JPH0579942B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Application Field] The present invention eliminates the need to prepare a container each time it is used, has a long shelf life for urine test reagents, has a small volume during storage, is self-supporting, and is easy to handle. The present invention relates to a convenient and improved urine test container. [Conventional technology] Conventionally, in order to detect sugar, protein, PH, occult blood, etc. in urine, urine test sticks applied to urine test strips or plastic sticks in which filter paper is impregnated with urine test reagents have been used. Something was being done. [Problem to be solved by the invention] However, with the above method, there is the inconvenience of having to prepare the urine collection container and the urine test strips separately, and the urine test strips are usually packed in dozens. Since the product is sealed, there is a problem that once the package is opened, the test function will deteriorate due to the effects of moisture and carbon dioxide in the air. The inconvenience of preparing containers and test strips separately can be alleviated by using urine test strips with test strips attached to the inner surface of the paper strip. However, because the test paper is exposed, the usable period is shortened, and if the opening of the paper tip is sealed with a lid, stacking becomes ineffective, and even if several paper tips are stacked and sealed, it is still bulky. There is. Furthermore, in the case of urine test strips with test strips attached to the inner surface of the paper strip, the test paper is attached to the inner surface of the urine collection container and the container is opaque, so the coloring state of the test strip can be measured by the container. Another drawback is that it is impossible and inconvenient to check from the side. [Means for Solving the Problems] The present invention has been made for the purpose of solving the above-mentioned drawbacks of the prior art, and the structure of the present invention for solving the problems is to It is constructed using a composite sheet with
A body comprising a body and a bottom provided at one opening of the body, the bottom being folded into the body so that when the body is collapsed, the other opening of the body is sealed. and a container that becomes self-supporting when the body is expanded and the bottom is pushed out from within the body when the container is opened, and a urine test reagent area formed on the inner surface of the container. A container for urine testing, characterized in that a cutout line is provided in the part to form a cutout when the container is opened, and the container is constructed using a composite sheet of an aluminum sheet and a plastic film, and the container has a body part and a cutout line formed in the body part. and a bottom provided in one opening of the body, and when the body is collapsed by folding the bottom into the body, the other opening of the body is sealed, and when the body is opened, the body is closed. The container is provided with a container whose bottom part is expanded and whose bottom part is pushed out from inside the body part so that it can stand on its own; and a urine test reagent area formed on an inner surface of the container, and a part of the container is cut out when the container is opened. This is a urine test container characterized by being provided with a cutout line that forms a . [Example] The present invention will be described in detail below with reference to the drawings. FIG. 1 shows one embodiment of the urine test container of the present invention, and is a plan view with a portion of the front side cut away to show the inside thereof. In FIG. 1, the container 6 represents a self-supporting packaging bag, which is inserted so as to be folded between the front side sheet 7, the back side sheet 8, and both sheets, which are made of a composite sheet with a gas barrier sheet on the inside and paper on the outside. Each sheet is made up of a bottom sheet 9 whose fold lines are shown in broken lines. The periphery indicated by diagonal lines is sealed on all sides, and a urine test reagent area 4 is formed above the inside of the back sheet 8. In this way, in the first embodiment of the present invention,
A urine test reagent area 4 is formed on the inner surface of a sealed packaging bag constructed using an opaque composite sheet having gas barrier properties. The urine test reagent area 4 is exposed when the opposing parts of the sealed packaging bag are opened and cut out along the cutout line 41, so that the urine test reagent area 4 can be easily accessed from the outside. Visual observation becomes possible. Specifically, for example, by forming perforations along the notch line 41 in the front sheet 7 or by strengthening both sides of the notch line 41, the cut in the front sheet 7 can be easily removed when opening the package. A notch is formed by cutting out a portion surrounded by the notch line 41. As shown in FIG. 2, which is a cross-sectional view taken along line A-A, the packaging bag 6 has both the front side sheet 7 and the back side sheet 8 in most of the sealed side parts without the bottom sheet 9. are directly sealed, and in some parts of the bottom sheet 9, the top sheet 7 and the bottom sheet 9
During this time, the folded inner sides of the bottom sheet 9 and each location between the bottom sheet 9 and the back sheet 8 are sealed. In addition, as shown in FIG. 3, which is a cross-sectional view taken along the line B-B, the packaging bag 6 has a surface sheet 7 at the upper edge 10 in areas other than the side seals.
and the back side sheet 8 are directly sealed, and the lower edge 11
The bottom sheet 9 facing the front sheet 7 at
and between the back side sheet 8 and the opposing bottom sheet 9 are sealed. Further, there is no sealing between the folded inner sides of the bottom sheet 9 or between a large part of the upper part 12 of the bottom sheet 9 and both the front and back sheets facing that part. In the packaging bag 6 having such a structure, the bottom sheet 9 is pushed out of the packaging bag 6 by injecting liquid, blowing into the interior, or expanding it by hand, and the lower end 13 has a shape close to a circle. Since it can stand on its own in the shape of a thread bottom (Figure 4), it is suitable for standing upright on a horizontal surface. In such an embodiment, 5 in FIG.
If you make a V-shaped cut 5 or make a perforated cut about half the thickness of the sheet to make it easier to open the package by tearing as shown in Can be opened. In either method, the urine to be tested is opened, and the urine is brought into contact with the urine test reagent area 4 to develop a color, which is then compared with a standard color prepared in advance to make a determination. As described above, in the first embodiment of the present invention, a urine test reagent area is formed on the inner surface of a sealed packaging bag constructed using a composite sheet having barrier properties, and the packaging bag is opened. By expanding the bottom, it stands up on its own without any assistance. In other words, it is self-reliant. FIG. 5 shows a second example of the urine test container of the present invention, in which a urine test reagent area 4 is formed inside the container 14. The container 14 is formed using the above-mentioned composite sheet, and the outside of the container is made of relatively rigid paperboard, and the inside of the container is made of a gas barrier sheet. Then, there is a perforation-like cut 1 that does not reach the inside from the paperboard located on the outer surface of the container.
5, 16, 17, and 18 are provided, and after opening the upper part, pull the front side material 19 toward the front of the drawing and the back side material 20 toward the back of the drawing, or preferably pull the left and right side materials. By pushing the side edges 21 and 22 toward the center of the container, the container can be expanded as a whole, and can stand on its own in the shape shown in FIG. FIG. 7 shows the shape shown in FIG. 6 turned over. FIG. 8 shows a developed view of the composite sheet for creating the container 14 shown in FIGS. 5 to 7.
The outside of this composite sheet is a highly rigid material such as paperboard 23, and the inside is a gas barrier sheet 2.
It consists of 4. The paperboard 23 and the sheet 24 are laminated together over the entire surface by heat fusion, dry lamination, or the like. Here, the size of the sheet 24 may be the same as the paperboard 23, and is drawn larger for convenience to show the shape of the sheet 24. Furthermore, although the tips 29 and 30 and 31 and 32 of the four folded pieces 25 to 28 may be in contact with each other, they are drawn spaced apart for convenience in order to clearly show the shape and the fold line 35 of the sheet 24. In addition, in the material shown in FIG. 8, perforation-like cuts 15, 15', 16, 16', 1 extending from the surface of the paperboard 23 to most of the thickness of the paperboard 23, preferably the entire thickness of the paperboard, are used.
7, 17', 18, 18', 33, 33', and 34 are provided. Fold the material shown in the developed view of FIG. 8 inward along perforations 34 and fold lines 35,
Furthermore, by bending it outward along the perforations 33, 33' and sealing the left and right sides and the top three sides, the inside is sealed and the shape shown in FIG. 5 can be obtained. In addition, the container 1 shown in FIGS. 5 to 8
4 may be opened at the top with scissors or the like, but it is better to provide a cut line 36 for opening so that no tools are required for opening. Also in these containers, a cutout line 41 is provided at the top of the container 14 to form a cutout when the container is opened. This cutout exposes the urine test reagent area 4 from inside the container, so that the coloring state of the urine test reagent area 4 can be easily checked from the side of the container 14. The second embodiment of the present invention whose embodiments are shown in FIGS. 5 to 8
In the embodiment, since a rigid material such as hard paperboard is used as the paper constituting the composite sheet,
Once opened and expanded, it will not return to its original shape and fall over even with a little external force, and will easily maintain its shape when held in the hand. In this embodiment, in addition to the embodiments shown in FIGS. 5 to 8, 25, 26, 27, 28 in FIG.
It is also possible to omit either or both of the folding piece shown at 37 and the paperboard at the bottom position shown at 37.
In addition, if the perforations 17, 17', 18, and 18' are formed to reach the opening and bent to the edge of the opening, it will be easier to maintain the shape.
This is particularly effective when the folded piece 8 and the bottom part 37 are omitted. Or perforations 15, 15', 16, 1
6' as a crease, or perforations 17, 17', 1
8 and 18' can be omitted, and in this way the shape of the container can be simplified. In each of FIGS. 1 to 9, the manufacturer's name, purpose, date of manufacture, expiration date, usage, precautions, etc. may be printed so that they can be seen from the outside of the container. As the gas barrier sheet constituting the composite sheet in the above, a flexible sheet having gas barrier properties can be used. Specific materials include plastic sheets with high gas barrier properties, such as plain cellophane (PT), polyethylene terephthalate (PET),
Films such as nylon (Ny), polypropylene (PP), polyethylene (PE), polyvinylidene chloride (PVDC), and composite films with these or other films. As an example of a composite film, using the symbols in parentheses above, PT/
PE, PVDC coat/PT/PE, PET/PE, polycarbonate/PE, PP (stretched)/PE/PT/PE,
PVDC/PET/PE, PVC (unplasticized)/PE, PP
(stretched)/PVA/PE, PP/PE/PVDC, Ny/
PE etc. The above plastic film and composite film may be either transparent or opaque. Alternatively, the gas barrier properties can be further improved by using a composite of a plastic film and aluminum foil (Al) instead of the composite film of plastic films as described above. For example,
There are PT/PE/Al/PE, Ny/PE/Al/PE, etc., and each of the above films and composite films are appropriately selected and used depending on the intended use. Further, the paper used for the composite sheet can be appropriately determined depending on the rigidity required for the container. The urinalysis reagent area 4 is an area where the color tone changes due to pathological components in the urine, such as sugar, protein, occult blood, ketone bodies (acetoacetic acid or acetone), urobilinogen, bilirubin, etc. or the pH of the urine. be. The change in color tone occurs when the dye or dye precursor contained in the reagent changes color or develops color due to the reaction between the pathological component and the reagent. Examples of specific pathological components and reagents used therefor are shown in the table below.

【table】

[Table] For example, in the table above, when detecting sugar,
Glucose in the urine is oxidized by glucose osidase, and the hydrogen peroxide produced at this time oxidizes O-tolidine in the presence of peroxidase, causing the color to change from beige to bluish-purple. In the case of proteins, tetrabromophenol blue changes from yellow to blue due to the combination of albumin and tetrabromophenol blue. As is well known, acid/base indicators are used for pH. Occult blood utilizes the pseudoperoxidase activity of hemoglobin, and O-tolidine oxidizes and develops color in the presence of peroxide and O-tolidine. The color tone is similar to sugar. Ketones turn from colorless to purple when sodium nitroprusside reacts with acetoacetic acid or acetone in the urine. As for urobilinogen, red coloring occurs due to the reaction between urobilinogen in urine and p-dimethylaminobenzaldehyde, and as for biliruhin, a pigment is produced through a coupling reaction with dichlorobenzenediazonium salt, resulting in red color. To form a urine test reagent area using an indicator or enzyme, use a commercially available urine test tape impregnated with a material with good impregnability such as filter paper, or a urine test stick applied to a rod-shaped substrate. One method is to attach it to the inner surface of the container by an appropriate means, such as using an adhesive or adhesive tape, or directly heat-sealing it. The attachment position may be at any position such as the bottom of the container or the inner wall surface. Another method is to prepare a composition containing an indicator and an enzyme and apply the composition to a predetermined location on the inner surface of the container. Alternatively, instead of applying it directly to the inner surface of the container, it may be applied once onto another substrate and then attached to the inner surface of the container in the same manner as the tape or stick described above. The application method may be any method such as printing or coating. The urine test reagent area may be formed on the inner surface of the container either before or after the container is assembled. In terms of production efficiency, it is desirable for the urinalysis reagents used to form the urinalysis reagent areas by the printing method to be constructed using non-aqueous solvents, and among these, especially those using the enzymes glucose oxidase and peroxidase. Non-aqueous solvent-based sugar detection reagents are better suited to compositions using aqueous solvents (patent application 1983-
No. 90664), and it is even better to use it in the present invention. The components of the non-aqueous solvent composition are the above-mentioned enzyme, an indicator, a binder, and an additive, of which the enzyme is not necessary when detecting substances other than sugar. The binder in the composition needs to be one that does not affect urine, the target components in urine, the enzymes and indicators mentioned above, and does not interfere with the tests, and the appropriate tests must be carried out each time. Although it is preferable to check the method before use, according to the experiments of the present inventors, the following polymer compounds can be used; As synthetic polymers, polyacrylic ester, polyacrylic acid ester,
polyphenylacetal, polymethacrylate,
Polyacrylamide, polyurethane, polyvinyl chloride, polystyrene, polymers of maleic acid and other components, polyvinyl acetate, polyvinyl alcohol, polyvinylpyrrolidone, etc.; as semi-synthetic polymers, cellulose derivatives such as methylcellulose, ethylcellulose, propylcellulose; Starch ether, etc. Natural polymers such as starch, casein, polysaccharides, etc. Among the above-mentioned polymer compounds, it is particularly preferable to use maleic acid-based copolymers containing maleic acid as a component, such as isobutylene-maleic anhydride copolymers and styrene-maleic acid copolymers. Furthermore, in addition to the enzymes, indicators and binders mentioned above, water absorption is added as an additive to improve the water absorption and water retention of the test area and to facilitate the reaction between enzymes and indicators and pathological components in urine. Fine particles of silica-based clay, calcium carbonate, aluminum silicate, glass, cellulose, etc. are added as appropriate carriers. To describe the method for creating a non-aqueous solvent composition using each of the above components, first, lyophilized enzymes, indicators, and if necessary, buffers, etc. are pulverized;
and particles of 25 μm or less. Next, particles of the enzyme, indicator, and buffer are dispersed and kneaded together with the above-mentioned fine particles as a water-absorbing carrier in a binder solution in which the binder is previously dissolved in a non-aqueous solvent. For dispersion and kneading, a high-speed stirrer, sand mill, ball mill, homogenizer, three-roll mill, ultrasonic disperser, etc. are used. In addition, considering the solubility of the binder, select organic solvents such as alcohols, ketones, aromatics, various esters, and hydrocarbons as non-aqueous solvents.
Although any organic solvent can be selected and used, it is preferable to dehydrate the organic solvent before use. In addition, when preparing a composition for the purpose of detecting sugar, it is not preferable to use methanol as a solvent because enzyme activity is lost more rapidly than when water is used. Furthermore, if necessary, a surfactant or the like may be added to the composition in order to improve water wettability and uniformity of color development. As the surfactant, any of anionic, cationic, and nonionic surfactants can be used. For the purpose of applying such a composition to the inner surface of the container or to another substrate subsequently attached to the inner surface of the container,
Although any known printing method can be used, in the present invention, a method in which the coating amount is relatively large and the coating amount is constant is preferable, and in that sense, silk screen printing, intaglio printing, gravure printing, etc. are preferable.
Although it is difficult to generalize the coating amount, it is usually 2g/m ²
~30g/m ² (dry). Any other substrate may be used as long as it does not react with the reagent and does not inhibit the reaction of the reagent in the color development process. For example, paper, synthetic paper, various plastics and films, a laminate of paper and plastic, etc. can be used. The present invention basically consists of the above configuration, but the following modifications may be made. For example, the urine test reagent area 4 may be made into several areas with different test substances, or may be a urine test reagent area where the concentration can be determined.Furthermore, if these areas are colored, characters or A symbol, especially a judgment symbol, may be made to stand out. In the examples shown in Figures 1 to 9, the urine test reagent area is designed to determine the coloring state by looking at the notch formed at the opening when the seal is opened, but in all examples, it is made of a transparent member. An observation window may be provided above the container and the coloring state may be observed through this window. FIG. 9 shows an example of the shape after a notch 41' is formed in the front side 39 of the container 38 by opening the container. You can use this shape as is, but first collect urine and use it in the urine test reagent area 4.
After coloring and discarding the contents, it is folded again and compared with the standard color 40 provided in advance as required, the colored area 4 and the standard color 40 are lined up, making it easy to compare. The required number of standard colors 40 may be provided as appropriate depending on the substance to be tested and its concentration. In the above explanation, reference has been made to providing the standard color on the surface of the container in advance, but the standard color may also be provided on a base material other than the container, or the urine test reagent area 4 may be provided on the inner surface of the container. It may be formed side by side. When forming the composite sheet side by side on the inner surface of the container, it may be formed with a composition that does not discolor due to urine collection, or a protective layer may be provided after the formation, or a protective layer may be provided between the gas barrier film of the composite sheet and the paper. You may devise measures such as providing a Next, the present invention will be explained in more detail by showing more specific examples. Example 1 Using paperboard with a basis weight of 200 g/ ^m2 , paper/PE (thickness 30μ
A rectangular pattern with a side of 6 mm was provided on a composite sheet of m)/PET (thickness 12 μm/Al (thickness 9 μm)/PE (thickness 20 μm) using the following composition. Composition for glucose Glucose oxidase ...0.5g (manufactured by Toyobo, Grade) Peroxidase ...0.15g (manufactured by Toyobo, Grade) O-tolidine ...0.9g Stearic acid monoglyceride ...1.0g (manufactured by Kao Soap, Atomul T-95) Isobutylene/maleic anhydride copolymer Combination (manufactured by Clareisoptylene Chemical, Isoban #
60)...3.0g n-butanol...60g Microcrystalline cellulose...35g (Asahi Kasei, Avicel SF) In addition, a yellow or red coloring agent (dye or pigment) may be added to the above composition for glucose. good. The above composition was finely dispersed using a homomixer and then printed using a screen printing method. The screen plate used was 100 mesh, and the total thickness of the resist and screen gauze was 100 μm. After printing, 80
It was dried for 1 hour at a temperature of .degree. The container shown in FIG. 5 was created using the composite sheet printed in this way. The obtained container was opened at the upper part at the perforation and expanded to take the shape shown in FIG. 6, and the shape was maintained even when held by hand. Further, when urine was collected in this container and brought into contact with the printed area, the printed area changed color. This coloring state was achieved from the lateral direction of the container by forming a cutout when the container was opened. Separately, a similar print was made on day-colored polystyrene film, which was briefly dipped in urine of a known glucose concentration, and the color tone was measured 30 seconds later.The results are shown in the table below. The color tones in the table below are based on the standard color standard specified in JIS Z 8721. The following table shows that glucose concentrations of 0.05% can be measured.

〔Effect of the invention〕

The urine test container of the present invention is composed of a composite sheet having gas barrier properties, and the urine test reagent area is sealed within the container, thereby eliminating the trouble of preparing test strips and containers for urine tests separately. It has the advantage that the reagent can be used for a long time in the urine test reagent area, and its small volume does not take up much space during storage.The container also becomes a self-supporting container by opening the container and expanding the bottom. Therefore, it is extremely easy to handle, and since it has a notch formed when the container is opened, the coloring state of the urine test reagent can be easily checked from the lateral direction of the container.

[Brief explanation of the drawing]

FIG. 1 and FIG. 5 are both a partially cutaway plan view showing an embodiment of the present invention, and FIG.
The figure is a cross-sectional view taken along the line A-A of the container shown in Figure 1, Figure 3 is a cross-sectional view taken along the line B-B of the container shown in Figure 1, and Figure 4 shows the container shown in Figure 1 opened and erected. 6 and 7 are both perspective views showing the container shown in FIG. 5 in an opened and expanded state. FIG. 8 is an explanatory view showing the container shown in FIG. 5 in an unfolded state. , FIG. 9 is a partially drawn perspective view of another embodiment of the container of the present invention. 1, 6, 14, 38, 42, 45...container, 7
...Front side sheet, 8... Back side sheet, 9...
Bottom sheet, 15, 16, 17, 18...perforation, 40...standard color, 41...notch line, 4
1'...notch.

Claims (1)

[Scope of Claims] 1. Constructed using a composite sheet of a gas barrier sheet and paper, comprising a body and a bottom provided in one opening of the body, the bottom being inserted into the body. A container in which the other opening of the body is sealed when the body is collapsed in a folded manner, and when the body is opened, the body expands and the bottom is pushed out from within the body so that it can stand on its own; A container for a urine test, comprising: a reagent area for a urine test formed on an inner surface of the container, and a cutout line that forms a cutout when the container is opened. 2. It is constructed using a composite sheet of an aluminum sheet and a plastic film, and includes a body part and a bottom part provided at one opening of the body part, and the body part is folded into the body part by folding the bottom part into the body part. The other opening of the body is sealed when the body is crushed, and when the body is opened, the body expands and the bottom is pushed out from within the body so that it can stand on its own; 1. A container for a urine test, comprising a reagent area for a urine test, and a cutout line that forms a cutout when the container is opened. 3. Claim 1 or 2, characterized in that a part of the container is provided with a standard color.
Container for urine test as described in section.