 229940036358 bismuth subcarbonate Drugs 0.000 description 7
- 239000002631 root canal filling material Substances 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- OKJPEAGHQZHRQV-UHFFFAOYSA-N iodoform Chemical compound IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 6
- 210000000214 mouth Anatomy 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 5
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 229910000392 octacalcium phosphate Inorganic materials 0.000 description 3
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 239000002872 contrast media Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000003796 zinc oxide eugenol cement Substances 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 208000016192 Demyelinating disease Diseases 0.000 description 1
- 206010012305 Demyelination Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 229940036348 bismuth carbonate Drugs 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000002639 bone cement Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000003479 dental cement Substances 0.000 description 1
- GMZOPRQQINFLPQ-UHFFFAOYSA-H dibismuth;tricarbonate Chemical compound [Bi+3].[Bi+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O GMZOPRQQINFLPQ-UHFFFAOYSA-H 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Landscapes
- Dental Preparations (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、歯科治療に用いるペー
スト状根管充てん用硬化型糊材に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a paste type curable paste material for filling root canals used for dental treatment.
【０００２】[0002]
【従来の技術】歯科治療において抜髄、あるいは感染根
管治療後、空隙となった根管系に対し、根管充てん材を
てん入することによって根端部創傷の保護、治癒を目的
とする根管充てん操作を行う。従って、歯牙の治療処理
に至る前段階としてのこれらの処理は歯科臨床上もっと
も頻度が高く、重要な処理法である。これらの処理は従
来より種々の根管充てん材が使用されてきたが、治療的
な材品で糊材系のもの（例えば水酸化カルシウム系糊
材）、または物理的な封鎖を主体とした固形状のもの
（例えばガッタパーチャーポイント）がある。固形状の
根管充てん材を用いる場合においても根端部の確実な封
鎖を得るためには、他にシーラーと呼ばれる一種の封鎖
材を用いた併用根管充てんを行う必要がある。また、シ
ーラーにも練和後、ある一定時間を経て硬化する硬化固
形状（セメントタイプ）の根管充てんと呼ばれるものも
ある。従来から知られているセメントタイプの根管充て
ん材としては酸化亜鉛を主成分とし、これに酸化亜鉛ユ
ージノールセメントが多く用いられてきた。また酸化亜
鉛の代わりにハイドロキシアパタイトを用いた根管充て
ん材もある。2. Description of the Related Art Roots for the purpose of protecting and healing root end wounds by filling root canal filling material into the voided root canal system after demyelination or infection root canal treatment in dental treatment. Perform tube filling operation. Therefore, these treatments are the most frequent and important treatment methods in dental clinical treatment as a step before the treatment treatment of teeth. Various root canal filling materials have been used for these treatments, but they are therapeutic materials such as glue-based materials (for example, calcium hydroxide-based glue materials) or solid materials mainly composed of physical blockages. There are shapes (for example, gutta-perture points). Even when a solid root canal filling material is used, it is necessary to perform a combined root canal filling using a kind of sealing material called a sealer in order to obtain a reliable sealing of the root end. There is also a sealer, called a root canal filling, which is a hardened solid (cement type) that hardens after a certain period of time after kneading. A conventionally known cement-type root canal filler is zinc oxide as a main component, and zinc oxide eugenol cement has been often used. There is also a root canal filling material using hydroxyapatite instead of zinc oxide.
【０００３】[0003]
【発明が解決しようとする課題】酸化亜鉛ユージノール
セメントは根端部の周囲組織に対し、組織刺激性を有す
るとされ、いわゆる生物学的根管充てん材としては、満
足できるものとはいえず、また、ハイドロキシアパタイ
トを用いても、化学反応性に乏しく硬化性に問題がある
ものである。また、従来から知られているセメントタイ
プの根管充てん材は口腔内外を問わず、一定時間経過後
硬化固形化する為に、混練物をペースト状のまま長期保
存する事は不可能で、使用毎にセメントを混練しなくて
はならず、操作性が悪かった。Zinc oxide eugenol cement is said to have tissue irritation to the tissues around the root end, and is not satisfactory as a so-called biological root canal filling material. Even if hydroxyapatite is used, it has a poor chemical reactivity and a problem of curability. In addition, the conventionally known cement-type root canal filling material, whether inside or outside the oral cavity, hardens and solidifies after a certain period of time, so it is not possible to store the kneaded product in a paste form for a long period of time. Cement had to be kneaded every time, and the operability was poor.
【０００４】[0004]
【課題を解決するための手段および作用】近年、歯牙や
骨など生体硬組織の代替材として注目を集めているリン
酸四カルシウムはそのすぐれた生体適合性から、歯科用
セメント、人工骨セメントなどに応用されているが、本
発明者らはこの様なリン酸四カルシウムの生体、特に歯
髄及び根端部周囲に及ぼす影響、および混練物の硬化性
について多くの研究を重ねた結果、リン酸四カルシウム
および／またはリン酸三カルシウムに対し、ロジン、カ
ルボン酸、液材を配合してして得られるペースト状根管
充てん用硬化型糊材を見い出した。[Means and Actions for Solving the Problems] In recent years, tetracalcium phosphate, which has been attracting attention as an alternative material for living hard tissues such as teeth and bones, is excellent in biocompatibility, and therefore, dental cement, artificial bone cement, etc. However, as a result of many studies conducted by the present inventors on the effects of such tetracalcium phosphate on the living body, particularly on the pulp and around the root end, and the hardening property of the kneaded product, A paste-like root canal filling curable paste material obtained by mixing rosin, carboxylic acid, and a liquid material with tetracalcium and / or tricalcium phosphate was found.
【０００５】本発明の根管充てん用硬化型糊材の主剤で
あるリン酸カルシウムとカルボン酸とロジンの３成分
は、根管充てん用硬化型糊材のうち３成分全量として１
０〜６５wt％であるのが好ましく、これら３成分の混合
比率はリン酸カルシウム：カルボン酸：ロジン＝０．１
１〜７．７：１：０．４〜８の範囲であるのが好まし
い。これら主剤である３成分の混合比率が適切な硬化時
間にするのに重要なこととなる。すなわち、リン酸カル
シウム量が上記の比率を越えると硬化反応が早くなり、
室内放置時２週間程度で混練ペーストが硬化してしま
い、上記の比率未満では、口腔内での硬化時間が２４時
間以上となり、また生体親和性等の効果も少ないことと
なる。The three components of calcium phosphate, carboxylic acid and rosin, which are the main ingredients of the curable sizing material for root canal filling of the present invention, consist of 1 of the three components of the sizing material for root canal filling.
The mixing ratio of these three components is preferably calcium phosphate: carboxylic acid: rosin = 0.1.
It is preferably in the range of 1-7.7: 1: 0.4-8. The mixing ratio of these three main components is important for achieving an appropriate curing time. That is, if the amount of calcium phosphate exceeds the above ratio, the curing reaction will be accelerated,
The kneading paste hardens in about 2 weeks when left indoors, and if the ratio is less than the above, the hardening time in the oral cavity will be 24 hours or more, and the effect of biocompatibility and the like will be small.
【０００６】カルボン酸の量が上記の比率未満では口腔
内での硬化時間が２４時間以上となり、上記の比率を越
えると室内放置時早期に硬化が起こってしまう。また、
ロジンは撥水性を有し、その添加量は硬化性に影響し、
上記の比率を越えると口腔内での硬化時間が長くなると
ともにリン酸カルシウム量が少ないと同様の現象が起こ
り、上記の比率未満では撥水性の効果が少なくなり、硬
化反応が早くなりリン酸カルシウム量が多いのと同様の
現象が起こるばかりでなく、根管を埋めた後で体液の浸
入による浸食を防ぐことができなくなる。If the amount of carboxylic acid is less than the above ratio, the curing time in the oral cavity will be 24 hours or more, and if it exceeds the above ratio, curing will occur early when left in the room. Also,
Rosin has water repellency, and its addition amount affects curability,
When the ratio exceeds the above, the curing time in the oral cavity becomes longer and the same phenomenon occurs when the amount of calcium phosphate is small, and when the ratio is less than the above, the effect of water repellency is reduced, the curing reaction is accelerated, and the amount of calcium phosphate is large. Not only the phenomenon similar to the above occurs, but it becomes impossible to prevent the erosion due to the infiltration of body fluid after the root canal is buried.
【０００７】また、本発明たる根管充てん用組成物を長
期にわたってペースト状に維持させるために液材を配合
するが、その液材として、グリセリン、エチレングリコ
ール、シリコーンオイル、植物油、ポリソルベート、低
分子量パラフィン型炭化水素等の不揮発性のものが適し
ている。この液材の添加量は３５〜８５％が好ましい。A liquid material is added to the root canal filling composition of the present invention to maintain it in a paste form for a long period of time. As the liquid material, glycerin, ethylene glycol, silicone oil, vegetable oil, polysorbate, and low molecular weight are used. Non-volatile substances such as paraffin hydrocarbons are suitable. The addition amount of this liquid material is preferably 35 to 85%.
【０００８】上記の３成分である主剤および液材の他に
Ｘ線造影材や抗菌材を添加混合してもよく、また、リン
酸四カルシウムおよび／またはリン酸三カルシウムのリ
ン酸カルシウム成分に対し更にハイドロキシアパタイト
および／またはリン酸八カルシウムを添加配合してもよ
い。リン酸四カルシウム等自身も弱いＸ線造影性を有す
るが歯牙をより鮮明に区別するために、次炭酸ビスマ
ス、タンタルパウダー、硫酸バリウム等をＸ線造影材と
添加してもよいが添加する場合には５〜１２wt％添加す
るのが好ましい。In addition to the above-mentioned three main components, the main component and the liquid material, an X-ray contrast material or an antibacterial material may be added and mixed, and the calcium phosphate component of tetracalcium phosphate and / or tricalcium phosphate may be further mixed. Hydroxyapatite and / or octacalcium phosphate may be added and blended. Tetracalcium phosphate itself also has a weak X-ray contrast property, but bismuth subcarbonate, tantalum powder, barium sulfate, etc. may be added with the X-ray contrast medium in order to distinguish the teeth more clearly, but in the case of addition It is preferable to add 5 to 12 wt%.
【０００９】また、抗菌材としてはヨードホルム、クロ
ルヘキシジン等が用いられ、添加量としては０〜１０wt
％が好ましい量である。As the antibacterial material, iodoform, chlorhexidine, etc. are used, and the addition amount is 0 to 10 wt.
% Is the preferred amount.
【００１０】ハイドロキシアパタイトおよび／またはリ
ン酸八カルシウムを更に添加する場合もこれらの成分と
リン酸四カルシウムおよび／またはリン酸三カルシウム
の全添加配合量、比率は前述の場合の配合量、比率と同
じ範囲であるのが好ましい。なお、本発明である根管充
てん用硬化型糊材はシリンジ等に詰めて根管に充てん
し、充てん物については口腔内で硬化するものの、未使
用部についてはシリンジ内等にペースト状のまま室内長
期保存が可能である。Even when hydroxyapatite and / or octacalcium phosphate are further added, the total amount of these components and tetracalcium phosphate and / or tricalcium phosphate to be added is the same as the above-mentioned amounts and ratios. The same range is preferable. The curable paste material for root canal filling according to the present invention is filled in a syringe or the like to fill the root canal, and the filled material is cured in the oral cavity, but the unused portion remains in a paste form in the syringe or the like. Can be stored indoors for long periods.
【００１１】[0011]
【実施例】本発明を実施例により詳細に説明する。本発
明に係わるペースト状硬化型糊材の配合例を実施例１〜
７に示す。 実施例１ リン酸四カルシウム ２５％ ロジン １２％ リンゴ酸 １２％ 次炭酸ビスマス １２％ ヨードホルム ２％ グリセリン ３７％ 実施例２ リン酸三カルシウム ２０％ ロジン ２０％ クエン酸 １０％ 次炭酸ビスマス ５％ グリセリン ３５％ 実施例３ リン酸四カルシウム １５％ リン酸三カルシウム １０％ ロジン １５％ マロン酸 ５％ 次炭酸ビスマス １０％ グリセリン ４５％ 実施例４ リン酸四カルシウム １０％ ハイドロキシアパタイト ５％ ロジン １０％ リンゴ酸 １０％ 次炭酸ビスマス １０％ エチレングリコール ５５％ 実施例５ リン酸三カルシウム １５％ リン酸八カルシウム ５％ ロジン ２０％ リンゴ酸 １０％ 次炭酸ビスマス １０％ エチレングリコール ４０％ 実施例６ リン酸四カルシウム ４０％ ロジン ２０％ リンゴ酸 ５％ 次炭酸ビスマス ５％ ヨードホルム ５％ グリセリン ２５％ 実施例７ リン酸三カルシウム ５％ ロジン ４０％ クエン酸 １０％ 次炭酸ビスマス １０％ グリセリン ３５％EXAMPLES The present invention will be described in detail with reference to Examples. Examples of compounding of the pasty curable paste material according to the present invention
7 shows. Example 1 Tetracalcium phosphate 25% Rosin 12% Malic acid 12% Bismuth subcarbonate 12% Iodoform 2% Glycerin 37% Example 2 Tricalcium phosphate 20% Rosin 20% Citric acid 10% Bismuth subcarbonate 5% Glycerin 35 % Example 3 Tetracalcium phosphate 15% Tricalcium phosphate 10% Rosin 15% Malonic acid 5% Bismuth subcarbonate 10% Glycerin 45% Example 4 Tetracalcium phosphate 10% Hydroxyapatite 5% Rosin 10% Malate 10 % Bismuth subcarbonate 10% Ethylene glycol 55% Example 5 Tricalcium phosphate 15% Octacalcium phosphate 5% Rosin 20% Malic acid 10% Bismuth subcarbonate 10% Ethylene glycol 40% Example 6 Tetracalcium phosphate 40% Rosin 20% apple 5% following bismuth carbonate 5% iodoform 5% Glycerin 25% Example 7 tricalcium phosphate 5% rosin 40% citric acid 10% following bismuth subcarbonate 10% Glycerin 35%
【００１２】実施例８ 実施例１〜７のペースト状糊材を室内（３〜２１℃、４
８〜８７ＲＨ）および３７℃、９５ＲＨ下に放置し長期
安定性および口腔内における硬化について検討した結果
を表１に示した。この表１から明かな様に、請求範囲内
の配合によるペースト状糊材は室内では１ヶ月以上硬化
せず、３７℃、９５ＲＨ下では２４時間以内に硬化する
性質を有する。Example 8 The paste-like paste materials of Examples 1 to 7 were used in a room (3 to 21 ° C., 4
Table 8 shows the results of examining the long-term stability and the curing in the oral cavity after leaving it under the conditions of 8 to 87 RH), 37 ° C. and 95 RH. As is apparent from Table 1, the paste-like paste material having the composition within the scope of the claims does not cure in the room for one month or more, and has the property of curing within 24 hours at 37 ° C. and 95 RH.
【００１３】[0013]
【表１】 [Table 1]
【００１４】実施例９ 実施例１〜５のペースト状糊材を成犬１２頭の下顎前臼
歯１２０根管に対し適用し、３ヶ月後に屠殺し、病理組
織的に検索したところ表２の様な結果を得た。なお、所
見は軽微（±）、軽度（＋）、中程度（＋＋）、強度
（＋＋＋）の４段階の程度で判定した。Example 9 The paste-like paste materials of Examples 1 to 5 were applied to 120 root canals of the lower anterior molars of 12 adult dogs, sacrificed 3 months later, and histopathologically searched, as shown in Table 2. I got good results. The findings were evaluated in four grades: slight (±), mild (+), moderate (++), and intensity (++).
【００１５】[0015]
【表２】 [Table 2]
【００１６】この表２から明かな様に、これらの組成に
よるペースト状糊材はいずれも根端部の生物学的治癒を
助長し、根管充てん材として優れた効果を有するもので
あった。As is apparent from Table 2, all of the paste-like paste materials having these compositions promoted the biological healing of the root end and had an excellent effect as a root canal filling material.
【００１７】[0017]
【発明の効果】以上の様に本発明に係わる根管充てん用
硬化型糊材は主成分がリン酸四カルシウム等のリン酸カ
ルシウムであり、金属酸化物である酸化亜鉛を全く含有
しないので生体組織との親和性を有し、組織刺激性が少
なく、根端部周囲組織の治癒を助長し根端部の閉鎖が期
待できる。また、根管充てん物は２４時間以内で硬化し
根管を封鎖するものの、室内では長期に渡ってペースト
状を維持し、未使用部についてはシリンジ内等にペース
ト状のまま室内長期保存が可能である。As described above, the curable sizing material for root canal filling according to the present invention contains calcium phosphate such as tetracalcium phosphate as the main component and does not contain zinc oxide which is a metal oxide at all, so that It has low affinity to the tissue, has less tissue irritation, promotes healing of the tissue around the root tip, and can be expected to close the root tip. Also, although the root canal filling hardens within 24 hours and seals the root canal, it maintains a paste form for a long time indoors, and unused parts can be stored in the syringe as a paste for a long time indoors. Is.
Claims (1)
および／またはリン酸三カルシウム（Ｃａ3 （ＰＯ4）2
）に対し、ロジン、カルボン酸、液材を配合してなる
根管充てん用硬化型糊材。1. Tetracalcium phosphate (Ca 4 P 2 O 9 ).
And / or tricalcium phosphate (Ca 3 (PO 4 ) 2
), A curable paste material for root canal filling, which is prepared by mixing rosin, carboxylic acid, and liquid material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3062611A JP2554402B2 (en) | 1991-03-04 | 1991-03-04 | Curable adhesive for root canal filling |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3062611A JP2554402B2 (en) | 1991-03-04 | 1991-03-04 | Curable adhesive for root canal filling |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0558836A true JPH0558836A (en) | 1993-03-09 |
| JP2554402B2 JP2554402B2 (en) | 1996-11-13 |
Family
ID=13205287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3062611A Expired - Lifetime JP2554402B2 (en) | 1991-03-04 | 1991-03-04 | Curable adhesive for root canal filling |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2554402B2 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59182263A (en) * | 1983-03-31 | 1984-10-17 | 科学技術庁無機材質研究所長 | Method for producing hardened calcium phosphate cement |
| JPS6283348A (en) * | 1985-10-08 | 1987-04-16 | 株式会社アドバンス | Curable composition for medical use |
| JPH02200606A (en) * | 1989-01-27 | 1990-08-08 | Ube Ind Ltd | Root canal-filler of curable paste |
| JPH02200605A (en) * | 1989-01-27 | 1990-08-08 | Ube Ind Ltd | Curable glue root canal filling material |
-
1991
- 1991-03-04 JP JP3062611A patent/JP2554402B2/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59182263A (en) * | 1983-03-31 | 1984-10-17 | 科学技術庁無機材質研究所長 | Method for producing hardened calcium phosphate cement |
| JPS6283348A (en) * | 1985-10-08 | 1987-04-16 | 株式会社アドバンス | Curable composition for medical use |
| JPH02200606A (en) * | 1989-01-27 | 1990-08-08 | Ube Ind Ltd | Root canal-filler of curable paste |
| JPH02200605A (en) * | 1989-01-27 | 1990-08-08 | Ube Ind Ltd | Curable glue root canal filling material |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2554402B2 (en) | 1996-11-13 |
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