JPH0631300B6 - - Google Patents

Info

Publication number: JPH0631300B6
Authority: JP; Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP1988168637A

Other languages

Japanese (ja)

Other versions

JPH0631300B2 (ja

JPS6438096A (en

Filing date

1988-07-06

Publication date

2006-10-11

1987-07-09 Priority claimed from PCT/US1987/001612 external-priority patent/WO1989000576A1/en

1988-07-06 Application filed filed Critical

1989-02-08 Publication of JPS6438096A publication Critical patent/JPS6438096A/ja

1994-04-27 Publication of JPH0631300B2 publication Critical patent/JPH0631300B2/ja

2006-10-11 Application granted granted Critical

2006-10-11 Publication of JPH0631300B6 publication Critical patent/JPH0631300B6/ja

2009-04-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

JP63168637A 1987-07-09 1988-07-06 結晶性アジスロマイシン２水和物及びその製法 Expired - Lifetime JPH0631300B2 (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
WO87/1612		1987-07-09
PCT/US1987/001612 WO1989000576A1 (en)	1987-07-09	1987-07-09	Azithromycin dihydrate

Publications (3)

Publication Number	Publication Date
JPS6438096A JPS6438096A (en)	1989-02-08
JPH0631300B2 JPH0631300B2 (ja)	1994-04-27
JPH0631300B6 true JPH0631300B6 (2)	2006-10-11

Family

ID=22202456

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP63168637A Expired - Lifetime JPH0631300B2 (ja)	1987-07-09	1988-07-06	結晶性アジスロマイシン２水和物及びその製法

Country Status (45)

Country	Link
US (1)	US6268489B1 (2)
EP (1)	EP0298650B1 (2)
JP (1)	JPH0631300B2 (2)
KR (1)	KR900006218B1 (2)
CN (1)	CN1016785B (2)
AP (1)	AP44A (2)
AR (1)	AR243532A1 (2)
AT (1)	ATE72446T1 (2)
AU (1)	AU604553B2 (2)
BA (1)	BA98213B1 (2)
BG (1)	BG47348A3 (2)
CA (1)	CA1314876C (2)
CS (1)	CS272241B2 (2)
CY (1)	CY1776A (2)
DD (1)	DD271705A5 (2)
DE (1)	DE3868296D1 (2)
DK (1)	DK172573B1 (2)
EG (1)	EG18527A (2)
ES (1)	ES2038756T3 (2)
FI (1)	FI91263C (2)
GR (1)	GR3003737T3 (2)
HK (1)	HK127594A (2)
HU (1)	HU211862A9 (2)
IE (1)	IE60354B1 (2)
IL (1)	IL86979A (2)
IN (1)	IN168879B (2)
IS (1)	IS1540B (2)
LV (1)	LV10624B (2)
MA (1)	MA21323A1 (2)
MX (1)	MX12213A (2)
MY (1)	MY103744A (2)
NO (1)	NO171556C (2)
NZ (1)	NZ225338A (2)
OA (1)	OA08743A (2)
PH (1)	PH30953A (2)
PL (1)	PL157145B1 (2)
PT (1)	PT87933B (2)
RO (1)	RO107257B1 (2)
RU (1)	RU2066324C1 (2)
SG (1)	SG27794G (2)
SI (1)	SI8811325A8 (2)
UA (1)	UA27040C2 (2)
WO (1)	WO1989000576A1 (2)
YU (1)	YU45075B (2)
ZA (1)	ZA884925B (2)

Families Citing this family (78)

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HRP20020231A2 (en) *	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US5912331A (en) *	1991-03-15	1999-06-15	Merck & Co., Inc.	Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) *	1992-03-26	1999-11-16	Merck & Co., Inc.	Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) *	1992-04-02	1993-02-23	Merck & Co., Inc.	8a-AZA-8a-homoerythromycin cyclic iminoethers
CA2081268A1 (en) *	1991-10-25	1993-04-26	Katsuhiro Imaki	Glycine derivative monosodium salt tetrahydrate
US5215980A (en) *	1992-01-17	1993-06-01	Merck & Co., Inc.	10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) *	1992-08-26	1993-05-11	Merck & Co., Inc.	Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) *	1993-04-14	1994-07-26	Merck & Co., Inc.	Process of producing 8A- and 9A-azalide antibiotics
CN1034734C (zh) *	1993-12-10	1997-04-30	北京市集才药物研究所	一种新的阿齐红霉素结晶及其制备方法
US5605889A (en)	1994-04-29	1997-02-25	Pfizer Inc.	Method of administering azithromycin
JP2977907B2 (ja) *	1994-05-06	1999-11-15	ファイザー・インコーポレーテッド	アジスロマイシンの放出調節された剤形
ES2122905B1 (es) *	1996-07-11	1999-11-16	Astur Pharma Sa	Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
JP2001520234A (ja) *	1997-10-16	2001-10-30	プリバフアルマセウトスカインダストリヤデイオニツコドルストヴオ	９ａ−アザリド類から誘導される新規３，６−ヘミケタール類
US6861411B1 (en)	1997-12-02	2005-03-01	Pfizer, Inc.	Method of treating eye infections with azithromycin
PT102130A (pt) *	1998-03-13	1999-09-30	Hovione Sociedade Quimica S A	Processo de preparacao de dihidrato de azitromicina
TW546302B (en) *	1998-05-08	2003-08-11	Biochemie Sa	Improvements in macrolide production
US6245903B1 (en)	1998-08-21	2001-06-12	Apotex, Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
AU768219B2 (en) *	1998-11-30	2003-12-04	Teva Pharmaceutical Industries Ltd.	Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
US7056893B2 (en)	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
US6239113B1 (en)	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
UA67842C2 (uk) *	1999-05-18	2004-07-15	Пфайзер Продактс Інк.	Кристалічні форми макролідного антибіотика
DE60044515D1 (de)	1999-06-29	2010-07-15	Sandoz Ag	Azithromycinmonohydrat
ES2177373B1 (es) *	1999-11-26	2003-11-01	Astur Pharma Sa	Preparacion de azitromicina en su forma no cristalina
WO2001049697A1 (en)	2000-01-04	2001-07-12	Teva Pharmaceutical Industries Ltd.	Preparation method of azithromycin dihydrate
ES2162764B1 (es) *	2000-05-17	2003-04-01	Ercros Ind Sa	Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
WO2002010144A1 (es)	2000-07-25	2002-02-07	Laboratorio Silanes, S.A. De C.V.	PROCESO PARA LA PREPARACION EN UN SOLO PASO DE 7,16-DIOXA-2-AZA-10-O-CLADINOSIL-12-O-DESOSAMINIL-4,5-DIHIDROXI-6-ETIL-3,5,9,11,13,15-HEXAMETILBICICLO[11.2.1]HEXADECA-1(2)-EN-8-ONA Y OBTENCION DE UNA FORMA NUEVA DE 9-DESOXO-9a-AZA-9a-METIL-9a-HOMOERITROMICINA A
ES2172417B1 (es) *	2000-07-31	2003-09-16	Sint Quimica Sa	Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
AU2001280000A1 (en)	2000-08-23	2002-03-04	Jaweed Mukarram, Siddiqui Mohammed	Process for preparation of anhydrous azithromycin
CN100341886C (zh) *	2000-11-27	2007-10-10	桑多斯股份公司	大环内酯类化合物的溶剂化物
CA2429639C (en) *	2000-11-27	2009-07-14	Biochemie S.A.	Stable azithromycin monohydrate
IN190080B (2) *	2001-01-29	2003-06-07	Alembic Ltd
KR100491183B1 (ko)	2001-03-21	2005-05-25	한미약품 주식회사	아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
US6861413B2 (en)	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
PL367091A1 (en) *	2001-05-22	2005-02-21	Pfizer Products Inc.	Crystal forms of azithromycin
EP1671978A1 (en)	2001-05-22	2006-06-21	Pfizer Products Inc.	New Cristal Form of Azithromycin
SK1012004A3 (sk) *	2001-08-21	2005-04-01	Pfizer Products Inc.	Použitie azitromycínu na výrobu liečiva na liečenie respiračných infekcií u človeka
EP1455758A1 (en) *	2001-12-21	2004-09-15	Pfizer Products Inc.	Directly compressible formulations of azithromycin
MXPA04003027A (es) *	2001-12-21	2004-07-05	Pfizer Prod Inc	Metodos para granulacion humeda de azitromicina.
EP1478347A1 (en) *	2002-02-01	2004-11-24	Pfizer Products Inc.	Dry granulated formulations of azithromycin
US7376064B2 (en)	2002-02-25	2008-05-20	Samsung Electronics Co., Ltd.	Method and apparatus for recording data on optical recording medium
ITMI20021209A1 (it) *	2002-06-04	2003-12-04	Chemi Spa	Processo di preparazione di azitromicina ad elevata purezza
US6855813B2 (en) *	2002-07-19	2005-02-15	Alembic Limited	Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en)	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB2395482A (en) *	2003-07-03	2004-05-26	Jubilant Organosys Ltd	Process for preparing non-hygroscopic azithromycin dihydrate
US20050013835A1 (en) *	2003-07-15	2005-01-20	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
BRPI0417348A (pt) *	2003-12-04	2007-03-13	Pfizer Prod Inc	processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
WO2005053652A1 (en)	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
MXPA06005913A (es) *	2003-12-04	2006-06-27	Pfizer Prod Inc	Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
KR20060109481A (ko) *	2003-12-04	2006-10-20	화이자 프로덕츠 인코포레이티드	바람직하게는 폴록사머와 글리세라이드를 함유하는다미립자 아지트로마이신 조성물의 제조를 위해 압출기를사용하는 분무응결 방법
RU2331410C2 (ru) *	2003-12-04	2008-08-20	Пфайзер Продактс Инк.	Способ получения фармацевтических мультичастиц
WO2005053639A2 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Controlled release multiparticulates formed with dissolution enhancers
CA2547597A1 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate compositions with improved stability
US6984403B2 (en) *	2003-12-04	2006-01-10	Pfizer Inc.	Azithromycin dosage forms with reduced side effects
RU2260012C1 (ru) *	2004-01-29	2005-09-10	Открытое акционерное общество "Акционерное курганское общество медицинских препаратов и изделий "Синтез"	Способ кристаллизации азитромицина дигидрата
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
WO2006011160A1 (en)	2004-06-28	2006-02-02	Alembic Limited	Process for the preparation of azithromycin monohydrate isopropanol clathrate
CN1308361C (zh) *	2004-08-09	2007-04-04	大连振邦氟涂料股份有限公司	乙烯－三氟氯乙烯共聚物的制备方法
US7683162B2 (en) *	2004-08-30	2010-03-23	Taro Pharmaceutical Industries Limited	Process of preparing a crystalline azithromycin monohydrate
JP2007519758A (ja) *	2004-12-01	2007-07-19	テバジョジセルジャールザ−トケルエンムケドレ−スベニュタ−ルシャシャ−グ	結晶マクロライドの生成方法
US20080199527A1 (en) *	2004-12-21	2008-08-21	Pfizer Inc.	Enteric Coated Azithromycin Multiparticulates
US8524734B2 (en)	2005-05-18	2013-09-03	Mpex Pharmaceuticals, Inc.	Aerosolized fluoroquinolones and uses thereof
CN100366686C (zh) *	2006-01-12	2008-02-06	济南瑞氟化工科技有限公司	一种氟硅超双疏不粘涂料
EP2023721A2 (en) *	2006-06-05	2009-02-18	Auspex Pharmaceuticals Inc.	Preparation and utility of substituted erythromycin analogs
US7704959B2 (en)	2006-10-03	2010-04-27	Dow Pharmaceutical Sciences	Azithromycin for the treatment of nodular acne
US20090062220A1 (en) *	2007-08-29	2009-03-05	Protia, Llc	Deuterium-enriched azithromycin
CN101177441B (zh) *	2007-12-05	2012-05-23	浙江耐司康药业有限公司	一种稳定的阿奇霉素一水合物结晶的制备方法
CN101624412B (zh)	2008-07-10	2012-07-04	刘力	大环内酯类衍生物及其制备和用途
KR20110091510A (ko)	2008-10-07	2011-08-11	엠펙스 파마슈티컬즈, 인코포레이티드	약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형
EP2346509B1 (en)	2008-10-07	2020-05-13	Horizon Orphan LLC	Inhalation of levofloxacin for reducing lung inflammation
CN101418026B (zh) *	2008-10-09	2011-05-18	南京工业大学	一种晶型和粒度可控的阿奇霉素结晶工艺
CN101787063B (zh) *	2009-01-23	2012-12-19	刘力	抗感染药物及其制备和用途
BRPI1009823A2 (pt)	2009-03-13	2019-09-24	Da Volterra Assistance Publique Hopitaux De Paris E Univ Paris Diderot Paris 7	"composição compreendendo um sistema de dispensação de droga, conjunto de uma primeira e uma segunda composição, e, kit."
RU2015130524A (ru)	2009-09-04	2018-12-21	Раптор Фармасьютикалз Инк.	Применение левофлоксацина в форме аэрозоля для лечения муковисцидоза
CN102911219A (zh) *	2011-08-03	2013-02-06	山东方明药业集团股份有限公司	一种阿齐霉素在水相直接结晶的方法
CN103159811A (zh) *	2011-12-10	2013-06-19	山东方明药业集团股份有限公司	一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法
WO2013088274A1 (en)	2011-12-14	2013-06-20	Wockhardt Limited	Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN102417531B (zh) *	2011-12-20	2014-06-11	浙江国邦药业有限公司	一种阿奇霉素一水合物的制备方法

Family Cites Families (9)

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US4020270A (en) *	1974-05-02	1977-04-26	Societa' Farmaceutici Italia S.P.A.	L-lyxohex-1-enopyranose derivative
US4219641A (en) *	1979-06-14	1980-08-26	The Upjohn Company	Process for preparing erythromycin succinate
SI8110592A8 (en)	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) *	1982-11-15	1986-03-04	Pfizer	Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4526889A (en) *	1982-11-15	1985-07-02	Pfizer Inc.	Epimeric azahomoerythromycin A derivative, intermediates and method of use
US4512982A (en) *	1984-04-13	1985-04-23	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
YU43402B (en) *	1985-03-04	1989-06-30	Pliva Pharm & Chem Works	Process for preparation of 11-aza-10-deoxo-10-dihydroeritromycin "a" by using electro-chemical reduction
WO1989002271A1 (en)	1987-09-10	1989-03-23	Pfizer	Azithromycin and derivatives as antiprotozoal agents

1987
- 1987-07-09 RO RO143593A patent/RO107257B1/ro unknown
- 1987-07-09 MX MX1221388A patent/MX12213A/es unknown
- 1987-07-09 UA UA93004522A patent/UA27040C2/uk unknown
- 1987-07-09 RU SU874742955A patent/RU2066324C1/ru active
- 1987-07-09 WO PCT/US1987/001612 patent/WO1989000576A1/en not_active Ceased
1988
- 1988-05-11 IN IN418/DEL/88A patent/IN168879B/en unknown
- 1988-06-15 AP APAP/P/1988/000093A patent/AP44A/en active
- 1988-06-28 AT AT88305921T patent/ATE72446T1/de not_active IP Right Cessation
- 1988-06-28 DE DE8888305921T patent/DE3868296D1/de not_active Expired - Lifetime
- 1988-06-28 ES ES198888305921T patent/ES2038756T3/es not_active Expired - Lifetime
- 1988-06-28 EP EP88305921A patent/EP0298650B1/en not_active Expired - Lifetime
- 1988-07-04 IL IL86979A patent/IL86979A/xx not_active IP Right Cessation
- 1988-07-05 MY MYPI88000744A patent/MY103744A/en unknown
- 1988-07-05 BG BG084783A patent/BG47348A3/xx unknown
- 1988-07-06 JP JP63168637A patent/JPH0631300B2/ja not_active Expired - Lifetime
- 1988-07-06 CS CS884896A patent/CS272241B2/cs not_active IP Right Cessation
- 1988-07-07 PH PH37189A patent/PH30953A/en unknown
- 1988-07-07 PT PT87933A patent/PT87933B/pt not_active IP Right Cessation
- 1988-07-07 DD DD88317672A patent/DD271705A5/de unknown
- 1988-07-07 PL PL1988273590A patent/PL157145B1/pl unknown
- 1988-07-07 AR AR88311356A patent/AR243532A1/es active
- 1988-07-07 EG EG376/88A patent/EG18527A/xx active
- 1988-07-07 CA CA000571381A patent/CA1314876C/en not_active Expired - Lifetime
- 1988-07-07 IS IS3370A patent/IS1540B/is unknown
- 1988-07-08 KR KR1019880008463A patent/KR900006218B1/ko not_active Expired
- 1988-07-08 CN CN88104331A patent/CN1016785B/zh not_active Expired
- 1988-07-08 NZ NZ225338A patent/NZ225338A/xx unknown
- 1988-07-08 AU AU18839/88A patent/AU604553B2/en not_active Expired
- 1988-07-08 ZA ZA884925A patent/ZA884925B/xx unknown
- 1988-07-08 YU YU1325/88A patent/YU45075B/xx unknown
- 1988-07-08 SI SI8811325A patent/SI8811325A8/sl unknown
- 1988-07-08 DK DK198803806A patent/DK172573B1/da not_active IP Right Cessation
- 1988-07-08 OA OA59384A patent/OA08743A/xx unknown
- 1988-07-08 IE IE210888A patent/IE60354B1/en not_active IP Right Cessation
- 1988-07-11 MA MA21565A patent/MA21323A1/fr unknown
1990
- 1990-01-08 NO NO90900077A patent/NO171556C/no not_active IP Right Cessation
- 1990-01-08 FI FI900087A patent/FI91263C/fi not_active IP Right Cessation
1992
- 1992-02-06 GR GR920400067T patent/GR3003737T3/el unknown
- 1992-12-21 US US07/994,040 patent/US6268489B1/en not_active Expired - Lifetime
1993
- 1993-11-17 LV LVP-93-1240A patent/LV10624B/xx unknown
1994
- 1994-02-22 SG SG27794A patent/SG27794G/en unknown
- 1994-11-17 HK HK127594A patent/HK127594A/en not_active IP Right Cessation
1995
- 1995-06-30 HU HU95P/P00738P patent/HU211862A9/hu unknown
- 1995-10-20 CY CY177695A patent/CY1776A/xx unknown
1998
- 1998-03-30 BA BA980213A patent/BA98213B1/bs active

Publication	Publication Date	Title
JPH0631300B6 (2)	2006-10-11
FR2628587B1 (2)	1992-11-27
FR2635881B1 (2)	1992-12-11
FR2633276B1 (2)	1994-01-21
GR3005663T3 (2)	1993-06-07
FR2631415B1 (2)	1994-08-19
FR2636569B1 (2)	1994-11-04
GR3005171T3 (2)	1993-05-24
DE3991484T (2)	1991-11-21
FR2634699B1 (2)	1994-12-23
FR2633793B1 (2)	1997-02-07
FR2638586B1 (2)	1995-04-07
CH674604GA3 (2)	1990-06-29
FR2633158B1 (2)	1992-07-03
FR2632057B1 (2)	1992-10-30
FR2631291B1 (2)	1995-03-31
FR2641127B1 (2)	1993-12-24
IN169818B (2)	1991-12-28
FR2635663B1 (2)	1991-09-27
FR2630166B1 (2)	1994-07-13
FR2629432B1 (2)	1992-05-07
FR2636418B1 (2)	1993-10-22
FR2628406B1 (2)	1991-08-16
FR2636442B1 (2)	1993-04-09
FR2635225B1 (2)	1995-04-07