JPH0586220B2 - - Google Patents
Info
- Publication number
- JPH0586220B2 JPH0586220B2 JP4417286A JP4417286A JPH0586220B2 JP H0586220 B2 JPH0586220 B2 JP H0586220B2 JP 4417286 A JP4417286 A JP 4417286A JP 4417286 A JP4417286 A JP 4417286A JP H0586220 B2 JPH0586220 B2 JP H0586220B2
- Authority
- JP
- Japan
- Prior art keywords
- abrasive material
- vibrator
- present
- vibration
- stratum corneum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003082 abrasive agent Substances 0.000 claims description 28
- 230000037380 skin damage Effects 0.000 claims description 3
- 210000000434 stratum corneum Anatomy 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 8
- 230000006378 damage Effects 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 230000005540 biological transmission Effects 0.000 description 6
- 239000010419 fine particle Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 102000011782 Keratins Human genes 0.000 description 3
- 108010076876 Keratins Proteins 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000005498 polishing Methods 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 229910052593 corundum Inorganic materials 0.000 description 2
- 239000010431 corundum Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 229910052580 B4C Inorganic materials 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- INAHAJYZKVIDIZ-UHFFFAOYSA-N boron carbide Chemical compound B12B3B4C32B41 INAHAJYZKVIDIZ-UHFFFAOYSA-N 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 229910000423 chromium oxide Inorganic materials 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 229910001651 emery Inorganic materials 0.000 description 1
- 239000002223 garnet Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000004579 marble Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- -1 prints Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 description 1
- 229910010271 silicon carbide Inorganic materials 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Landscapes
- Surgical Instruments (AREA)
Description
【発明の詳細な説明】
本発明は経皮投薬を行う際、皮膚乃至主として
その角質層に微細孔や微細クラツク等の実質的に
イリテーシヨンの無い程度の損傷を与える為の装
置に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a device for inflicting damage to the skin, or mainly the stratum corneum, with substantially no irritation, such as micropores or microcracks, when administering transdermal medication.
経皮投薬による薬物の投与は、経口投薬に比べ
胃腸障害等の副作用を惹起することなく、薬効を
充分に発揮する手段として期待されており、更に
電気的手段を加えて経皮呼吸を促進させるイオン
トフオレーゼが近時益々注目されつつある。（（グ
ラス ジエイムスら．，インターナシヨナル ジ
ヤーナル オブ ダーマトロジイ（Glass JM et
al.，Int.J.Dermatol.）19 519（1980）；ルツソ
ジエイ．，アメリカン ジヤーナル オブ ホス
ピタル フアーマシイ（Russo j.，Am.J.Hosp.
Pharm.）37 843（1980）；ガンガロサ エルピー
ら．，ジヤーナル オブ フアーマコロジカル
エクペリメント アンド セラピー（Gangarosa
LP et al.，J.Pharmacol.Exp.Ther.）212 377
（1980）；クワンビイエスら．，ジヤーナル オブ
インフエクシヨナル デシーズ（Kwon BS
et al.，J.Infect.Dis.）140 1014（1979）；ヒル
ジエイエムら．，アニユアル オブ ニユーヨー
クアカデミイ オブ サイエンス（Hill JM et
al.，Ann.NY.Acad.Sci.）284 604（1977）及びタ
ンネバウム エム．，フイジカル セラピー
（Tannebaum M.，Phys.Ther.）60 792（1980）
等々））。しかしながら、経皮投薬方法は、薬効成
分の経皮吸収性が未だ充分に解明されておらず、
イオントフオレーゼについても、薬効を充分に発
現し得る薬物が限定されている等、薬物の経皮投
与に関する利用範囲は極かぎられているものであ
つた。 Transdermal drug administration is expected to be a means of fully demonstrating drug efficacy without causing side effects such as gastrointestinal disorders compared to oral administration, and transdermal respiration can be further promoted by adding electrical means. Iontophoresis has recently been attracting more and more attention. (Glass JM et al., International Journal of Dermatology)
al., Int.J.Dermatol.) 19 519 (1980); Lutuso
J.A. , American Journal of Hospital Pharmacy (Russo J., Am.J.Hosp.
Pharm.) 37 843 (1980); Gangarosa L.P. et al. , Journal of Pharmacology
Experiment and Therapy (Gangarosa)
LP et al., J. Pharmacol. Exp. Ther.) 212 377
(1980); Kwambies et al. , Journal of Infectious Diseases (Kwon BS
et al., J. Infect. Dis.) 140 1014 (1979); Hill
GM et al. , Annual of the New York Academy of Sciences (Hill JM et
al., Ann. NY. Acad. Sci.) 284 604 (1977) and Tannebaum M. , Physical Therapy (Tannebaum M., Phys.Ther.) 60 792 (1980)
and so on)). However, in transdermal administration methods, the percutaneous absorption of medicinal ingredients has not yet been fully elucidated.
Regarding iontophoresis, the scope of use for transdermal administration of drugs has been extremely limited, such as the limited number of drugs that can sufficiently exhibit medicinal efficacy.
従つて、本発明装置は、単なる受動拡散方式の
経皮投薬のみならず、イオントフオレーゼにも又
好適な皮膚前処理を提供するものであり、本発明
者らは、鋭意研究の結果、皮膚組織の有するイン
ピーダンス乃至バリヤー能は主として厚さ十数ミ
クロンの硬タンパク質から成る角質層に依存する
ことから、研摩材を高速振動させることにより、
角質層に対し、実質的に無痛で且つイリテーシヨ
ンなくマイクロクラツクや微細孔を生成し得、そ
の結果、インスリン、カルミトニン等のペプタイ
ドの様な分子量の大きい薬物の投与等を効果的に
達成し得ることを知見し、本発明に到達したもの
である。 Therefore, the device of the present invention provides skin pretreatment suitable not only for passive diffusion transdermal administration but also for iontophoresis.As a result of extensive research, the present inventors have found that Since the impedance or barrier ability of tissues mainly depends on the stratum corneum, which is made of hard proteins and has a thickness of several tens of microns, by vibrating the abrasive material at high speed,
Microcracks and micropores can be generated in the stratum corneum virtually painlessly and without irritation, and as a result, drugs with large molecular weights such as peptides such as insulin and calmitonin can be effectively administered. Based on this knowledge, we have arrived at the present invention.
次に、本発明経皮投薬用皮膚損傷装置に於け
る、研摩材、振動子、駆動手段につき詳細に説明
する。 Next, the abrasive material, vibrator, and driving means in the skin damage device for transdermal administration of the present invention will be explained in detail.
本発明経皮投薬用皮膚損傷装置に於ける研摩材
は、基体表面に接着固定された好ましくは粒径が
10μm〜100μmの硬質微粒子、又は適当な寸法の
針状物から成る。硬質微粒子としては、天然品と
してダイヤモンド、コランダム、エメリー、ザク
ロ石、プリント、粘土、大理石、人造品として
は、人造ダイヤモンド、人造コランダム、炭化ケ
イ素、炭化ホウ素、酸化クロム、化鉄、アルミナ
等が例示され得る。又、針状物は、先頭が鋭角の
微細針であればよく、その材料としてはステンレ
ス、鉄等の金属やセラミツク、プラスチツクが例
示されるが、その硬度等は皮膚組織の状態に応じ
て適宜選択されるものである。一方、硬質微粒子
や針状物を基体上に設定する方法としては、硬質
微粒子では基体上にスプレーコーテイングする、
又は接着層を設け硬質微粒子をふりかける、硬質
微粒子を軟膏状基材に含有せしめ基体上に塗布す
る等々、任意の手段を例示し得る。他方、針状物
の場合は、基体上に接着剤で固定する。あるいは
機械的に接続する等々により窄孔材乃至研摩材と
なし得る。このような本発明研摩材は、皮膚表面
の角質層１cm2当たり有効面積10-2〜10-5cm2程度の
マイクロクラツクや微細孔を形成し得るように、
その粒径、針径、配置等々、適宜選択実施され得
る。 The abrasive material in the skin damage device for transdermal administration of the present invention is adhesively fixed to the substrate surface and preferably has a particle size of
It consists of hard fine particles of 10 μm to 100 μm or needles of appropriate size. Examples of hard particles include natural products such as diamond, corundum, emery, garnet, prints, clay, and marble; examples of artificial products include artificial diamonds, artificial corundum, silicon carbide, boron carbide, chromium oxide, iron oxide, alumina, etc. can be done. In addition, the needle-like object may be a fine needle with an acute angle at the tip, and examples of the material thereof include metals such as stainless steel and iron, ceramics, and plastics, but the hardness etc. may be determined as appropriate depending on the condition of the skin tissue. It is selected. On the other hand, methods for setting hard fine particles or needle-like objects on a substrate include spray coating on the substrate for hard fine particles.
Alternatively, any means may be used, such as providing an adhesive layer and sprinkling hard fine particles, or incorporating hard fine particles into an ointment-like base material and applying the hard fine particles onto the base material. On the other hand, in the case of a needle-like object, it is fixed on the substrate with an adhesive. Alternatively, it can be made into a hole punching material or an abrasive material by mechanically connecting it or the like. The abrasive material of the present invention is designed to form microcracks and fine pores with an effective area of about 10 -2 to 10 -5 cm 2 per 1 cm 2 of the stratum corneum on the skin surface.
The particle size, needle diameter, arrangement, etc. can be selected as appropriate.
本発明に於ける振動子としては、振動数が好ま
しくは100Hz〜100kHz程度の機械的振動を生ずる
ものであれば足り、一般に圧電リレー、ブザー、
アクチユエータ等として用いられる圧電素子、圧
電バイモルフ、磁歪素子等、更には電動機が具体
的に例示される。又、この振動子は、皮膚表面に
対して縦の振動、又は横の振動を生ずるものであ
り、振動幅は特に限定するものではないが、研摩
材が角質層以外の組織に損傷を負わさないように
選択されるものである。尚、その振動時、損傷の
形態が深さ10〜100μm程度の微細孔あるいはマイ
クロクラツク等の損傷を形成し得るようにその振
幅等が設定される。 As the vibrator in the present invention, it is sufficient as long as it generates mechanical vibration with a frequency of preferably about 100Hz to 100kHz, and generally piezoelectric relays, buzzers,
Specific examples include piezoelectric elements, piezoelectric bimorphs, magnetostrictive elements, etc. used as actuators, and furthermore, electric motors. In addition, this vibrator generates vertical vibration or horizontal vibration with respect to the skin surface, and the vibration width is not particularly limited, but the abrasive material does not damage tissues other than the stratum corneum. It is selected as follows. Incidentally, the amplitude and the like are set so that, during the vibration, damage such as fine holes or microcracks with a depth of about 10 to 100 μm can be formed.
次に、本発明の実施例を図面を参照して詳細に
説明する。 Next, embodiments of the present invention will be described in detail with reference to the drawings.
実施例 １
第１図は本発明の実施例を示す断面図及びブロ
ツク図である。１１は振動子である。振動子１１
は、例えば1kHzの振動を行なう圧電素子から成
る。１２は研摩材である。研摩材１２は、例えば
シート状の基体に長さが５mmのステンレスから成
る針（径10−100μm）が100本／cm2植設されてい
る。１３は支持部材である。支持部材１３は、振
動子１１を支持することに加えて、振動を本体１
４へ伝達しない構造を有する。本体１４は凹状
で、その内部に支持部材１３、振動子１１研摩材
１２が接着剤等によつて接着固定されている。支
持部１３から研摩材１２までの高さは、本体１４
の内側底部から開口部上部までの高さとほぼ一致
するように配置されている。１５は制御回路であ
る。制御回路１５は、電源１６から振動子への軌
道出力を開閉するスイツチを含む制御を行なう振
動子駆動電気回路である。Embodiment 1 FIG. 1 is a sectional view and a block diagram showing an embodiment of the present invention. 11 is a vibrator. Vibrator 11
consists of a piezoelectric element that vibrates at, for example, 1 kHz. 12 is an abrasive material. The abrasive material 12 has, for example, a sheet-like base material in which 100 stainless steel needles (diameter 10-100 μm) each having a length of 5 mm are implanted at a rate of 100/cm 2 . 13 is a support member. In addition to supporting the vibrator 11, the support member 13 also supports the vibration of the main body 1.
It has a structure that does not transmit to 4. The main body 14 has a concave shape, and a support member 13, a vibrator 11, and an abrasive material 12 are fixed therein with an adhesive or the like. The height from the support part 13 to the abrasive material 12 is the height of the main body 14
The height is approximately the same as the height from the inside bottom to the top of the opening. 15 is a control circuit. The control circuit 15 is a vibrator drive electric circuit that performs control and includes a switch that opens and closes the orbital output from the power source 16 to the vibrator.
次に、上記構成から成る本発明装置の動作を説
明する。 Next, the operation of the apparatus of the present invention having the above configuration will be explained.
研摩材１２が接着固定された振動子１１は、制
御回路１５及び電源１６からの起動出力により振
動を行なう。振動子１１の振動は研摩材１２を振
動させる。研摩材１２の針は、上下の振動により
角質層へ衝突を繰り返して角質層へ微細孔を生じ
させる。 The vibrator 11 to which the abrasive material 12 is adhesively fixed vibrates in response to activation output from the control circuit 15 and power source 16. The vibration of the vibrator 11 causes the abrasive material 12 to vibrate. The needles of the abrasive material 12 repeatedly collide with the stratum corneum due to vertical vibrations, thereby creating micropores in the stratum corneum.
実施例 ２
第２図は本発明の全体構成の実施例を示す断面
図である。２１は研摩材である。研摩材２１は長
さ３mm、先頭の直径が50μmの鉄製針を１cm2当た
り500本の割合で配置されている。２２は振動子
である。振動幅約50μmで約10kHzの振動数で振
動を行なう圧電素子から成る。２３は伝達部であ
る。伝達部２３はアクリル樹脂から成り、振動子
２２と研摩材２１との間に固定配置され、振動子
２２の振動を研摩材２１に伝えている。但し、伝
達部２３を設けた研摩材２１の位置は、第１の実
施例と同様、本体２６の開口部上部の位置と同じ
高さに配置されている。２４は制御装置である。
制御装置２４は、駆動電気回路等から成り、必要
に応じて振動子２２の振動を制御するものであ
る。２５は電源である。電源２５は電池類から成
る。Embodiment 2 FIG. 2 is a sectional view showing an embodiment of the overall configuration of the present invention. 21 is an abrasive material. The abrasive material 21 includes iron needles each having a length of 3 mm and a leading diameter of 50 μm, arranged at a rate of 500 per 1 cm 2 . 22 is a vibrator. It consists of a piezoelectric element that vibrates at a frequency of approximately 10kHz with a vibration width of approximately 50μm. 23 is a transmission section. The transmission section 23 is made of acrylic resin, is fixedly arranged between the vibrator 22 and the abrasive material 21, and transmits the vibration of the vibrator 22 to the abrasive material 21. However, the position of the abrasive material 21 provided with the transmission part 23 is arranged at the same height as the position of the upper part of the opening of the main body 26, as in the first embodiment. 24 is a control device.
The control device 24 is composed of a drive electric circuit and the like, and controls the vibration of the vibrator 22 as necessary. 25 is a power source. The power source 25 consists of batteries.
以上の構成から成る本発明の動作は、電源２３
及び制御装置２４からの出力が振動子２２を振動
させ、伝達部２３を経て研摩材２１が振動数10k
Hz、振動幅約50μmで上下に振動する。これを経
皮投薬適用部分に数秒間当接する。勿論、当接時
間等は皮膚部位等に応じて可変であり、当接部位
は研摩材２１の振動により角質層に衝突し、微細
孔を窄孔するものとなる。 The operation of the present invention having the above configuration is as follows:
The output from the control device 24 causes the vibrator 22 to vibrate, and the abrasive material 21 vibrates at a frequency of 10 k via the transmission section 23.
It vibrates up and down at Hz with a vibration width of approximately 50μm. This is applied to the transdermal medication application area for several seconds. Of course, the contact time etc. are variable depending on the skin region, etc., and the contact region collides with the stratum corneum due to the vibration of the abrasive material 21, thereby enlarging minute pores.
第２図に示す振動子は上下に振動する場合であ
るが、横方向に振動する場合を第３図に示した。
振動子３２が磁歪素子で、なおかつ横方向の振動
を行なう以外は第２図と同様の構成を有する。振
動数は10kHz、振動幅0.1mmである振動子の振動は
伝達部３３を伝達し、研摩材３１を横方向に振動
させる。 The vibrator shown in FIG. 2 is a case in which it vibrates vertically, and FIG. 3 shows a case in which it vibrates in a horizontal direction.
It has the same configuration as that in FIG. 2 except that the vibrator 32 is a magnetostrictive element and vibrates in the lateral direction. The vibration of the vibrator, which has a frequency of 10 kHz and a vibration width of 0.1 mm, is transmitted through the transmission section 33 and causes the abrasive material 31 to vibrate in the lateral direction.
研摩材３１は、その研摩粒径100μm程度の通常
のサンドペーパである。使用方法は第１図に示す
実施例と同様、皮膚表面に研摩材３１の部分を数
秒〜数分間当接し、その振動によつて角質を研摩
損傷させる。振動幅が極少で且つ振動数が大きい
ので、実質的に角質層のみが損傷をこうむる。 The abrasive material 31 is ordinary sandpaper with an abrasive particle size of about 100 μm. The method of use is similar to the embodiment shown in FIG. 1, in which the abrasive material 31 is brought into contact with the skin surface for several seconds to several minutes, and the vibrations abrasively damage the stratum corneum. Since the vibration amplitude is extremely small and the vibration frequency is high, substantially only the stratum corneum is damaged.
以下、本発明を実施例により詳細に説明する。 Hereinafter, the present invention will be explained in detail with reference to Examples.
実験例 １
直径１mm、長さ５mm、先頭が鋭角（先端径
50μm）であるステンレス製針を１mm2当たり１本
の割合で、支持体上に固定した研摩材を振動数
15kHz、振幅100μmで上下に振動させる本発明角
質損傷装置を用いて、ヒト上腕屈側部表面の幅
100mmの間隔をおいた２ケ所に対し、研摩を行な
つた。Experimental example 1 1 mm in diameter, 5 mm in length, with an acute angle at the tip (tip diameter
The abrasive material was fixed on a support with stainless steel needles (50μm) at a rate of one needle per mm2 , and the frequency was
Using the keratin damage device of the present invention, which vibrates up and down at 15kHz and an amplitude of 100μm, the width of the flexor surface of the human upper arm was measured.
Polishing was performed at two locations separated by 100 mm.
次に、この２ケ所に対し、本発明角質損傷装置
による処理前後において周波数10Hzの電圧を印加
し、そのインピーダンスを測定した。 Next, a voltage with a frequency of 10 Hz was applied to these two locations before and after treatment with the keratin damaging device of the present invention, and the impedance was measured.
その結果、研摩を行なう前に比べて、研摩した
後の抵抗値は1/100に低下した。 As a result, the resistance value after polishing decreased to 1/100 compared to before polishing.
実験例 ２
更に、平均粒径50μのアルミナ微粒子をコツト
ンに一様に固定化した研摩材500Hzの振動数で左
右に振幅200μm振動させる本発明角質損傷装置を
用いて上記と同様にインピーダンス低下を測定し
た結果、処理後インピーダンスは約1/50に低下
し、しかもなんら発赤等のイリテーシヨンは見ら
れなかつた。Experimental Example 2 Furthermore, impedance reduction was measured in the same manner as above using the keratin damage device of the present invention, which vibrates an abrasive material made of fine alumina particles with an average particle size of 50 μm uniformly fixed onto a piece at a frequency of 500 Hz and an amplitude of 200 μm from side to side. As a result, the impedance after treatment was reduced to about 1/50, and no irritation such as redness was observed.
以上、詳述の如く本発明は、極微小な硬質材料
によつて成る研摩材を皮膚表面で振動させること
により無痛でイリテーシヨンがなく、確実に角質
層にマイクロクラツク等の損傷を生成し得るの
で、処理角質層はイオントフオレーゼ等の経皮投
薬時において、特に分子量の大きいインスリン、
カルミトニン等々のペプタイド系薬物の投入をも
可能とする等、極めてすぐれた効果を奏効するも
のである。 As described above, the present invention is painless, eliminates irritation, and reliably causes damage such as microcracks to the stratum corneum by vibrating an abrasive made of a microscopic hard material on the skin surface. Therefore, during transdermal administration of iontophoresis, etc., the treated stratum corneum cannot be treated with insulin, which has a particularly large molecular weight.
It has extremely excellent effects, such as making it possible to administer peptide drugs such as calmitonin.
第１図は本発明の実施例を示す断面図及びブロ
ツク図、第２図乃至第３図は本発明の全体構成の
実施例を示す断面図である。
１１，２２，３２……振動子、１５，２４，３
４……制御回路、１２，２１，３１……研摩材、
１６，２５，３５……電源、１３……支持部材、
２３，３３……伝達部、１４，２６，３６……本
体。
FIG. 1 is a cross-sectional view and a block diagram showing an embodiment of the present invention, and FIGS. 2 and 3 are cross-sectional views showing an embodiment of the overall structure of the present invention. 11, 22, 32... vibrator, 15, 24, 3
4... Control circuit, 12, 21, 31... Abrasive material,
16, 25, 35...power supply, 13...support member,
23, 33...Transmission section, 14, 26, 36...Main body.
Claims (1)
速振動子より成る経皮投薬用皮膚損傷装置。1. A skin damage device for transdermal administration consisting of an abrasive material and a high-speed vibrator for causing the abrasive material to move at high speed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4417286A JPS62270144A (en) | 1986-03-03 | 1986-03-03 | Skin damaging device for subcataneous administration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4417286A JPS62270144A (en) | 1986-03-03 | 1986-03-03 | Skin damaging device for subcataneous administration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62270144A JPS62270144A (en) | 1987-11-24 |
| JPH0586220B2 true JPH0586220B2 (en) | 1993-12-10 |
Family
ID=12684163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4417286A Granted JPS62270144A (en) | 1986-03-03 | 1986-03-03 | Skin damaging device for subcataneous administration |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62270144A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2703035B2 (en) * | 1989-02-28 | 1998-01-26 | 久光製薬株式会社 | Device for iontophoresis |
| US6835184B1 (en) * | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
| PT2152358E (en) * | 2007-04-27 | 2011-06-07 | Echo Therapeutics Inc | Skin permeation device for analyte sensing or transdermal drug delivery |
| WO2012078649A1 (en) * | 2010-12-06 | 2012-06-14 | Follica, Inc. | Methods for treating baldness and promoting hair growth |
-
1986
- 1986-03-03 JP JP4417286A patent/JPS62270144A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62270144A (en) | 1987-11-24 |
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| EXPY | Cancellation because of completion of term |