JPH0564925B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a hair tonic, and more particularly to a hair tonic containing as an active ingredient an extract (extract component) of Toshi and/or Senega, which are known as herbal medicines belonging to the family Polygonaceae. BACKGROUND ART Considerable research has been carried out on hair nourishing agents containing natural ingredients as active ingredients. For example, the extract of the fruit of Goshuyu (Rutaceae)
(No. 29922), extracts of wolfberry, wolfberry, chaihu, and chuan (Japanese Patent Publication No. 58-40923), extracts of the roots of mutants of Sasanishiki (Japanese Patent Application Publication No. 58-88303), He-ku-karasu or He-ku-karasu There have been reports of extracts (Japanese Patent Publication No. 59-55815); Although it is said to be effective in preventing and improving dandruff, itching, and hair loss, and to promote hair growth, there is currently nothing satisfactory in terms of practical use. On the other hand, substances used as hair nourishing agents are required to have excellent hair nourishing effects and to be particularly safe since they are used continuously over a relatively long period of time. In general, natural products are safer than chemically synthesized products and have multiple effects.
There are expectations that the action will be mild, and there is a need for something more effective. As a result of intensive search and research for substances that exhibit superior hair growth and hair growth effects, the present inventors have found that extracts (extract components) of Toshi and Senega, which are known as herbal medicines from the Aceraceae family, using various solvents (extract components) for human or human use. The present invention was completed based on the discovery that when applied to the skin of animals, it exhibits extremely significant hair growth and hair growth promoting effects. That is, the present invention relates to a hair nourishing agent characterized by containing an extract of Enshi and/or Senega, which are known as herbal medicines belonging to the family Polygonaceae. The senega used in the present invention is Polygala senega L.var.
TORR.et GRAY.) roots, and toshi refers to the roots of P. tenuifolia WILLD., a member of the family P. tenuifolia. In Chinese medicine, they are used as antitussives and expectorants, as well as tonics and sedatives. Senega contains 6-10% Senegin, a triterpene saponin.
In addition, methyl salicylate and its glycoside gaultherin, fatty oil 4-10%,
It is also known to contain many sugars. In addition, other known components of Enshi include tenuigenin, which is similar to Senega saponin, as well as polygalitol and onsitin. The extract of Enshi and/or Senega used in the present invention can be obtained by extracting the ground product of Enshi and/or Senega using a water-soluble solvent such as methanol, ethanol, water, or an organic solvent such as ethyl acetate or chloroform. or a mixture thereof. It is appropriate to blend the extract of Enshi and/or Senega as a dry product in an amount of usually 0.01 to 15% by weight, preferably 0.1 to 5% by weight, based on the total weight of the hair nourishing composition (formulation ingredients).
If the amount is less than 0.01% by weight, a sufficient effect cannot be obtained, and if the amount exceeds 15% by weight, the effect will not be enhanced, which is uneconomical. The extraction operation (extraction temperature) may be performed at cold temperature, room temperature, or high temperature. When blended into a base material such as a hair tonic, Toshi and/or Senega extracts are
The extract itself or the dried one may be used. The extract of Enshi and/or Senega of the present invention is in liquid or paste form and is safe for the human body and does not cause skin irritation.A sample of the extract dispersed in white petrolatum at 1 and 5% by weight was prepared according to the method of Draize. As a result of a skin irritation test, both animal skin irritation and human skin irritation scores were 0, confirming that there was no skin irritation. The hair tonic of the present invention can be applied to hair tonics, along with base materials for various cosmetics, pharmaceuticals, etc., in accordance with conventional methods.
hair cream, hair lotion, tincture,
It can be used in the form of lotions, ointments, etc. In the present invention, extracts of Enshi and/or Senega may be used alone, and are known as herbal medicines, for example. When used in combination with extracts of Qianghui, Onna Sadako, Mulberry Parasitic, and Keishi, the same or slightly better hair growth effect as Toshi or Senega was obtained. Extracts of these herbal medicines can be used in combination with one or more of the extracts of Enzhi and/or Senega. Hereinafter, the effectiveness of the hair tonic of the present invention will be explained with reference to Examples. Note that the content of the present invention is not limited to these. In the examples, parts mean parts by weight, and % means weight %. Example 1 Soak 100g of Toshi pulverized product in 400ml of ethanol,
After heating under reflux for an hour, the mixture was filtered under reduced pressure. The residue is further heated and extracted with 400 ml of ethanol, and then filtered under reduced pressure. Both solutions are combined and concentrated and dried under reduced pressure to obtain an ethanol extract (yield: 15-30 g) of Toshi. 5 g of the obtained extract was dissolved in 95 g of ethanol and used as a sample for testing the hair growth effect of the hair growth agent of the present invention. Test samples such as hexane extract, ether extract, and water extract were prepared in a similar manner. Example 2 In the same manner as in Example 1, Senegal ethanol extract (yield: 10-18 g) is obtained from 100 g of Senegal.
Similarly, hexane extract, ether extract,
Test samples such as 50% ethanol extract and water extract were prepared. As a sample of the hair growth effect of the hair growth agent of the present invention, 5 g of the extract dissolved in 95 g of ethanol was used as in the case of Toshi. Test Example 1 ICR mice (male, 6 weeks old, average weight 26 g) were used as animals, and the entire region from the back to both sides of the abdomen was shaved with clippers. Starting from the next day, 0.1 ml of the extract of the present invention per animal was applied to the skin of the test subject twice daily, morning and evening. There were 6 animals in each group, and a sample was applied to the right flank of the experimental animals, and ethanol was applied to the left flank as a control. The hair growth state was determined by comparing the evaluation scores determined with the naked eye. The hair growth effect was judged according to the criteria shown in Table 1, and the average value of 6 animals was used as an index.

【table】

[Table] On the 20th and 30th day after the start of the experiment, visual judgment was performed according to the criteria shown in Table 1, and the average evaluation score per animal was determined. Table 2 summarizes these experimental results.
Shown below.

[Table] As is clear from the results in Table 2, the hair growth effect of the extract of Toshi and Senega of the present invention using each solvent is remarkable, and the extract of Toshi and/or Senega of the present invention is effective as a hair growth agent. gender was recognized. Test Example 2 The hair growth effect was evaluated using ICR mice (male, 4 weeks old, average weight 20 g) whose hair was shaved from the back to both sides of the abdomen using clippers, and then the hair was removed using a hair removal cream. In the same manner as in Test Example 1, the extract of Enshi or Senega of the present invention was applied to the skin of the test area of mice twice daily, in the morning and evening, in an amount of 0.1 ml per mouse. A group of six animals was used, and a sample was applied to the right flank, and ethanol was applied to the left flank as a control. For example, when the ethanol extract of Enshi or Senega was applied, new hairs generated from the hair removal site were sampled on the 2nd, 4th, 7th, and 10th day, and the length of the body hair was measured. Table 3 shows the results. Body hair length was measured using the method of Tanaka et al. (J. Medicinal Plant Research, Supplement,
P84, 1980). That is, 20 arbitrary hairs sampled using a stereomicroscope were measured. The five longest hairs were selected from among the 20 hairs measured, and the average value was taken as the length of the mouse's body hair. As shown in Table 3, the group to which Enshi or Senega extract was applied showed a significant hair growth promoting effect compared to the control group (ethanol application group).

[Table] Example 3 Hair Tonik 95% Ethanol 60.0 parts Enshi Ethanol Extract 2.0 Glycerin 2.0 Purified Water 36.0 [Production Method] Ingredients ~ were thoroughly stirred and mixed, and after filtration,
Pack it into a container and use it as a product. Example 4 Hair tonic Hair tonic is obtained in the same manner as in Example 3, using Senega ethanol extract instead of Enshi ethanol extract. Example 5 Hair cream Stearic acid 4.0 parts Cetyl alcohol 3.0 Stearyl alcohol 1.0 Liquid paraffin 6.5 Vaseline 10.0 Sorbitan monostearate 1.5 Polyoxyethylene (25) monostearate
3.0 Toshi hexane extract 1.0 Glycerin 5.0 Potassium hydroxide 0.2 Preservative Appropriate amount Purified water 64.9 [Manufacturing method] Ingredient ~ and ingredient ~ respectively
After heating and dissolving at 70-75°C, add component ~ to emulsify it, and cool to 30°C to form a product. Example 6 Hair lotion Stearic acid 5.0 parts Cetyl alcohol 5.0 Liquid paraffin 2.0 Glycerin monostearate 1.3 Sorbitan monooleate 1.5 Polyoxyethylene (10) Sorbitan monooleate 0.8 Senega ether extract 1.0 Glycerin 6.0 Preservative Appropriate amount Purified water 77.4 [ Manufacturing method] A product is obtained in the same manner as in Example 5. Example 7 Ointment Purified lanolin 5.0 parts White beeswax 5.0 Toshi extract 2.0 Vaseline 88.0 [Manufacturing method] Each component is dissolved and mixed by heating, and then cooled to prepare a product. Example 8 Ointment Purified lanolin 5.0 parts Beeswax 5.0 Senega extract 2.0 Yellow petrolatum 88.0 [Production method] Each component is dissolved and mixed by heating, and then cooled to prepare a product.

Claims (1)

[Claims] 1. A hair nourishing agent characterized by containing an extract of Toshi and/or Senega, which are herbal medicines belonging to the family Polygonaceae.