JPH0710741A - Bath agent composition - Google Patents

Abstract

(57) [Summary] [Object] The present invention provides a bath preparation containing a cooling sensation, which has a refreshing sensation and provides analgesia, stiff shoulders, itching, sterilization, rhinitis,
It is an object to provide a bath agent effective for antiemetic and hyperactivity of the digestive tract. [Structure] The present invention is a bath agent composition comprising a cooling sensation agent and a water-soluble solvent. The concentration of the cooling sensation agent in the bath water is preferably 0.1 to 50 ppm, and the water-soluble solvent is preferably a lower alcohol or a polyhydric alcohol. Also, as a dispersion aid in a bath of a cooling sensation,
Selected from surfactants, water-soluble polymers, sugar alcohols
It is preferable to mix one kind or two or more kinds.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bath agent containing a cooling sensation, which has a refreshing sensation and is effective for analgesia, stiff shoulders, antipruritus, sterilization, rhinitis, vomiting, enhancement of digestive tract function, etc. It is related to agents.

[0002]

[Prior Art and Problems] In order to relieve body pain, stiff shoulder, etc. by taking a bath, there is no choice but to rely on a conventional bath agent having a thermal effect, and it is recommended for a user suffering from dermatitis and when using in summer. Had a problem that it was not suitable for healthy people.

On the other hand, the cooling sensation agent is generally known to have an effect of analgesia and the like, and in order to produce a bath agent containing the cooling sensation agent,
Although many attempts have been made, cooling agents are generally volatile,
It has high sublimation property, and it may come off from the formulation or recrystallize.
In addition, since it volatilizes from the bath water instantly during use, it is not effective in analgesia, and there are many problems such as irritation to the eyes and nose.

As a result of intensive studies to solve the above-mentioned problems, the inventors of the present invention have high safety and stability by adding a water-soluble solvent in order to add a cooling sensation agent to the bath agent. It was found that a bath preparation was obtained, and the present invention was completed.

That is, the present invention is as shown below.

(1) A bath agent composition comprising a cooling sensation agent and a water-soluble solvent. (2) The bath agent composition according to (1), wherein the concentration of the cooling sensation agent in the bath water is 0.1 to 50 ppm. (3) The bath agent composition according to (1) or (2), wherein the water-soluble solvent is a lower alcohol or a polyhydric alcohol. (4) As a dispersion aid in a bath of a cooling sensation agent, one or more selected from surfactants, water-soluble polymers and sugar alcohols are blended (1), (2 ) Or (3) The bath agent composition.

Hereinafter, (1), (2), (3) and (4) are collectively referred to as the bath agent composition of the present invention.

Examples of the cooling sensation agent in the present invention include menthol, camphor, thymol, menthol derivatives, etc., but the scent is particularly good, and an analgesic effect can be expected with a small amount.
l-menthol is preferred.

The water-soluble solvent in the present invention is preferably a lower alcohol or a polyhydric alcohol.

The lower alcohol is particularly preferably methanol, ethanol or propanol, and the polyhydric alcohol is propylene glycol (PG), polyethylene glycol, 1,3-butylene glycol (1,3-BG), glycerin or isoprene glycol. Hexylene glycol is particularly preferred.

By adding these water-soluble solvents, not only the safety and stability of the preparation can be improved, but also the dispersibility of the cooling sensation agent in the bath water can be improved.

The blending ratio of the cooling sensation agent is 0.1 to 50 p with respect to the bath water.
It is preferably pm and more preferably 1 to 10 ppm.

When it is less than 0.1 ppm, it is difficult to obtain the effect of alleviating pain relief and stiff shoulders, and when it is more than 50 ppm, the refreshing feeling is regarded as a burning sensation, and extreme irritation is felt, which is preferable. Absent.

The mixing ratio of the water-soluble solvent is preferably 1 part by weight or more per 1 part by weight of the cooling sensation agent.

When the mixing ratio of the water-soluble solvent is 1 part by weight or less with respect to 1 part by weight of the cooling sensation agent, the cooling sensation agent may be removed from the formulation or recrystallized, or the cooling sensation agent may be contained in the bath water. Not being dispersed, it floats on the surface of the bath and causes irritation to the eyes and nose, and also locally adheres during bathing, which causes skin irritation or discomfort, which is not preferable.

The bath agent composition of the present invention is not limited to a dosage form, and the intended effect can be obtained in any of powder form, granule form, tablet form and liquid form.

Further, the bath agent composition of the present invention comprises a dispersion aid selected from a surfactant, a water-soluble polymer and a sugar alcohol.
By blending 1 or 2 or more, it stabilizes the cooling sensation in the preparation and also keeps the cooling sensation in the bath water even during use, so the desired effects are more sustained.
To be enhanced.

Examples of the dispersion aid in the present invention include surfactants, water-soluble polymers and sugar alcohols.

Specific examples of the surfactant include those shown below.

1) Nonionic surfactant Glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, tetraoleic acid polyoxyethylene sorbit, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene Alkyl ether, polyethylene glycol fatty acid ester, polyoxyethylene castor oil, polyglycerin fatty acid ester, etc.

2) Anionic surfactant Sodium α-olefin sulfonate, sodium lauryl sulfate, sodium cetyl sulfate, sodium polyoxyethylene lauryl sulfate, disodium lauryl sulfosuccinate and the like.

3) Amphoteric surfactant: carboxybetaine type, aminocarboxylic acid, sulfobetaine type and the like.

4) Cationic Surfactant As mentioned above, any of a nonionic surfactant, an anionic surfactant, an amphoteric surfactant and a cationic surfactant can be used, but from the viewpoint of safety. It is preferred to use nonionic surfactants.

Examples of the water-soluble polymer include those shown below.

1) Natural polymer Carrageenan, dextrin, gelatin, xanthan gum, starch, guar gum, agar, mannan, casein, albumin, collagen and the like.

2) Semi-synthetic polymer Methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, cationized cellulose and other cellulose derivatives, soluble starch, methyl starch and other starch derivatives, alginates, alginic acid propylene glycol esters, etc. Alginic acid derivatives and the like.

3) Synthetic Polymers Polyvinyl alcohol, sodium polyacrylate, polyvinyl methyl ether, polyethylene oxide, polyvinylpyrrolidone, carboxyvinyl polymer and the like.

4) Inorganic substances Bentonite and the like.

Examples of sugar alcohols include maltitol, sorbitol, mannitol and the like.

In addition to the above components, the bath agent composition of the present invention may further contain inorganic salts, organic acids, oily components, vitamins, amino acids, proteolytic enzymes, herbal medicines and their extracts, and the like, if necessary. Ingredients can be added.

Specific examples thereof are shown below.

As the inorganic salts, sodium sulfate, sodium hydrogen carbonate, sodium carbonate, sodium sesquicarbonate, sodium chloride, ammonium chloride, sodium nitrate, potassium nitrate, calcium nitrate, sodium polyphosphate, sodium phosphate, sodium iron sulfate sulfate, Calcium oxide, calcium carbonate, magnesium oxide, magnesium sulfate, aluminum sulfate, sodium thiosulfate, magnesium carbonate, potassium chloride, potassium sulfide,
Examples include alum, metasilicic acid, and silicic acid anhydride.

The organic acids include benzoic acid, succinic acid,
Malic acid, fumaric acid, tartaric acid, citric acid, pyrrolidonecarboxylic acid and the like can be mentioned.

Examples of the oily component include those shown below.

1) Fats and oils Natural fats and oils such as soybean oil, bran oil, jojoba oil, avocado oil, almond oil, olive oil, cacao butter, sesame oil, persic oil, castor oil, coconut oil, mink oil, beef tallow, and pork fat,
Hardened oil obtained by hydrogenating these natural fats and oils, myristic acid glyceride, synthetic glyceride such as 2-ethylhexanoic acid glyceride, diglyceride and the like.

2) Waxes Carnauba wax, whale wax, beeswax, lanolin and the like.

3) Hydrocarbons Liquid paraffin, petrolatum, paraffin, microcrystalline wax, ceresin, squalane, pristane, etc.

4) Higher fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid, isostearic acid and the like.

5) Higher alcohols Lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, cholesterol, 2-hexyldecanol, etc.

6) Esters Cetyl octanoate, myristyl lactate, cetyl lactate, myristyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate and the like.

7) Essential oils

8) Silicone oils

As vitamins, vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin F,
Examples thereof include vitamin K, vitamin P, vitamin U, carnitine, ferulic acid, γ-oryzanol, lipoic acid, orotic acid and its derivatives.

As amino acids, glycine, alanine,
Examples include valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, tryptophan, cystine, cystine, methionine, proline, hydroxyproline, aspartic acid, glutamic acid, arginine, histidine, lysine and derivatives thereof.

Examples of proteolytic enzymes include pepsin, trypsin, chymotrypsin, cathepsin, papain, promeline, ficin, bacterial yeast, and mold protease.

Examples of the herbal medicines are soybean, sandalnut, valerian, kayi, pearl oyster, senkyu, spruce, sugi, algal, carrot, peony, peony, peppermint, saccharum, saccharum, saccharum, saccharum, saccharum, saccharum, sycamore, saccharum, saccharum, saccharus, saccharum sacrum , Juniper, deer, sycamore, saffron, oleander, fennel, cock, campi, chamomile, melissa, radish, willow, camphor tree, elderberry, socks,
Naginakokou, yamde, yam, weed, mugwort, hypericum, yuzu, red sea bream, peach, psyche, loquat, honeysuckle, yellow dragonfly, bodice, horse chestnut, yarrow, hops, rosemary, birch, kissweed corn, horse chestnut, arnica, etc. These may be the powder or the extract.

Other components include sulfur, mineral sand, yunohana, neutral clay, egg yolk powder, iris bran, mica powder, skim milk powder,
Examples include seaweed extract, fragrances, pigments, bactericides, and the like.

[0048]

EFFECTS OF THE INVENTION In the bath agent composition of the present invention, when the cooling sensation agent is used alone or in the conventionally known method, the cooling sensation agent has high volatility and sublimation property, so that it may be removed from the preparation or recrystallized. In addition, since it volatilizes from the bath water instantly during use, it does not provide analgesic effects, and it has solved problems such as irritation to the eyes and nose.

That is, the effects of using the bath agent composition of the present invention are that there is no irritation to the eyes and nose and a refreshing sensation, and that analgesia, stiff shoulders, itching, sterilization, rhinitis, antiemetic and digestive tract Examples include hyperactivity.

Next, the effects of the present invention will be described with reference to experimental examples.

Experimental Example 1 (Evaluation 1) Effervescent bath agents having the composition shown in Table 1 below (Examples 1 to 4 as the bath agent composition of the present invention and Comparative Examples 1 and 2 as comparative examples) were prepared. Then, one tablet of 40 g was produced using a single-shot tableting machine (made by Masina). The tablets were sealed and packaged one by one in a film laminated with aluminum, and the following tests were conducted.

The blending amounts (%) shown below are weight standards.

Table 1

Test 1) After storage at a temperature of 0 ° C. for 1 month, the tablet appearance (recrystallization of d-camphor) was confirmed and evaluated according to the evaluation criteria shown below.

Evaluation Criteria ○ No abnormality × d-camphor crystals are observed on the tablet surface

Test 2) Stored at a temperature of 40 ° C. and a relative humidity of 75% RH for 6 months, then opened and d-
A quantitative test of camphor was performed to confirm the release of d-camphor from the tablets, and the evaluation was performed according to the evaluation criteria shown below.

Evaluation criteria ○ d-camphor residual rate 90% or more △ d-camphor residual rate 50% or more but less than 90% × d-camphor residual rate less than 50%

The results are shown in Table 2.

Table 2

As is clear from Table 2, the bath composition of the present invention showed no abnormal tablet appearance even after being stored for 1 month.
It was excellent in stability. Also at a temperature of 40 ° C and relative humidity of 75% RH
The residual rate of d-camphor is high even after storage for 6 months, and the amount of d-camphor released from the tablets is small. On the other hand, in the comparative example in which the water-soluble solvent was not added, both stability and d-camphor residual ratio were not good.

Experimental Example 2 (Evaluation 2) Liquid bath agents having the component compositions shown in Table 3 below (Examples 5 to 9 as the bath agent composition of the present invention and Comparative Examples 3 and 4 as comparative examples) were prepared. , For 30 people who complain of stiff shoulders and low back pain, use it according to the usual method for 1 month (use 200 ml of bath water and 20 ml of the present invention)
The improvement effect and eye irritation were investigated.

The blending amounts (%) shown below are weight standards.

Table 3

The results for the effect of improving stiff shoulders and low back pain are shown in the table below.
4 and the eye irritation is shown in Table 5.

Table 4 (Amelioration effect on stiff shoulders and low back pain)

Table 5 (Irritation to eyes and nose)

As is clear from Tables 4 and 5, the bath agent composition of the present invention has an effect of improving stiff shoulders and low back pain, whereas no effect is exhibited in Comparative Examples, or nose irritation is strong. The result was obtained.

Next, examples of the production of a bath agent using the bath agent composition of the present invention are shown below, but the present invention is not limited thereto.

Example 10 (Powder Type) Sodium Sulfate 60 Maltitol 30 Silicon Dioxide Appropriate Dye Color Trace Aroma 1 Menthyl Acetate 1 Hexylene Glycol 3

Powder raw materials ~ were mixed by a Nauta mixer for 10 minutes, liquid raw materials ~ mixed in advance were added, and the mixture was stirred for 20 minutes.

Example 11 (Granular Type) Sodium Sulfate 20 Anhydrous Maltose 70 Dye Trace Aroma 1 Cismentenol 3 1,3-BG 5 Ethanol 5 Purified Water Appropriate amount

Are mixed with a universal mixer for 10 minutes,
The previously mixed ~ was added thereto, and the mixture was stirred and mixed for 30 minutes. Add more to make paste, 25 ° C
・ Lefted in a closed state for 24 hours, crushed and sieved.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Nobuyuki Nakanishi 392 Tsukiji, Fujieda City, Shizuoka Prefecture Tsumura Co., Ltd.

Claims (4)

[Claims] 1. A bath agent composition comprising a cooling sensation agent and a water-soluble solvent. 2. The concentration of the cooling sensation agent in the bath water is 0.1 to 50 ppm.
2. The bath agent composition according to claim 1, wherein 3. The bath agent composition according to claim 1 or 2, wherein the water-soluble solvent is a lower alcohol or a polyhydric alcohol. 4. The one or more selected from surfactants, water-soluble polymers and sugar alcohols is blended as a cooling aid of a cooling sensation in a bath water. The bath agent composition according to claim 2 or 3.