JPH06319768A - Sticking material for affected part and dosing method for liquid medicine - Google Patents

Abstract

(57) [Summary] [Purpose] To ensure that liquid drugs can be administered to affected areas of the skin surface reliably and easily. [Structure] An adhesive layer is formed on one surface of a sheet-shaped substrate,
The pad is fixed on this adhesive layer. The pad has a through hole, and the base material has a dosing portion such as a hole communicating with the through hole. The through hole of the pad is positioned on the affected area and attached to the skin. The drug solution is administered to the affected area from the administration site through the through hole. This allows the drug solution to be accurately administered to the affected area. The pad wraps around the affected area to protect it from external irritation and promote healing.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch and a method for administrating a medicinal solution, which is used for protecting keratinous parts of the skin such as sea urchins and octopuses and other affected areas, and for administering a liquid drug.

[0002]

2. Description of the Related Art Conventionally, when treating keratinized skin such as sea urchins and octopuses, a keratin softening agent such as salicylic acid is held on a pad, which is applied to the affected area. Therefore, it may be difficult to adapt to the affected area. Therefore, the use of liquid medicine has become popular. In this case, the medicinal solution can be applied to any part, which is convenient, but undesired parts may be applied or dripping may occur. In addition, the keratinous part may directly touch other things and cause pain, which is not yet satisfactory.

In addition, when various kinds of liquid medicines are to be administered to an affected area, the liquid medicine is applied to a wider area than necessary or dripping occurs as described above, and an appropriate amount of the medicine is concentrated on the necessary area. Are difficult to administer, and effective treatment is often insufficient.

[0004]

Therefore, an effective treatment can be performed by protecting the affected area, concentrating the liquid drug to the affected area in a concentrated manner and reliably administering the required amount and facilitating the administration method. It is something to do.

[0005]

According to the present invention, a pad is placed on a pressure-sensitive adhesive layer provided on one surface of a base material, and the pad has a through hole so as to correspond to an affected area. The base material for fixing the pad to the affected area is formed with a hole communicating with the through hole of the pad, and this hole forms an administration portion capable of supplying a drug solution to the affected area. Apply the through hole of the pad to the affected area, and protect the affected area by sticking and fixing it on the skin, and administer the drug solution from the outside to the affected area through the through hole of the administration part and the pad, to accurately apply the drug solution. It is intended to supply and provide reliable treatment.

[0006]

EXAMPLES Examples will be described below. A pressure-sensitive adhesive layer 2 is provided on one surface of a base material 1, and a pad 3 is placed substantially at the center of the pressure-sensitive adhesive layer. The base material 1 is a plastic sheet,
A cloth, a non-woven cloth, or another sheet having an appropriate flexibility can be used, and a sheet having air permeability and appropriate stretchability is more preferable. This base material is often flesh-colored so as to be inconspicuous when it is applied to the skin described later, but other colors may be used. The pressure-sensitive adhesive layer 2 is formed by applying a pressure-sensitive adhesive such as a rubber-based, acrylic-based, or silicon-based pressure-sensitive adhesive. Generally, an acrylic-based pressure-sensitive adhesive is preferably used because it causes less irritation to the skin.

The pad 3 usually has a through hole 4 formed in the center thereof so that the horny part of the skin such as a sea urchin and an octopus and other affected parts can be positioned in the through hole. There is. What is shown is for softening the horny part such as a sea urchin and an octopus. The whole is disk-shaped, the outer diameter is about 15 to 25 mm, the diameter of the through hole (inner diameter) is about 5 to 15 mm, The thickness is formed to about 2 to 4 mm, and the circumference of the sea urchin and the like is surrounded to protect it from external stimuli. In addition, depending on the state of the affected area and the drug solution to be administered, the outer shape and the shape of the through hole may be made into a square shape, a polygonal shape, a rounded corner shape, an elliptical shape, or the like, and various shapes appropriately combining these. You can Further, the thickness may be made thinner or thicker depending on the condition of the affected area such as the amount of drug solution to be administered and the degree of necessary protection from the outside.

The pad 3 which is not impregnated with a chemical solution, which is impregnated with the chemical solution, and which is appropriately impregnated is appropriately selected according to the type of the affected area and the administered chemical solution. It is formed of a plastic foam having closed cells that are not impregnated with, for example, a foam in which closed cells are formed by foaming polyethylene about 8 to 12 times.

When the pad is fixed at an interval 5 which is equal to or larger than the thickness of the pad from the edge of the base material, the base material can be attached so as to cover the entire side surface of the pad as will be described later. There may be a case where the side surface of the is partially exposed.

This pad can be placed in a stationary state by the adhesive of the adhesive layer 2 of the base material, but in the illustrated one, a double-sided adhesive tape having a stronger adhesive action is provided between the pad 3 and the adhesive layer 2. -Put 6 or is placed with an adhesive interposed.
Further, in the illustrated pad, a double-sided adhesive tape 7 is attached to the surface side in contact with the skin, or an adhesive is applied so that it adheres well to the skin and makes it more difficult for the liquid medicine to leak, but this is omitted. You can also do it.

An administration section 9 for externally supplying the drug solution to the affected area located in the pad is provided on the base material of the area where the pad is located. In the illustrated example, the holes are formed to have the same size as the through holes of the pad, but a large number of small holes may be formed so as to communicate with the above through holes, or a large number of holes may be formed in a net shape. It is also possible to form a suitable hole form that communicates with the through hole, such as by making the hole slightly smaller than the through hole.

In such a patch 10, the surface of the adhesive layer of the base material and the surface of the pad are covered with one or a plurality of release papers 11 of two or more, and further two wrapping papers are sealed. It is advisable to enclose it in a packaging bag that is weakly adhered with an agent (not shown). In this case, if a polyethylene film, polypropylene film, polystyrene film or other transparent material is used on one side of the packaging bag, it may be convenient to check the quality of the enclosed material. Further, in the illustrated example, the release paper 12 with holes is attached to the surface of the pad, but this release paper can be omitted in some cases.

The adhesive material is peeled off by removing the release paper 11 and the release paper 12 on the pad surface so that the horny part 13 of the skin such as the sea urchin, octopus and the like enters the through hole 4 of the pad 3. Then, the tape is adhered by the double-sided adhesive tape 7 on the pad surface and the adhesive layer 2 of the base material, and fixed to the affected skin 14. The above-mentioned horny part is surrounded by a pad, and since there is also a base material on the pad, it prevents the pad from being caught even when wearing shoes, for example, even after putting it on, the affected part does not hurt and does not hit anything. However, the affected area does not hit directly and is well protected. In addition, ventilation can be favorably performed through the holes of the applied patch to promote healing, and the treatment state of the affected area can be seen at any time.

When a keratin softening drug solution containing salicylic acid or the like as the main component is dripped from the hole of the administration part 9 on the base material side of such patch, the drug solution is surely given to the keratin part through the through hole and surrounds the circumference. There is no possibility that the liquid medicine will flow out due to the pad. The solvent of the administered drug solution easily volatilizes from the administration hole, and the drug solution concentrates on the affected area to gradually soften the keratinous area. Then, depending on the progress of treatment and the state of healing, the drug solution may be further dropped from the administration section. In addition, the patch material may be replaced if necessary. In this way, the horny part softens,
After confirming that the treatment has been completed, peel it off.

In addition to the above-mentioned case of softening the keratinous area, the patch is similarly applied to the affected area for the treatment of athlete's foot, itch prevention, and other treatments, and the medicinal solution is applied to the through hole of the pad from the outside. Effective administration can be performed by administering the drug and transdermally administering the drug solution. When such a transdermal drug solution is applied, if the volume of the through-hole is adjusted, the amount of the drug solution to be administered can be naturally adjusted and regulated by putting the drug solution into the through-hole, which makes it easier to use.

In the structure shown in FIG. 5, the through hole located on the base material side of the pad is small 16, and the side in contact with the affected area is large 17.
It is in the shape of a pyramid, and the drug solution can be administered to a wide range of affected areas.

[0017]

[Prototype example] Next, an example of a prototype is shown, and the physical properties of the prototype are measured and shown. Base material: Polyurethane non-woven fabric Width 28 mm x length 72 mm, with both ends arcuate with a radius of 20 mm. Adhesive layer: Acrylic adhesive is used. Pad: Polyethylene foam (10 times closed cell foam), thickness 3mm Manufacturing method: The pad has a circular shape with an outer diameter of 20mm, and double-sided adhesive tape of the same diameter using an acrylic adhesive is attached to both sides, A small release paper fixed on the pressure-sensitive adhesive layer at the center of the base material, the surface of which was treated with silicon, was placed on the pad to form a hole having a diameter of 9 mm which penetrates the entire center of the pad. Get the patch.

With respect to the above-mentioned patch, the following items were measured. (1) Hardness of pad portion, stress relaxation rate Measuring instrument: Sun Rheometer CR-200D ((Ltd.)
(San Kagaku Co., Ltd.) Test method: The pad portion of the patch is applied with a cylindrical contactor (probe: diameter 20 mm) at an initial load of 1 at a speed of 60 mm / min.
It is compressed until it reaches kg and the strain amount (displacement amount) is maintained for 60 seconds. The hardness and the stress relaxation rate were obtained by the following formulas, and the average value of 10 samples was taken. Hardness = G (load) x 1 (sample height) / [L (displacement amount) x
a (Sample cross-sectional area)] Stress relaxation rate = [(P ₀ −P ₁ ) / P ₀ ] × 100 (P ₀ : Initial stress under constant strain amount) (P ₁ : After 60 seconds under constant strain amount) Stress)

(2) Chemical resistance Chemicals used: Collodion salicylate solution 15% Salicylic acid 85% collodion liquid Test method: The above pad is immersed in the chemicals used and the pad is visually inspected for changes such as swelling and discoloration.

[0020]

【result】

Hardness: 1.9 kgf / cm ² Displacement when a load of 1 kg is applied: 0.8 mm Stress relaxation rate: 31% Chemical resistance: No expansion or discoloration of the pad, no change.

[Discussion] The hardness of the pad part is 1.9 kgf / cm ² , which is harder than the normal one, and the displacement amount (strain amount) under the same load (1 kg) is smaller than the normal one. Since the applied relaxation rate is low, it is possible to surely protect the affected area such as the eyes of the eye, and the chemical resistance is good, so that the drug can be accurately administered.

[0021]

As described above, according to the present invention, since the patch is first applied to the affected area and the drug solution is administered from the outside, the administration is easy and reliable. Moreover, the healing state can be easily known by observing the affected area from the administration site. Also, the affected area can be protected from external stimuli, and early treatment is possible without causing pain.
Further, it can be widely used for treatment of various affected areas by a drug administration method.

[Brief description of drawings]

FIG. 1 is a perspective view showing an embodiment of the present invention.

FIG. 2 is a cross-sectional view of FIG.

FIG. 3 is a cross-sectional view of the state of FIG. 1 covered with release paper.

FIG. 4 is an explanatory diagram showing a usage state.

FIG. 5 is a cross-sectional view showing a modified example.

[Explanation of symbols]

 1 Base Material 2 Adhesive Layer 3 Pad 6,7 Double-sided Adhesive Tape 9 Dosing Part 10 Adhesive 11 Release Paper

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Terumi Reikawa 2-4, 9-2, Mindan, Chiyoda-ku, Tokyo Nichiban Co., Ltd.

Claims (6)

[Claims] 1. A sheet-shaped base material, a pressure-sensitive adhesive layer is formed on one surface of the base material, and a pad having a through hole is provided on the pressure-sensitive adhesive layer to surround the affected area. A diseased part patch, in which a hole communicating with the through hole is formed in a base material portion corresponding to the through hole. 2. A substrate having a sheet-shaped base material, a pressure-sensitive adhesive layer formed on one surface of the base material, a pad having a through-hole placed on the pressure-sensitive adhesive layer, and a base corresponding to the through-hole. A patch for administration of a drug solution, which has an administration part capable of supplying a drug solution from the outside into the through hole in the material part. 3. The affected part patch according to claim 1, wherein the pad is formed of a plastic foam having closed cells, and an adhesive layer is provided on the surface of the pad that comes into contact with the skin. 4. The substrate having an adhesive layer present around the fixed pad has a width of at least the thickness of the pad so as to cover the entire pad.
The patch for administration of a drug solution according to any one of 3 to 3. 5. A pad having a hole is applied to the horny part of the skin such as a sea urchin and an octopus, and other affected areas, and the pad is fixed to the skin with an adhesive tape that does not block the hole of the pad, and the outside is passed through the hole of the pad. A method for administering a liquid medicine to a affected area from a medicine. 6. The patch according to claim 1, wherein a pad is fixed on the adhesive layer of the adhesive tape and a hole is formed through both the pad and the adhesive tape on the horny part of the skin such as a sea urchin and an octopus, and other affected areas. A method for administering a liquid medicine, which is applied by applying a hole to a pad and externally administering the liquid medicine to the affected area through the hole.